20 research outputs found
Following experimental stroke, the recovering brain is vulnerable to lipoxygenase‐dependent semaphorin signaling
Inhibiting 12/15-lipoxygenase to treat acute stroke in permanent and tPA induced thrombolysis models
Life-Threatening Neurological Complications after Bone Marrow Transplantation in Children
Neurological complications may occur in BMT recipients (11-59%), frequently contributing to morbidity or mortality. They are the main causes of death in 10-15%. Life-threatening neurological complications were seen in 11 out of 113 (9.7%) children who underwent BMT from HLA-matched family (n=7) or mismatched donors (n=4) at our institution. Diagnoses of patients with neurological complications were acute myeloblastic leukemia (AML) (five), thalassemia major (two), Fanconi anemia (two), Omenn syndrome (one) and leukodystrophy (one), and the neurological events were seen between days +13 and +85 after transplantation. Minor symptoms including reversible, nonrepetitive seizures were excluded. Cyclosporine A toxicity was diagnosed in six children. The rest of the complications were brain abscess/ meningoencephalitis (two), severe hypomagnesemia (one), busulfan toxicity (one), sustained hypertension (three), and intracranial hemorrhage (three). Six patients with neurological complications suffered from >grade II graft-versus-host disease (GvHD), and all were high risk for transplant-related complications. In this study, risk status of the underlying disease, mismatched transplantation, a diagnosis of AML ( advanced stage), older age and >grade II GvHD were important adverse factors for the development of severe life-threatening neurological complications.WoSScopu
Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia
Internal Reduction Established by Occiput-C<sub>2</sub> Pedicle Polyaxial Screw Stabilization in Pediatric Atlantoaxial Rotatory Fixation
Subacute Subdural Hygroma and Presyrinx Formation After Foramen Magnum Decompression With Duraplasty for Chiari Type 1 Malformation -Case Report-
Sodium sulfide prevents water diffusion abnormality in the brain and improves long term outcome after cardiac arrest in mice
Contributions of 12/15-Lipoxygenase to Bleeding in the Brain Following Ischemic Stroke
Ischemic strokes are caused by one or more blood clots that typically obstruct one of the major arteries in the brain, but frequently also result in leakage of the blood-brain barrier and subsequent hemorrhage. While it has long been known that the enzyme 12/15-lipoxygenase (12/15-LOX) is up-regulated following ischemic strokes and contributes to neuronal cell death, recent research has shown an additional major role for 12/15-LOX in causing this hemorrhagic transformation. These findings have important implications for the use of 12/15-LOX inhibitors in the treatment of stroke