16 research outputs found
Reorganization of functional brain network architecture in chronic osteoarthritis pain
Osteoarthritis (OA) manifests with chronic pain, motor impairment, and proprioceptive changes. However, the role of the brain in the disease is largely unknown. Here, we studied brain networks using the mathematical properties of graphs in a large sample of knee and hip OA (KOA, n = 91; HOA, n = 23) patients. We used a robust validation strategy by subdividing the KOA data into discovery and testing groups and tested the generalizability of our findings in HOA. Despite brain global topological properties being conserved in OA, we show there is a network wide pattern of reorganization that can be captured at the subject-level by a single measure, the hub disruption index. We localized reorganization patterns and uncovered a shift in the hierarchy of network hubs in OA: primary sensory and motor regions and parahippocampal gyrus behave as hubs and insular cortex loses its central placement. At an intermediate level of network structure, frontoparietal and cingulo-opercular modules showed preferential reorganization. We examined the association between network properties and clinical correlates: global disruption indices and isolated degree properties did not reflect clinical parameters; however, by modeling whole brain nodal degree properties, we identified a distributed set of regions that reliably predicted pain intensity in KOA and generalized to hip OA. Together, our findings reveal that while conserving global topological properties, brain network architecture reorganizes in OA, at both global and local scale. Network connectivity related to OA pain intensity is dissociated from the major hub disruptions, challenging the extent of dependence of OA pain on nociceptive signaling.CCDRN, Grant/Award Number: Norte‐08‐5369‐FSE‐000026; Unilabs Boavista and the Grünenthal Young Pain Researcher 2017 Grant; Luso‐American Development Foundation R&D@PhD Scholarship Grant; OARSI Collaborative Scholarship 201
Effects of the and of other processes on the mixing hierarchies in the four-generation model
We analyze in the four-generation model the first measurement of the
branching ratio of rare kaon decay , along with the
other processes of mass difference , CP-violating
parameter mixing, mixing,
, and the upper bound values of mixing
and , and try to search for mixing of the fourth
generation in the hierarchical mixing scheme of the Wolfenstein
parametrization. Using the results for the mixing of the fourth generation, we
discuss predictions of the mixing () and the
branching ratio of directly CP-violating decay process
, and the effects on the CP asymmetry in neutral B
meson decays and the unitarity triangle.Comment: 29 pages written in LaTex. 6 figures(drawn on LaTeX). Revised from
" in the four-generation model" of the same
Authors(TOKUSHIMA 99-1, January 1999). A minor chang
CP violation effect in long-baseline neutrino oscillation in the four-neutrino model
We investigate CP-violation effect in the long-baseline neutrino oscillation
in the four-neutrino model with mass scheme of the two nearly degenerate pairs
separated with the order of 1 eV, by using the data from the solar neutrino
deficit, the atmospheric neutrino anomaly and the LSND experiments along with
the other accelerator and reactor experiments. By use of the most general
parametrization of the mixing matrix with six angles and six phases, we show
that the genuine CP-violation effect could attain as large as 0.3 for and that the matter effect is negligibly
small such as at most 0.01 for for , which is the mass-squared difference relevant
to the long-baseline oscillation.Comment: 21 pages in LaTeX, 9 ps figures. Some changes in the Introduction and
Reference
New Physics in CP Asymmetries and Rare B Decays
We review and update the effects of physics beyond the standard model on CP
asymmetries in B decays. These asymmetries can be significantly altered if
there are important new-physics contributions to \bqbqbar mixing. This same new
physics will therefore also contribute to rare, flavor-changing B decays.
Through a study of such decays, we show that it is possible to partially
distinguish the different models of new physics.Comment: 42 pages, plain TeX (macros included), 1 figure (included). A few
sentences added, references updated. Present manuscript is now identical to
the version accepted for publication in Phys. Rev.