Temporal profile of endogenous anatomical repair and functional recovery following spinal cord injury in adult zebrafish

Regenerated cerebrospinal axons are considered to be involved in the spontaneous recovery of swimming ability following a spinal cord injury in adult zebrafish. We employed behavioral analysis, neuronal tracing, and immunocytochemistry to determine the exact temporal relationship between swimming ability and regenerated cerebrospinal axon number in adult zebrafish with a complete spinal cord transection. Between two and eight weeks post-lesion, swimming gradually improved to 44% of sham-injured zebrafish. Neurons within the reticular formation, magnocellular octaval nucleus, and nucleus of the medial longitudinal fascicle grew their axon across and at least four millimeters beyond the lesion. The largest increases in swimming ability and number of regenerated cerebrospinal axons were observed between two and four weeks post-lesion. Regression analyses revealed a significant correlation between swimming ability and the number of regenerated axons. Our results indicate the involvement of cerebrospinal axons in swimming recovery after spinal cord injury in adult zebrafish. © 2014 Vajn et al

Effect of Spinal Cord Tissue Preservation by Bone Marrow Stromal Cells on Functional Recovery After Spinal Cord Contusion in Rats: More Is Better

Neurological Motor Disorder

Bone Marrow Stromal Cell-Mediated Tissue Sparing Enhances Functional Repair After Spinal Cord Contusion in Adult Rats

Neurological Motor Disorder