PENERAPAN MESIN PENGERING JAGUNG UNTUK PETANI TEBUWUNG

Extend the shelf life of food products so that they can be consumed longer. Corn is an important food commodity in Tebuwung Village, Dukun District, Gresik Regency because it is a food other than rice. To extend the shelf life of corn, it is necessary to go through a drying process. One of the drying equipment that can be used is rotary rotating type dryer (rotary dryer). The heat source of the dryer can come from corn stalks to reduce the scent as a source of burning heat. The problem is there is no available drying equipment suitable for corn drying in Tebuwung Village, Dukun District, Gresik Regency. For this reason, a study was conducted to design a rotary type drying machine for heat-sourced corn originating from the burning of corn cobs. This study aims to produce a rotary type corn drying machine with a source of burning corn cobs. The test parameter is the rotating drying cylinder which affects the drying time of corn in the drying chamber. Through this research, a rotary type drying machine has been produced for drying corn in Tebuwung Village, Dukun District, Gresik Regency. The test results with a rotating cylinder speed ratio of 1400 rpm and 280 rpm are 42 minutes long drying and require power of 522.85 watts with electricity costs of Rp. 500.24 for 900 VA and Rp. 542,936 for 1,300 VA powe

Relationship between Affective Commitment and Work Engagement in Employees of Savings and Loans Cooperatives in Kupang City

Micro, Small, and Medium Enterprises (MSME) and cooperatives in NTT, especially in the city of Kupang, have a strategic role in the economic development of the community, especially in overcoming poverty. This makes organizations pay important attention to Organizational Commitment, especially the affective commitment that employees have so that services can be carried out properly. This study aims to determine the relationship between affective commitment and work engagement among cooperative employees in Kupang City. The type of research used is quantitative research with correlational methods. Sampling using purposive sampling technique with a total sample of 81 employees who work in cooperatives in Kupang City. Data collection used is a modification of the affective commitment scale developed by Meyer, Allen & Smith (1993) and an adaptation of the work engagement scale developed by Schaufeli & Bakker (2004). The analysis technique uses Pearson Product Moment Correlation and shows that there is a significant relationship between affective commitment and work engagement where the Pearson Correlation value= 0.225 with a significance of 0.044. This shows that employees who work in cooperatives in Kupang City have high work engagement and affect the level of affective commitment shown in the cooperative where they work

Perbedaan Efektivitas Antibiotik Pada Terapi Demam Tifoid Di Puskesmas Bancak Kabupaten Semarang Tahun 2014

There are differences on the use of antibiotics on typhoid fever's treatment. However, there was a research concluded that there were no differences between the efficacy of antibiotics on typhoid fever's therapy that shown as fever-free time and treatment duration. The purposes of this study are to determine the various antibiotics that used on typhoid fever's treatment and to compare the efficacy of that antibiotic at Bancak Public Health Center Semarang regency. This study was an analytically survey research, with retrospective data collection from medical records, used purposive sampling method. The research sample was all adult patients' typhoid fever hospitalization at Bancak Public Health Center Semarang regency. Data of antibiotic's efficacy in fever-free time and treatment duration were analyzed with Kruskal-Wallis test. The result showed that the antibiotics used on typhoid fever's treatment at Bancak Public Health Center Semarang regency were chloramphenicol, amoxicillin, cefotaxime, ceftriaxone, and ampicillin. Ceftriaxone was an antibiotic that provided the shortest fever's free-time and duration of treatment. However, there was no statistically significant difference between efficacy of that antibiotics at Bancak Public Health Center Semarang regency (p>0.05)

Akupresure pada Remaja untuk Mengurangi Nyeri Haid

Dysmenorrhea is a medical condition that occurs during menstruation or menstruation which can interfere with activities and require treatment. Dysmenorrhea is characterized by pain or pain in the abdomen or hips, menstrual pain that is cramping and is centered on the lower abdomen. Cramping pain that is felt before or during menstruation can also be pain in the buttocks. Pain in the stomach, nausea, vomiting, diarrhea, dizziness or even fainting. Menstrual pain has a significant impact on young women because it disrupts daily activities. Young women who are experiencing menstrual pain as well as participating in learning activities can cause learning activities to be disrupted, lackluster, decreased concentration and even difficulty concentrating so that the material delivered during learning cannot be well received even to those who do not attend school. The purpose of this program is to provide education and understanding to young women related to dysmenorrhea by providing appropriate non-pharmacological interventions, namely acupressure techniques. The implementation method used is online using whatsapp media group. After community service is done to the teenage daughter to overcome menstrual pain / disminore with acupressure techniques. Evaluation results indicate that the value of A obtained as many as 13 people (81%) have good knowledge and those who get a value of B as many as 3 people (19%) have less knowledge. It is expected that young women can find out how to handle disminore in order to be able to carry out daily activities at school and at home. AbstrakDismenore adalah kondisi medis yang terjadi sewaktu haid atau menstruasi yang dapat mengganggu aktifitas dan memerlukan pengobatan. Dismenore ditandai dengan nyeri atau rasa sakit di daerah perut atau pinggul, nyeri haid yang bersifat kram dan berpusat pada perut bagian bawah. Nyeri kram yang terasa sebelum atau selama menstruasi bisa juga nyeri pada pantat. Rasa nyeri pada bagian dalam perut, mual, muntah, diare, pusing atau bahkan pingsan. Nyeri haid memiliki dampak yang cukup besar bagi remaja putri karena meyebabkan terganggunya aktivitas sehari-hari. Remaja putri yang sedang mengalami nyeri haid sekaligus mengikuti kegiatan pembelajaran dapat menyebabkan aktivitas pembelajaran menjadi terganggu, tidak bersemangat, konsentrasi menjadi menurun bahkan sulit berkonsentrasi sehingga materi yang disampaikan selama pembelajaran tidak dapat diterima dengan baik bahkan sampai ada yang tidak masuk sekolah. Tujuan program ini adalah untuk memberikan edukasi dan pemahaman pada remaja putri yang berkaitan dengan dismenore dengan pemberian intervensi yang tepat secara non farmakologis yaitu dengan teknik akupresure. Metode pelaksanaan yang digunakan adalah dengan secara daring menggunakan media group whatsapp. Setelah dilakukan pengabdian masyarakat pada remaja puteri untuk mengatasi nyeri haid/disminore dengan teknik akupresure. Hasil evaluasi Menunjukkan bahwa nilai A didapatkan sebanyak 13 orang (81%) memiliki pengetahuan yang baik dan yang mendapatkan nilai B sebanyak 3 orang (19%) memiliki pengetahuan kurang. Diharapkan remaja putri dapat mengetahui cara penanganan disminore agar dapat melakukan aktivitas sehari-hari disekolah maupun diruma

Akupresure pada Remaja untuk Mengurangi Nyeri Haid

Dysmenorrhea is a medical condition that occurs during menstruation or menstruation which can interfere with activities and require treatment. Dysmenorrhea is characterized by pain or pain in the abdomen or hips, menstrual pain that is cramping and is centered on the lower abdomen. Cramping pain that is felt before or during menstruation can also be pain in the buttocks. Pain in the stomach, nausea, vomiting, diarrhea, dizziness or even fainting. Menstrual pain has a significant impact on young women because it disrupts daily activities. Young women who are experiencing menstrual pain as well as participating in learning activities can cause learning activities to be disrupted, lackluster, decreased concentration and even difficulty concentrating so that the material delivered during learning cannot be well received even to those who do not attend school. The purpose of this program is to provide education and understanding to young women related to dysmenorrhea by providing appropriate non-pharmacological interventions, namely acupressure techniques. The implementation method used is online using whatsapp media group. After community service is done to the teenage daughter to overcome menstrual pain / disminore with acupressure techniques. Evaluation results indicate that the value of A obtained as many as 13 people (81%) have good knowledge and those who get a value of B as many as 3 people (19%) have less knowledge. It is expected that young women can find out how to handle disminore in order to be able to carry out daily activities at school and at home. AbstrakDismenore adalah kondisi medis yang terjadi sewaktu haid atau menstruasi yang dapat mengganggu aktifitas dan memerlukan pengobatan. Dismenore ditandai dengan nyeri atau rasa sakit di daerah perut atau pinggul, nyeri haid yang bersifat kram dan berpusat pada perut bagian bawah. Nyeri kram yang terasa sebelum atau selama menstruasi bisa juga nyeri pada pantat. Rasa nyeri pada bagian dalam perut, mual, muntah, diare, pusing atau bahkan pingsan. Nyeri haid memiliki dampak yang cukup besar bagi remaja putri karena meyebabkan terganggunya aktivitas sehari-hari. Remaja putri yang sedang mengalami nyeri haid sekaligus mengikuti kegiatan pembelajaran dapat menyebabkan aktivitas pembelajaran menjadi terganggu, tidak bersemangat, konsentrasi menjadi menurun bahkan sulit berkonsentrasi sehingga materi yang disampaikan selama pembelajaran tidak dapat diterima dengan baik bahkan sampai ada yang tidak masuk sekolah. Tujuan program ini adalah untuk memberikan edukasi dan pemahaman pada remaja putri yang berkaitan dengan dismenore dengan pemberian intervensi yang tepat secara non farmakologis yaitu dengan teknik akupresure. Metode pelaksanaan yang digunakan adalah dengan secara daring menggunakan media group whatsapp. Setelah dilakukan pengabdian masyarakat pada remaja puteri untuk mengatasi nyeri haid/disminore dengan teknik akupresure. Hasil evaluasi Menunjukkan bahwa nilai A didapatkan sebanyak 13 orang (81%) memiliki pengetahuan yang baik dan yang mendapatkan nilai B sebanyak 3 orang (19%) memiliki pengetahuan kurang. Diharapkan remaja putri dapat mengetahui cara penanganan disminore agar dapat melakukan aktivitas sehari-hari disekolah maupun diruma

Defisiensi Besi dan Anemia Defisiensi Besi pada Anak Remaja Obes

Latar belakang. Remaja merupakan kelompok risiko tinggi untuk mengalami defisiensi besi. Obesitas pada remaja meningkatkan risiko defisiensi besi akibat perbedaan pola asupan dan inflamasi kronik derajat rendah. Tujuan. Mengetahui status besi dan asupan besi remaja obes usia 15 -17 tahun. Metode. Penelitian potong lintang pada remaja usia 15 – 17 tahun di dua SMU Jakarta Pusat pada bulan September – November 2015. Subjek dibagi menjadi 2 kelompok berdasarkan indeks massa tubuh (IMT). Subjek dinyatakan obes bila IMT≥P95 dan non-obes bila IMT ≥P5 - <P85. Kepada subjek dilakukan penilaian status besi, yaitu hemoglobin, mean corpusculus volume (MCV), besi serum, feritin, saturasi transferin, dan total iron bonding capacity (TIBC) serta analisis diet. Hasil. Sebanyak 100 subyek memenuhi kriteria inklusi yang terdiri dari 52 subjek obes dan 48 subjek non-obes. Tidak terdapat perbedaan bermakna proporsi defisiensi besi dan anemia defisiensi besi pada kelompok obes dan non-obes (9,6% vs 16,7%; p=0,295). Tidak terdapat perbedaan bermakna asupan zat besi total kelompok obes dan non-obes ( 8 (2,6 – 95,9) mg/hari vs 10 (1,8 – 83,4) mg/hari; p=0,188). Persentase asupan zat besi hem kelompok obes lebih tinggi dibandingkan kelompok non-obes (31 (0,0 – 95,6)% vs 20 (15,2 – 100,0)%; p=0,029). Kesimpulan. Tidak terdapat perbedaan proporsi defisiensi besi dan anemia defisiensi besi pada remaja obes dan non obes usia 15 – 17 tahun. Tidak terdapat perbedaan rerata asupan zat besi remaja obes dan non-obes usia 15 – 17 tahun

High Level of Perforin Expression Is Required for Effective Correction of Hemophagocytic Lymphohistiocytosis

Perforin-1 mutations result in a potentially fatal hemophagocytic lymphohistiocytosis (HLH) with heightened immune activation, hypercytokinemia, pancytopenia, and end-organ damage. At present, hematopoietic stem cell (HSC) transplantation is curative, but limited by donor availability and associated mortality, making gene therapy an attractive alternative approach for HLH. We reported that perforin expression driven by cellular promoters in lentiviral (LV) vectors resulted in significant, albeit partial, correction of the inflammatory features in a murine model of HLH. We hypothesized that the level of perforin expression achieved per cell from ectopic moderate-strength cellular promoters (phosphoglycerate kinase gene/perforin-1 gene) is inadequate and thus engineered an LV vector using a viral promoter (MND; a modified Moloney murine leukemia virus long terminal repeat with myeloproliferative sarcoma virus enhancer) containing microRNA126 target sequences to restrict perforin expression in HSCs. We show here that the MND-LV vector restored perforin expression to normal levels in a perforin-deficient human natural killer cell line and perforin gene-corrected Perforin1(-/-) transplant recipients, whereas cellular promoters drove only partial correction. On lymphocytic choriomeningitis virus challenge, the clinical scores and survival improved only with the MND-LV vector, but inflammatory markers and cytotoxicity were improved with all LV vectors. Our studies suggest that although moderate levels of expression can result in partial amelioration of the HLH phenotype, high levels of perforin expression per cell are required for complete correction of HLH

An A91V SNP in the perforin gene is frequently found in NK/T-cell lymphomas

NK/T-cell lymphoma (NKTCL) is the most frequent EBV-related NK/T-cell disease. Its clinical manifestations overlap with those of familial haemophagocytic lymphohistiocytosis (FHLH). Since PERFORIN (PRF1) mutations are present in FHLH, we analysed its role in a series of 12 nasal and 12 extranasal-NKTCLs. 12.5% of the tumours and 25% of the nasal-origin cases had the well-known g.272C>T(p.Ala91Val) pathogenic SNP, which confers a poor prognosis. Two of these cases had a double-CD4/CD8-positive immunophenotype, although no correlation was found with perforin protein expression. p53 was overexpressed in 20% of the tumoral samples, 80% of which were of extranasal origin, while none showed PRF1 SNVs. These results suggest that nasal and extranasal NKTCLs have different biological backgrounds, although this requires validation

Animal models for aberrations of gonadotropin action

During the last two decades a large number of genetically modified mouse lines with altered gonadotropin action have been generated. These mouse lines fall into three categories: the lack-of-function mice, gain-of-function mice, and the mice generated by breeding the abovementioned lines with other disease model lines. The mouse strains lacking gonadotropin action have elucidated the necessity of the pituitary hormones in pubertal development and function of gonads, and revealed the processes from the original genetic defect to the pathological phenotype such as hypo- or hypergonadotropic hypogonadism. Conversely, the strains of the second group depict consequences of chronic gonadotropin action. The lines vary from those expressing constitutively active receptors and those secreting follicle-stimulating hormone (FSH) with slowly increasing amounts to those producing human choriogonadotropin (hCG), amount of which corresponds to 2000-fold luteinizing hormone (LH)/hCG biological activity. Accordingly, the phenotypes diverge from mild anomalies and enhanced fertility to disrupted gametogenesis, but eventually chronic, enhanced and non-pulsatile action of both FSH and LH leads to female and male infertility and/or hyper- and neoplasias in most of the gonadotropin gain-of-function mice. Elevated gonadotropin levels also alter the function of several extra-gonadal tissues either directly or indirectly via increased sex steroid production. These effects include promotion of tumorigenesis in tissues such as the pituitary, mammary and adrenal glands. Finally, the crossbreedings of the current mouse strains with other disease models are likely to uncover the contribution of gonadotropins in novel biological systems, as exemplified by the recent crossbreed of LHCG receptor deficient mice with Alzheimer disease mice