Antecedents of hospital admission for deliberate self-harm from a 14-year follow-up study using data-linkage

Antecedents of hospital admission for deliberate self-harm from a 14-year follow-up study using data-linkageFrancis Mitrou1 email, Jennifer Gaudie1 email, David Lawrence1,2 email, Sven R Silburn1,2 email, Fiona J Stanley1 email and Stephen R Zubrick1,2 email1 Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia. PO Box 855, West Perth, WA. 6872, Australia2 Centre for Developmental Health, Curtin Health Innovation Research Institute, Curtin University of Technology, Perth, Western Australia, Australiaauthor email corresponding author emailBMC Psychiatry 2010, 10:82doi:10.1186/1471-244X-10-82The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-244X/10/82Received: 22 April 2010Accepted: 18 October 2010Published: 18 October 2010© 2010 Mitrou et al; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Season of Sampling and Season of Birth Influence Serotonin Metabolite Levels in Human Cerebrospinal Fluid

BACKGROUND: Animal studies have revealed seasonal patterns in cerebrospinal fluid (CSF) monoamine (MA) turnover. In humans, no study had systematically assessed seasonal patterns in CSF MA turnover in a large set of healthy adults. METHODOLOGY/PRINCIPAL FINDINGS: Standardized amounts of CSF were prospectively collected from 223 healthy individuals undergoing spinal anesthesia for minor surgical procedures. The metabolites of serotonin (5-hydroxyindoleacetic acid, 5-HIAA), dopamine (homovanillic acid, HVA) and norepinephrine (3-methoxy-4-hydroxyphenylglycol, MPHG) were measured using high performance liquid chromatography (HPLC). Concentration measurements by sampling and birth dates were modeled using a non-linear quantile cosine function and locally weighted scatterplot smoothing (LOESS, span = 0.75). The cosine model showed a unimodal season of sampling 5-HIAA zenith in April and a nadir in October (p-value of the amplitude of the cosine = 0.00050), with predicted maximum (PC(max)) and minimum (PC(min)) concentrations of 173 and 108 nmol/L, respectively, implying a 60% increase from trough to peak. Season of birth showed a unimodal 5-HIAA zenith in May and a nadir in November (p = 0.00339; PC(max) = 172 and PC(min) = 126). The non-parametric LOESS showed a similar pattern to the cosine in both season of sampling and season of birth models, validating the cosine model. A final model including both sampling and birth months demonstrated that both sampling and birth seasons were independent predictors of 5-HIAA concentrations. CONCLUSION: In subjects without mental illness, 5-HT turnover shows circannual variation by season of sampling as well as season of birth, with peaks in spring and troughs in fall

Dopamine D4 Receptor Gene Associated with Fairness Preference in Ultimatum Game

In experimental economics, the preference for reciprocal fairness has been observed in the controlled and incentivized laboratory setting of the ultimatum game, in which two individuals decide on how to divide a sum of money, with one proposing the share while the second deciding whether to accept. Should the proposal be accepted, the amount is divided accordingly. Otherwise, both would receive no money. A recent twin study has shown that fairness preference inferred from responder behavior is heritable, yet its neurogenetic basis remains unknown. The D4 receptor (DRD4) exon3 is a well-characterized functional polymorphism, which is known to be associated with attention deficit hyperactivity disorder and personality traits including novelty seeking and self-report altruism. Applying a neurogenetic approach, we find that DRD4 is significantly associated with fairness preference. Additionally, the interaction among this gene, season of birth, and gender is highly significant. This is the first result to link preference for reciprocal fairness to a specific gene and suggests that gene × environment interactions contribute to economic decision making

Adolescent predictors of adult social and psychiatric adversities:a prospective follow-up study of the Northern Finland 1966 Birth Cohort

Abstract The aim of this study was to investigate, using a longitudinal design, the possible long-term effects of adolescent family background, school performance and substance use on educational performance, psychiatric disorders and substance use related problems during adulthood. A large, prospectively collected general population birth cohort (n = 11017), the Northern Finland 1966 Birth cohort, was used as study population. The database provided information on features of the primary family. The information on the cohort members' school performance, smoking, alcohol use and other substance use was obtained from a questionnaire mailed to the cohort members in 1980. Also information on school performance in various school subjects was obtained at the end of compulsory schooling at the age of 16. The level of education by the age of 31 was gathered from the national Registry of Educational Statistics in Finland. The relevant data for drunk driving offences were collected from the Ministry of Justice files. The Finnish Hospital Discharge Register was used to identify all hospital-treated psychiatric patients. Parental divorce increased the risk of adult educational underachievement. Other family background factors such as unwanted pregnancy, low maternal education and large family size were also associated with low adult educational performance. A history of drunk driving offences was associated both with impaired school performance in adolescence and with educational underachievement in early adulthood. Adolescent regular alcohol use, smoking and other substance use increased the risk for drunk driving offences and hospital-treated substance use disorders in adulthood. The smoking rate among psychiatric patients was about 1.5 times higher than among control subjects without psychiatric hospital treatment. The proportion of smokers was about 50% among subjects with schizophrenia. The initiation age of regular smoking was closely related to the age of onset of schizophrenia, but not to other mental disorders. Among schizophrenia patients the increased likelihood of smoking was associated with paternal smoking in the family environment, but not with any other background factors. Low overall mean scores and low combined mathematical and natural science scores at the end of compulsory school were associated with adult regular smoking among schizophrenia patients. This study gives new information on risk factors that affect educational attainment, substance use related problems and psychiatric morbidity within the developmental pathway from adolescence to adulthood

Itsetuhoisuuden ja itsensä vahingoittamisen eri muodot

Tiivistelmä Suomalainen Itsemurhien ehkäisyn ja itsemurhaa yrittäneen Käypä hoito -suositus määrittelee itsetuhoisuuden laajasti pyrkimykseksi tai käyttäytymiseksi, johon sisältyy itsensä vahingoittaminen tai tarkoituksellinen henkeä uhkaavan riskin ottaminen. Itsetuhoisuudella tarkoitetaan itsemurha-ajatuksia, itsemurhasta puhumista, keskeytynyttä itsemurhayritystä, itsemurhayritystä ja itsemurhaa. Vaikka itsetuhoiseen tekoon jollain hetkellä ei liittyisi lainkaan pyrkimystä kuolla, voi kuolemanpyrkimys ilmetä samalla henkilöllä myöhemmin

Adolescence predictors for drug crime offending:a follow-up study of former adolescent psychiatric inpatients

Abstract Our aim was to examine adolescent predictors (family- and school-related factors, substance use, and psychiatric disorders) for drug crime offending. The initial study population consisted of 508 former adolescent psychiatric inpatients aged between 13 and 17 years. Of them, 60 (12%) had committed a drug crime by young adulthood and they were matched with 120 (24%) non-criminal controls by sex, age and family type. During adolescent hospitalization, study participants were interviewed using valid semi-structured research instruments. Criminal records were obtained from the Finnish Legal Register Centre up to young adulthood. A distant relationship with a father, lying, and thieving, moderate/high nicotine dependence and weekly use of stimulants were shown to be the most prominent predictors for drug crime offending. Our findings encourage the use of modern child- and family-centered approaches in preventing youth involvement in illegal drug use and drug crimes

Profile of substance misuse among adolescent and young adult gabapentinoid users:a register-based follow-up study of former adolescent psychiatric inpatients

Abstract Aims: Our study examined characteristics of adolescent and young adult study participants using gabapentinoids (gabapentin, pregabalin), with previous history of adolescent psychiatric inpatient hospitalization. Particular focus was on temporal association of age, at first prescription for gabapentinoids, to age at tobacco smoking initiation, regular alcohol use, diagnosis of substance dependence and prescriptions for benzodiazepines and opioids. Methods: The initial study population contained 508 adolescents (300 females, 208 males) admitted to psychiatric inpatient care in Oulu University hospital between the ages 13–17 years. Register-based follow-up information on prescriptions for gabapentinoids, benzodiazepines and opioids, as well as ICD-10 diagnosis for hospital-treated substance dependence, was obtained from the Finnish national health care registers. Results: The users of gabapentinoids accounted for 9.1% of the initial study population. Of adolescence-related characteristics, suicidal ideation, suicide attempts and non-suicidal self-injury was emphasized in females using gabapentinoids. The majority of participants using gabapentinoids had benzodiazepines (80.4%) and opioids (71.7%) as comorbid drugs. Initiation of tobacco smoking and alcohol use and first prescriptions for of benzodiazepines and opioids, and a diagnosis of substance dependence commonly predated first prescriptions for gabapentinoids. Conclusions: In clinical practice, the decision to prescribe gabapentinoids to adolescents or young adults must be made with caution, particularly for those with substance use problems and/or without a clinically approved indication