Novel Biomarkers to Understand Cardiovascular Complications in Diabetes

Diabetic subjects have shown two- to fourfold increased risk of cardiovascular diseases (CVDs) than without diabetes. Diabetes can be prevented if detected early at prediabetes stage. Progression of diabetes not only causes hyperglycaemia; it also increased the risk of macrovascular and microvascular complications. Different mechanisms, i.e. inflammation, abnormal adipocyte signalling, insulin resistance, endothelial dysfunction, and oxidative stress, are involved in the progression of diabetes and associated cardiovascular complication. These mechanisms alter different signalling molecules in blood and other body fluids. These altered molecules offer potential biomarkers for the identification and early detection of the disease progression. If we are able to detect the early biomarkers based on the alteration of different mediators responsible for cardiac complications in diabetes, we can prevent the cardiac diseases in diabetes by selective therapy. Different kinds of biomarkers, i.e. miRNA, protein, metabolites, cytokines, and adipokines, can be used together to detect the different stages of the disease. In the present book chapter, we are explaining briefly about characteristics of biomarkers and their applications and different approaches that were used to identify biomarkers. Different existing and novel biomarkers and their scope to detect patients with prediabetes, diabetes and cardiovascular complication in diabetes have been discussed

Consumer Acceptance of Genetically Modified Foods in South Korea: Factor and Cluster Analysis

This study extends biotechnology discourse to cover South Korea in the Asian sub-continent showing a marked difference in perceptions between traditional and GM foods. Factor analysis suggests South Koreans may treat foods that are locally produced and those with no artificial flavors or colorings preferentially to GM foods. Additionally, South Koreans have concerns about perceived risks related to biotechnology, and, given a choice, they may pay more to avoid GM foods. Cluster analysis results yielded four consumer segments: (a) ardent supporters of the attribute of “naturalness†in foods, (b) those apprehensive about biotechnology, (c) the food adventurous, and (d) information seekers about biotechnology.consumer perceptions, factor and cluster analysis, food attributes, genetic modification, Consumer/Household Economics, Food Consumption/Nutrition/Food Safety,

CONSUMER ACCEPTANCE OF GENETICALLY MODIFIED FOODS IN KOREA: FACTOR AND CLUSTER ANALYSIS

The study applies multivariate statistical and econometric tools to estimate the importance of the various factors driving Korean consumer acceptance of GM food products. The evidence thus far on biotechnology is decidedly mixed: public perceptions of food biotechnology are characterized by ongoing tension between opposing forces. The South Korean perceptions about food in general and ranges from excitement about the promise of environmental and economic benefits from GM products to fear and distrust of the technology for unknown risks. This highlights the importance of credibility of private and public institutions responsible for certifying the safety of GM foods and implementing necessary regulatory controls on GM processes and products. In between, many people are undecided, trying to learn more about the issues and reach a definitive position. Encouraging though is that some people are eager to try new foods. Koreans strongly favors food naturalness, familiarity, and access just as the west countries. Results suggest that the South Korean Consumer priorities with respect to various biotechnology and general food issues are related to their socioeconomic and value attributes. This implies that, at least in the near term, there will be considerable divergence within the society in terms of acceptance of food biotechnology. The finding that large segments of the Korean society are either not fully informed or interested in learning more about biotechnology calls for a public education program. A program that may play a constructive role in not only informing consumers but help them in arriving at a socially optimal collective decisions on the wisdom and desirability of food biotechnology.Research and Development/Tech Change/Emerging Technologies,

PUBLIC APPROVAL OF PLANT AND ANIMAL BIOTECHNOLOGY IN KOREA: AN ORDERED PROBIT ANALYSIS

This study analyzes predictors of Korean public acceptance of the use of biotechnology to create genetically modified food products. Results indicate that the consumers with above average knowledge of specific outcomes of genetic modification were more likely than those with inaccurate or no knowledge to approve use of plant or animal genetic modification for the creation of new food products. Young South Koreans consumers (ages 20 to 29 years old) were more likely than old consumers (ages 50 to 59) to approve use of biotechnology to create both plant and animal based foods. Further, those Koreans in favor of GM labeling were less likely to approve the use of biotechnology for the creation of food products. The results also suggest that public trust and confidence on various institutions associated with biotechnology is critical for the future of the technology. There was some evidence of differential biotechnology approval among consumers of different residential areas, income levels and political affiliation. Thus, those in cities, those with incomes above 40 million Won, and of liberal political affiliation were found to be more approving of animal biotechnology.Research and Development/Tech Change/Emerging Technologies,

Effect of Curing On the Strength Behaviour of Lime-Fly Ashexpansive Soil Mixes

Expansive soils occupying almost 3 lakh km2 in the Indian subcontinent found to be highly problematic due to their extensive swelling and shrinkage nature. This rapid volume change leads to upliftment of foundations, differential settlements, heaving, rutting, etc. on the overlying structures. Concerning with the above problems an effective, economical and long-term method lime stabilisation was selected. In this work it is attempted to study the effect of curing period on the strength behaviour expansive soil treated with lime and fly ash by conducting triaxial shear (UU) test for 0, 3, 7, 14, 28 days with some twenty different proportions

Bio-Analytical Method Development of Repaglinide Drug Delivery Systems

A sensitive, specific and rapid high-performance liquid chromatography-ultraviolet spectroscopy method was developed and successfully validated to estimate the repaglinide in rabbit plasma. The solvent extraction method was used for  repaglinide from serum by using ethyl acetate and 0.1N HCl. The mobile phase consists of acetonitrile: phosphate buffer pH 4.0 at 60:40 %v/v with 1% triethylamine at flow rate of 0.8ml/min and at fixed wavelength of 254nm. On ten minutes of run time, repaglinide was retention at 7.4min. The extraction efficiency 95% for repaglinide. The intra-day and inter-day precision was in the terms of %RSD less than 1.76%. The developed method was validated and proposed method is useful for pharmacokinetics studies.  Keywords: Anti-diabetics, HPLC,Methanol,Phosphate buffer, Repaglinid

Documents matches "Temperature- and pressure-dependent Study of 35Cl NQR Frequency and Spin Lattice Relaxation Time in 2,3-dichloroanisole

The temperature and pressure dependence of 35Cl NQR frequency and spin lattice relaxation time (T1) were investigated in 2,3-dichloroanisole. Two NQR signals were observed throughout the temperature and pressure range studied. T1 were measured in the temperature range from 77 to 300 K and from atmospheric pressure to 5 kbar. Relaxation was found to be due to the torsional motion of the molecule and also reorientation of motion of the CH3 group. T1 versus temperature data were analyzed on the basis of Woessner and Gutowsky model, and the activation energy for the reorientation of the CH3 group was estimated. The temperature dependence of the average torsional lifetimes of the molecules and the transition probabilities were also obtained.NQR frequency shows a nonlinear behavior with pressure, indicating both dynamic and static effects of pressure. The pressure coefficients were observed to be positive for both the lines. A thermodynamic analysis of the data was carried out to determine the constant volume temperature coefficients of the NQR frequency. The variation of spin lattice time with pressure was very small, showing that the relaxation is mainly due to the torsional motions of the molecules

Protecting big data mining association rules using fuzzy system

Recently, big data is granted to be the solution to opening the subsequent large fluctuations of increase in fertility. Along with the growth, it is facing some of the challenges. One of the significant problems is data security. While people use data mining methods to identify valuable information following massive database, people further hold the necessary to maintain any knowledge so while not to be worked out, like delicate common itemsets, practices, taxonomy tree and the like Association rule mining can make a possible warning approaching the secrecy of information. So, association rule hiding methods are applied to evade the hazard of delicate information misuse. Various kinds of investigation already prepared on association rule protecting. However, maximum of them concentrate on introducing methods with a limited view outcome for inactive databases (with only existing information), while presently the researchers facing the problem with continuous information. Moreover, in the era of big data, this is essential to optimize current systems to be suited concerning the big data. This paper proposes the framework is achieving the data anonymization by using fuzzy logic by supporting big data mining. The fuzzy logic grouping the sensitivity of the association rules with a suitable association level. Moreover, parallelization methods which are inserted in the present framework will support fast data mining process

Bearing Capacity of A Strip Footing Resting On Treated And Untreated Soils

Expansive soils are highly susceptible to volumetric changes leading to rapid loss in the bearing capacity of footings resting on them. Among several techniques available to treat expansive soils, lime or fly ash stabilization gained prominence during the past few decades due to its abundance and adaptability. Chemical stabilization is widely used to treat expansive soils as it develops base exchange and cementation processes between clay particles.When expansive soils are treated with chemicals, it is essential to obtain the load-settlement response of footing resting on stabilized ground. In this study, Finite Element Analysis is performed using the commercial software, PLAXIS 2D, to obtain the load-settlement response of a strip footing resting on untreated and treated expansive soil. The bearing capacity of strip footing resting on treated soil is found to be about 150% higher than that of footing resting on untreated soil

¿Es capaz el mindfulness de reducir la intensidad de juicio y el efecto de falso consenso?

Treball Final de Grau en Psicologia. Codi: PS1048. Curs acadèmic: 2016/2017El mindfulness es, por definición, la acción de prestar atención completa a la experiencia presente de una forma particular, con un propósito y sin hacer juicios o evaluaciones de los eventos privados experimentados y de los estímulos externos relacionados con estos eventos privados. Este ejercicio es una técnica de relajación que, en numerosos estudios, ha demostrado ser capaz de producir efectos positivos en el ámbito laboral, educativo y sanitario. Sin embargo, es escasa la literatura que explica los mecanismos cognitivos a los que afecta esta técnica y que explicarían estos efectos. Algunos de los estudios que pretenden dar una explicación a tales efectos han demostrado que el mindfulness es capaz de mejorar las capacidades cognitivas y los procesos atencionales. En lo referido a procesos atributivos, se ha demostrado que algunos de los sesgos atributivos elementales, como el sesgo de correspondencia, se reducen de forma significativa con la práctica de esta técnica dada la capacidad para otorgar a sus practicantes la habilidad de realizar observaciones centradas en el momento presente e impedir en gran medida la actuación de mecanismos automáticos de prejuicio y estereotipación. El presente estudio pretende conocer en qué medida es capaz el mindfulness de modificar la intensidad con la que las personas emiten juicios morales, así como a cometer errores atributivos, en concreto el efecto de falso consenso. Para este cometido se ha contado con una muestra de 440 participantes y se han utilizado herramientas como el cuestionario MINDSENS, la Escala de Necesidad de Cognición y cuestionarios de elaboración propia donde los participantes debían emitir juicios, considerar el consenso social existente y situar estas respuestas en una dimensión de intensidad. Los resultados obtenidos reflejan una reducción significativa del efecto de falso consenso en los participantes meditadores. Sin embargo, no se aprecian diferencias en la intensidad de los juicios emitidos entre meditadores y no meditadores.Mindfulness is, by definition, the action of paying attention to the actual experience in a particular way, with a purpose and without making judgments or evaluations of the experienced private events and the external stimuli related to these private events. This exercise is a relaxation technique that, in many studies, has shown to be able to produce positive effects in the labor, educational and health field. However, there are not many literature explaining the cognitive mechanisms that affect this technique and explain these effects. Some of the studies that attempt to explain the stories have shown that mindfulness is capable of improving cognitive abilities and attentional processes. With regard to attributive processes, it has been shown that some of the biases of elemental attributions, such as correspondence bias, are significantly reduced with the practice of this technique given the ability to give its practitioners the ability to perform observations centered on the present moment and greatly impede the performance of automatic mechanisms of prejudice and stereotyping. The present study intends to know to what extent the mindfulness is able to modify the intensity with which people emit moral judgments, as well as to commit attributive errors, in particular the effect of false consensus. For this purpose, a sample of 440 participants has used tools such as the MINDSENS questionnaire, the Cognition Need Scale and the self-elaboration questionnaires where participants should make judgments, consider the existing social consensus and find these answers in An intensity dimension The results obtained reflect a significant reduction of the effect of false consensus on the meditator participants. However, there are no differences in the intensity of the judgments emitted between meditators and non-meditators