A frictional Cosserat model for the flow of granular materials through a vertical channel

A rigid-plastic Cosserat model has been used to study dense, fully developed flow of granular materials through a vertical channel. Frictional models based on the classical continuum do not predict the occurrence of shear layers, at variance with experimental observations. This feature has been attributed to the absence of a material length scale in their constitutive equations. The present model incorporates such a material length scale by treating the granular material as a Cosserat continuum. Thus localised couple stresses exist and the stress tensor is asymmetric. The velocity profiles predicted by the model are in close agreement with available experimental data. The predicted dependence of the shear layer thickness on the width of the channel is in reasonable agreement with data. In the limit of the ratio of the particle diameter to the half-width of the channel being small, the model predicts that the shear layer thickness scaled by the particle diameter grows.Comment: 17 pages, 12 PostScript figures, uses AmsLaTeX, psfrag and natbib. Accepted for publication in Acta Mechanic

A frictional Cosserat model for the slow shearing of granular materials

A rigid-plastic Cosserat model for slow frictional flow of granular materials, proposed by us in an earlier paper, has been used to analyse plane and cylindrical Couette flow. In this model, the hydrodynamic fields of a classical continuum are supplemented by the couple stress and the intrinsic angular velocity fields. The balance of angular momentum, which is satisfied implicitly in a classical continuum, must be enforced in a Cosserat continuum. As a result, the stress tensor could be asymmetric, and the angular velocity of a material point may differ from half the local vorticity. An important consequence of treating the granular medium as a Cosserat continuum is that it incorporates a material length scale in the model, which is absent in frictional models based on a classical continuum. Further, the Cosserat model allows determination of the velocity fields uniquely in viscometric flows, in contrast to classical frictional models. Experiments on viscometric flows of dense, slowly deforming granular materials indicate that shear is confined to a narrow region, usually a few grain diameters thick, while the remaining material is largely undeformed. This feature is captured by the present model, and the velocity profile predicted for cylindrical Couette flow is in good agreement with reported data. When the walls of the Couette cell are smoother than the granular material, the model predicts that the shear layer thickness is independent of the Couette gap H when the latter is large compared to the grain diameter dp. When the walls are of the same roughness as the granular material, the model predicts that the shear layer thickness varies as (H/dp)1/3 (in the limit H/dp [dbl greater-than sign] 1) for plane shear under gravity and cylindrical Couette flow

Primary Sources of Polycyclic Aromatic Hydrocarbons to Streambed Sediment in Great Lakes Tributaries Using Multiple Lines of Evidence

Polycyclic aromatic hydrocarbons (PAHs) are among the most widespread and potentially toxic contaminants in Great Lakes (USA/Canada) tributaries. The sources of PAHs are numerous and diverse, and identifying the primary source(s) can be difficult. The present study used multiple lines of evidence to determine the likely sources of PAHs to surficial streambed sediments at 71 locations across 26 Great Lakes Basin watersheds. Profile correlations, principal component analysis, positive matrix factorization source-receptor modeling, and mass fractions analysis were used to identify potential PAH sources, and land-use analysis was used to relate streambed sediment PAH concentrations to different land uses. Based on the common conclusion of these analyses, coal-tar-sealed pavement was the most likely source of PAHs to the majority of the locations sampled. The potential PAH-related toxicity of streambed sediments to aquatic organisms was assessed by comparison of concentrations with sediment quality guidelines. The sum concentration of 16 US Environmental Protection Agency priority pollutant PAHs was 7.4-196 000 mu g/kg, and the median was 2600 mu g/kg. The threshold effect concentration was exceeded at 62% of sampling locations, and the probable effect concentration or the equilibrium partitioning sediment benchmark was exceeded at 41% of sampling locations. These results have important implications for watershed managers tasked with protecting and remediating aquatic habitats in the Great Lakes Basin.Environ Toxicol Chem2020;00:1-17. (c) 2020 The Authors.Environmental Toxicology and Chemistrypublished by Wiley Periodicals LLC on behalf of SETAC.Peer reviewe

Bench- and pilot-scale evaluation of mercury speciation measurement methods

The 1990 Clean Air Act Amendments require the US Environmental Protection Agency (EPA) to assess the health risks associated with mercury. Since the rate of mercury deposition and the type of control strategies used may depend on the type of mercury species emitted, a proven sampling method that can reliably and accurately speciate mercury at the very low concentrations found in coal combustion flue gas is necessary. A number of mercury speciation methods have been proposed, including wet-chemistry methods, such as EPA Method 29, the Ontario Hydro method, and the tris-buffer method, as well as dry methods such as the Mercury Speciation Absorption method (MESA). In addition, a number of companies are developing continuous emissions monitors to speciate mercury by difference. Bench- and pilot-scale tests, sponsored by the Electric Power Research Institute (EPRI) and the US Department of Energy (DOE), are currently under way at the Energy and Environmental Research Center (EERC) to determine the most accurate and precise mercury speciation method available. The overall objective of the test program is to determine whether EPA Method 29 or other sampling methods can reliably quantify and speciate mercury in flue gas from coal-fired boilers at both the inlet and outlet of a particulate control device such as a pulse-jet baghouse. A specific goal of the project is to determine the precision and bias of the various mercury speciation methods as a function of process variables

Gastrointestinal perforation in metastatic colorectal cancer patients with peritoneal metastases receiving bevacizumab

Published online: May 7, 2015Aim: To investigate the safety and efficacy of adding bevacizumab to first-line chemotherapy in metastatic colorectal cancer patients with peritoneal disease. Methods: We compared rates of gastrointestinal perforation in patients with metastatic colorectal cancer and peritoneal disease receiving first-line chemotherapy with and without bevacizumab in three distinct cohorts: (1) the AGITG MAX trial (Phase III randomised clinical trial comparing capecitabine vs capecitabine and bevacizumab vs capecitabine, bevacizumab and mitomycinC); (2) the prospective Treatment of Recurrent and Advanced Colorectal Cancer (TRACC) registry (any first-line regimen ± bevacizumab); and (3) two cancer centres in New South Wales, Australia [Macarthur Cancer Therapy Centre and Liverpool Cancer Therapy Centre (NSWCC) from January 2005 to Decenber 2012, (any first-line regimen ± bevacizumab). For the AGITG MAX trial capecitabine was compared to the other two arms (capecitabine/bevacizumab and capecitabine/bevacizumab/mitomycinC). In the AGITG MAX trial and the TRACC registry rates of gastrointestinal perforation were also collected in patients who did not have peritoneal metastases. Secondary endpoints included progression-free survival, chemotherapy duration, and overall survival. Time-to-event outcomes were estimated using the Kaplan-Meier method and compared using the log-rank test. Results: Eighty-four MAX, 179 TRACC and 69 NSWCC patients had peritoneal disease. There were no gastrointestinal perforations recorded in either the MAX subgroup or the NSWCC cohorts. Of the patients without peritoneal disease in the MAX trial, 4/300 (1.3%) in the bevacizumab arms had gastrointestinal perforations compared to 1/123 (0.8%) in the capecitabine alone arm. In the TRACC registry 3/126 (2.4%) patients who had received bevacizumab had a gastrointestinal perforation compared to 1/53 (1.9%) in the chemotherapy alone arm. In a further analysis of patients without peritoneal metastases in the TRACC registry, the rate of gastrointestinal perforations was 9/369 (2.4%) in the chemotherapy/bevacizumab group and 5/177 (2.8%) in the chemotherapy alone group. The addition of bevacizumab to chemotherapy was associated with improved progression-free survival in all three cohorts: MAX 6.9 m vs 4.9 m, HR = 0.64 (95%CI: 0.42-1.02); P = 0.063; TRACC 9.1 m vs 5.5 m, HR = 0.61 (95%CI: 0.37-0.86); P = 0.009; NSWCC 8.7 m vs 6.8 m, HR = 0.75 (95%CI: 0.43-1.32); P = 0.32. Chemotherapy duration was similar across the groups. Conclusion: Patients with peritoneal disease do not appear to have an increased risk of gastrointestinal perforations when receiving first-line therapy with bevacizumab compared to systemic therapy alone.Aflah Roohullah, Hui-Li Wong, Katrin M Sjoquist, Peter Gibbs, Kathryn Field, Ben Tran, Jeremy Shapiro, Joe Mckendrick, Desmond Yip, Louise Nott, Val Gebski, Weng Ng, Wei Chua, Timothy Price, Niall Tebbutt, Lorraine Chantril

Intra- and inter-individual genetic differences in gene expression

Genetic variation is known to influence the amount of mRNA produced by a gene. Given that the molecular machines control mRNA levels of multiple genes, we expect genetic variation in the components of these machines would influence multiple genes in a similar fashion. In this study we show that this assumption is correct by using correlation of mRNA levels measured independently in the brain, kidney or liver of multiple, genetically typed, mice strains to detect shared genetic influences. These correlating groups of genes (CGG) have collective properties that account for 40-90% of the variability of their constituent genes and in some cases, but not all, contain genes encoding functionally related proteins. Critically, we show that the genetic influences are essentially tissue specific and consequently the same genetic variations in the one animal may up-regulate a CGG in one tissue but down-regulate the same CGG in a second tissue. We further show similarly paradoxical behaviour of CGGs within the same tissues of different individuals. The implication of this study is that this class of genetic variation can result in complex inter- and intra-individual and tissue differences and that this will create substantial challenges to the investigation of phenotypic outcomes, particularly in humans where multiple tissues are not readily available.

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Comparative and functional analysis of intron-mediated enhancement signals reveals conserved features among plants

Introns in a wide range of organisms including plants, animals and fungi are able to increase the expression of the gene that they are contained in. This process of intron-mediated enhancement (IME) is most thoroughly studied in Arabidopsis thaliana, where it has been shown that enhancing introns are typically located near the promoter and are compositionally distinct from downstream introns. In this study, we perform a comprehensive comparative analysis of several sequenced plant genomes. We find that enhancing sequences are conserved in the multi-cellular plants but are either absent or unrecognizable in algae. IME signals are preferentially located towards the 5′-end of first introns but also appear to be enriched in 5′-UTRs and coding regions near the transcription start site. Enhancing introns are found most prominently in genes that are highly expressed in a wide range of tissues. Through site-directed mutagenesis in A. thaliana, we show that IME signals can be inserted or removed from introns to increase or decrease gene expression. Although we do not yet know the specific mechanism of IME, the predicted signals appear to be both functional and highly conserved