1,578 research outputs found
Predicting pharmacy naloxone stocking and dispensing following a statewide standing order, Indiana 2016
BACKGROUND:
While naloxone, the overdose reversal medication, has been available for decades, factors associated with its availability through pharmacies remain unclear. Studies suggest that policy and pharmacist beliefs may impact availability. Indiana passed a standing order law for naloxone in 2015 to increase access to naloxone.
OBJECTIVE:
To identify factors associated with community pharmacy naloxone stocking and dispensing following the enactment of a statewide naloxone standing order.
METHODS:
A 2016 cross-sectional census of Indiana community pharmacists was conducted following a naloxone standing order. Community, pharmacy, and pharmacist characteristics, and pharmacist attitudes about naloxone dispensing, access, and perceptions of the standing order were measured. Modified Poisson and binary logistic regression models attempted to predict naloxone stocking and dispensing, respectively.
RESULTS:
Over half (58.1%) of pharmacies stocked naloxone, yet 23.6% of pharmacists dispensed it. Most (72.5%) pharmacists believed the standing order would increase naloxone stocking, and 66.5% believed it would increase dispensing. Chain pharmacies were 3.2 times as likely to stock naloxone. Naloxone stocking was 1.6 times as likely in pharmacies with more than one full-time pharmacist. Pharmacies where pharmacists received naloxone continuing education in the past two years were 1.3 times as likely to stock naloxone. The attempted dispensing model yielded no improvement over the constant-only model.
CONCLUSIONS:
Pharmacies with larger capacity took advantage of the naloxone standing order. Predictors of pharmacist naloxone dispensing should continue to be explored to maximize naloxone access
Notes on Reproduction in the Brownback Salamander (Eurycea aquatica)
Life history data often are lacking for species with an uncertain taxonomic status. As phylogenetic analyses improve and our understanding of species boundaries become more refined, ecological information should likewise keep pace. Here, we report information on the timing of reproduction, clutch size, and nest attendance for the Brownback Salamander (Eurycea aquatica), a species recently documented to be a separate lineage after a long, controversial systematic history. We confirm that this species has the largest clutch size of any lineage within the Eurycea bislineata complex, and suggest that male and male-female nest attendance is not uncommon in this species. We suggest that, in addition to the genetic divergence documented between E. aquatica and other members of the E. bislineata complex, ecological differences also are present and possibly are influenced by the unique springs inhabited by Brownback Salamanders
Notes on Reproduction in the Brownback Salamander (Eurycea aquatica)
Life history data often are lacking for species with an uncertain taxonomic status. As phylogenetic analyses improve and our understanding of species boundaries become more refined, ecological information should likewise keep pace. Here, we report information on the timing of reproduction, clutch size, and nest attendance for the Brownback Salamander (Eurycea aquatica), a species recently documented to be a separate lineage after a long, controversial systematic history. We confirm that this species has the largest clutch size of any lineage within the Eurycea bislineata complex, and suggest that male and male-female nest attendance is not uncommon in this species. We suggest that, in addition to the genetic divergence documented between E. aquatica and other members of the E. bislineata complex, ecological differences also are present and possibly are influenced by the unique springs inhabited by Brownback Salamanders
Nonlocal effects in the shot noise of diffusive superconductor - normal-metal systems
A cross-shaped diffusive system with two superconducting and two normal
electrodes is considered. A voltage is applied between the normal
leads. Even in the absence of average current through the superconducting
electrodes their presence increases the shot noise at the normal electrodes and
doubles it in the case of a strong coupling to the superconductors. The
nonequilibrium noise at the superconducting electrodes remains finite even in
the case of a vanishingly small transport current due to the absence of energy
transfer into the superconductors. This noise is suppressed by
electron-electron scattering at sufficiently high voltages.Comment: 4 pages, RevTeX, 2 eps figure
Full Current Statistics in Diffusive Normal-Superconductor Structures
We study the current statistics in normal diffusive conductors in contact
with a superconductor. Using an extension of the Keldysh Green's function
method we are able to find the full distribution of charge transfers for all
temperatures and voltages. For the non-Gaussian regime, we show that the
equilibrium current fluctuations are enhanced by the presence of the
superconductor. We predict an enhancement of the nonequilibrium current noise
for temperatures below and voltages of the order of the Thouless energy
E_Th=D/L^2. Our calculation fully accounts for the proximity effect in the
normal metal and agrees with experimental data. We demonstrate that the
calculation of the full current statistics is in fact simpler than a concrete
calculation of the noise.Comment: 4 pages, 2 figures (included
Coherent low-energy charge transport in a diffusive S-N-S junction
We have studied the current voltage characteristics of diffusive mesoscopic
Nb-Cu-Nb Josephson junctions with highly-transparent Nb-Cu interfaces. We
consider the low-voltage and high-temperature regime eV<\epsilon_{c}<k_{B}T
where epsilon_{c} is the Thouless energy. The observed excess current as well
as the observed sub-harmonic Shapiro steps under microwave irradiation suggest
the occurrence of low-energy coherent Multiple Andreev Reflection (MAR).Comment: 4 pages, 4 figures, final versio
Multiple Andreev Reflection and Giant Excess Noise in Diffusive Superconductor/Normal-Metal/Superconductor Junctions
We have studied superconductor/normal metal/superconductor (SNS) junctions
consisting of short Au or Cu wires between Nb or Al banks. The Nb based
junctions display inherent electron heating effects induced by the high thermal
resistance of the NS boundaries. The Al based junctions show in addition
subharmonic gap structures in the differential conductance dI/dV and a
pronounced peak in the excess noise at very low voltages V. We suggest that the
noise peak is caused by fluctuations of the supercurrent at the onset of
Josephson coupling between the superconducting banks. At intermediate
temperatures where the supercurrent is suppressed a noise contribution ~1/V
remains, which may be interpreted as shot noise originating from large multiple
charges.Comment: 7 pages, 7 figures, extended versio
Two-dimensional array of diffusive SNS junctions with high-transparent interfaces
We report the first comparative study of the properties of two-dimensional
arrays and single superconducting film - normal wire - superconducting film
(SNS) junctions. The NS interfaces of our SNS junctions are really high
transparent, for superconducting and normal metal parts are made from the same
material (superconducting polycrystalline PtSi film). We have found that the
two-dimensional arrays reveal some novel features: (i) the significant
narrowing of the zero bias anomaly (ZBA) in comparison with single SNS
junctions, (ii) the appearance of subharmonic energy gap structure (SGS), with
up to n=16 (eV=\pm 2\Delta/n), with some numbers being lost, (iii) the
transition from 2D logarithmic weak localization behavior to metallic one. Our
experiments show that coherent phenomena governed by the Andreev reflection are
not only maintained over the macroscopic scale but manifest novel pronounced
effects as well. The behavior of the ZBA and SGS in 2D array of SNS junctions
strongly suggests that the development of a novel theoretical approach is
needed which would self-consistently take into account the distribution of the
currents, the potentials, and the superconducting order parameter.Comment: RevTex, 5 pages, 5 figure
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MicroRNAs Located in the Hox Gene Clusters Are Implicated in Huntington's Disease Pathogenesis
Transcriptional dysregulation has long been recognized as central to the pathogenesis of Huntington's disease (HD). MicroRNAs (miRNAs) represent a major system of post-transcriptional regulation, by either preventing translational initiation or by targeting transcripts for storage or for degradation. Using next-generation miRNA sequencing in prefrontal cortex (Brodmann Area 9) of twelve HD and nine controls, we identified five miRNAs (miR-10b-5p, miR-196a-5p, miR-196b-5p, miR-615-3p and miR-1247-5p) up-regulated in HD at genome-wide significance (FDR q-value<0.05). Three of these, miR-196a-5p, miR-196b-5p and miR-615-3p, were expressed at near zero levels in control brains. Expression was verified for all five miRNAs using reverse transcription quantitative PCR and all but miR-1247-5p were replicated in an independent sample (8HD/8C). Ectopic miR-10b-5p expression in PC12 HTT-Q73 cells increased survival by MTT assay and cell viability staining suggesting increased expression may be a protective response. All of the miRNAs but miR-1247-5p are located in intergenic regions of Hox clusters. Total mRNA sequencing in the same samples identified fifteen of 55 genes within the Hox cluster gene regions as differentially expressed in HD, and the Hox genes immediately adjacent to the four Hox cluster miRNAs as up-regulated. Pathway analysis of mRNA targets of these miRNAs implicated functions for neuronal differentiation, neurite outgrowth, cell death and survival. In regression models among the HD brains, huntingtin CAG repeat size, onset age and age at death were independently found to be inversely related to miR-10b-5p levels. CAG repeat size and onset age were independently inversely related to miR-196a-5p, onset age was inversely related to miR-196b-5p and age at death was inversely related to miR-615-3p expression. These results suggest these Hox-related miRNAs may be involved in neuroprotective response in HD. Recently, miRNAs have shown promise as biomarkers for human diseases and given their relationship to disease expression, these miRNAs are biomarker candidates in HD
Current noise in long diffusive SNS junctions in the incoherent MAR regime
Spectral density of current fluctuations at zero frequency is calculated for
a long diffusive SNS junction with low-resistive interfaces. At low
temperature, T << Delta, the subgap shot noise approaches linear voltage
dependence, S=(2/ 3R)(eV + 2Delta), which is the sum of the shot noise of the
normal conductor and voltage independent excess noise. This result can also be
interpreted as the 1/3-suppressed Poisson noise for the effective charge q =
e(1+2Delta/eV) transferred by incoherent multiple Andreev reflections (MAR). At
higher temperatures, anomalies of the current noise develop at the gap
subharmonics, eV = 2Delta/n. The crossover to the hot electron regime from the
MAR regime is analyzed in the limit of small applied voltages.Comment: improved version, to be published in Phys. Rev.
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