Acoustics of Sound Production and of Hearing in the Bladder Cicada Cystosoma Saundersii (Westwood)

The male cicada of the species Cystosoma saundersii has a grossly enlarged, hollow abdomen and emits a loud calling song with a fundamental frequency of about 800 Hz. At the song frequency, its hearing is nondirectional. The female of C. saundersii lacks sound producing organs, has no enlargement of the abdomen, but possesses an abdominal air sac and has well developed directional hearing at the frequency of the species' song. Physical mechanisms are proposed that explain these observations in semi-quantitative detail using the standard method of electrical network analogues. The abdomen in the male, with its enclosed air, is found to act as a system resonant at the song frequency, thus contributing a large gain in radiated sound intensity. Coupling between this resonator and the auditory tympana accounts for the observed hearing sensitivity in the male, but destroys directionality. In the female, the abdominal cavity acts in association with the two auditory tympana as part of a phase shift network which results in appreciable directionality of hearing at the unusually low frequency of the male song

A Dark Web of Personality: Network Analyses of Dark Personality Features and Pathological Personality Traits

Network analysis offers an opportunity to gain a more nuanced view of the connections between the darker aspects of personality by examining the interrelationships between the components that make up these constructs. We examined the associations that five dark personality dispositions (i.e., narcissism, Machiavellianism, psychopathy, sadism, and spitefulness) had with pathological personality traits (i.e., antagonism, disinhibition, detachment, negative affectivity, and psychoticism) via network analysis. These dark personality networks were examined in four studies (N = 1,800), wherein the second study attempted to replicate the network from the first study, while the last two studies incorporated more specific and independent measures of dark personality features (e.g., grandiose and vulnerable narcissism). Although there were differences across network structures in these studies, the pathological personality trait of antagonism consistently evinced high expected influence centrality (i.e., it was the most strongly connected and possibly influential trait in each network). Our discussion focuses on the implications of these results for the understanding of the connections between the darker aspects of personality

Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes.

The ratio of monocytes and lymphocytes (ML ratio) in peripheral blood is associated with tuberculosis and malaria disease risk and cancer and cardiovascular disease outcomes. We studied anti-mycobacterial function and the transcriptome of monocytes in relation to the ML ratio. Mycobacterial growth inhibition assays of whole or sorted blood were performed and mycobacteria were enumerated by liquid culture. Transcriptomes of unstimulated CD14 + monocytes isolated by magnetic bead sorting were characterised by microarray. Transcript expression was tested for association with ML ratio calculated from leucocyte differential counts by linear regression. The ML ratio was associated with mycobacterial growth in vitro (β = 2.23, SE 0.91, p = 0.02). Using sorted monocytes and lymphocytes, in vivo ML ratio (% variance explained R(2) = 11%, p = 0.02) dominated over in vitro ratios (R(2) = 5%, p = 0.10) in explaining mycobacterial growth. Expression of 906 genes was associated with the ML ratio and 53 with monocyte count alone. ML-ratio associated genes were enriched for type-I and -II interferon signalling (p = 1.2 × 10(− 8)), and for genes under transcriptional control of IRF1, IRF2, RUNX1, RELA and ESRRB. The ML-ratio-associated gene set was enriched in TB disease (3.11-fold, 95% CI: 2.28-4.19, p = 5.7 × 10(− 12)) and other inflammatory diseases including atopy, HIV, IBD and SLE. The ML ratio is associated with distinct transcriptional and anti-mycobacterial profiles of monocytes that may explain the disease associations of the ML ratio

Strangers of the north: South Asians, cricket and the culture of ‘Yorkshireness’

As a county, Yorkshire is what Wagg and Russell refer to as a ‘cultural region’: an imagined space, where culture is constructed, refined and articulated by a set of discursive relationships between local populations and a whole range of cultural forms. In this context however, culture is conceived as something which belongs to, and is only accessible by, certain groups of people. Our focus in this article is on the culture of Yorkshire cricket. Historically, Yorkshire cricket has been linked with white male privilege and some studies have shown that people within Yorkshire take a degree of pride in this. Consequently, the county and its cricket club have faced frequent accusations from minority ethnic communities of inveterate and institutionalised racism. Drawing upon Bauman’s notion of ‘liquid modernity’, we argue that the processes of deregulation and individualisation championed by New Right policies have led to a divorce between power and politics, a corner stone of the old solid modern world. This in turn has led to an erosion of the state, causing individuals to navigate turbulent life projects which are consistently haunted by the spectres of fear and insecurity. Such an environment has caused cricket to be pushed further behind gated social spaces, in an attempt to maintain a semblance of ‘community’

Optimising physiotherapy for people with lateral elbow tendinopathy - Results of a mixed-methods pilot and feasibility randomised controlled trial (OPTimisE)

The OPTimisE intervention was developed to address uncertainty regarding the most effective physiotherapy treatment strategy for people with Lateral Elbow Tendinopathy (LET). To assess the feasibility of conducting a fully-powered randomised controlled trial (RCT) evaluating whether the OPTimisE intervention is superior to usual physiotherapy treatment for adults with LET. A mixed-methods multi-centred, parallel pilot and feasibility RCT, conducted in three outpatient physiotherapy departments in the UK. Patients were independently randomised 1:1 in mixed blocks, stratified by site, to the OPTimisE intervention or usual care. Outcomes were assessed using pre-defined feasibility progression criteria. 50 patients were randomised (22 Female, 28 Male), mean age 48 years (range 27-75). Consent rate was 71% (50/70), fidelity to intervention 89% (16/18), attendance rate in the OPTimisE group 82% (55/67) vs 85% (56/66) in usual care, outcome measure completion 81% (39/48) at six-month follow-up. There were no related adverse events. Patients and physiotherapists reported that the OPTimisE intervention was acceptable but suggested improvements to the trial design. 49 patients were recruited from physiotherapy referrals vs one from primary care records. Outcome measure return rates were higher when completed online (74%) compared to postal questionnaire (50%). Exploratory analysis showed improvements in both groups over time. It is methodologically feasible to conduct a fully powered RCT comparing the clinical and cost-effectiveness of the OPTimisE intervention versus usual physiotherapy treatment. Considering the similar improvements observed in both groups, careful consideration is needed regarding the priority research question to be addressed in future research. [Abstract copyright: Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

How skilful are nowcasting satellite applications facility products for tropical Africa?

Satellite nowcasting potentially provides a vital opportunity to mitigate against the risks of severe weather in tropical Africa, where population growth and climate change are exposing an ever growing number of people to weather hazards. Numerical weather prediction demonstrates limited skill for much of Africa and weather radars are rare. However, geostationary satellites provide excellent spatial and temporal coverage of the often long‐lasting convective storms that deliver heavy rain, lightning and strong winds, presenting a valuable opportunity for satellite nowcasting. Here, we evaluate the skill of satellite nowcasting products for tropical Africa: these products are routinely generated, but to our best knowledge never routinely used in tropical Africa before the Global Challenges Research Fund African SWIFT (Science for Weather Information and Forecasting Techniques) project. Focusing in particular on convective rainfall rate (CRR) and rapidly developing thunderstorm convection warning (RDT‐CW) products, we demonstrate that both are useful nowcasting tools. The CRR product produces very different rainfall climatologies for day and night in tropical Africa. This is associated with greater skill of the product during daytime, particularly for heavier rain rates. The RDT‐CW product is able to identify around 60% of heavy (>5 mm·hr−1) rainfall events with the fraction detected increasing with increasing rainfall rate. For both products, extrapolation forwards in time (up to 90 and 60 min, respectively) maintains useful skill in tropical Africa, motivating work to develop longer lead‐time nowcasts. We conclude that widespread uptake of satellite nowcasting could provide new skilful weather predictions on short time‐scales in much of tropical Africa

Activation of Ventral Tegmental Area 5-HT2C Receptors Reduces Incentive Motivation

FUNDING AND DISCLOSURE The research was funded by Wellcome Trust (WT098012) to LKH; and National Institute of Health (DK056731) and the Marilyn H. Vincent Foundation to MGM. The University of Michigan Transgenic Core facility is partially supported by the NIH-funded University of Michigan Center for Gastrointestinal Research (DK034933). The remaining authors declare no conflict of interest. ACKNOWLEDGMENTS We thank Dr Celine Cansell, Ms Raffaella Chianese and the staff of the Medical Research Facility for technical assistance. We thank Dr Vladimir Orduña for the scientific advice and technical assistance.Peer reviewedPublisher PD

Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1.

BACKGROUND: Influenza A viruses cause occasional pandemics and frequent epidemics. Licensed influenza vaccines that induce high antibody titers to the highly polymorphic viral surface antigen hemagglutinin must be re-formulated and readministered annually. A vaccine providing protective immunity to the highly conserved internal antigens could provide longer-lasting protection against multiple influenza subtypes. METHODS: We prepared a Modified Vaccinia virus Ankara (MVA) vector encoding nucleoprotein and matrix protein 1 (MVA-NP+M1) and conducted a phase I clinical trial in healthy adults. RESULTS: The vaccine was generally safe and well tolerated, with significantly fewer local side effects after intramuscular rather than intradermal administration. Systemic side effects increased at the higher dose in both frequency and severity, with 5 out of 8 volunteers experiencing severe nausea/vomiting, malaise, or rigors. Ex vivo T-cell responses to NP and M1 measured by IFN-γ ELISPOT assay were significantly increased after vaccination (prevaccination median of 123 spot-forming units/million peripheral blood mononuclear cells, postvaccination peak response median 339, 443, and 1443 in low-dose intradermal, low-dose intramuscular, and high-dose intramuscular groups, respectively), and the majority of the antigen-specific T cells were CD8(+). CONCLUSIONS: We conclude that the vaccine was both safe and remarkably immunogenic, leading to frequencies of responding T cells that appear to be much higher than those induced by any other influenza vaccination approach. Further studies will be required to find the optimum dose and to assess whether the increased T-cell response to conserved influenza proteins results in protection from influenza disease

Virtual environment navigation with look-around mode to explore new real spaces by people who are blind

Background. This paper examines the ability of people who are blind to construct a mental map and perform orientation tasks in real space by using Nintendo Wii technologies to explore virtual environments. The participant explores new spaces through haptic and auditory feedback triggered by pointing or walking in the virtual environments and later constructs a mental map, which can be used to navigate in real space. Methods. The study included 10 participants who were congenitally or adventitiously blind, divided into experimental and control groups. The research was implemented by using virtual environments exploration and orientation tasks in real spaces, using both qualitative and quantitative methods in its methodology. Results. The results show that the mode of exploration afforded to the experimental group is radically new in orientation and mobility training; as a result 60% of the experimental participants constructed mental maps that were based on map model, compared to only 30% of the control group participants. Conclusion. Using technology that enabled them to explore and to collect spatial information in a way that does not exist in real space influenced the ability of the experimental group to construct a mental map based on the map model