98 research outputs found
Recurrent goiter and amenorrhea-galactorrhea Syndrome in a patient with a thyrotrophin- and prolactin-producing pituitary adenoma
Determination of the chemical equator from GEOS-Chem model simulation: a focus on the tropical western Pacific region
The tropical western Pacific (TWP) plays an important role in global stratosphere–troposphere exchange and is an active region of the interhemispheric transport (IHT). Common indicators for transport between the hemispheres like the tropical rain belt are too broad or lack precision in the TWP. In this paper, we provide a method to determine the atmospheric chemical equator (CE), which is a boundary for air mass transport between the two hemispheres in the tropics. This method used the model output from an artificial passive tracer simulated by the chemical transport model GEOS-Chem in the troposphere. We investigated the movement of the CE in the tropics, which indicates the migration of atmospheric circulation systems and air mass origins. Our results show the CE on different timescales, suggesting that the different features of the IHT in different regions are highly related to the variation in the circulation systems. We compared the CE with the tropical wind fields, indicating that the region of IHT does not coincide with the convergence of the 10 m wind fields in the tropical land sectors and the TWP region. We compared the CE with the atmospheric composition such as satellite data of CH4 and model simulation of sulfur hexafluoride (SF6). The results show that the CE and north–south gradient of CH4 in the Indian Ocean in January are well consistent with each other, which indicates the CE has good potential to estimate the IHT inferred by observations. We discussed the vertical extent and the meridional extent of the IHT. We find that the vertical structure above 2 km has a slight northern tilt in the Northern Hemisphere (NH) winter season and a southern tilt in the NH summer, meaning the seasonality of the migration of the CE at the lower altitude is larger than that at the higher altitude. The meridional extent of the CE indicates a narrow transition zone where IHT happens throughout the year. We find that the meridional extent above South America is larger compared to other regions. The distribution of the land–sea contrast plays an important role in the meridional extent of IHT. We focus on the TWP region and further compared the tropical rain belt with the CE. There is a broad region of high precipitation occurring in the TWP region, and it is difficult to determine the IHT by the rain belt. In the NH winter, the CE is not consistent with the tropical rain belt in the TWP but is confined to the southern branch of the peak of the rain belt. For the other seasons, both indicators of IHT agree.</p
High-contrast, fast chemical imaging by coherent Raman scattering using a self-synchronized two-colour fibre laser
Kong C, Pilger C, Hachmeister H, et al. High-contrast, fast chemical imaging by coherent Raman scattering using a self-synchronized two-colour fibre laser. Light: Science & Applications. 2020;9(1): 25.Coherent Raman scattering (CRS) microscopy is widely recognized as a powerful tool for tackling biomedical problems based on its chemically specific label-free contrast, high spatial and spectral resolution, and high sensitivity. However, the clinical translation of CRS imaging technologies has long been hindered by traditional solid-state lasers with environmentally sensitive operations and large footprints. Ultrafast fibre lasers can potentially overcome these shortcomings but have not yet been fully exploited for CRS imaging, as previous implementations have suffered from high intensity noise, a narrow tuning range and low power, resulting in low image qualities and slow imaging speeds. Here, we present a novel high-power self-synchronized two-colour pulsed fibre laser that achieves excellent performance in terms of intensity stability (improved by 50 dB), timing jitter (24.3 fs), average power fluctuation (20 dB) and pulse width variation (<1.8%) over an extended wavenumber range (2700–3550 cm−1). The versatility of the laser source enables, for the first time, high-contrast, fast CRS imaging without complicated noise reduction via balanced detection schemes. These capabilities are demonstrated in this work by imaging a wide range of species such as living human cells and mouse arterial tissues and performing multimodal nonlinear imaging of mouse tail, kidney and brain tissue sections by utilizing second-harmonic generation and two-photon excited fluorescence, which provides multiple optical contrast mechanisms simultaneously and maximizes the gathered information content for biological visualization and medical diagnosis. This work also establishes a general scenario for remodelling existing lasers into synchronized two-colour lasers and thus promotes a wider popularization and application of CRS imaging technologies
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Rapid Risk Assessment: FY05 Annual Summary Report
The Pacific Northwest National Laboratory (PNNL) is developing decision support tools that will assist in the transition of incident information into Protective Action Recommendations (PARs) that are understandable and can be executed in a real-world, operational environment. During emergencies, responders must rapidly assess risks and decide on the best course of action—all within minutes to hours. PNNL is blending existing modeling and decision support technology to develop new methods for transitioning science-based threat assessment to PARs. The rapid risk assessment tool will be both understandable and applicable to the emergency management community and would be a valuable tool during any water security-related incident. In 2005, PNNL demonstrated the integration of the multi-thematic modeling with emergency management decision support tools to create a Rapid Risk Assessment (RRA) tool that will transition risk to PARs that assist in responding to or mitigating the direct and indirect impacts of the incident(s). The RRA tool does this by aligning multi-thematic modeling capabilities with real-world response zones established by emergency and site operations managers. The RRA tool uses the risk assessment tool to drive prognostic models that use the type of incident, time of impact, severity of impact, and duration of impact to select the most appropriate PAR. Because PARs (and the thresholds by which they are selected) are jointly established by the technologists and the emergency management and operations decision makers, the science-based risk assessment can transition into a recommendation that can be understood and executed by people in the field
Separation – integration – and now …? - An historical perspective on the relationship between German management accounting and financial accounting
German accounting has traditionally followed a dual ledger approach with strictly separated internal cost accounting, as the basis for management information, and external financial accounting focusing on creditor protection and based on the commercial law. However, the increased adoption of integrated accounting system implies a significant change in the relationship between financial and management accounting systems. We use Hegelian dialectic to trace the historical development of German accounting from separated systems towards antithetical propositions of full integration, and the emergence of partial integration as the synthesis of this transformation process. For this reason, our paper provides a comprehensive analysis of the literature on the relationship between financial and management accounting in Germany. On this basis, we elaborate how financial accounting in Germany has been shaped by its economic context and legislation, and how financial accounting – accompanied by institutional pressures – in turn influenced management accounting. We argue that the changing relationship between management and financial accounting in the German context illustrates how current accounting practice is shaped not only by its environment, but also by its historical path. Based on this reasoning, we discuss several avenues for future research
Mineral trioxyde aggregate versus calcium hydroxide in apexification of non vital immature teeth: Study protocol for a randomized controlled trial
<p>Abstract</p> <p>Background</p> <p>Pulp necrosis is one of the main complications of dental trauma. When it happens on an immature tooth, pulp necrosis implies a lack of root maturation and apical closure. A therapy called apexification is required to induce the formation of a calcified apical barrier allowing a permanent and hermetic root filling. The aim of this prospective randomized clinical trial is to compare Mineral Trioxide Aggregate(MTA)with Calcium Hydroxide(CH)as materials used to induce root-end closure in necrotic permanent immature incisors.</p> <p>Methods/Design</p> <p>This study, promoted by AP-HP, was approved by the ethics committee(CPP Paris Ile de France IV). 34 children aged from 6 to 18 years and presenting a non-vital permanent incisor are selected. Prior to treatment, an appropriate written consent has to be obtained from both parents and from children. Patients are then randomly assigned to either the MTA(experimental)or CH(control)groups. Recalls are performed after 3, 6 and 12 months to determine the presence or absence of a calcified apical barrier through the use of clinical and radiographic exams. Additional criteria such as clinical symptoms, apical radiolucencies, periapical index(PAI)are also noted.</p> <p>Trial registration</p> <p>ClinicalTrials.gov no. <a href="http://www.clinicaltrials.gov/ct2/show/NCT00472173">NCT00472173</a> (First inclusion: May 10, 2007; Last inclusion: April 23, 2009; study completed: April 15, 2010)</p
Sealing ability, marginal adaptation and their correlation using three root-end filling materials as apical plugs
The effect of Dakota Gold®-brand dried distiller’s grains with solubles of varying levels on sensory and color characteristics of ribeye steaks
We evaluated the effect of varying levels of Dakota Gold-brand dried distiller’s grains with solubles (DDGS) on meat quality characteristics including sensory traits and display color stability. Rib cuts from heifers from a 153-day feeding trial were selected randomly so that each level of DDGS had 10 steaks in a seven-day retail display color study, and 10 steaks that were cooked for evaluation by a trained sensory panel. Color reflectance value L* (lightness) exhibited an interaction (P<0.05) between diet and day, as well as a quadratic effect (P<0.05). Diet had no effect on a* (redness) or b* (yellowness) values, but a* and b* for all treatments decreased with longer display (P<0.05). A trained sensory panel detected small but significant (P<0.05) linear improvements in myofibrillar tenderness and overall tenderness as DDGS increased. The effect on sensory traits or display color stability were too small to warrant the feeding of DDGS to improve these traits
A molten salt electrolytic process for recovering chlorine and ammonia from ammonium chloride. I
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