La estructura de la teoría política de Hume

The present essay explores the structural unity of Hume’s political theory, as it is sketched out mainly in Book III of the Treatise of Human Nature, his Essays and in the History of England

Crossing the Gould Belt in the Orion vicinity

We present a study of the large-scale spatial distribution of 6482 RASS X-ray sources in approximately 5000 deg^2 in the direction of Orion. We examine the astrophysical properties of a sub-sample of ~100 optical counterparts, using optical spectroscopy. This sub-sample is used to investigate the space density of the RASS young star candidates by comparing X-ray number counts with Galactic model predictions. We characterize the observed sub-sample in terms of spectral type, lithium content, radial and rotational velocities, as well as iron abundance. A population synthesis model is then applied to analyze the stellar content of the RASS in the studied area. We find that stars associated with the Orion star-forming region do show a high lithium content. A population of late-type stars with lithium equivalent widths larger than Pleiades stars of the same spectral type (hence younger than ~70-100 Myr) is found widely spread over the studied area. Two new young stellar aggregates, namely "X-ray Clump 0534+22" (age~2-10 Myr) and "X-ray Clump 0430-08" (age~2-20 Myr), are also identified. The spectroscopic follow-up and comparison with Galactic model predictions reveal that the X-ray selected stellar population in the direction of Orion is characterized by three distinct components, namely the clustered, the young dispersed, and the widespread field populations. The clustered population is mainly associated with regions of recent or ongoing star formation and correlates spatially with molecular clouds. The dispersed young population follows a broad lane apparently coinciding spatially with the Gould Belt, while the widespread population consists primarily of active field stars older than 100 Myr. We expect the "bi-dimensional" picture emerging from this study to grow in depth as soon as the distance and the kinematics of the studied sources will become available from the future Gaia mission.Comment: 17 pages, 13 figures, 4 tables. Accepted for publication in Astronomy and Astrophysics. Abstract shortene

Unawareness of illness in chronic schizophrenia and its relationship to structural brain measures and neuropsychological tests

peer reviewe

Orphan quality control shapes network dynamics and gene expression

AbstractAll eukaryotes require intricate protein networks to translate developmental signals into accurate cell fate decisions. Mutations that disturb crucial interactions between network components often result in disease, but how the composition and dynamics of complex networks are established is unknown. Here, we identify the tumor suppressor E3 ligase UBR5 as a quality control enzyme that helps degrade unpaired subunits of multiple transcription factors that operate within a single network. By constantly turning over orphan subunits, UBR5 forces cells to continuously replenish network components through new protein synthesis. The resulting cycles of transcription factor synthesis and degradation allow cells to effectively execute the gene expression program, while remaining susceptible to environmental signals. We conclude that orphan quality control plays an essential role in establishing the dynamics of protein networks, which may explain the conserved need for protein degradation in transcription and offers unique opportunities to modulate gene expression in disease