Das pT4-Pankreaskarzinom: Chirurgische und multimodale Behandlung

Zusammenfassung: Grundlagen: Die Resektion, unterstützt durch multimodale Therapieschemata, gilt auch beim T4-Pankreaskarzinom als einzige kurative Therapie. Methodik: Beim T4-Pankreaskarzinom muß häufig ein erweitertes Resektionsverfahren gewählt werden, das eine En-bloc-Entfernung des Tumors erlaubt und heute mit einer niederen Morbidität und Moralität vorgenommen werden kann. Der Stellenwert der Lymphknotendissektion bei diesen lokal fortgeschrittenen Pankreaskarzinomen ist nicht geklärt. Die hohe Lokalrezidivrate kann eventuell durch eine radikalere Lymphknotendissektion zusammen mit einer präoperativen, intraoperativen oder postoperativen kombinierten Chemotherapie verbessert werden. Ergebnisse: Die Ergebnisse multimodaler Therapieschemata zur Behandlung des Pankreaskarzinoms werden vorgestellt und der Stellenwert der einzelnen potentiell kurativen und palliativen Modalitäten diskutiert. Schlußfolgerungen: Obwohl der Einfluß auf Lokalrezidivraten und Überleben beim T4-Pankreaskarzinom noch nicht geklärt ist, scheint eine multimodale Behandlung bei der Gesamtgruppe der Patienten mit Pankreaskarzinom diesbezüglich bessere Resultate zu erzielen. Diese Resultate werden in Zukunft noch in prospektiv randomisiert durchgeführten Multicenter-Studien geklärt werde

REMOVED: Multicomponent Gas and Vapour Sorption in High Free Volume Polymers

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The Energy of a Moving Quark-Antiquark Pair in an N=4 SYM Plasma

We make use of the AdS/CFT correspondence to determine the energy of an external quark-antiquark pair that moves through strongly-coupled thermal N=4 super-Yang-Mills plasma, both in the rest frame of the plasma and in the rest frame of the pair. It is found that the pair feels no drag force, has an energy that reproduces the expected 1/L (or gamma/L) behavior at small quark-antiquark separations, and becomes unbound beyond a certain screening length whose velocity-dependence we determine. We discuss the relation between the high-velocity limit of our results and the lightlike Wilson loop proposed recently as a definition of the jet-quenching parameter.Comment: LaTeX 2e, 27 pages, 8 eps figures; v2: added computation of the pair energy in the plasma rest frame, clarified the comparison with hep-ph/0607062, corrected typos, added reference

Drag force in SYM plasma with B field from AdS/CFT

We investigate drag force in a thermal plasma of N=4 super Yang-Mills theory via both fundamental and Dirichlet strings under the influence of non-zero NSNS $B$-field background. In the description of AdS/CFT correspondence the endpoint of these strings correspondes to an external monopole or quark moving with a constant electromagnetic field. We demonstrate how the configuration of string tail as well as the drag force obtains corrections in this background.Comment: 13 pages, 2 figures, more discussion and reference adde

Melanoma Inhibitory Activity (MIA) increases the invasiveness of pancreatic cancer cells

BACKGROUND: Melanoma inhibitory activity (MIA) is a small secreted protein that interacts with extracellular matrix proteins. Its over-expression promotes the metastatic behavior of malignant melanoma, thus making it a potential prognostic marker in this disease. In the present study, the expression and functional role of MIA was analyzed in pancreatic cancer by quantitative real-time PCR (QRT-PCR), immunohistochemistry, immunoblot analysis and ELISA. To determine the effects of MIA on tumor cell growth and invasion, MTT cell growth assays and modified Boyden chamber invasion assays were used. RESULTS: The mRNA expression of MIA was 42-fold increased in pancreatic cancers in comparison to normal pancreatic tissues (p < 0.01). In contrast, MIA serum levels were not significantly different between healthy donors and pancreatic cancer patients. In pancreatic tissues, MIA was predominantly localized in malignant cells and in tubular complexes of cancer specimens, whereas normal ductal cells, acinar cells and islets were devoid of MIA immunoreactivity. MIA significantly promoted the invasiveness of cultured pancreatic cancer cells without influencing cell proliferation. CONCLUSION: MIA is over-expressed in pancreatic cancer and has the potential of promoting the invasiveness of pancreatic cancer cells

A case study of a transported bromine explosion event in the Canadian high arctic

Ozone depletion events in the polar troposphere have been linked to extremely high concentrations of bromine, known as bromine explosion events (BEE). However, the optimum meteorological conditions for the occurrence of these events remain uncertain. On 4–5 April 2011, a combination of both blowing snow and a stable shallow boundary layer was observed during a BEE at Eureka, Canada (86.4°W, 80.1°N). Measurements made by a Multi-Axis Differential Optical Absorption Spectroscopy spectrometer were used to retrieve BrO profiles and partial columns. During this event, the near-surface BrO volume mixing ratio increased to ~20 parts per trillion by volume, while ozone was depleted to ~1 ppbv from the surface to 700 m. Back trajectories and Global Ozone Monitoring Experiment-2 satellite tropospheric BrO columns confirmed that this event originated from a bromine explosion over the Beaufort Sea. From 30 to 31 March, meteorological data showed high wind speeds (24 m/s) and elevated boundary layer heights (~800 m) over the Beaufort Sea. Long-distance transportation (~1800 km over 5 days) to Eureka indicated strong recycling of BrO within the bromine plume. This event was generally captured by a global chemistry-climate model when a sea-salt bromine source from blowing snow was included. A model sensitivity study indicated that the surface BrO at Eureka was controlled by both local photochemistry and boundary layer dynamics. Comparison of the model results with both ground-based and satellite measurements confirmed that the BEE observed at Eureka was triggered by transport of enhanced BrO from the Beaufort Sea followed by local production/recycling under stable atmospheric shallow boundary layer conditions

Genetic polymorphisms of manganese-superoxide dismutase and glutathione-S-transferase in chronic alcoholic pancreatitis

Chronic alcohol consumption is a major risk factor for the development of chronic pancreatitis. However, chronic pancreatitis occurs only in a minority of heavy drinkers. This variability may be due to yet unidentified genetic factors. Several enzymes involved in the degradation of reactive oxidants and xenobiotics, such as glutathione-S-transferase P1 (GSTP1) and manganese-superoxide dismutase (MnSOD) reveal functional polymorphisms that affect the antioxidative capacity and may therefore modulate the development of chronic pancreatitis and long-term complications like endocrine and exocrine pancreatic insufficiency. Two functional polymorphisms of the MnSOD and the GSTP1 gene were assessed by polymerase chain reaction and restriction fragment length polymorphism in 165 patients with chronic alcoholic pancreatitis, 140 alcoholics without evidence of pancreatic disease and 160 healthy control subjects. The distribution of GSTP1 and MnSOD genotypes were in Hardy-Weinberg equilibrium in the total cohort. Genotype and allele frequencies for both genes were not statistically different between the three groups. Although genotype MnSOD Ala/Val was seemingly associated with the presence of exocrine pancreatic insufficiency, this subgroup was too small and the association statistically underpowered. None of the tested genotypes affected the development of endocrine pancreatic insufficiency. Polymorphisms of MnSOD and GSTP1 are not associated with chronic alcoholic pancreatitis. The present data emphasize the need for stringently designed candidate gene association studies with well-characterized cases and controls and sufficient statistical power to exclude chance observation

First Experiences with Navigated Radio-Guided Surgery Using Freehand SPECT

Background: Sentinel lymph node biopsy (SLNB) in melanoma using one-dimensional gamma probes is a standard of care worldwide. Reports on the performance are claimed by most groups to successfully detect the SLNs during the surgical procedure in almost 100% of the patients. In clinical practice, however, several issues remain which are usually not addressed: the difficulty of intraoperative detection of deeply located nodes, SLN detection in obese patients or in the groin and the impossibility to make a scan of the entire wound after SLN resection to avoid false negative testing for eventually remaining SLNs. Materials and Methods: The concept behind freehand SPECT is to combine a gamma probe as used for conventional radio-guided surgery with a tracking system as used in neurosurgical navigation. From this combination and a proper algorithm framework the 3D reconstruction of radioactivity distributions and displaying these intraoperatively is possible. Conclusion: In summary, the feasibility of freehand SPECT could be shown and provides an image-guided SLNB and a truly minimally invasive and optimized surgical procedure

Diffusion in an Expanding Plasma using AdS/CFT

We consider the diffusion of a non-relativistic heavy quark of fixed mass M, in a one-dimensionally expanding and strongly coupled plasma using the AdS/CFT duality. The Green's function constructed around a static string embedded in a background with a moving horizon, is identified with the noise correlation function in a Langevin approach. The (electric) noise decorrelation is of order 1/T(\tau) while the velocity de-correlation is of order MD(\tau)/T(\tau). For MD>1, the diffusion regime is segregated and the energy loss is Langevin-like. The time dependent diffusion constant D(\tau) asymptotes its adiabatic limit 2/\pi\sqrt{\lambda} T(\tau) when \tau/\tau_0=(1/3\eta_0\tau_0)^3 where \eta_0 is the drag coefficient at the initial proper time \tau_0.Comment: 19 pages, 2 figures, minor corrections, version to appear in JHE