Current and future drugs for treatment of MS-associated bladder dysfunction

AbstractA majority of patients diagnosed with multiple sclerosis (MS) will develop lower urinary tract symptoms (LUTS) during the course of the disease. Even if antimuscarinic (anticholinergic) treatment is currently the mainstay of conservative treatment of neurogenic detrusor overactivity (NDO), including MS-induced NDO, extensive data regarding their effectiveness and safeness are lacking. When antimuscarinic medications fail to prove efficacious, a further option is intradetrusor injections of onabotulinumtoxin A. In several studies, more than half (and up 76%) of the patients treated with onabotulinumtoxin A experienced significant improvement in symptoms or even achieved complete continence. Cannabis extracts have shown some promise but has still not gained wide acceptance as an effective treatment. Over the last few years many new disease-modifying drugs that have been approved and introduced for treatment of MS. These drugs may have effects not only on the MS disease process, but also on the disease symptoms, including LUTS. However, MS is not primarily a bladder disease and treatment of the underlying pathophysiology should be the main goal of treatment. Since most of the urology drugs are targeting LUTS, these drugs should be regarded as “adds on” to treatments modifying the underlying disorder. Considering that most of these drugs have not been studied specifically with respect to efficacy on LUTS, and since they are not without significant side effects, it seems important that if and when they are going to be used for treatment of bladder symptoms should be a joint decision between the neurologist and urologist taking care of the patient

Ancilla-Driven Universal Quantum Computation

We propose a method of manipulating a quantum register remotely with the help of a single ancilla that steers the evolution of the register. The fully controlled ancilla qubit is coupled to the computational register solely via a fixed unitary two-qubit interaction, E, and then measured in suitable bases. We characterize all interactions E that induce a unitary, step-wise deterministic measurement back-action on the register sufficient to implement any arbitrary quantum channel. Our scheme offers significant experimental advantages for implementing computations, preparing states and performing generalized measurements as no direct control of the register is required.Comment: 4 pages, 3 figure

A detailed study of quasinormal frequencies of the Kerr black hole

We compute the quasinormal frequencies of the Kerr black hole using a continued fraction method. The continued fraction method first proposed by Leaver is still the only known method stable and accurate for the numerical determination of the Kerr quasinormal frequencies. We numerically obtain not only the slowly but also the rapidly damped quasinormal frequencies and analyze the peculiar behavior of these frequencies at the Kerr limit. We also calculate the algebraically special frequency first identified by Chandrasekhar and confirm that it coincide with the $n=8$ quasinormal frequency only at the Schwarzschild limit.Comment: REVTEX, 15 pages, 7 eps figure

Stability of the r-modes in white dwarf stars

Stability of the r-modes in rapidly rotating white dwarf stars is investigated. Improved estimates of the growth times of the gravitational-radiation driven instability in the r-modes of the observed DQ Her objects are found to be longer (probably considerably longer) than 6x10^9y. This rules out the possibility that the r-modes in these objects are emitting gravitational radiation at levels that could be detectable by LISA. More generally it is shown that the r-mode instability can only be excited in a very small subset of very hot (T>10^6K), rather massive (M>0.9M_sun) and very rapidly rotating (P_min<P<1.2P_min) white dwarf stars. Further, the growth times of this instability are so long that these conditions must persist for a very long time (t>10^9y) to allow the amplitude to grow to a dynamically significant level. This makes it extremely unlikely that the r-mode instability plays a significant role in any real white dwarf stars.Comment: 5 Pages, 5 Figures, revte

Hereditary Hair Changes Revealed by Analysis of Single Hair Fibres by Scanning Electron Microscopy

In many disorders with a genetic background the sparsity of scalp hairs may deter the clinician from trying to extract information from single hair fibres. Presenting a number of diverse conditions, we propose to show that simple measures can be taken in the doctor\u27s office which makes single fibre analysis a useful tool for assessment of factors involved in genetic disorders including the integument and its appendages. The paper is focussed on the utilization of the scanning electron microscope with the goal of demonstrating that pertinent information can be gained where information from transmission electron microscopy and other techniques are not immediately available

Advanced ceramic coating development for industrial/utility gas turbine applications

The effects of ceramic coatings on the lifetimes of metal turbine components and on the performance of a utility turbine, as well as of the turbine operational cycle on the ceramic coatings were determined. When operating the turbine under conditions of constant cooling flow, the first row blades run 55K cooler, and as a result, have 10 times the creep rupture life, 10 times the low cycle fatigue life and twice the corrosion life with only slight decreases in both specific power and efficiency. When operating the turbine at constant metal temperature and reduced cooling flow, both specific power and efficiency increases, with no change in component lifetime. The most severe thermal transient of the turbine causes the coating bond stresses to approach 60% of the bond strengths. Ceramic coating failures was studied. Analytic models based on fracture mechanics theories, combined with measured properties quantitatively assessed both single and multiple thermal cycle failures which allowed the prediction of coating lifetime. Qualitative models for corrosion failures are also presented

Delocalization power of global unitary operations on quantum information

We investigate how originally localized two pieces of quantum information represented by a tensor product of two unknown qudit states are delocalized by performing two-qudit global unitary operations. To characterize the delocalization power of global unitary operations on quantum information, we analyze the necessary and sufficient condition to deterministically relocalize one of the two pieces of quantum information to its original Hilbert space by using only LOCC. We prove that this LOCC one-piece relocalization is possible if and only if the global unitary operation is local unitary equivalent to a controlled-unitary operation. The delocalization power and the entangling power characterize different non-local properties of global unitary operations.Comment: 14 pages, 1 figur

High-accuracy sampling of saproxylic diversity indicators at regional scales with pheromones: The case of "Elater ferrugineus" (Coleoptera, Elateridae)

The rare beetle Elater ferrugineus was sampled at 47 sites in the county of Östergötland, Sweden by means of pheromone-baited traps to assess its value as an indicator species for hollow oak stands rich in rare saproxylic beetle species. In addition, Osmoderma eremita was also sampled with pheromone baits. These data were then compared against species survey data collected at the same sites by pitfall and window traps. Both species co-occur with many Red Listed saproxylic beetles, with E. ferrugineus being a somewhat better indicator for the rarest species. The conservation value of a site (measured as Red List points or number of Red Listed species) increased with the number of specimens of E. ferrugineus and O. eremita caught. Accuracy of sampling by means of pheromone trapping turned out to be radically different for the two model species. E. ferrugineus traps put out during July obtained full accuracy after only 6 days, whereas O. eremita traps needed to be out from early July to mid-August in order to obtain full accuracy with one trap per site. By using E. ferrugineus, or preferably both species, as indicator species, accuracy would increase and costs decrease for saproxylic biodiversity sampling, monitoring and identification of hotspots

Non-adiabatic holonomic quantum computation

We develop a non-adiabatic generalization of holonomic quantum computation in which high-speed universal quantum gates can be realized by using non-Abelian geometric phases. We show how a set of non-adiabatic holonomic one- and two-qubit gates can be implemented by utilizing optical transitions in a generic three-level $\Lambda$ configuration. Our scheme opens up for universal holonomic quantum computation on qubits characterized by short coherence times.Comment: Some changes, journal reference adde

High-Order Contamination in the Tail of Gravitational Collapse

It is well known that the late-time behaviour of gravitational collapse is {\it dominated} by an inverse power-law decaying tail. We calculate {\it higher-order corrections} to this power-law behaviour in a spherically symmetric gravitational collapse. The dominant ``contamination'' is shown to die off at late times as $M^2t^{-4}\ln(t/M)$. This decay rate is much {\it slower} than has been considered so far. It implies, for instance, that an `exact' (numerical) determination of the power index to within $\sim 1$ requires extremely long integration times of order $10^4 M$. We show that the leading order fingerprint of the black-hole electric {\it charge} is of order $Q^2t^{-4}$.Comment: 12 pages, 2 figure