Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications

Superparamagnetic iron oxide nanoparticles can providemultiple benefits for biomedical applications in aqueous environments such asmagnetic separation or magnetic resonance imaging. To increase the colloidal stability and allow subsequent reactions, the introduction of hydrophilic functional groups onto the particles’ surface is essential. During this process, the original coating is exchanged by preferably covalently bonded ligands such as trialkoxysilanes. The duration of the silane exchange reaction, which commonly takes more than 24 h, is an important drawback for this approach. In this paper, we present a novel method, which introduces ultrasonication as an energy source to dramatically accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove the generic character, different functional groups were introduced on the surface including polyethylene glycol chains, carboxylic acid, amine, and thiol groups. Their colloidal stability in various aqueous buffer solutions as well as human plasma and serum was investigated to allow implementation in biomedical and sensing applications.status: publishe

Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016: a systematic analysis for the Global Burden of Disease Study 2016

BACKGROUND: Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to development status can identify exemplars for best practice. To accomplish this, the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) estimated age-specific and sex-specific all-cause mortality between 1970 and 2016 for 195 countries and territories and at the subnational level for the five countries with a population greater than 200 million in 2016. METHODS: We have evaluated how well civil registration systems captured deaths using a set of demographic methods called death distribution methods for adults and from consideration of survey and census data for children younger than 5 years. We generated an overall assessment of completeness of registration of deaths by dividing registered deaths in each location-year by our estimate of all-age deaths generated from our overall estimation process. For 163 locations, including subnational units in countries with a population greater than 200 million with complete vital registration (VR) systems, our estimates were largely driven by the observed data, with corrections for small fluctuations in numbers and estimation for recent years where there were lags in data reporting (lags were variable by location, generally between 1 year and 6 years). For other locations, we took advantage of different data sources available to measure under-5 mortality rates (U5MR) using complete birth histories, summary birth histories, and incomplete VR with adjustments; we measured adult mortality rate (the probability of death in individuals aged 15-60 years) using adjusted incomplete VR, sibling histories, and household death recall. We used the U5MR and adult mortality rate, together with crude death rate due to HIV in the GBD model life table system, to estimate age-specific and sex-specific death rates for each location-year. Using various international databases, we identified fatal discontinuities, which we defined as increases in the death rate of more than one death per million, resulting from conflict and terrorism, natural disasters, major transport or technological accidents, and a subset of epidemic infectious diseases; these were added to estimates in the relevant years. In 47 countries with an identified peak adult prevalence for HIV/AIDS of more than 0·5% and where VR systems were less than 65% complete, we informed our estimates of age-sex-specific mortality using the Estimation and Projection Package (EPP)-Spectrum model fitted to national HIV/AIDS prevalence surveys and antenatal clinic serosurveillance systems. We estimated stillbirths, early neonatal, late neonatal, and childhood mortality using both survey and VR data in spatiotemporal Gaussian process regression models. We estimated abridged life tables for all location-years using age-specific death rates. We grouped locations into development quintiles based on the Socio-demographic Index (SDI) and analysed mortality trends by quintile. Using spline regression, we estimated the expected mortality rate for each age-sex group as a function of SDI. We identified countries with higher life expectancy than expected by comparing observed life expectancy to anticipated life expectancy on the basis of development status alone. FINDINGS: Completeness in the registration of deaths increased from 28% in 1970 to a peak of 45% in 2013; completeness was lower after 2013 because of lags in reporting. Total deaths in children younger than 5 years decreased from 1970 to 2016, and slower decreases occurred at ages 5-24 years. By contrast, numbers of adult deaths increased in each 5-year age bracket above the age of 25 years. The distribution of annualised rates of change in age-specific mortality rate differed over the period 2000 to 2016 compared with earlier decades: increasing annualised rates of change were less frequent, although rising annualised rates of change still occurred in some locations, particularly for adolescent and younger adult age groups. Rates of stillbirths and under-5 mortality both decreased globally from 1970. Evidence for global convergence of death rates was mixed; although the absolute difference between age-standardised death rates narrowed between countries at the lowest and highest levels of SDI, the ratio of these death rates-a measure of relative inequality-increased slightly. There was a strong shift between 1970 and 2016 toward higher life expectancy, most noticeably at higher levels of SDI. Among countries with populations greater than 1 million in 2016, life expectancy at birth was highest for women in Japan, at 86·9 years (95% UI 86·7-87·2), and for men in Singapore, at 81·3 years (78·8-83·7) in 2016. Male life expectancy was generally lower than female life expectancy between 1970 and 2016, an

Uptake of some heavy metal ions on dibenzo-18-crown-6 immobilized on heteropolyacids

1042-1045Crown ether dibenzo-18-crown-6, immobilized on tungstoarsenic and molybdoarsenic acids, exhibits good affinity for Ag+, Pb2+, Hg2+ and Cd2+ ions. Sorption data fit the Langmuir and Freundlich adsorption models. Thermodynamic parameters reflect the feasibility of the process which is highly endothermic in nature

Antiulcer Activity of Methanolic Root Extract of Baliospermum Montanum in Ethanol and Indomethacin Induced Ulcer Models

The objective of this study was to evaluate the anti-ulcer activity of standardized methanolic extract of Baliospermum montanum root and to find out the possible mechanism of this activity. The root extract was evaluated in ethanol and Indomethacin induced ulcer model separately. The ulcer healing effect was studied in wistar albino rats by scoring the ulcer index. The biochemical parameters like reduced Glutathione (GSH), Superoxide dismutase (SOD), Nitrates and Thiobarbituric acid reactive substances (TBARS) were individually studied for both the models at a dose level of 250 mg/kg and 500 mg/kg. The preliminary phytochemical studies show identification of phytochemicals such as alkaloids, tannins, flavonoids and terpenoids. The ulcer index study revealed that the ulcer was reduced significantly in both the models. The biochemical study suggested a marked increase in level of GSH, SOD and Nitrates and decreased lipid peroxidation after the administration of the extract at both dose levels. The result indicated that the extract may exhibited the antiulcer activity due to antioxidant action as it reduced the oxidative stress and consequently improved the integrity of gastric mucosa and enhances the generation of nitric oxide and mucus

In Silico 3D QSAR Analysis of New Furanones Derivatives as Antibacterial Agent

Three-dimensional quantitative structure activity relationship studies were carried out on a series of 21 Furanones derivative to find out the structural requirements for anti-bacterial activity by using Molecular Design Suite (MDS) 3.0.The best predictions were obtained from the model where seventeen compounds were considered in the training set and remaining five compounds in the test set. 3D QSAR approach was developed based on principles of the k-nearest neighbor method combined with various variable selection procedures was used. The kNN-MFA approach was used to generate models for given data set and these models were used to predict the activity of test molecules

An 8 MeV Electron Beam Modified In:ZnO Thin Films for CO Gas Sensing towards Low Concentration

In the present investigation, electron beam-influenced modifications on the CO gas sensing properties of indium doped ZnO (IZO) thin films were reported. Dose rates of 5, 10, and 15 kGy were irradiated to the IZO nano films while maintaining the In doping concentration to be 15 wt%. The wurtzite structure of IZO films is observed from XRD studies post electron beam irradiation, confirming structural stability, even in the intense radiation environment. The surface morphological studies by SEM confirms the granular structure with distinct and sharp grain boundaries for 5 kGy and 10 kGy irradiated films whereas the IZO film irradiated at 15 kGy shows the deterioration of defined grains. The presence of defects viz oxygen vacancies, interstitials are recorded from room temperature photoluminescence (RTPL) studies. The CO gas sensing estimations were executed at an optimized operating temperature of 300 °C for 1 ppm, 2 ppm, 3 ppm, 4 ppm, and 5 ppm. The 10 kGy treated IZO film displayed an enhanced sensor response of 2.61 towards low concentrations of 1 ppm and 4.35 towards 5 ppm. The enhancement in sensor response after irradiation is assigned to the growth in oxygen vacancies and well-defined grain boundaries since the former and latter act as vital adsorption locations for the CO gas

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Not AvailableDeveloping suitable crop rotations and crop establishment practices is an important mechanism that can enhance factor productivity and sustainability of an agro-ecosystem. However, the impact of Conservation Agriculture (CA) on alternate crop rotation of the most-dominant but tillage- and input-intensive rice (Oryza sativa L.)-wheat (Triticum aestivum (L.) emend Fiori & Paol) rotation of the Indo-Gangetic Plains (IGP) of India is not elaborately studied. Hence, we evaluated the effect of CA on crop and water productivity, profitability, and soil carbon status in rice-mustard (Brassica juncea L.) rotation in the North-western IGP of India for five consecutive years. Eight treatments comprising of tillage, crop residue, brown manuring (BM) using Sesbania bispinosa, and summer mungbean [Vigna radiata (L.) Wilczek] (SMB) were adopted in rice - mustard cropping system. The conventional transplanted puddled rice (TPR) - conventional till mustard (CTM) (∼TPR-CTM) rotation resulted in significantly higher rice grain yield than zero till direct-seeded rice (ZTDSR) – ZT mustard (ZTM) system with or without crop residue in all five years. However, in this regard, the CA-based ZT rice – mustard - SMB with residue [ZTDSR-ZTM-ZTSMB ( + R)] was comparable with it during first three years, but was inferior to it in 4th and 5th years. The ZTDSR-ZTM-ZTSMB ( + R) had overall 10.9 % lower five-year mean rice yield than that in the TPR-CTM system. This CA-based system gave significantly higher mustard grain yield in all the years (except first year), and the five-year mean mustard yield was 30.3 % higher than in the TPR-CTM. Another CA-based double cropping system having ZTDSR + BM – ZTM ( + R) was comparable with TPR-CTM in all the years and resulted in 27.6 % higher five-year mean mustard yield than the TPR–CTM practice. The ZTDSR-ZTM-ZTSMB ( + R) practice gave 44 % (including SMB) and 8.1 % (excluding SMB) higher system productivity and significantly higher sustainable yield index of the rice-mustard system compared with the TPR-CTM practice. The ZTDSR-ZTM-ZTSMB ( + R) practice encountered significantly lower weed density in mustard in all five years than TPR-CTM system. The cost-benefit analysis revealed that this CA practice fetched higher net returns by INR 53,000 and 21,400 ha−1 from the rice-mustard system with and without SMB, respectively over the TPR-CTM system. Again, this ZTDSR -ZTM- ZTSMB ( + R) system led to an increase in irrigation water productivity by 27.8 % in rice and 35.1 % in mustard, and the total water (irrigation + rainfall) productivity by 35.7 % in mustard crop compared with the TPR-CTM system (P ≤ 0.05). This CA-based rice-mustard system resulted in significantly higher very labile (∼50.6 %) and labile (∼47.7 %) carbon concentration at 0–5 cm depth of soil compared to the conventional TPR-CTM system. The CA system being productive, profitable, and resource-efficient can be recommended for North-western IGP of India and in similar agro-ecologies of the tropics and sub-tropics. It can be adopted with suitable site-specific refinement in South-Asian countries, where decline in crop productivity and soil health is a consistent pervasive problem due to continuous cereal-cereal rotation.Not Availabl