Florida: The Mediated State

The Mediated State addresses the perceived and the real experience linked to Florida and demonstrates the state acts as a bellwether for understanding postwar America in the late twentieth and early twenty-first centuries. Examining historical shifts linked to perceptions of the state, Chambliss and Cummings argue contemporary observers, like their historical antecedents, look to Florida to glean some greater understanding of the broader national experience

Oral History Interview with President Emeritus Thaddeus Seymour, January 30, 2009.

Thaddeus Seymour came to Rollins in 1978 as the twelfth president of the College. During his twelve-year tenure, he not only transformed the school through fund-raising efforts, but also enhanced the academic excellence of its liberal arts education and strengthened the relationship with the local community. Seymour was born on June 29, 1928, in New York City. His father was Whitney North Seymour, a well-known attorney and president of the American Bar Association. Seymour attended Princeton and the University of California at Berkley as an undergraduate. From there, he went to the University of North Carolina, studied eighteenth-century English literature, and received his master’s degree and Ph.D. Seymour began his academic career as an English professor at Dartmouth, and five years later became Dean of the College. Before coming to Rollins, Seymour served as president of Wabash College in Indiana for nine years. While at Rollins, Seymour led the college’s centennial celebration, rededicated the Walk of Fame, raised funds for the construction of the Olin Library and the Cornell Social Science Building, reinstated Fox Day, and actively contributed to various community activities. He served as chairman, vice-chairman, and committee member of numerous academic and civic organizations. Throughout his life, Seymour has been widely known not only as dean and college president, but also an inspiring teacher, a caring counselor, a supportive friend, a charming magician and a leading citizen of the community. Upon his retirement in 1990, Seymour received an honorary degree from Rollins College. He has also been recognized with honorary doctorates from Wilkes College (PA), Butler University, and Indiana State University. In 1994, he received the Citizen\u27s Award from the Sullivan Committee. Three years later, in 1997, Seymour and his wife, Polly, became Winter Park’s Citizens of the Year, in recognition of their continued service to the community

Oral History Interview with President Emeritus Thaddeus Seymour, February 20, 2009.

Thaddeus Seymour came to Rollins in 1978 as the twelfth president of the College. During his twelve-year tenure, he not only transformed the school through fund-raising efforts, but also enhanced the academic excellence of its liberal arts education and strengthened the relationship with the local community. Seymour was born on June 29, 1928, in New York City. His father was Whitney North Seymour, a well-known attorney and president of the American Bar Association. Seymour attended Princeton and the University of California at Berkley as an undergraduate. From there, he went to the University of North Carolina, studied eighteenth-century English literature, and received his master’s degree and Ph.D. Seymour began his academic career as an English professor at Dartmouth, and five years later became Dean of the College. Before coming to Rollins, Seymour served as president of Wabash College in Indiana for nine years. While at Rollins, Seymour led the college’s centennial celebration, rededicated the Walk of Fame, raised funds for the construction of the Olin Library and the Cornell Social Science Building, reinstated Fox Day, and actively contributed to various community activities. He served as chairman, vice-chairman, and committee member of numerous academic and civic organizations. Throughout his life, Seymour has been widely known not only as dean and college president, but also an inspiring teacher, a caring counselor, a supportive friend, a charming magician and a leading citizen of the community. Upon his retirement in 1990, Seymour received an honorary degree from Rollins College. He has also been recognized with honorary doctorates from Wilkes College (PA), Butler University, and Indiana State University. In 1994, he received the Citizen\u27s Award from the Sullivan Committee. Three years later, in 1997, Seymour and his wife, Polly, became Winter Park’s Citizens of the Year, in recognition of their continued service to the community

A ‘healthy baby’: The double imperative of preimplantation genetic diagnosis

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2010 The Authors.This article reports from a study exploring the social processes, meanings and institutions that frame and produce ‘ethical problems’ and clinical dilemmas for practitioners, scientists and others working in the specialty of preimplantation genetic diagnosis (PGD). A major topic in the data was that, in contrast to IVF, the aim of PGD is to transfer to the woman’s womb only those embryos likely to be unaffected by serious genetic disorders; that is, to produce ‘healthy babies’. Staff described the complex processes through which embryos in each treatment cycle must meet a double imperative: they must be judged viable by embryologists and ‘unaffected’ by geneticists. In this article, we focus on some of the ethical, social and occupational issues for staff ensuing from PGD’s double imperative.The Wellcome Trus

Design of a High Temperature Radiator for the Variable Specific Impulse Magnetoplasma Rocket

The Variable Specific Impulse Magnetoplasma Rocket (VASIMR), currently under development by Ad Astra Rocket Company (Webster, TX), is a unique propulsion system that could change the way space propulsion is performed. VASIMR's efficiency, when compared to that of a conventional chemical rocket, reduces the propellant needed for exploration missions by a factor of 10. Currently plans include flight tests of a 200 kW VASIMR system, titled VF-200, on the International Space Station (ISS). The VF-200 will consist of two 100 kW thruster units packaged together in one engine bus. Each thruster core generates 27 kW of waste heat during its 15 minute firing time. The rocket core will be maintained between 283 and 573 K by a pumped thermal control loop. The design of a high temperature radiator is a unique challenge for the vehicle design. This paper will discuss the path taken to develop a steady state and transient-based radiator design. The paper will describe the radiator design option selected for the VASIMR thermal control system for use on ISS, and how the system relates to future exploration vehicles

Estrogen signaling in the cardiovascular system

Estrogen exerts complex biological effects through the two isoforms of estrogen receptors (ERs): ERα and ERβ. Whether through alteration of gene expression or rapid, plasma membrane-localized signaling to non-transcriptional actions, estrogen-activated ERs have significant implications in cardiovascular physiology. 17-β-estradiol (E2) generally has a protective property on the vasculature. Estrogen treatment is anti-atherogenic, protecting injured endothelial surfaces and lowering LDL oxidation in animal models. Increased NO production stimulated by E2 results in vasodilation of the coronary vascular bed, and involves rapid activation of phosphotidylinositol-3 kinase (PI3K)/Akt signaling to eNOS in carotid and femoral arteries. Both isoforms of ERs impact various vascular functions, modulating ion channel integrity, mitigating the response to arterial injury, inducing vasodilation, and preventing development of hypertension in animal models. In addition to reducing afterload by vasodilation, ERs have a direct antihypertrophic effect on the myocardium. E2-activated ERs (E2/ER) antagonize the hypertrophic pathway induced by vasoactive peptides such as angiotensin II by activating PI3K, subsequent MICIP gene expression, leading to the inhibition of calcineurin activity and the induction of hypertrophic genes. In models of ischemia-reperfusion, E2/ER is antiapoptotic for cardiomyocytes, exerting the protective actions via PI3K and p38 MAP kinases and suppressing the generation of reactive oxygen species. In sum, E2-activated ERs consistently and positively modulate multiple aspects of the cardiovascular system

SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis

© 2019, The Author(s), under exclusive licence to Springer Nature Limited. Atherosclerosis, which underlies life-threatening cardiovascular disorders such as myocardial infarction and stroke1, is initiated by passage of low-density lipoprotein (LDL) cholesterol into the artery wall and its engulfment by macrophages, which leads to foam cell formation and lesion development2,3. It is unclear how circulating LDL enters the artery wall to instigate atherosclerosis. Here we show in mice that scavenger receptor class B type 1 (SR-B1) in endothelial cells mediates the delivery of LDL into arteries and its accumulation by artery wall macrophages, thereby promoting atherosclerosis. LDL particles are colocalized with SR-B1 in endothelial cell intracellular vesicles in vivo, and transcytosis of LDL across endothelial monolayers requires its direct binding to SR-B1 and an eight-amino-acid cytoplasmic domain of the receptor that recruits the guanine nucleotide exchange factor dedicator of cytokinesis 4 (DOCK4)4. DOCK4 promotes internalization of SR-B1 and transport of LDL by coupling the binding of LDL to SR-B1 with activation of RAC1. The expression of SR-B1 and DOCK4 is increased in atherosclerosis-prone regions of the mouse aorta before lesion formation, and in human atherosclerotic arteries when compared with normal arteries. These findings challenge the long-held concept that atherogenesis involves passive movement of LDL across a compromised endothelial barrier. Interventions that inhibit the endothelial delivery of LDL into artery walls may represent a new therapeutic category in the battle against cardiovascular disease

TSIS-1 SIM V09 Solar Spectral Irradiance

NASA&rsquo;s Total and Spectral Solar Irradiance Sensor-1 (TSIS-1) operates on the International Space Station. TSIS-1 provides absolute measurements of the total solar irradiance (TSI) and spectral solar irradiance (SSI), important for accurate scientific models of climate change and solar variability. TSIS-1 is comprised of two instruments, the Total Irradiance Monitor (TIM), and the Spectral Irradiance Monitor (SIM). This repository archives Version 9 (V09) of the TSIS-1 SIM Level 3 (L3) data release, and contains SSI in two cadences, 12-hour and 24-hour. The TSIS-1 SIM L3 V09 data release contains data from 2018-03-14 to 2022-11-11. TSIS-1 SIM data obtained between 2022-03-19 and 2022-05-19 were affected by an anomaly of the sun-pointing sensor (HFSS-B), which offset pointing by ~1 arcminute. V08 introduced a spectral correction for this period, and V09 introduced the ADDITIONAL_UNCERTAINTY column in the data release which reflects the additional irradiance uncertainty associated with the spectral correction. See the attached TSIS_SIM_V09_Release_Notes.pdf or the TSIS SIM Data Products Release Notes page (https://lasp.colorado.edu/tsis/data/ssi-data/sim-ssi-release-notes/) for further details. Data is archived in ASCII, netCDF, and IDL SAVfile format. Creator Penton, Steven Chambliss, Michael Richard, Erik B&eacute;land, St&eacute;phane Brooks, Keira Charbonneau, Luke Coddington, Odele </ul