63 research outputs found

    Mean first-passage times of non-Markovian random walkers in confinement

    Get PDF
    The first-passage time (FPT), defined as the time a random walker takes to reach a target point in a confining domain, is a key quantity in the theory of stochastic processes. Its importance comes from its crucial role to quantify the efficiency of processes as varied as diffusion-limited reactions, target search processes or spreading of diseases. Most methods to determine the FPT properties in confined domains have been limited to Markovian (memoryless) processes. However, as soon as the random walker interacts with its environment, memory effects can not be neglected. Examples of non Markovian dynamics include single-file diffusion in narrow channels or the motion of a tracer particle either attached to a polymeric chain or diffusing in simple or complex fluids such as nematics \cite{turiv2013effect}, dense soft colloids or viscoelastic solution. Here, we introduce an analytical approach to calculate, in the limit of a large confining volume, the mean FPT of a Gaussian non-Markovian random walker to a target point. The non-Markovian features of the dynamics are encompassed by determining the statistical properties of the trajectory of the random walker in the future of the first-passage event, which are shown to govern the FPT kinetics.This analysis is applicable to a broad range of stochastic processes, possibly correlated at long-times. Our theoretical predictions are confirmed by numerical simulations for several examples of non-Markovian processes including the emblematic case of the Fractional Brownian Motion in one or higher dimensions. These results show, on the basis of Gaussian processes, the importance of memory effects in first-passage statistics of non-Markovian random walkers in confinement.Comment: Submitted version. Supplementary Information can be found on the Nature website : http://www.nature.com/nature/journal/v534/n7607/full/nature18272.htm

    Nuclear Catastrophe Risk Bonds in a Markov Dependent Environment

    Get PDF
    The financing of the 2011 Fukushima disaster and the UK Hinkley nuclear power plant in vestment, respectively by the Japanese, and UK and Chinese governments and the private sector provide a strong motivation for this paper to explore deeper the concept of modeling and pricing Nuclear Catastrophe (N-CAT) risk bonds. Due to the magnitude of the potential liabilities and re-investments needed, the demand to develop a dependable liability coverage product that can be triggered in a case of emergency is required more than ever and it should be considered thoroughly. Thus, in the present paper, under a semi-Markov structure environment to model the relationship between claims severity and intensity, the N-CAT risk bond is further explored under various scenarios supporting further the bond sponsors, allowing them to appreciate more their significance. Consequently, the new version of the N-CAT risk bond includes several absorbing and transit states to make it more suitable for practitioners. Additionally, this paper employs the two most commonly used interest rate models and considers four types of payoff functions. Finally, two numerical examples illustrate the main findings

    Modeling the Risk Process in the XploRe Computing Environment

    Full text link
    A user friendly approach to modeling the risk process is presented. It utilizes the insurance library of the XploRe computing environment which is accompanied by on-line, hyperlinked and freely downloadable from the web manuals and e-books. The empirical analysis for Danish fire losses for the years 1980-90 is conducted and the best fitting of the risk process to the data is illustrated

    Statistical Modeling of Solar Flare Activity from Empirical Time Series of Soft X-ray Solar Emission

    Full text link
    A time series of soft X-ray emission observed on 1974-2007 years (GOES) is analyzed. We show that in the periods of high solar activity 1977-1981, 1988-1992, 1999-2003 the energy statistics of soft X-ray solar flares for class M and C is well described by a FARIMA time series with Pareto innovations. The model is characterized by two effects. One of them is a long-range dependence (long-term memory), and another corresponds to heavy-tailed distributions. Their parameters are statistically stable enough during the periods. However, when the solar activity tends to minimum, they change essentially. We discuss possible causes of this evolution and suggest a statistical model for predicting the flare energy statistics.Comment: 21 pages, 7 figure

    Multifractional Brownian Motion with Telegraphic, Stochastically Varying Exponent

    Get PDF
    The diversity of diffusive systems exhibiting long-range correlations characterized by a stochastically varying Hurst exponent calls for a generic multifractional model. We present a simple, analytically tractable model which fills the gap between mathematical formulations of multifractional Brownian motion and empirical studies. In our model, called telegraphic multifractional Brownian motion, the Hurst exponent is modeled by a smoothed telegraph process which results in a stationary beta distribution of exponents as observed in biological experiments. We also provide a methodology to identify our model in experimental data and present concrete examples from biology, climate, and finance to demonstrate the efficacy of our approach

    Single-molecule imaging reveals receptor-G protein interactions at cell surface hot spots

    Get PDF
    G-protein-coupled receptors mediate the biological effects of many hormones and neurotransmitters and are important pharmacological targets. They transmit their signals to the cell interior by interacting with G proteins. However, it is unclear how receptors and G proteins meet, interact and couple. Here we analyse the concerted motion of G-protein-coupled receptors and G proteins on the plasma membrane and provide a quantitative model that reveals the key factors that underlie the high spatiotemporal complexity of their interactions. Using two-colour, single-molecule imaging we visualize interactions between individual receptors and G proteins at the surface of living cells. Under basal conditions, receptors and G proteins form activity-dependent complexes that last for around one second. Agonists specifically regulate the kinetics of receptor-G protein interactions, mainly by increasing their association rate. We find hot spots on the plasma membrane, at least partially defined by the cytoskeleton and clathrin-coated pits, in which receptors and G proteins are confined and preferentially couple. Imaging with the nanobody Nb37 suggests that signalling by G-protein-coupled receptors occurs preferentially at these hot spots. These findings shed new light on the dynamic interactions that control G-protein-coupled receptor signalling
    corecore