Concurrent 43 and 86 GHz Very Long Baseline Polarimetry of 3C273

We present sub-milliarcsecond resolution total intensity and linear polarization VLBI images of 3C273, using concurrent 43 and 86 GHz data taken with the Very Long Baseline Array in May 2002. The structure seen in the innermost jet suggest that we have fortuitously caught the jet in the act of changing direction. The polarization images confirm that the core is unpolarized (fractional polarization m < 1 %) at 86 GHz, but also show well ordered magnetic fields (m ~ 15 %) in the inner jet, at a projected distance of 2.3 pc from the core. In this strongly polarized region, the rotation measure changes across the jet by 4.2 x 10^{4} rad m^{-2} over an angular width of about 0.3 milliarcseconds. If the lack of polarization in the core is also attributed to a Faraday screen, then a rotation measure dispersion > 5.2 x 10^{4} rad m^{-2} must be present in or in front of that region. These are among the highest rotation measures reported so far in the nucleus of any active galaxy or quasar, and must occur outside (but probably close to) the radio emitting region. The transverse rotation measure gradient is in the same sense as that observed by Asada et al and by Zavala and Taylor at greater core distances. The magnitude of the transverse gradient decreases rapidly with distance down the jet, and appears to be variable.Comment: 4 pages, LaTeX, 3 postscript figures, submitted to Astrophysical Journal Letter

IL-21 Promotes CD4 T Cell Responses by Phosphatidylinositol 3-Kinase-Dependent Upregulation of CD86 on B Cells.

The cytokine IL-21 is a potent immune modulator with diverse mechanisms of action on multiple cell types. IL-21 is in clinical use to promote tumor rejection and is an emerging target for neutralization in the setting of autoimmunity. Despite its clinical potential, the biological actions of IL-21 are not yet fully understood and the full range of effects of this pleiotropic cytokine are still being uncovered. In this study, we identify a novel role for IL-21 as an inducer of the costimulatory ligand CD86 on B lymphocytes. CD86 provides critical signals through T cell-expressed CD28 that promote T cell activation in response to Ag engagement. Expression levels of CD86 are tightly regulated in vivo, being actively decreased by regulatory T cells and increased in response to pathogen-derived signals. In this study, we demonstrate that IL-21 can trigger potent and sustained CD86 upregulation through a STAT3 and PI3K-dependent mechanism. We show that elevated CD86 expression has functional consequences for the magnitude of CD4 T cell responses both in vitro and in vivo. These data pinpoint CD86 upregulation as an additional mechanism by which IL-21 can elicit immunomodulatory effects

Evaluation of a multi-sensor horizontal dual arm Coordinate Measuring Machine for automotive dimensional inspection

Multi-sensor coordinate measuring machines (CMM) have a potential performance advantage over existing CMM systems by offering the accuracy of a touch trigger probe with the speed of a laser scanner. Before these systems can be used, it is important that both random and systematic errors are evaluated within the context of its intended application. At present, the performance of a multi-sensor CMM, particularly of the laser scanner, has not been evaluated within an automotive environment. This study used a full-scale CNC machined physical representation of a sheet metal vehicle body to evaluate the measurement agreement and repeatability of critical surface points using a multi-sensor horizontal dual arm CMM. It was found that there were errors between CMM arms and with regard to part coordinate frame construction when using the different probing systems. However, the most significant effect upon measurement error was the spatial location of the surface feature. Therefore, for each feature on an automotive assembly, measurement agreement and repeatability has to be individually determined to access its acceptability for measurement with a laser scanner to improve CMM utilisation, or whether the accuracy of a touch trigger probe is required

Multifrequency VLBA Monitoring of 3C 273 during the INTEGRAL Campaign in 2003 - I. Kinematics of the Parsec Scale Jet from 43 GHz Data

In this first of a series of papers describing polarimetric multifrequency Very Long Baseline Array (VLBA) monitoring of 3C 273 during a simultaneous campaign with the INTEGRAL gamma-ray satellite in 2003, we present 5 Stokes I images and source models at 7 mm. We show that a part of the inner jet (1-2 milliarcseconds from the core) is resolved in a direction transverse to the flow, and we analyse the kinematics of the jet within the first 10 mas. Based on the VLBA data and simultaneous single-dish flux density monitoring, we determine an accurate value for the Doppler factor of the parsec scale jet, and using this value with observed proper motions, we calculate the Lorentz factors and the viewing angles for the emission components in the jet. Our data indicates a significant velocity gradient across the jet with the components travelling near the southern edge being faster than the components with more northern path. We discuss our observations in the light of jet precession model and growing plasma instabilities.Comment: Accepted for publication in Astronomy & Astrophysics, 16 pages, 15 figure

Firearm Safety, Gun Violence and Chicago Families: Voices of Child Health in Chicago Report

Chicago has seen continuing firearm violence, with over 2,000 shooting victims so far in 2021. The epidemic of firearm violence impacts children across the state, as it remains the number one cause of death in children and youth across Illinois. In some of our previous reports, Chicago parents identified gun violence as their top social concern for kids in the city, and in recent years, they reported it was the main social problem getting worse the fastest for Chicago youth. In this month's Voices of Child Health in Chicago Report, we focus on the importance of firearm safety and parents' concerns about gun violence in the city. We asked 1,505 Chicago parents from all 77 community areas in the city about their experiences with firearm safety as well as other gun violence prevention and concern-related questions.

Faraday Rotation Measure Gradients from a Helical Magnetic Field in 3C 273

Using high frequency (12-22 GHz) VLBA observations we confirm the existence of a Faraday rotation measure gradient of ~ 500 rad/m^2/mas transverse to the jet axis in the quasar 3C 273. The gradient is seen in two epochs spaced roughly six months apart. This stable transverse rotation measure gradient is expected if a helical magnetic field wraps around the jet. The overall order to the magnetic field in the inner projected 40 parsecs is consistent with a helical field. However, we find an unexpected increase in fractional polarization along the edges of the source, contrary to expectations. This high fractional polarization rules out internal Faraday rotation, but is not readily explained by a helical field. After correcting for the rotation measure, the intrinsic magnetic field direction in the jet of 3C 273 changes from parallel to nearly perpendicular to the projected jet motion at two locations. If a helical magnetic field causes the observed rotation measure gradient then the synchrotron emitting electrons must be separate from the helical field region. The presence or absence of transverse rotation measure gradients in other sources is also discussed.Comment: Accepted to ApJ Letters; 11 pages, 4 figures (1 color figure

Faraday rotation in the MOJAVE blazars: 3C 273 a case study

Radio polarimetric observations of Active Galactic Nuclei can reveal the magnetic field structure in the parsec-scale jets of these sources. We have observed the gamma-ray blazar 3C 273 as part of our multi-frequency survey with the Very Long Baseline Array to study Faraday rotation in a large sample of jets. Our observations re-confirm the transverse rotation measure gradient in 3C 273. For the first time the gradient is seen to cross zero which is further indication for a helical magnetic field and spine-sheath structure in the jet. We believe the difference to previous epochs is due to a different part of the jet being illuminated in our observations.Comment: 6 pages, 3 figures. To appear in the proceedings of "Beamed and Unbeamed Gamma-rays from Galaxies", held in Muonio, Finland, April 11-15, 2011. Journal of Physics: Conference Serie

Interleukin 21 inhibits cancer-mediated FOXP3 induction in naïve human CD4 T cells

IL-21 is known to promote anti-tumour immunity due to its ability to promote T cell responses and counteract Treg-mediated suppression. It has also been shown to limit Treg frequencies during tumour-antigen stimulations. However, whether this represents inhibition of FOXP3 induction in naïve CD4 T cells or curtailed expansion of natural Treg remains unclear. Moreover, whether this effect is maintained in an environment of tumour-derived immunosuppressive factors is not known. Here, we show that in the context of a number of cancers, naïve CD45RA+ CD4 T cells are induced to express high levels of FOXP3, and that FOXP3 expression correlates with inhibition of T cell proliferation. FOXP3 expression was most potently induced by tumours secreting higher levels of total and active TGFβ1 and this induction could be potently counteracted with IL-21, restoring T cell proliferation. We conclude that Treg induction in naïve T cells is a common phenomenon amongst a number of different cancers and that the ability of IL-21 to counteract this effect is further evidence of its promise in cancer therapy

Evidence for early disk-locking among low-mass members of the Orion Nebula Cluster

We present high-resolution spectroscopic observations for 91 PMS stars in ONC with masses in the range 0.10-0.25Msun carried out with the multi-fiber spectrograph FLAMES@ESO. Our aim is to better understand the disk-locking scenario in very low-mass stars. We have derived radial velocities, vsini, and full width at 10% of the Halpha emission peak. Using published measurements of infrared excess as disk tracer, and equivalent width of the NIR CaII line lambda8542, mid-IR difference [3.6]-[8.0]micron derived by Spitzer data, and 10% Halpha width as diagnostic of the level of accretion, we have looked for any correlation between vsini divided by the radius and presence of disk and accretion. Four low-mass stars are SB2 systems. The distribution of rotation periods derived from our vsini measurements is unimodal with a peak of few days. Our is lower than the one expected for a random distribution. We find no evidence for a population of fast rotators close to the break-up velocity. A clear correlation between vsini/R and Delta(Ic-K) has been found. While for stars with no circumstellar disk a spread in the rotation rates is seen, stars with a circumstellar disk show an abrupt drop in their rotation rates by a factor of ~5. On the other hand, only a partial correlation between vsini and accretion is observed when other indicators are used. The X-ray coronal activity level shows no dependence on vsini/R suggesting that all stars are in a saturated regime limit. The critical velocity is probably below our vsini detection limit of 9 km/s. The ONC low-mass stars in our sample at present seem to be not locked, but the clear correlation we find between rotation and IR color excess suggests that they were locked once. In addition, the percentage of accretors seems to scale inversely to the stellar mass.Comment: 16 pages, 2 Tables, 17 figures. Accepted by Astronomy and Astrophysics. Full version of abstract is available in the manuscrip