A comparative study of efficacy and tolerability of doxofylline over other methylxanthenes in mild to moderate persistent bronchial asthma patients in a tertiary care hospital

Background: Studies have shown that doxofylline is endowed with a remarkable bronchodilator activity with less extra respiratory effects than other methylxanthines. To compare the efficacy and tolerability of doxofylline over other methylxanthines in mild to moderate persistent bronchial Asthma patients.Methods: It is a comparative study conducted in patients of mild to moderate persistent bronchial Asthma in the outpatient department of regional chest hospital. The subjects were randomly assigned into 2 groups, one group treated with oral doxofylline and the other with theophylline oral or Deriphylline. Efficacy was measured objectively using spirometric parameters like FEV1 (Forced Expiratory Volume at the end of 1 second), FVC (Forced Vital Capacity), FEV1/FVC and PEFR (Peak Expiratory flow Rate), Subjectively by the Asthma control test questionnaire, subjective rating of Asthma control and the need for use of rescue medications like β2 agonists in the previous four weeks. Tolerability were done at base line and at the end of study.Results: Doxofylline compared to other methylxanthines groups was statistically better with respect to subjective parameters like Asthma control tests questionnaire, subjective rating of Asthma control. Doxofylline had equal efficacy with spirometric parameters compared to other methylxanthines. Doxofylline was significantly better tolerated with adverse drug reactions noted in 10% compared to 28% in other methylxanthins group.Conclusions: Doxofylline with better tolerability profile and equivalent efficacy seemed to be a good alternative to other methylxanthines in the treatment of bronchial Asthma

On additive partitions of integers

AbstractGiven a linear recurrence integer sequence U = {un}, un+2 = un+1 + ur, n ⩾ 1, u1 = 1, u2> u1, we prove that the set of positive integers can be partitioned uniquely into two disjoint subsets such that the sum of any two distinct members from any one set can never be in U. We give a graph theoretic interpretation of this result, study related problems and discuss possible generalizations

An inequality for multiplicative functions

Let k be a positive integer and f a multiplicative function with 0 f(p) k for all primes p. Then, for squarefree n, we have This improves some recent results of Alladi, Erds, and Vaaler.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/30330/1/0000732.pd

A double bounded key identity for Goellnitz's (big) partition theorem

Given integers i,j,k,L,M, we establish a new double bounded q-series identity from which the three parameter (i,j,k) key identity of Alladi-Andrews-Gordon for Goellnitz's (big) theorem follows if L, M tend to infinity. When L = M, the identity yields a strong refinement of Goellnitz's theorem with a bound on the parts given by L. This is the first time a bounded version of Goellnitz's (big) theorem has been proved. This leads to new bounded versions of Jacobi's triple product identity for theta functions and other fundamental identities.Comment: 17 pages, to appear in Proceedings of Gainesville 1999 Conference on Symbolic Computation

Low Cost, Efficient Output- Only Infrastructure Damage Detection with Wireless Sensor Networks

Sensor network comprises of sensors and actuators with universally useful processing components to agreeably screen physical or ecological conditions, for example, temperature, pressure, and so on. Wireless Sensor Networks are particularly portrayed by properties like the constrained power they can reap or store, dynamic network topology, expansive size of the arrangement. Sensor networks have an enormous application in fields which incorporates territory observing, object tracking, fire detection, landslide recognition and activity observing. Given the network topology, directing conventions in sensor networks can be named at based steering, various levelled based directing and area-based directing. Low Energy Adaptive Clustering Hierarchy (LEACH) is a vitality productive various levelled based steering convention. Our prime spotlight was on the examination of LEACH given specific parameters like network lifetime, soundness period, and so forth and furthermore the impact of particular sending assault and level of heterogeneity on LEACH convention

Kikuchi-Fujimoto disease presenting as pyrexia of unknown origin

Background: Kikuchi-Fujimoto disease, a benign self-limited lymphadenopathy is an uncommon cause of pyrexia of unknown origin (PUO). Methods: We retrospectively studied the case-records of 13 patients presenting with PUO who were diagnosed to have Kikuchi-Fujimoto disease on peripheral lymph node excision biopsy and report the salient clinical manifestations and histopathological findings in them. All of them received symptomatic treatment. Results: Their median age was 28 [interquartile range (IQR) 18.5-38.0] years. Women (11/13, 84.6%) were more frequently affected. All of them were human immunodeficiency virus (HIV) seronegative. Prior to presenting to us, two were being treated for lymph node tuberculosis with DOTS. Cervical lymph nodes were predominantly involved, the distribution being: right cervical (n=10, 76.9%); left cervical (n=4); and bilateral cervical (n=2). Axillary and generalized lymphadenopathy were rare being seen in 2 and 1 patient respectively. The median (IQR) erythrocyte sedimentation rate (n=11) was 53 (35-89) mm at the end of first hour. Salient histopathological features were paracortical patchy zones of eosinophilic fibrinoid necrosis with karyorrhectic debris, large numbers of histiocytes, including histiocytes with peripherally placed “crescentic” nuclei. Spontaneous regression of fever and lymphadenopathy was observed over a median (IQR) period of 8 (6.75-10.25) months in all of them. Conclusions: Kikuchi-Fujimoto disease is a rare but important cause of PUO presenting with peripheral lymphadenopathy. Women are most often affected and cervical lymph nodes are the most frequently involved site. Clinical suspicion and thoughtful collaboration between clinicians and pathologists are essential for accurate diagnosis, and to minimize unnecessary investigations and inappropriate aggressive treatment

On the decomposition of the Feynman propagator

The Feynman propagator, in momentum representation, is a four-dimensional transform over space and time variables. If the space and time integrations are performed separately, the propagator can be decomposed into two parts, one corresponding to positive and the other to negative energy intermediate state. By the use of this decomposed propagator, the relative contributions of the positive and negative energy intermediate states to the matrix element can be estimated. For example in Compton scattering it leads to the apparently paradoxical result that in the "non-relativistic approximation" it is only the negative energy intermediate state that contributes to the matrix element

Gaps in clinical research in frontotemporal dementia: A call for diversity and disparities–focused research

Frontotemporal dementia (FTD) is one of the leading causes of dementia before age 65 and often manifests as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). FTD's exact clinical presentation varies by culture, language, education, social norms, and other socioeconomic factors; current research and clinical practice, however, is mainly based on studies conducted in North America and Western Europe. Changes in diagnostic criteria and procedures as well as new or adapted cognitive tests are likely needed to take into consideration global diversity. This perspective paper by two professional interest areas of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment examines how increasing global diversity impacts the clinical presentation, screening, assessment, and diagnosis of FTD and its treatment and care. It subsequently provides recommendations to address immediate needs to advance global FTD research and clinical practice