Reconstruction of solar activity for the last millennium using 10^{10}Be data

In a recent paper (Usoskin et al., 2002a), we have reconstructed the concentration of the cosmogenic $^{10}$Be isotope in ice cores from the measured sunspot numbers by using physical models for $^{10}$Be production in the Earth's atmosphere, cosmic ray transport in the heliosphere, and evolution of the Sun's open magnetic flux. Here we take the opposite route: starting from the $^{10}$Be concentration measured in ice cores from Antarctica and Greenland, we invert the models in order to reconstruct the 11-year averaged sunspot numbers since 850 AD. The inversion method is validated by comparing the reconstructed sunspot numbers with the directly observed sunspot record since 1610. The reconstructed sunspot record exhibits a prominent period of about 600 years, in agreement with earlier observations based on cosmogenic isotopes. Also, there is evidence for the century scale Gleissberg cycle and a number of shorter quasi-periodicities whose periods seem to fluctuate in the millennium time scale. This invalidates the earlier extrapolation of multi-harmonic representation of sunspot activity over extended time intervals.Comment: Submitted to A&

The cell sets the tone

In zebrafish larvae, it is the cell type that determines how the cell responds to a chemokine signal

Dynamic Micropatterning Reveals Substrate-Dependent Differences in the Geometric Control of Cell Polarization and Migration

Cells are highly dynamic and adopt variable shapes and sizes. These variations are biologically important but challenging to investigate in a spatiotemporally controlled manner. Micropatterning, confining cells on microfabricated substrates with defined geometries and molecular compositions, is a powerful tool for controlling cell shape and interactions. However, conventional binary micropatterns are static and fail to address dynamic changes in cell polarity, spreading, and migration. Here, a method for dynamic micropatterning is reported, where the non-adhesive surface surrounding adhesive micropatterns is rapidly converted to support specific cell-matrix interactions while allowing simultaneous imaging of the cells. The technique is based on ultraviolet photopatterning of biotinylated polyethylene glycol-grafted poly-L-lysine, and it is simple, inexpensive, and compatible with a wide range of streptavidin-conjugated ligands. Experiments using biotinylation-based dynamic micropatterns reveal that distinct extracellular matrix ligands and bivalent integrin-clustering antibodies support different degrees of front-rear polarity in human glioblastoma cells, which correlates to altered directionality and persistence upon release and migration on fibronectin. Unexpectedly, however, neither an asymmetric cell shape nor centrosome orientation can fully predict the future direction of migration. Taken together, biotinylation-based dynamic micropatterns allow easily accessible and highly customizable control over cell morphology and motility

Global heliospheric parameters and cosmic ray modulation: an empirical relation for the last decades. Solar Phys

Abstract. We study empirical relations between the modulation of galactic cosmic rays quantified in terms of the modulation potential and the following global heliospheric parameters: the open solar magnetic flux, the tilt angle of the heliospheric current sheet, and the polarity of the heliospheric magnetic field. We show that a combination of these parameters explains the majority of the modulation potential variations during the neutron monitor era 1951 -2005. Two empirical models are discussed: a quasi-linear model and a model assuming a power-law relation between the modulation potential and the magnetic flux. Both models describe the data fairly well. These empirical models provide a simple tool for evaluating various cosmic-ray related effects on different time scales. The models can be extended backwards in time or used for predictions, if the corresponding global heliospheric variables can be independently estimated

Cyclic variations of the heliospheric tilt angle and cosmic ray modulation,

Abstract Using data on cosmic ray modulation parameter since 1951, we have estimated the evolution of the heliospheric current sheet tilt angle for the period 1951-1975, i.e., 25 years before regular observations of the tilt angle. This estimate is based on our recent empirical model relating cosmic ray intensity with global heliospheric parameters. We propose a simple model to describe the cyclic evolution of the tilt angle with the solar cycle. This model agrees with available observational data. Using this model, we have estimated the cosmic ray intensity since 1710. This estimate is consistent with the results based on cosmogenic isotopes ( 14 C and 10 Be)

A scoping review of constructs measured following intervention for school refusal: are we measuring up?

Reviews of the effectiveness of interventions for school refusal (SR) rely upon well-conducted primary studies. Currently there are no guidelines for those conducting primary studies about the measurement of outcome following intervention for SR. Most people would agree that it is important to measure school attendance as an outcome but there has been little discussion about other constructs that warrant measurement. To facilitate this discussion and support the development of guidelines, we conducted a scoping review of constructs measured in studies evaluating intervention for SR. We screened the title and abstract of 3,213 publications found in peer-reviewed journals between 1980 and 2019. After full text review of 271 publications, 50 publications describing 51 studies were included. Results address the frequency with which constructs were measured, along with instruments used, informants, and time-points for measurement. Based on the results, we offer guidelines for choosing constructs to measure following intervention for SR and considerations for how to measure the constructs. Guidelines can increase consistency across primary studies, with benefits for future meta-analyses and international comparisons. They also provide support for practitioners contemplating routine evaluation of their interventions for SR. Ultimately, a core outcome set for SR can be developed.Pathways through Adolescenc

A Transdisciplinary Approach to Determining the Provenience of a Distorted, Pre-Columbian Skull Recovered in Rural Idaho

Transdisciplinary research involves cooperation, exchange of information, sharing of resources and integration of disciplines to achieve a common scientific goal. In this study, collaborators utilized tools and knowledge of materials science, anthropology, archaeology, geosciences and biology in an attempt to determine the provenience of skeletal remains of unknown origin. The exchange of ideas and skills along with the crossing of disciplines in this study sucessfully allowed the incorporation of expertise from many team members. This transdisciplinary approach to research provided a more comprehensive and detailed analysis than any one field alone could provide. An archaeological assessment of a human skull recovered in rural Idaho recognized cranial deformation and post-mortem application of a red pigment. A combination of scanning electron microscopy (SEM), x-ray fluorescence (XRF) and energy-dispersive x-ray spectroscopy (EDS) identified the major and trace elements present in the red post-mortem pigment as cinnabar and rare earth metals. Analysis via carbon and oxygen stable isotopes from teeth and bone to provided insight into the diet and habitat for distinct segments of the individual’s life, indicating a regional separation in early life versus late adulthood. Radiocarbon dating determined the approximate age of the skull to be between 600-700 years old and a forensic mtDNA assessmentcategorized a mitochondrial haplogroup for the remains as originating from the East African or Arabian Peninsula

Integrin endosomal signalling suppresses anoikis

Integrin-containing focal adhesions transmit extracellular signals across the plasma membrane to modulate cell adhesion, signalling and survival. Although integrins are known to undergo continuous endo/exocytic traffic, the potential impact of endocytic traffic on integrin-induced signals is unknown. Here, we demonstrate that integrin signalling is not restricted to cell-ECM adhesions and identify an endosomal signalling platform that supports integrin signalling away from the plasma membrane. We show that active focal adhesion kinase (FAK), an established marker of integrin-ECM downstream signalling, localizes with active integrins on endosomes. Integrin endocytosis positively regulates adhesion-induced FAK activation, which is early endosome antigen-1 and small GTPase Rab21 dependent. FAK binds directly to purified endosomes and becomes activated on them, suggesting a role for endocytosis in enhancing distinct integrin downstream signalling events. Finally, endosomal integrin signalling contributes to cancer-related processes such as anoikis resistance, anchorage independence and metastasis.</p