2,507 research outputs found
A thematic analysis of barriers and facilitators to participant engagement in group exposure and response prevention therapy for obsessive-compulsive disorder
Exposure and response prevention (ERP) is the gold standard in the treatment of the obsessive-compulsive disorder (OCD). It can be delivered effectively using an individual or group therapy format. Nonetheless, a sizeable proportion of people diagnosed with OCD do not experience OCD symptom remission following ERP. Research suggests that participant engagement with ERP tasks predicts therapy outcomes but there is little consistent evidence across studies on what predicts engagement. A recent meta-analysis of participant engagement in cognitive-behavioral therapy for OCD found that group ERP had a comparatively lower dropout rate than individual ERP. Little is known about participant perceptions of ERP to guide an understanding of how the group therapy format may affect participant engagement. This study conducted a qualitative exploration of what helps or hinders participants' engagement in group ERP. It involved thematic analysis of semi-structured interview data collected at a 6-month follow-up from 15 adults with OCD who took part in group ERP. The study identified five main themes that captured participants' perceived facilitators and barriers to engagement in therapy: 'Group processes', 'Understanding how to overcome OCD', 'Personal relevance', 'Personal circumstances', and 'Attitudes towards ERP', which captured dynamically inter-related barriers and facilitators at the level of the client, therapist, therapy and social environment. Each theme and associated sub-themes are discussed in turn, followed by a consideration of the study's limitations and implications
On the Renormalization of Theories of a Scalar Chiral Superfield
An exact renormalization group for theories of a scalar chiral superfield is
formulated, directly in four dimensional Euclidean space. By constructing a
projector which isolates the superpotential from the full Wilsonian effective
action, it is shown that the nonperturbative nonrenormalization theorem
follows, quite simply, from the flow equation. Next, it is argued that there do
not exist any physically acceptable non-trivial fixed points. Finally, the
Wess-Zumino model is considered, as a low energy effective theory. Following an
evaluation of the one and two loop beta-function coefficients, to illustrate
the ease of use of the formalism, it is shown that the beta-function in the
massless case does not receive any nonperturbative power corrections.Comment: 52 pages, 4 figures; v2: 57 pages - refs added and some minor
corrections/clarifications made; v3: published in JHEP - some further
clarifications mad
Low-intensity guided help through mindfulness (LIGHTMIND): study protocol for a randomised controlled trial comparing supported mindfulness-based cognitive therapy self-help to supported cognitive behavioural therapy self-help for adults experiencing depression
Background: Depression has serious personal, family and economic consequences. It is estimated that it will cost £12.15 billion to the economy each year in England by 2026. Improving Access to Psychological Therapies (IAPT) is the National Health Service talking therapies service in England for adults experiencing anxiety or depression. Over 1 million people are referred to IAPT every year, over half experiencing depression. Where symptoms of depression are mild/moderate, people are typically offered Cognitive Behavioural Therapy (CBT) self-help supported by a psychological wellbeing practitioner (PWP). The problem is that over half of people who complete treatment for depression in IAPT remain depressed despite receiving National Institute of Health and Care Excellent (NICE) recommended treatment. Furthermore, less than half of IAPT service users complete treatment. This study seeks to investigate the effectiveness of an alternative to CBT self-help. Mindfulness-based cognitive therapy differs from CBT in focus, approach and practice and may be more effective with a higher number of treatment completions.
Methods/Design: This is a definitive randomised controlled trial comparing supported mindfulness-based cognitive therapy self-help (MBCT-SH) with supported cognitive behavioural therapy self-help (CBT-SH) for adults experiencing mild/moderate depression being treated in IAPT services. Four hundred and ten participants experiencing mild/moderate depression will be recruited from IAPT services and randomised to receive either an MBCT-based self-help workbook or a CBT-based self-help workbook. Participants will be asked to complete their workbook within 16 weeks, with six support sessions with a PWP. The primary outcome is depression symptom severity upon treatment completion. Secondary outcomes are treatment completion rates and measures of generalized anxiety, wellbeing, functioning and mindfulness. An exploratory non-inferiority analysis will be conducted in the event the primary hypothesis is not supported. A semi-structured interview with participants will guide understanding of change processes.
Discussion: If the findings from this randomised controlled trial demonstrate that MBCT-SH is more effective than CBT-SH for adults experiencing depression, this will provide evidence for policy makers and lead to changes to clinical practice in IAPT services, leading to greater choice of self-help treatment options and better outcomes for service users. If the exploratory non-inferiority analysis is conducted and this indicates non-inferiority of MBCT-SH in comparison to CBT-SH this will also be of interest to policy makers when seeking to increase service user choice of self-help treatment options for depression.
Trial registration: Current Controlled Trial registration number ISRCTN 13495752. Registered on 31 August 2017 (www.isrctn.com/ISRCTN13495752).
Protocol Version: Version 1 (18 January 2020)
Recruitment Status: Recruiting: participants are currently being recruited and enrolled
Date first participant randomised: 24 November 2017
Trial Sponsor: Sussex Partnership NHS Foundation Trust ([email protected]
Clinical effectiveness and cost-effectiveness of supported mindfulness-based cognitive therapy self-help compared with supported cognitive behavioral therapy self-help for adults experiencing depression: The low-intensity guided help through mindfulness (LIGHTMind) randomized clinical trial
Importance
Depression is prevalent. Treatment guidelines recommend practitioner-supported cognitive behavioral therapy self-help (CBT-SH) for mild to moderate depression in adults; however, dropout rates are high. Alternative approaches are required.
Objective
To determine if practitioner-supported mindfulness-based cognitive therapy self-help (MBCT-SH) is superior to practitioner-supported CBT-SH at reducing depressive symptom severity at 16 weeks postrandomization among patients with mild to moderate depression and secondarily to examine if practitioner-supported MBCT-SH is cost-effective compared with practitioner-supported CBT-SH.
Design, Setting, and Participants
This was an assessor- and participant-blinded superiority randomized clinical trial with 1:1 automated online allocation stratified by center and depression severity comparing practitioner-supported MBCT-SH with practitioner-supported CBT-SH for adults experiencing mild to moderate depression. Recruitment took place between November 24, 2017, and January 31, 2020. The study took place in 10 publicly funded psychological therapy services in England (Improving Access to Psychological Therapies [IAPT]). A total of 600 clients attending IAPT services were assessed for eligibility, and 410 were enrolled. Participants met diagnostic criteria for mild to moderate depression. Data were analyzed from January to October 2021.
Interventions
Participants received a copy of either an MBCT-SH or CBT-SH workbook and were offered 6 support sessions with a trained practitioner.
Main Outcomes and Measures
The preregistered primary outcome was Patient Health Questionnaire (PHQ-9) score at 16 weeks postrandomization. The primary analysis was intention-to-treat with treatment arms masked.
Results
Of 410 randomized participants, 255 (62.2%) were female, and the median (IQR) age was 32 (25-45) years. At 16 weeks postrandomization, practitioner-supported MBCT-SH (n = 204; mean [SD] PHQ-9 score, 7.2 [4.8]) led to significantly greater reductions in depression symptom severity compared with practitioner-supported CBT-SH (n = 206; mean [SD] PHQ-9 score, 8.6 [5.5]), with a between-group difference of −1.5 PHQ-9 points (95% CI, −2.6 to −0.4; P = .009; d = −0.36). The probability of MBCT-SH being cost-effective compared with CBT-SH exceeded 95%. However, although between-group effects on secondary outcomes were in the hypothesized direction, they were mostly nonsignificant. Three serious adverse events were reported, all deemed not study related.
Conclusions and Relevance
In this randomized clinical trial, practitioner-supported MBCT-SH was superior to standard recommended treatment (ie, practitioner-supported CBT-SH) for mild to moderate depression in terms of both clinical effectiveness and cost-effectiveness. Findings suggest that MBCT-SH for mild to moderate depression should be routinely offered to adults in primary care services.
Trial Registration
isrctn.org Identifier: ISRCTN1349575
Monocular Visual-IMU Odometry: A Comparative Evaluation of the Detector-Descriptor Based Methods
Low-Intensity Guided Help Through Mindfulness (LIGHTMIND): study protocol for a randomised controlled trial comparing supported mindfulness-based cognitive therapy self-help to supported cognitive behavioural therapy self-help for adults experiencing depression
Background
Depression has serious personal, family and economic consequences. It is estimated that it will cost £12.15 billion to the economy each year in England by 2026. Improving access to psychological therapies (IAPT) is the National Health Service talking therapies service in England for adults experiencing anxiety or depression. Over 1 million people are referred to IAPT every year, over half experiencing depression. Where symptoms of depression are mild to moderate, people are typically offered cognitive behavioural therapy (CBT) self-help (CBT-SH) supported by a psychological well-being practitioner. The problem is that over half of people who complete treatment for depression in IAPT remain depressed despite receiving National Institute of Health and Care Excellent recommended treatment. Furthermore, less than half of IAPT service users complete treatment. This study seeks to investigate the effectiveness of an alternative to CBT-SH. Mindfulness-based cognitive therapy (MBCT) differs from CBT in focus, approach and practice, and may be more effective with a higher number of treatment completions.
Methods/design
This is a definitive randomised controlled trial comparing supported MBCT self-help (MBCT-SH) with CBT-SH for adults experiencing mild to moderate depression being treated in IAPT services. We will recruit 410 participants experiencing mild to moderate depression from IAPT services and randomise these to receive either an MBCT-based self-help workbook or a CBT-based self-help workbook. Participants will be asked to complete their workbook within 16 weeks, with six support sessions with a psychological well-being practitioner. The primary outcome is depression symptom severity on treatment completion. Secondary outcomes are treatment completion rates and measures of generalized anxiety, well-being, functioning and mindfulness. An exploratory non-inferiority analysis will be conducted in the event the primary hypothesis is not supported. A semi-structured interview with participants will guide understanding of change processes.
Discussion
If the findings from this randomised controlled trial demonstrate that MBCT-SH is more effective than CBT-SH for adults experiencing depression, this will provide evidence for policy makers and lead to changes to clinical practice in IAPT services, leading to greater choice of self-help treatment options and better outcomes for service users. If the exploratory non-inferiority analysis is conducted and this indicates non-inferiority of MBCT-SH in comparison to CBT-SH this will also be of interest to policy makers when seeking to increase service user choice of self-help treatment options for depression.
Trial registration
Current Controlled Trial registration number: ISRCTN 13495752. Registered on 31 August 2017 (www.isrctn.com/ISRCTN13495752)
Chiral phase boundary of QCD at finite temperature
We analyze the approach to chiral symmetry breaking in QCD at finite
temperature, using the functional renormalization group. We compute the running
gauge coupling in QCD for all temperatures and scales within a simple truncated
renormalization flow. At finite temperature, the coupling is governed by a
fixed point of the 3-dimensional theory for scales smaller than the
corresponding temperature. Chiral symmetry breaking is approached if the
running coupling drives the quark sector to criticality. We quantitatively
determine the phase boundary in the plane of temperature and number of flavors
and find good agreement with lattice results. As a generic and testable
prediction, we observe that our underlying IR fixed-point scenario leaves its
imprint in the shape of the phase boundary near the critical flavor number:
here, the scaling of the critical temperature is determined by the
zero-temperature IR critical exponent of the running coupling.Comment: 39 pages, 8 figure
Asymptotic Safety, Emergence and Minimal Length
There seems to be a common prejudice that asymptotic safety is either
incompatible with, or at best unrelated to, the other topics in the title. This
is not the case. In fact, we show that 1) the existence of a fixed point with
suitable properties is a promising way of deriving emergent properties of
gravity, and 2) there is a sense in which asymptotic safety implies a minimal
length. In so doing we also discuss possible signatures of asymptotic safety in
scattering experiments.Comment: LaTEX, 20 pages, 2 figures; v.2: minor changes, reflecting published
versio
Combined Analysis of all Three Phases of Solar Neutrino Data from the Sudbury Neutrino Observatory
We report results from a combined analysis of solar neutrino data from all
phases of the Sudbury Neutrino Observatory. By exploiting particle
identification information obtained from the proportional counters installed
during the third phase, this analysis improved background rejection in that
phase of the experiment. The combined analysis resulted in a total flux of
active neutrino flavors from 8B decays in the Sun of (5.25 \pm
0.16(stat.)+0.11-0.13(syst.))\times10^6 cm^{-2}s^{-1}. A two-flavor neutrino
oscillation analysis yielded \Deltam^2_{21} = (5.6^{+1.9}_{-1.4})\times10^{-5}
eV^2 and tan^2{\theta}_{12}= 0.427^{+0.033}_{-0.029}. A three-flavor neutrino
oscillation analysis combining this result with results of all other solar
neutrino experiments and the KamLAND experiment yielded \Deltam^2_{21} =
(7.41^{+0.21}_{-0.19})\times10^{-5} eV^2, tan^2{\theta}_{12} =
0.446^{+0.030}_{-0.029}, and sin^2{\theta}_{13} =
(2.5^{+1.8}_{-1.5})\times10^{-2}. This implied an upper bound of
sin^2{\theta}_{13} < 0.053 at the 95% confidence level (C.L.)
Quantum Einstein Gravity
We give a pedagogical introduction to the basic ideas and concepts of the
Asymptotic Safety program in Quantum Einstein Gravity. Using the continuum
approach based upon the effective average action, we summarize the state of the
art of the field with a particular focus on the evidence supporting the
existence of the non-trivial renormalization group fixed point at the heart of
the construction. As an application, the multifractal structure of the emerging
space-times is discussed in detail. In particular, we compare the continuum
prediction for their spectral dimension with Monte Carlo data from the Causal
Dynamical Triangulation approach.Comment: 87 pages, 13 figures, review article prepared for the New Journal of
Physics focus issue on Quantum Einstein Gravit
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