Evaluation of serum paraoxonase level and dyslipidemia in psoriasis

Background: Psoriasis is a chronic recurrent inflammatory skin disorder that is associated with oxidative stress, altered lipid metabolism and with high risk of cardiovascular events. High density lipoprotein (HDL) bound serum paraoxonase enzyme exhibits anti-atherogenic properties. It protects against the development of coronary heart disease by preventing low density lipoprotein (LDL) oxidation. The aim of our work was to evaluate the serum paraoxonase levels and dyslipidemia in psoriasis.Methods: Present study involved 100 participants of which 50 were diagnosed cases of psoriasis and 50 were age and sex matched healthy controls, who fulfilled inclusion criteria. Serum paraoxonase (PON), and lipid profile were estimated in cases and controls. Lipid profile was estimated by using autoanalyser EM 200 and serum paraoxonase by spectrophotometric method.Results: Patients presented risk changes in lipid profile [(increase in triglycerides (p=0.005), low density lipoprotein cholesterol (p=0.009), very low density levels (p=0.002) and a reduction in high density lipoprotein cholesterol (p≤0.001)] which were highly significant when compared to controls. Serum paraoxonase levels was decreased in psoriasis patient compared to control which was statistically highly significant (p= 0.001).Conclusions: Present data suggest that psoriasis patients must be considered as a group at risk for cardiovascular disease

Adverse drug reactions in the department of dermatology at a tertiary care hospital: a prospective study

Background: To study cutaneous adverse drug reactions with regard to their clinical pattern. etiology, causality and severity.Methods: It was a prospective study undertaken in a 300 bedded tertiary care hospital. Patients with cutaneous ADRs presenting in Dermatology OPD were studied. Causality and severity of the adverse drug reactions were analysed and other parameters such as gender wise distribution of the ADRs and types of ADR were studied.Results: 35 cases of ADRs were enrolled for the study in the duration of Sept.2016 to May 2017. The majority of the patients were in the age group of 21-30 years (37.14%). The most common CADRs were Acne vulgaris (22.86%), followed by Fixed Drug eruption (11.43%) and Tinea cruris (8.57%). The most common class of drugs causing ADRs were topical steroids (64%), followed by non-steroidal anti-inflammatory drugs (14.29%).Conclusions: Female preponderance was seen. Topical steroids were the most offending drug followed by Diclofenac Sodium, the analgesic. Causality assessment showed a high score of Certain category. These variations may be explained by variations in drug usage patterns. The knowledge of the adverse drug reactions and the drugs causing them is essential for the clinician so that the choice of drug therapy can be made keeping these adverse drug reactions in mind

Adolescent Neuroblastoma of Lower Limb

Neuroblastoma is an embryonic tumour of neural crest origin, commonly seen in children with upper abdomen involvement. Rarely neuroblastomas present in adolescents and adults involving lower limb. Histopathologically neuroblastoma of lower limb can be confused with other small round cell tumour especially with Ewing’s sarcoma and rhabdomyosarcoma. A 16 year old male presented with 15x11cm swelling, pain and multiple discharging sinuses of right leg since 4 months. Routine haematological and biochemical analysis were within normal limits. Radiology of right leg showed large soft tissue swelling encompassing the pathological fracture of tibia and bowing of fibula. Fine needle aspiration of the swelling revealed malignant small round cell tumour. Histopathology revealed poorly differentiated neuroblastoma of lower limb. The immunohistochemistry of Synaptophysin and Chromogranin were positive and CD 99 was negative. Neuroblastoma diagnosed at unusual site with uncommon age has poor prognosis. Hence, one must keep in mind the differential diagnosis of neuroblastoma as one of the differential diagnosis in evaluating the soft tissue tumours of lower limb

Trust And Energy-Aware Routing Protocol for Wireless Sensor Networks Based on Secure Routing

Wireless Sensor Network (WSN) is a network area that includes a large number of nodes and the ability of wireless transmission. WSNs are frequently employed for vital applications in which security and dependability are of utmost concern. The main objective of the proposed method is to design a WSN to maximize network longevity while minimizing power usage. In a WSN, trust management is employed to encourage node collaboration, which is crucial for achieving dependable transmission. In this research, a novel Trust and Energy Aware Routing Protocol (TEARP) in wireless sensors networks is proposed, which use blockchain technology to maintain the identity of the Sensor Nodes (SNs) and Aggregator Nodes (ANs). The proposed TEARP technique provides a thorough trust value for nodes based on their direct trust values and the filtering mechanisms generate the indirect trust values. Further, an enhanced threshold technique is employed to identify the most appropriate clustering heads based on dynamic changes in the extensive trust values and residual energy of the networks. Lastly, cluster heads should be routed in a secure manner using a Sand Cat Swarm Optimization Algorithm (SCSOA). The proposed method has been evaluated using specific parameters such as Network Lifetime, Residual Energy, Throughpu,t Packet Delivery Ratio, and Detection Accuracy respectively. The proposed TEARP method improves the network lifetime by 39.64%, 33.05%, and 27.16%, compared with Energy-efficient and Secure Routing (ESR), Multi-Objective nature-inspired algorithm based on Shuffled frog-leaping algorithm and Firefly Algorithm (MOSFA) , and Optimal Support Vector Machine (OSVM)

Leadership Qualities Among Women Leaders in Educational Institutions at Bangalore City

Purpose: First, it seeks to investigate the factors that influence women's leadership traits within academic institutions located in Bangalore. Second, it aims to gain a deeper understanding of the evolving role of women in leadership positions within modern society.   Design/Methodology/Approach: To achieve its objectives, this study employs a qualitative research approach. Researchers conduct interviews and surveys within academic institutions in Bangalore. By gathering and analyzing this data, they intend to uncover key themes and patterns that shed light on the factors impacting women's leadership traits.   Findings: The findings of this research reveal several noteworthy insights. It becomes evident that women's leadership traits are significantly influenced by societal perceptions and economic circumstances. Furthermore, the progression of women in their professional lives has played a crucial role in altering societal views. The study also acknowledges the importance of India's long-standing policy efforts to promote women's development. Additionally, it highlights the remarkable achievements of women in various fields, including academia and athletics.   Research, Practical & Social implications: In terms of implications, this study carries significance on multiple fronts. From a research standpoint, it offers valuable insights into the factors that shape women's leadership roles within academic institutions. Practically, the findings can inform strategies and initiatives aimed at promoting and enhancing women's leadership within the educational sector. On a broader social level, the study underscores the evolving role of women in Indian society, emphasizing the importance of gender equality as a key societal value.   Originality/Value: In terms of originality, this research distinguishes itself by focusing on the specific context of academic institutions in Bangalore. Its value lies in its contribution to a deeper understanding of women's leadership within a culturally diverse context, shedding light on the unique factors at play in this region

The nature of the resistance in groundnut to rosette disease

Groundnut rosette disease is caused by a complex of three agents, groundnut rosette virus (GRV) and its satellite RNA, and groundnut rosette assistor virus (GRAV); the satellite RNA is mainly responsible for the disease symptoms. Groundnut genotypes possessing resistance to rosette disease were shown to be highly resistant (though not immune) to GRV and therefore to its satellite RNA, but were fully susceptible to GRAV

3′-UTR SNP rs2229611 in G6PC1 affects mRNA stability, expression and Glycogen Storage Disease type-Ia risk

The frequency of rs2229611, previously reported in Chinese, Caucasians, Japanese and Hispanics, was investigated for the first time in Indian ethnicity. We analyzed its role in the progression of Glycogen Storage Disease type-Ia (GSD-Ia) and breast cancer. Genotype data on rs2229611 revealed that the risk of GSD-Ia was higher (P = 0.0195) with CC compared to TT/TC genotypes, whereas no such correlation was observed with breast cancer cases. We observed a strong linkage disequilibrium (LD) among rs2229611 and other disease causing G6PC1 variants (| D′| = 1, r2 = 1). Functional validation performed in HepG2 cells using luciferase constructs showed significant (P < 0.05) decrease in expression than wild-type 3′-UTR due to curtailed mRNA stability. Furthermore, AU-rich elements (AREs) mediated regulation of G6PC1 expression characterized using 3′-UTR deletion constructs showed a prominent decrease in mRNA stability. We then examined whether miRNAs are involved in controlling G6PC1 expression using pmirGLO-UTR constructs, with evidence of more distinct inhibition in the reporter function with rs2229611. These data suggests that rs2229611 is a crucial regulatory SNP which in homozygous state leads to a more aggressive disease phenotype in GSD-Ia patients. The implication of this result is significant in predicting disease onset, progression and response to disease modifying treatments in patients with GSD-Ia

Salmonella Paratyphi B bacteremia in Systemic Lupus Erythematosus with an unusual presentation- a case report

Background- Systemic Lupus Erythematosus (SLE) is an inflammatory and multisystem autoimmune disorder. Patients of SLE are at increased risk of infections owing to underlying immunological derangements and to the use of therapeutic regimens like immunosuppressive agents. Among the bacterial infections presenting as bacteremia in these patients, non typhoidal and typhoidal salmonellosis are commonly encountered. We report a rare case of Salmonella Paratyphi B bacteremia in a patient with juvenile onset SLE on treatment with corticosteroids

IDENTIFICATION OF ANTIULCER ACTIVITY BY INSILICO METHOD IN SELECTED MEDICINAL PLANTS

Ulcer occurs when stomach acid damages the lining of the digestive tract caused by the bacteria Helicobacter pylori. Many pharmacological activities such as antiulcer activity can act against ulcer. Medicinal plants like Mimosa pudica and Vachellia nilotica has the antiulcer activity in a wide range. To study the antiulcer activity in medicinal plants using insilco studies by comparing the phytocompounds of plants with histamine 2 receptor as a binding protein, which is present in the stomach lining of homosapiens. Histamine 2 receptor was modelled using Swiss model and the ligand structures are obtained from PUB-CHEM, viewed easily via PYMOL. All the phytocompounds showed good binding energy with modelled protein on the docking methodology. Specifically ascorbic acid exhibited the lower binding energy of value -3.24 kcal/mol, indole and catechin shows highest binding energy of value -4.99 kcal/mol and -4.98 kacl/mol respectively. The results can be useful for the design and development of phytocompounds having better inhibitory activity against several types of ulcer