Constructing optimal entanglement witnesses. II

We provide a class of optimal nondecomposable entanglement witnesses for 4N x 4N composite quantum systems or, equivalently, a new construction of nondecomposable positive maps in the algebra of 4N x 4N complex matrices. This construction provides natural generalization of the Robertson map. It is shown that their structural physical approximations give rise to entanglement breaking channels.Comment: 6 page

Constructing new optimal entanglement witnesses

We provide a new class of indecomposable entanglement witnesses. In 4 x 4 case it reproduces the well know Breuer-Hall witness. We prove that these new witnesses are optimal and atomic, i.e. they are able to detect the "weakest" quantum entanglement encoded into states with positive partial transposition (PPT). Equivalently, we provide a new construction of indecomposable atomic maps in the algebra of 2k x 2k complex matrices. It is shown that their structural physical approximations give rise to entanglement breaking channels. This result supports recent conjecture by Korbicz et. al.Comment: 9 page

Strategic management approaches in the evolution of cinema chains

This article delves into the critical role of strategic management in the context of cinema chains, aiming to identify the key strategic elements that influence their development and operation. It addresses two primary research questions: “What are the main strategic elements that impact the development of cinema chains?” and “How do strategic management components such as market positioning, innovation, strategic planning, analysis, formulation, and implementation assist cinema chains in navigating market challenges, including the shift to digital content distribution?” This study contributes meaningfully to the discourse on strategic management within the entertainment sector, offering practical insights for decision-makers in cinema chains. The research involved a comprehensive literature review, utilizing renowned academic sources such as Scopus, EBSCO, and JSTOR, covering publications from 1990 to 2022. This approach aimed to dissect the complex layers of strategic management in the cinema industry, shedding light on the unique challenges and opportunities within this segment of the entertainment market. Our research highlights a notable gap in the existing literature concerning strategic management practices specifically within the realm of cinema chains. This deficiency points to a need for more focused research in this area. Based on our findings, it is recommended that cinema chains prioritize the adoption of technological innovations and diversify their revenue streams to remain competitive. Strategic adaptability, informed by continuous monitoring of internal and external factors, is essential for sustainable growth in the rapidly evolving film industry. The findings of this study could significantly enrich the academic dialogue and offer pragmatic advice for industry practitioners. The identified gap in the literature underscores the urgency of initiating primary research, such as surveys, interviews, or case studies, in the field of cinema chain management. Such research promises to deepen the empirical understanding of strategic management practices and provide actionable guidance for industry stakeholders

Optimal entanglement witnesses from generalized reduction and Robertson maps

We provide a generalization of the reduction and Robertson positive maps in matrix algebras. They give rise to a new class of optimal entanglement witnesses. Their structural physical approximation is analyzed. As a byproduct we provide a new examples of PPT (Positive Partial Transpose) entangled states.Comment: 14 page

Clinical and neuropathological picture of ethylmalonic aciduria : diagnostic dilemma

Increased ethylmalonic acid (EMA) in urine is a non-specific finding, and is observed in a number of inborn errors of metabolism, as well as in individuals who carry one of two common polymorphisms identified in the SCAD coding region. The authors present an 8-month-old girl with a suspicion of neuroinfection, although the clinical presentation led to diagnosis of ethylmalonic aciduria. From the neuropathological point of view the most remarkable changes were observed in the brain cortex, which was diffusely damaged practically in all regions of the brain. Of note, the most severe destruction was observed in the deepest regions of the sulci. The cortex of the affected regions showed no normal stratification and its structure was almost totally replaced by a form of "granulation tissue" with a markedly increased number of capillaries. To the authors’ knowledge this is the first clinical report of ethylmalonic aciduria with brain autopsy findings

Combined assessment of clinical and patient factors on doctors’ decisions to prescribe antibiotics

BACKGROUND: Antibiotic overprescription is a worldwide problem. Decisions regarding antibiotic prescription for respiratory tract infections (RTIs) are influenced by medical and non-medical factors. METHODS: In family medicine practices in Białystok, Poland, family medicine residents directly observed consultations with patients with RTI symptoms. The observing residents completed a questionnaire including patient data, clinical symptoms, diagnosis, any prescribed antibiotic, and assessment of ten patient pressure factors. RESULTS: Of 1546 consultations of patients with RTIs, 54.26 % resulted in antibiotic prescription. Antibiotic prescription was strongly associated with rales (OR 26.90, 95 % CI 9.00–80.40), tonsillar exudates (OR 13.03, 95 % CI 7.10–23.80), and wheezing (OR 14.72, 95 % CI 7.70–28.10). The likelihood of antibiotic prescription was increased by a >7-day disease duration (OR 3.94, 95 % CI 2.80–5.50), purulent nasal discharge (OR 3.87, 95 % CI 2.40–6.10), starting self-medication with antibiotics (OR 4.11, 95 % CI 2.30–7.30), and direct request for antibiotics (OR 1.87, 95 % CI 1.30–2.80). Direct request not to prescribe antibiotics decreased the likelihood of receiving antibiotics (OR 0.34, 95 % CI 0.27–0.55). CONCLUSION: While clinical signs and symptoms principally impact prescribing decisions, patient factors also contribute. The most influential patient pressure factors were starting self-medication with antibiotics, and directly requesting antibiotic prescription or no antibiotic prescription. Interventions aiming to improve clinical sign and symptom interpretation and to help doctors resist direct patient pressure could be beneficial for reducing unnecessary antibiotic prescribing

Strategic management approaches in the evolution of cinema chains

This article delves into the critical role of strategic management in the context of cinema chains, aiming to identify the key strategic elements that influence their development and operation. It addresses two primary research questions: “What are the main strategic elements that impact the development of cinema chains?” and “How do strategic management components such as market positioning, innovation, strategic planning, analysis, formulation, and implementation assist cinema chains in navigating market challenges, including the shift to digital content distribution?” This study contributes meaningfully to the discourse on strategic management within the entertainment sector, offering practical insights for decision-makers in cinema chains. The research involved a comprehensive literature review, utilizing renowned academic sources such as Scopus, EBSCO, and JSTOR, covering publications from 1990 to 2022. This approach aimed to dissect the complex layers of strategic management in the cinema industry, shedding light on the unique challenges and opportunities within this segment of the entertainment market. Our research highlights a notable gap in the existing literature concerning strategic management practices specifically within the realm of cinema chains. This deficiency points to a need for more focused research in this area. Based on our findings, it is recommended that cinema chains prioritize the adoption of technological innovations and diversify their revenue streams to remain competitive. Strategic adaptability, informed by continuous monitoring of internal and external factors, is essential for sustainable growth in the rapidly evolving film industry. The findings of this study could significantly enrich the academic dialogue and offer pragmatic advice for industry practitioners. The identified gap in the literature underscores the urgency of initiating primary research, such as surveys, interviews, or case studies, in the field of cinema chain management. Such research promises to deepen the empirical understanding of strategic management practices and provide actionable guidance for industry stakeholders

Potencjalne zastosowanie terapeutyczne inhibitorów PERK

Ostatnie badania mające na celu poznanie molekularnych mechanizmów chorób człowieka wskazują, iż w patogenezie wielu zaburzeń metabolicznych, włączając w to procesy zapalne, starzenie organizmu, a także nowotworowy oraz choroby neurodegeneracyjne, znaczącą rolę odgrywa stres ER, który jest związany z gromadzeniem się nieprawidłowo sfałdowanych białek w świetle ER. W odpowiedzi na stres ER indukowany jest szlak UPR, który może pełnić dwojaką rolę.  Szlak UPR może przywracać homeostazę w obrębie ER poprzez degradację nieprawidłowych białek, hamowanie dalszej translacji i mobilizację białek opiekuńczych, ale może również promować apoptozę w warunkach przedłużającego się stresu ER. Szlak UPR rozgałęzia się na trzy odrębne ścieżki sygnałowe, w którym uczestniczą trzy receptory transmembranowe: PERK, IRE1 oraz ATF6. Najbardziej obiecująca dla rozwoju nowych terapii wielu schorzeń człowieka, a w szczególności chorób neurodegeneracyjnych oraz nowotworowych, jest ścieżka związana z PERK, której inhibicja wykazywała pozytywne efekty terapeutyczne zarówno w badaniach in vitro jak i in vivo.</jats:p