Polymorphisms, diet and nutrigenomics

Every human being possesses an exclusive nutritional blueprint inside their genes. Bioactive food components and nutrients affect the expression of such genes. Nutrigenomics is the  science that analyzes gene-nutrient interactions (nutrigenetics), which can lead to the development of personalized nutritional recommendations to maintain optimal health and prevent disease. Genomic diversity among various ethnic groups might affect nutrients bioavailability as well as their metabolism. Nutrigenomics combines different branches of science including nutrition, bioinformatics, genomics, molecular biology, molecular medicine, and epidemiology. Genes regulate intake and metabolism of different nutrients, while nutrients positively or negatively influence the expression of a number of genes; testing of specific genetic polymorphisms may therefore become a useful tool to manage weight loss and to fully understand gene-nutrient interactions. Indeed, several approaches are used to study gene-nutrient interactions: epigenetics, the study of genome modification not related to changes in nucleotide sequence; transcriptomics, the study of tissue-specific and time-specific RNA transcripts; proteomics, the study of proteins involved in biological processes; and metabolomics, the study of changes of primary and secondary metabolites in body fluids and tissues. Hence, the use of nutrigenomics to improve and optimize a healthy, balanced diet in clinical settings could be an effective approach for long-term lifestyle changes that might lead to consistent weight loss and improve quality of life

Requiem for a German Past. A Boyhood among the Nazis

Herbst J. Requiem für eine deutsche Vergangenheit. Eine Jugend im Nationalsozialismus. 1st ed. Schütze SB, tran. Wolfenbüttel: HMS-Media-Service ; 2015

Aligning the LINC-NIRVANA Natural Guide Stars MCAO system

LINC-NIRVANA (LN) is an instrument built to be a Fizeau interferometric imager for the Large Binocular Telescope that will achieve ELT-like spatial resolution. Of course achieving this outstanding resolution requires a very complex instrument, assuring the delivery of plane wavefronts, parallel input beams, homoteticity and zero Optical Path Difference. LN will be one of the most complex ground-based instruments ever built, consisting of a Multi-Conjugate Adaptive Optics (MCAO) system, a fringe tracker, a beam combiner and a Near-InfraRed science camera, for a total of more than 250 indivudual lenses and mirrors.The MCAO sub-unit itself is the state of the art in the sector of wide field adaptive optics. It consists of 4 Wavefront Sensors (WFSs), two for each arm of the telescope, to sense the turbulence at the ground layer and at 7.1 km above the telescope. They operate in a layer oriented, Multiple Field of View mode, using up to 12 Natural Guide Stars (NGSs) for the ground layer correction and up to 8 NGSs for the mid layer correction.The ambitious nature of LN, which compels us to meet very tight requirements, together with the high number of subsystems lead to a challenging alignment procedure of the instrument. Despite of the complexity, the Alignment, Integration and Verification phase of the instrument has been recently completed with success in Heidelberg and LN is currently on its way to the LBT, where it will be re-aligned and finally mounted at one of the bend focal stations of the telescope. In this paper the integration and alignment procedure of the MCAO subsystem to the rest of LN is described and results are presented

Aligning the LINC-NIRVANA Natural Guide Stars MCAO system

LINC-NIRVANA (LN) is an instrument built to be a Fizeau interferometric imager for the Large Binocular Telescope that will achieve ELT-like spatial resolution. Of course achieving this outstanding resolution requires a very complex instrument, assuring the delivery of plane wavefronts, parallel input beams, homoteticity and zero Optical Path Difference. LN will be one of the most complex ground-based instruments ever built, consisting of a Multi-Conjugate Adaptive Optics (MCAO) system, a fringe tracker, a beam combiner and a Near-InfraRed science camera, for a total of more than 250 indivudual lenses and mirrors.The MCAO sub-unit itself is the state of the art in the sector of wide field adaptive optics. It consists of 4 Wavefront Sensors (WFSs), two for each arm of the telescope, to sense the turbulence at the ground layer and at 7.1 km above the telescope. They operate in a layer oriented, Multiple Field of View mode, using up to 12 Natural Guide Stars (NGSs) for the ground layer correction and up to 8 NGSs for the mid layer correction.The ambitious nature of LN, which compels us to meet very tight requirements, together with the high number of subsystems lead to a challenging alignment procedure of the instrument. Despite of the complexity, the Alignment, Integration and Verification phase of the instrument has been recently completed with success in Heidelberg and LN is currently on its way to the LBT, where it will be re-aligned and finally mounted at one of the bend focal stations of the telescope. In this paper the integration and alignment procedure of the MCAO subsystem to the rest of LN is described and results are presented