Metodologias para estudos integrados de recursos naturais: uma discussão a partir do zoneamento ecológico-econômico

This article examines methodological developments in integrated zoning, which are used in the environmental planning and land use in Brazil. In particular, it focuses on Ecological-Economic Zoning (EEZ), a methodology that has become the primary instrument of territorial planning in the Brazilian government. Throughout its historical development process, EEZ has become an interdisciplinary zoning method, which incorporates various environmental and socio-economic themes. However, there are still several central issues in constant discussion and many challenges to be resolved. Various sides of this discussion are analyzed, and new methodologies are suggested from other research areas, which may contribute to the efficiency of integrated environmental studies.Este artigo adentra-se no debate sobre as evoluções metodológicas dos zoneamentos integrados constantes nos instrumentos de planejamento ambiental e de ordenamento territorial do Brasil. Em especial, enfoca o debate promovido em torno da metodologia do Zoneamento Ecológico-Econômico – ZEE - brasileiro, instrumento basilar de planejamento territorial do país. Ao longo de seu processo histórico de desenvolvimento, o ZEE tornou-se um zoneamento amplo, que incorpora diversas temáticas ambientais e sócio-econômicas. Contudo, ainda existem diversos pontos nevrálgicos em constante discussão, bem como vários desafios a serem vencidos. O artigo pretende cobrir várias facetas desse debate, além de sugerir novas metodologias provenientes de outras áreas de estudo, e que podem contribuir para que os estudos integrados de meio ambiente tornem-se cada vez mais eficientes

CARACTERÍSTICAS GRANULOMÉTRICAS DO SOLO DA FUNDAÇÃO CAIO MARTINS, SÃO FRANCISCO, MG

Este estudo busca apresentar o perfil granulométrico do solo da Fundação Caio Martins (FUCAM), área estadual localizada à beira do rio São Francisco, no município também denominado São Francisco, no Norte de Minas Gerais. Para isso coletou-se amostras de solo no ano de 2016 e através do uso de peneiras próprias do laboratório de Laboratório de Mecânica dos Solos da UFOP, foi possível reconhecer o perfil granulométrico de cada uma das seis amostragens realizadas que representavam toda a área de estudo pesquisada. Como resultado foi possível afirmar que todas as amostras apresentaram textura siltosa, destacando-se o fato de que a medida que a ação antrópica por local de coleta era detectada, maiores frações de pedregulho eram detectadas, por consequência, o aumento do perfil síltico por região amostral se dá à medida que o solo se apresenta mais conservado da ação humana, sendo possível afirmar que o mais degradado, sobre a ótica granulométrica é exatamente o setor Leste, onde se localizam a maior parte das atividades impactantes do local e onde estão a maior parte das ações da Fundação. Obviamente mais estudos, em especial o geoquímico, são importantes de serem realizados para se afirmar quais as espécies mais adequadas ao cultivo, mas sob um ponto de vista granulométrico do solo, todos os vegetais arbóreos originários do Cerrado são indicados para o plantio na área da FUCAM

Superpulsed low-level laser therapy protects skeletal muscle of mdx mice against damage, inflammation and morphological changes delaying dystrophy progression.

Aim: To evaluate the effects of preventive treatment with low-level laser therapy (LLLT) on progression of dystrophy in mdx mice. Methods: Ten animals were randomly divided into 2 experimental groups treated with superpulsed LLLT (904 nm, 15 mW, 700 Hz, 1 J) or placebo-LLLT at one point overlying the tibialis anterior muscle (bilaterally) 5 times per week for 14 weeks (from 6th to 20th week of age). Morphological changes, creatine kinase (CK) activity and mRNA gene expression were assessed in animals at 20th week of age. Results: Animals treated with LLLT showed very few morphological changes in skeletal muscle, with less atrophy and fibrosis than animals treated with placebo-LLLT. CK was significantly lower (p = 0.0203) in animals treated with LLLT (864.70 U.l−1, SEM 226.10) than placebo (1708.00 U.l−1, SEM 184.60). mRNA gene expression of inflammatory markers was significantly decreased by treatment with LLLT (p<0.05): TNF-α (placebo-control = 0.51 µg/µl [SEM 0.12], - LLLT = 0.048 µg/µl [SEM 0.01]), IL-1β (placebo-control = 2.292 µg/µl [SEM 0.74], - LLLT = 0.12 µg/µl [SEM 0.03]), IL-6 (placebo-control = 3.946 µg/µl [SEM 0.98], - LLLT = 0.854 µg/µl [SEM 0.33]), IL-10 (placebo-control = 1.116 µg/µl [SEM 0.22], - LLLT = 0.352 µg/µl [SEM 0.15]), and COX-2 (placebo-control = 4.984 µg/µl [SEM 1.18], LLLT = 1.470 µg/µl [SEM 0.73]). Conclusion: Irradiation of superpulsed LLLT on successive days five times per week for 14 weeks decreased morphological changes, skeletal muscle damage and inflammation in mdx mice. This indicates that LLLT has potential to decrease progression of Duchenne muscular dystrophy

Lifetime cannabis use and childhood trauma associated with CNR1 genetic variants increase the risk of psychosis: findings from the STREAM study

Objectives: Gene-environment interactions increase the risk of psychosis. The objective of this study was to investigate gene-gene and gene-environment interactions in psychosis, including single nucleotide variants (SNVs) of dopamine-2 receptor (D2R), N-methyl-d-aspartate receptor (NMDAR), and cannabinoid receptor type 1 (CB1R), lifetime cannabis use, and childhood trauma. Methods: Twenty-three SNVs of genes encoding D2R (DRD2: rs1799978, rs7131056, rs6275), NMDAR (GRIN1: rs4880213, rs11146020; GRIN2A: rs1420040, rs11866328; GRIN2B: rs890, rs2098469, rs7298664), and CB1R (CNR1: rs806380, rs806379, rs1049353, rs6454674, rs1535255, rs2023239, rs12720071, rs6928499, rs806374, rs7766029, rs806378, rs10485170, rs9450898) were genotyped in 143 first-episode psychosis patients (FEPp) and 286 communitybased controls by Illumina HumanCoreExome-24 BeadChip. Gene-gene and gene-environment associations were assessed using nonparametric Multifactor Dimensionality Reduction software. Results: Single-locus analyses among the 23 SNVs for psychosis and gene-gene interactions were not significant (p 4 0.05 for all comparisons); however, both environmental risk factors showed an association with psychosis (p o 0.001). Moreover, gene-environment interactions were significant for an SNV in CNR1 and cannabis use. The best-performing model was the combination of CNR1 rs12720071 and lifetime cannabis use (p o 0.001), suggesting an increased risk of psychosis. Conclusion: Our study supports the hypothesis of gene-environment interactions for psychosis involving T-allele carriers of CNR1 SNVs, childhood trauma, and cannabis use

Evaluation of Depression, Anxiety and Sleep Quality in the Brazilian Population During Social Isolation Due to the New Coronavirus (SARS-CoV-2) pandemic: the DEGAS-CoV Study/ Avaliação da Depressão, Ansiedade e Qualidade do Sono na População Brasileira Durante o Isolamento Social Devido à Nova Pandemia do Coronavírus (SARS-CoV-2): o Estudo DEGAS-CoV

Introduction: The new coronavirus infection (COVID-19) has caused distress and repercussions in mental and physical health of individuals. Depression, anxiety and worsening of sleep quality have been reported in several recent articles that surveyed populations all over the globe. Our work meant to access, through a cross-sectional study, these disorders in the Brazilian population, through the application of an online questionnaire conducted on the second trimester of 2020. Materials and Methods: We applied an online questionnaire, filled with questions regarding social, economic, financial, educational and health status, as well as questions from the Hospital Anxiety and Depression Scale (HAD), and from the Pittsburgh Sleep Quality Index (PSQI).Results: We collected 2,695 valid answers, from April 24th to May 31st, 2020. Age ranged from 18 to 79 years, mean of 31.3. Women were 76.3%, men 23.7%. Symptoms of Anxiety were found in 56.5%, of depression in 46.1%, and of bad sleep in 49.2%. Some groups were more prone than others to one or more of those conditions, such as: younger people, women, mestizos, people with lesser years of education, of lower income or whose income dropped significantly during the pandemic, caregivers, students, sedentary or people practicing less physical activity, people who followed more hours of news of COVID-19 and those less engaged in social and instrumental activities.Conclusion: anxiety, depression and bad sleep quality were significantly high in our survey. Mental and sleep health is heterogeneously affected among individuals, depending on social, economic, financial, educational and health status