Der inhalt der psychose.

Akademischer vortrag, gehalten im rathause der stadt Zürich am 16. jänner 1908

Psychological type and attitude towards Celtic Christianity among committed Churchgoers in the United Kingdom: an empirical study

This article takes the burgeoning interest in Celtic Christianity as a key example of the way in which churches may be responding to the changing spiritual and religious landscape in the United Kingdom today and examines the power of psychological type theory to account for variation in the attitude of committed churchgoers to this innovation. Data provided by a sample of 248 Anglican clergy and lay church officers (who completed the Francis Psychological Type Scales together with the Attitude toward Celtic Christianity Scale) demonstrated that intuitive types, feeling types, and perceiving types reported a more positive attitude towards Celtic Christianity than sensing types, thinking types, and judging types. These findings are interpreted to analyse the appeal of Celtic Christianity and to suggest why some committed churchgoers may find this innovation less attractive

Технологические решения для строительства эксплуатационной наклонно-направленной скважины глубиной 2850 метров на Игольско-Таловом нефтяном месторождении (Томская область)

Объектом работы эффективный являются эксплуатационная работы скважина для добычи нефти. Цель работы - продуктивный разработка техники и конструкция технологии бурения буровой эксплуатационной скважины технологии глубиной 2850 метров на Игольско-Тaловом месторождении. Работа разработка выполнена по сроки геологическим материалам Игольско-Тaлового месторождения.Ob"yekt raboty effektivnyy - ekspluatatsionnaya rabota skvazhina dlya dobychi nefti. Tselevaya rabota - produktivnaya razrabotka i razrabotka tekhnologiy bureniya burovoy ekspluatatsionnoy skvazhiny tekhnologii glubinoy 2850 metrov na Igol'sko-Talovom mestorozhdenii. Rabota razrabotka po pogodnym geologicheskim materialam Igol'sko-Talovogo mestorozhdeniya

ccTSA: A Coverage-Centric Threaded Sequence Assembler

De novo sequencing, a process to find the whole genome or the regions of a species without references, requires much higher computational power compared to mapped sequencing with references. The advent and continuous evolution of next-generation sequencing technologies further stress the demands of high-throughput processing of myriads of short DNA fragments. Recently announced sequence assemblers, such as Velvet, SOAPdenovo, and ABySS, all exploit parallelism to meet these computational demands since contemporary computer systems primarily rely on scaling the number of computing cores to improve performance. However, most of them are not tailored to exploit the full potential of these systems, leading to suboptimal performance. In this paper, we present ccTSA, a parallel sequence assembler that utilizes coverage to prune k-mers, find preferred edges, and resolve conflicts in preferred edges between k-mers. We minimize computation dependencies between threads to effectively parallelize k-mer processing. We also judiciously allocate and reuse memory space in order to lower memory usage and further improve sequencing speed. The results of ccTSA are compelling such that it runs several times faster than other assemblers while providing comparable quality values such as N50

The next detectors for gravitational wave astronomy

This paper focuses on the next detectors for gravitational wave astronomy which will be required after the current ground based detectors have completed their initial observations, and probably achieved the first direct detection of gravitational waves. The next detectors will need to have greater sensitivity, while also enabling the world array of detectors to have improved angular resolution to allow localisation of signal sources. Sect. 1 of this paper begins by reviewing proposals for the next ground based detectors, and presents an analysis of the sensitivity of an 8 km armlength detector, which is proposed as a safe and cost-effective means to attain a 4-fold improvement in sensitivity. The scientific benefits of creating a pair of such detectors in China and Australia is emphasised. Sect. 2 of this paper discusses the high performance suspension systems for test masses that will be an essential component for future detectors, while sect. 3 discusses solutions to the problem of Newtonian noise which arise from fluctuations in gravity gradient forces acting on test masses. Such gravitational perturbations cannot be shielded, and set limits to low frequency sensitivity unless measured and suppressed. Sects. 4 and 5 address critical operational technologies that will be ongoing issues in future detectors. Sect. 4 addresses the design of thermal compensation systems needed in all high optical power interferometers operating at room temperature. Parametric instability control is addressed in sect. 5. Only recently proven to occur in Advanced LIGO, parametric instability phenomenon brings both risks and opportunities for future detectors. The path to future enhancements of detectors will come from quantum measurement technologies. Sect. 6 focuses on the use of optomechanical devices for obtaining enhanced sensitivity, while sect. 7 reviews a range of quantum measurement options

ADAM9 is highly expressed in renal cell cancer and is associated with tumour progression

<p>Abstract</p> <p>Background</p> <p><b>A D</b>isintegrin <b>A</b>nd <b>M</b>etalloprotease (ADAM) 9 has been implicated in tumour progression of various solid tumours, however, little is known about its role in renal cell carcinoma. We evaluated the expression of ADAM9 on protein and transcript level in a clinico-pathologically characterized renal cell cancer cohort.</p> <p>Methods</p> <p>108 renal cancer cases were immunostained for ADAM9 on a tissue-micro-array. For 30 additional cases, ADAM9 mRNA of microdissected tumour and normal tissue was analyzed via quantitative RT-PCR. SPSS 14.0 was used to apply crosstables (Fisher's exact test and χ²-test), correlations and univariate as well as multivariate survival analyses.</p> <p>Results</p> <p>ADAM9 was significantly up-regulated in renal cancer in comparison to the adjacent normal tissue on mRNA level. On protein level, ADAM9 was significantly associated with higher tumour grade, positive nodal status and distant metastasis. Furthermore, ADAM9 protein expression was significantly associated with shortened patient survival in the univariate analysis.</p> <p>Conclusion</p> <p>ADAM9 is strongly expressed in a large proportion of renal cell cancers, concordant with findings in other tumour entities. Additionally, ADAM9 expression is significantly associated with markers of unfavourable prognosis. Whether the demonstrated prognostic value of ADAM9 is independent from other tumour parameters will have to be verified in larger study cohorts.</p

Die Wassermetaphorik als Grenzraumgestaltung in Uwe Tellkamps „Der Turm“ (2008)

Español El objetivo de este capítulo es analizar las metáforas del agua como elementos clave para la representación literaria de los espacios de frontera relacionados con la última fase de la República Democrática Alemana en la novela Der Turm de Uwe Tellkamp. El análisis se centra en los siguientes motivos y temas topográficos: Atlantis como negación de la utopía de la RDA; Archipiélago e isla como contraposición a la imagen continente de la utopía de la RDA; Aguas residuales y agua estancada como oposición al agua fluída en el barrio heterotópico de la torre; Fuentes y arroyos como símbolos del inconsciente (colectivo); y, por último, fluidez y porosidad como imágenes que visualizan la historia. El uso de estas metáforas no sólo cuestiona la topografía oficial del aparato estatal y del partido en la RDA y los diversos espacios fronterizos, sino que las imágenes de fluidez y porosidad también representan la discursividad de la memoria y la memoria colectiva en relación con el pasado de la RDA. La Dresde atlante de Der Turm de Tellkamp se representada mediante metáforas acuáticas como un universo topográfico, social e ideológico ambivalente y complejo con numerosos espacios fronterizos interiores y exteriores. English The aim of this chapter is to analyze the water metaphors as key elements for the literary representation of borderland spaces in the late German Democratic Republic in the novel The Tower by Uwe Tellkamp. The analysis focuses on the following topographic motives and topics: Atlantis as a denial of the GDR utopia; Archipelago and island as a contrast of the image continent of the GDR utopia; Wastewater and dammed up water as opposed to running water in the heterotopic tower district; fountains and streams as symbols of (collective) unconscious; and finally, fluidity and porosity as images of history. Not only does the use of these metaphors question the official topography of the state and party apparatus and the various borderland spaces, but images of fluidity and porosity also represent the discursiveness of memory and collective memory in relation to GDR’s past. The Atlantean Dresden in Tellkamp’s The Tower is portrayed by means of water metaphors as an ambivalent and complex topographical, social and ideological universe with many inner and outer borderland spaces.MINECO, proyecto de investigación FFI2017-84342-

AFM-Detected Apoptotic Changes in Morphology and Biophysical Property Caused by Paclitaxel in Ishikawa and HeLa Cells

The apoptosis of cancer cells is associated with changes in the important cell properties including morphology, surface roughness and stiffness. Therefore, the changes in morphology and biophysical properties can be a good way of evaluating the anticancer activity of a drug. This study examined the effect of paclitaxel on the properties of Ishikawa and HeLa cells using atomic force microscopy (AFM), and the relationship between the changes in morphology and the biophysical properties and apoptosis was discussed. The viability and proliferation of the cells were analyzed using the methylthiazol tetrazolium (MTT) method and a TUNEL assay to confirm cellular apoptosis due to a paclitaxel treatment. AFM observations clearly showed the apoptotic morphological and biophysical changes in Ishikawa and HeLa cells. After the paclitaxel treatment, the cell membrane was torn and holed, the surface roughness was increased, and the stiffness was decreased. These changes were observed more apparently after a 24 h treatment and in Ishikawa cells compared to HeLa cells. The MTT and TUNEL assays results revealed the Ishikawa cells to be more sensitive to paclitaxel than HeLa cells and definite apoptosis occurred after a 24 h treatment. These results showed good agreement with the AFM results. Therefore, research on the morphological and biophysical changes by AFM in cancer cells will help to evaluate the anticancer activities of the drugs

Psychological Type and Attitude towards Celtic Christianity among Committed Churchgoers in the United Kingdom: An Empirical Study

This article takes the burgeoning interest in Celtic Christianity as a key example of the way in which churches may be responding to the changing spiritual and religious landscape in the United Kingdom today and examines the power of psychological type theory to account for variation in the attitude of committed churchgoers to this innovation. Data provided by a sample of 248 Anglican clergy and lay church officers (who completed the Francis Psychological Type Scales together with the Attitude toward Celtic Christianity Scale) demonstrated that intuitive types, feeling types, and perceiving types reported a more positive attitude towards Celtic Christianity than sensing types, thinking types, and judging types. These findings are interpreted to analyse the appeal of Celtic Christianity and to suggest why some committed churchgoers may find this innovation less attractive