Heteropterys Tomentosa (a. Juss.) Infusion Counteracts Cyclosporin A Side Effects On The Ventral Prostate.

Cyclosporin A (CsA) is an immunosuppressive drug widely used in treatment of auto-immune diseases or after organ transplants. However, several side effects are commonly associated with CsA long term intake, some regarding to loss of reproductive organ function due to oxidative damage. Considering that phytotherapy is an important tool often used against oxidative stress, we would like to describe the beneficial effects of Heteropterys tomentosa intake to minimize the damage caused by CsA to the ventral prostate tissue of Wistar rats under laboratorial conditions. Thirty adult Wistar rats (Rattus norvegicus albinus) were divided into: control group (water); CsA group (Cyclosporin A); Ht group (H. tomentosa infusion) and CsA + Ht group (CsA and H. tomentosa infusion). Plasmic levels of hepatotoxicity markers, triglycerides, cholesterol and glucose were quantified. The ventral prostate tissue was analyzed under light microscopy, using stereological, morphometrical and immunohistochemical techniques. H. tomentosa did not cause any alterations either of the plasmic parameters or of the ventral prostate structure. CsA caused alterations of GOT, total and indirect bilirubin, cholesterol, triglycerides and glucose levels in the plasma; CsA-treated rats showed alterations of the ventral prostate tissue. There were no alterations regarding the plasma levels of GOT, triglycerides and glucose of CsA + Ht animals. The same group also showed normalization of most of the parameters analyzed on the ventral prostate tissue when compared to the CsA group. The treatments did not alter the pattern of AR expression or the apoptotic index of the ventral prostate epithelium. The results suggest a protective action of the H. tomentosa infusion against the side effects of CsA on the ventral prostate tissue, which could also be observed with plasmic biochemical parameters.133

Quality of infant sleep, electronic devices and bullying behaviors in schools

This research investigates the relationship betweenthe quality of infant sleep, the use of electronic devices and of videogames before bedtime and bullying behaviors in school context. Research Questions: Is the quality of infant sleep and the use of electronic devices at bedtime related to bullying? The use of electronic devices before bedtime affects sleep duration and latency? Purpose of the Study: To analyze the relationship between the use of electronic devices before bed and the sleep infant quality. As well as, the relation between the quality of the children sleep duration, children’ sleep latency, use of electronic devices, videogames in a daily basis, and bullying behaviors in school context. Research Methods: Participants are divided into two groups; one of these groups consists of the children who responded to the Pittsburgh Sleep Quality Index andthe Children’s Sleep Habits Questionnaire (CSHQ-PT), totalling 860. The other group had a sample of 51 children, the Sociodemographic Questionnaire and the Children’s Sleep Habits Questionnaire (CSHQ-PT) were applied. Findings: A statistically significant relationship was found between sleep quality and use of electronic devices before bed, with the exception of television. As a relationship between sleep quality and bullying behaviors, and also between using electronic gadgets before bedtime and bullying behaviors just for listening to music. Considering the sleep latency, a negative correlation was found with daily videogames use. Conclusions: There seems to be a relationship between sleep quality and bullying behaviors in school, and between the use of electronic devices and sleep quality. Also listening to music at bedtime is positively related to bullying behaviors. On the other hand, the videogames daily use before bedtime affects in a significant manner the children’ sleep latency (and the sleep REM)..info:eu-repo/semantics/publishedVersio

Colonization by aquatic macroinvertebrates in leaves of Miconia sp. and Eucalyptus sp. in hight microcatchment of Chinchiná river, Colombia

Los procesos de colonización en ambientes lóticos son regulados por la interacción entre el tipo de vegetación y la cantidad de hojarasca que se incorpora a los ríos e influye sobre la estructura y dinámica del bentos. Los macroinvertebrados bentónicos son un componente importante en los ecosistemas dulceacuícolas, cumplen un papel fundamental en la descomposición y recirculación de nutrientes, además de contribuir en la red trófica como alimento de otros animales. Con el objetivo de comparar la colonización de macroinvertebrados en hojas de árboles nativos e introducidos a través del tiempo en las quebradas El Diamante, La Oliva y el río Chinchiná, se utilizó la metodología de paquetes de hojarasca. La primera quebrada presenta como vegetación ribereña un bosque nativo, la segunda está influenciada por plantaciones de Eucalyptussp. y la tercera no presenta vegetación ribereña. Para el estudio se utilizaron paquetes de tela plástica, donde fueron depositadas hojas de Miconia sp. (especie nativa), hojas de Eucalyptussp. y una mezcla de las dos especies, las cuales demoraron aproximadamente 60 días para descomponerse. En total, se colectaron 8595 individuos de macroinvertebrados, la menor riqueza se presentó a los 30 días y la mayor entre los 45 y 60 días. No se encontraron diferencias significativas en la riqueza y abundancia de macroinvertebrados con respecto a las dos especies vegetales utilizadas. Al evaluar la diversidad (q=0, q=1) no se encontraron diferencias significativas en el número efectivo de géneros o morfotipos entre sustratos (paquetes con hojas nativas, introducidas y mezcladas). El grupo funcional de los recolectores generalistas fue dominante entre los macroinvertebrados colectados.Colonization processes in lotic environments are regulated by the interaction between the type of forest and the amount of litter that goes to the rivers and influences the structure and dynamics of the benthos. Benthic macroinvertebrates are an important component of freshwater ecosystems, playing a fundamental role in decomposition and nutrient recirculation, in addition to contributing to the food chain as food for other animals. Leaf litter methodology was used with the objective of to compare the colonization by macroinvertebrates on native and introduced tree leaves throughout time, in El Diamante Creek, La Oliva Creek, and the Chinchiná River. The first creek presents native forest riparian vegetation, the second creek is influenced by Eucalyptussp. plantations, and the third creek does not present riverine vegetation. In the study, plastic cloth bags were used, in which leaves from a native species (Miconia sp.), leaves from a Eucalyptussp., and a mix of leaves from both species were deposited; the native and introduced leaves decomposed in approximately 60 days. In total, 8595 macroinvertebrate individuals were collected, the least richness was seen after 30 days and the greatest richness was seen between 45 days and 60 days. With diversity (q=0, q=1) no significant differences in the effective number of genres and/or morphotypes found between substrates (packs with native, introduced and mixed leaves). The dominant group within the macroinvertebrates collected was the trophic guild of the generalist collectors

Non-Anticoagulant Heparan Sulfate from the Ascidian Phallusia nigra Prevents Colon Carcinoma Metastasis in Mice by Disrupting Platelet-Tumor Cell Interaction

Although metastasis is the primary cause of death in patients with malignant solid tumors, efficient anti-metastatic therapies are not clinically available currently. Sulfated glycosaminoglycans from marine sources have shown promising pharmacological effects, acting on different steps of the metastatic process. Oversulfated dermatan sulfates from ascidians are effective in preventing metastasis by inhibition of P-selectin, a platelet surface protein involved in the platelet-tumor cell emboli formation. We report in this work that the heparan sulfate isolated from the viscera of the ascidian Phallusia nigra drastically attenuates metastases of colon carcinoma cells in mice. Our in vitro and in vivo assessments demonstrate that the P. nigra glycan has very low anticoagulant and antithrombotic activities and a reduced hypotension potential, although it efficiently prevented metastasis. Therefore, it may be a promising candidate for the development of a novel anti-metastatic drug

Embryonal rhabdomyosarcoma of the uterine cervix: a rare case report

Embryonal rhabdomyosarcoma of the female genital tract is a rare tumour. It tends to occur during childhood in the vagina and, rarely, it can arise in the uterine cervix, with a peak incidence in the second decade. We report a case of a 18-year-old female with an embryonal rhabdomyosarcoma (sarcoma botryoides) presenting himself as a cervical polyp. This tumour consisted of rhabdomyoblasts with miscellaneous differentiation surrounded by a loose, myxoid stroma. The patient was successfully treated with cervical conization and adjuvant chemotherapy. She is now disease-free at the 28th month follow-up. Awareness of this uncommon lesion in the cervix and its clinical implications is important to prevent misdiagnosis. Therapy has recently inclined to conservative and fertility-sparing treatment

Dermoscopic and reflectance confocal microscopy findings in extra-genital hpv16-associated pigmented squamous cell carcinoma in situ

Cutaneous Oncology Department AC Camargo Cancer Center, Rua Professor Antonio Prudente, 211, São Paulo, BrazilPathology Department, AC Camargo Cancer Center, Rua Professor Antonio Prudente, 211, São Paulo, BrazilDepartment of Dermatology, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelDermatology Department, Federal University of São Paulo, São Paulo, BrazilDermatology Department, Federal University of São Paulo, São Paulo, BrazilWeb of Scienc

Family, Reproduction and Religious Ethos in Brazil

Il s’agit d’examiner et d’approfondir l’hypothèse selon laquelle non seulement les valeurs laïques, non confessionnelles, de la liberté individuelle (choix, subjectivité, autonomie) et de la nature (vie, sang, science) constituent le noyau cosmologique des sociétés occidentales, comme elles sont critiques pour la définition de l’ethos privé (virginité, contraception, avortement, homosexualité), même dans les situations où l’appartenance à des religions qui suivent des valeurs contraires ou alternatives semble constituer la dimension cruciale de l’identité sociale. Même la formule canonique de ces valeurs dans chaque église semble dépendre fondamentalement du rapport aux valeurs de la liberté et de la nature. Les auteurs s’appuient sur des données de recherche de terrain originale et récente.Based on primary ethnographic research conducted by its authors, this article aims to deepen the hypothesis that contemporary Western societies are not only pervaded by lay, non-denominational, structuring values such as those of individual “freedom” (choice, subjectivity, autonomy, etc.) and “nature” (life, blood, science) but that they play a crucial role in defining key aspects of private ethos (virginity, abortion and homosexuality) and thereby encompass not only the alternatives pursued by the doctrinal and pastoral guidelines of specific religions, but also the differing dispositions of religious adherence found among social subjects.El presente artículo trata de examinar y de profundizar la hipótesis según la cual no sólo los valores laicos, no confesionales, de la libertad individual (elección, subjetividad, autonomía) y de la naturaleza (vida, sangre, ciencia) constituyen el nudo cosmológico de las sociedades occidentales, sino también son críticos para la definición del ethos privado (virginidad, contracepción, aborto, homosexualidad), hasta en las situaciones en las cuales la pertenencia a religiones que siguen valores contrarios o alternativos parece constituir la dimensión crucial de la identidad social. Incluso la fórmula canónica de estos valores en cada iglesia parece depender fundamentalmente de la relación a los valores de la libertad y de la naturaleza. Los autores se apoyan en datos surgidos de trabajo de campo original y reciente

Family, Reproduction and Religious Ethos in Brazil

Il s’agit d’examiner et d’approfondir l’hypothèse selon laquelle non seulement les valeurs laïques, non confessionnelles, de la liberté individuelle (choix, subjectivité, autonomie) et de la nature (vie, sang, science) constituent le noyau cosmologique des sociétés occidentales, comme elles sont critiques pour la définition de l’ethos privé (virginité, contraception, avortement, homosexualité), même dans les situations où l’appartenance à des religions qui suivent des valeurs contraires ou alternatives semble constituer la dimension cruciale de l’identité sociale. Même la formule canonique de ces valeurs dans chaque église semble dépendre fondamentalement du rapport aux valeurs de la liberté et de la nature. Les auteurs s’appuient sur des données de recherche de terrain originale et récente.Based on primary ethnographic research conducted by its authors, this article aims to deepen the hypothesis that contemporary Western societies are not only pervaded by lay, non-denominational, structuring values such as those of individual “freedom” (choice, subjectivity, autonomy, etc.) and “nature” (life, blood, science) but that they play a crucial role in defining key aspects of private ethos (virginity, abortion and homosexuality) and thereby encompass not only the alternatives pursued by the doctrinal and pastoral guidelines of specific religions, but also the differing dispositions of religious adherence found among social subjects.El presente artículo trata de examinar y de profundizar la hipótesis según la cual no sólo los valores laicos, no confesionales, de la libertad individual (elección, subjetividad, autonomía) y de la naturaleza (vida, sangre, ciencia) constituyen el nudo cosmológico de las sociedades occidentales, sino también son críticos para la definición del ethos privado (virginidad, contracepción, aborto, homosexualidad), hasta en las situaciones en las cuales la pertenencia a religiones que siguen valores contrarios o alternativos parece constituir la dimensión crucial de la identidad social. Incluso la fórmula canónica de estos valores en cada iglesia parece depender fundamentalmente de la relación a los valores de la libertad y de la naturaleza. Los autores se apoyan en datos surgidos de trabajo de campo original y reciente

Functional characterization of a putative Glycine max ELF4 in transgenic arabidopsis and its role during flowering control.

Flowering is an important trait in major crops like soybean due to its direct relation to grain production. The circadian clock mediates the perception of seasonal changes in day length and temperature to modulate flowering time. The circadian clock gene EARLY FLOWERING 4 (ELF4) was identified in Arabidopsis thaliana and is believed to play a key role in the integration of photoperiod, circadian regulation, and flowering. The molecular circuitry that comprises the circadian clock and flowering control in soybeans is just beginning to be understood. To date, insufficient information regarding the soybean negative flowering regulators exist, and the biological function of the soybean ELF4 (GmELF4) remains unknown. Here, we investigate the ELF4 family members in soybean and functionally characterize a GmELF4 homologous gene. The constitutive overexpression of GmELF4 delayed flowering in Arabidopsis, showing the ELF4 functional conservation among plants as part of the flowering control machinery. We also show that GmELF4 alters the expression of Arabidopsis key flowering time genes (AtCO and AtFT), and this down-regulation is the likely cause of flowering delay phenotypes. Furthermore, we identified the GmELF4 network genes to infer the participation of GmELF4 in soybeans. The data generated in this study provide original insights for comprehending the role of the soybean circadian clock ELF4 gene as a negative flowering controller