Measurement of an AGN Central Mass on Centiparsec Scales: Results of Long-Term Optical Monitoring of Arp 102B

The optical spectrum of the broad-line radio galaxy Arp 102B has been monitored for more than thirteen years to investigate the nature of the source of its broad, double-peaked hydrogen Balmer emission lines. The shape of the lines varied subtly; there was an interval during which the variation in the ratio of the fluxes of the two peaks appeared to be sinusoidal, with a period of 2.16 years and an amplitude of about 16% of the average value. The variable part of the broad H-alpha line is well fit by a model in which a region of excess emission (a quiescent ``hot spot'') within an accretion disk (fitted to the non-varying portion of the double-peaked line) completes at least two circular orbits and eventually fades. Fits to spectra from epochs when the hot spot is not present allow determination of the disk inclination, while fits for epochs when it is present provide a measurement of the radius of the hot spot's orbit. From these data and the period of variation, we find that the mass within the hot spot's orbit is 2.2 +0.2/-0.7 times 10^8 solar masses, within the range of previous estimates of masses of active galactic nuclei. Because this mass is determined at a relatively small distance (~1000 AU) from the central body, it is extremely difficult to explain without assuming that a supermassive black hole lies within Arp 102B. The lack of any systematic change in the velocity of the blue peak over time yields a lower limit on the combined mass of the two bodies in a binary black hole model like that of Gaskell (1983) of 10^10 solar masses.Comment: 29 pages, including 6 figures; to appear in the Astrophysical Journal 199

Bosons in high temperature superconductors: an experimental survey

We review a number of experimental techniques that are beginning to reveal fine details of the bosonic spectrum \alpha^2F(\Omega) that dominates the interaction between the quasiparticles in high temperature superconductors. Angle-resolved photo emission (ARPES) shows kinks in electronic dispersion curves at characteristic energies that agree with similar structures in the optical conductivity and tunnelling spectra. Each technique has its advantages. ARPES is momentum resolved and offers independent measurements of the real and imaginary part of the contribution of the bosons to the self energy of the quasiparticles. The optical conductivity can be used on a larger variety of materials and with the use of maximum entropy techniques reveals rich details of the spectra including their evolution with temperature and doping. Scanning tunnelling spectroscopy offers spacial resolution on the unit cell level. We find that together the various spectroscopies, including recent Raman results, are pointing to a unified picture of a broad spectrum of bosonic excitations at high temperature which evolves, as the temperature is lowered into a peak in the 30 to 60 meV region and a featureless high frequency background in most of the materials studied. This behaviour is consistent with the spectrum of spin fluctuations as measured by magnetic neutron scattering. However, there is evidence for a phonon contribution to the bosonic spectrum as well.Comment: 71 pages, 52 figure

Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria

How antibodies naturally acquired during Plasmodium falciparum infection provide clinical immunity to blood-stage malaria is unclear. We studied the function of natural killer (NK) cells in people living in a malaria-endemic region of Mali. Multi-parameter flow cytometry revealed a high proportion of adaptive NK cells, which are defined by the loss of transcription factor PLZF and Fc receptor γ-chain. Adaptive NK cells dominated antibody-dependent cellular cytotoxicity responses, and their frequency within total NK cells correlated with lower parasitemia and resistance to malaria. P. falciparum–infected RBCs induced NK cell degranulation after addition of plasma from malaria-resistant individuals. Malaria-susceptible subjects with the largest increase in PLZF-negative NK cells during the transmission season had improved odds of resistance during the subsequent season. Thus, antibody-dependent lysis of P. falciparum–infected RBCs by NK cells may be a mechanism of acquired immunity to malaria. Consideration of antibody-dependent NK cell responses to P. falciparum antigens is therefore warranted in the design of malaria vaccines

Inorganic nitrate, hypoxia, and the regulation of cardiac mitochondrial respiration-probing the role of PPARα.

Dietary inorganic nitrate prevents aspects of cardiac mitochondrial dysfunction induced by hypoxia, although the mechanism is not completely understood. In both heart and skeletal muscle, nitrate increases fatty acid oxidation capacity, and in the latter case, this involves up-regulation of peroxisome proliferator-activated receptor (PPAR)α expression. Here, we investigated whether dietary nitrate modifies mitochondrial function in the hypoxic heart in a PPARα-dependent manner. Wild-type (WT) mice and mice without PPARα (Ppara-/-) were given water containing 0.7 mM NaCl (control) or 0.7 mM NaNO3 for 35 d. After 7 d, mice were exposed to normoxia or hypoxia (10% O2) for the remainder of the study. Mitochondrial respiratory function and metabolism were assessed in saponin-permeabilized cardiac muscle fibers. Environmental hypoxia suppressed mass-specific mitochondrial respiration and additionally lowered the proportion of respiration supported by fatty acid oxidation by 18% (P < 0.001). This switch away from fatty acid oxidation was reversed by nitrate treatment in hypoxic WT but not Ppara-/- mice, indicating a PPARα-dependent effect. Hypoxia increased hexokinase activity by 33% in all mice, whereas lactate dehydrogenase activity increased by 71% in hypoxic WT but not Ppara-/- mice. Our findings indicate that PPARα plays a key role in mediating cardiac metabolic remodeling in response to both hypoxia and dietary nitrate supplementation.-Horscroft, J. A., O'Brien, K. A., Clark, A. D., Lindsay, R. T., Steel, A. S., Procter, N. E. K., Devaux, J., Frenneaux, M., Harridge, S. D. R., Murray, A. J. Inorganic nitrate, hypoxia, and the regulation of cardiac mitochondrial respiration-probing the role of PPARα

The roles and values of wild foods in agricultural systems

Almost every ecosystem has been amended so that plants and animals can be used as food, fibre, fodder, medicines, traps and weapons. Historically, wild plants and animals were sole dietary components for hunter–gatherer and forager cultures. Today, they remain key to many agricultural communities. The mean use of wild foods by agricultural and forager communities in 22 countries of Asia and Africa (36 studies) is 90–100 species per location. Aggregate country estimates can reach 300–800 species (e.g. India, Ethiopia, Kenya). The mean use of wild species is 120 per community for indigenous communities in both industrialized and developing countries. Many of these wild foods are actively managed, suggesting there is a false dichotomy around ideas of the agricultural and the wild: hunter–gatherers and foragers farm and manage their environments, and cultivators use many wild plants and animals. Yet, provision of and access to these sources of food may be declining as natural habitats come under increasing pressure from development, conservation-exclusions and agricultural expansion. Despite their value, wild foods are excluded from official statistics on economic values of natural resources. It is clear that wild plants and animals continue to form a significant proportion of the global food basket, and while a variety of social and ecological drivers are acting to reduce wild food use, their importance may be set to grow as pressures on agricultural productivity increase.</jats:p

Absorption-Line Systems and Galaxies in Front of the Second Brightest Quasar, PHL 1811

The extraordinarily bright quasar PHL 1811 at a redshift z = 0.192 provides an attractive opportunity to use ultraviolet absorption-line spectroscopy to study the properties of gas systems in the local universe. An R = 20,000 far-UV spectrum recorded by FUSE revealed 7 extragalactic absorption systems, one of which is a Lyman limit system at z = 0.08093 accompanied by three systems having redshifts which differ from it by less than 0.008. The abundance of O with respect to Fe in the Lyman limit system is not much different from the solar abundance ratio. Supplementary low resolution spectra recorded by STIS (on HST) at longer wavelengths helped to substantiate our identifications of systems in the FUSE spectrum and suggested the presence of an additional 4 systems that could be detected only through their Ly-alpha features. Spectroscopy at visible wavelengths of 7 galaxies within approximately 2' of PHL 1811 indicated that 2 of them are near the redshift of the quasar and 4 have redshifts within 850 km/s of the extragalactic absorption systems. The Lyman limit system is likely associated with an L* galaxy lying 23" from the sightline. Finally, in addition to prominent features at very low velocities arising from the disk of our Galaxy, the strong resonance transitions of C II and Mg II show evidence for material at v = -200 km/s; the column densities of these two species suggest that 17.7 < log N(H I) < 18.1 if the material has a solar composition.Comment: 47 pages, 5 figures, to appear in the June 2003 issue of the Astronomical Journa

Walks4work: Rationale and study design to investigate walking at lunchtime in the workplace setting

Background: Following recruitment of a private sector company, an 8week lunchtime walking intervention was implemented to examine the effect of the intervention on modifiable cardiovascular disease risk factors, and further to see if walking environment had any further effect on the cardiovascular disease risk factors. Methods. For phase 1 of the study participants were divided into three groups, two lunchtime walking intervention groups to walk around either an urban or natural environment twice a week during their lunch break over an 8week period. The third group was a waiting-list control who would be invited to join the walking groups after phase 1. In phase 2 all participants were encouraged to walk during their lunch break on self-selecting routes. Health checks were completed at baseline, end of phase 1 and end of phase 2 in order to measure the impact of the intervention on cardiovascular disease risk. The primary outcome variables of heart rate and heart rate variability were measured to assess autonomic function associated with cardiovascular disease. Secondary outcome variables (Body mass index, blood pressure, fitness, autonomic response to a stressor) related to cardiovascular disease were also measured. The efficacy of the intervention in increasing physical activity was objectively monitored throughout the 8-weeks using an accelerometer device. Discussion. The results of this study will help in developing interventions with low researcher input with high participant output that may be implemented in the workplace. If effective, this study will highlight the contribution that natural environments can make in the reduction of modifiable cardiovascular disease risk factors within the workplace. © 2012 Brown et al.; licensee BioMed Central Ltd

Evolution of the Nuclear Accretion Disk Emission in NGC 1097: Getting Closer to the Black Hole

We study the evolution of the broad, double-peaked Halpha emission-line profile of the LINER/Seyfert 1 nucleus of NGC 1097, using 24 spectra obtained over a time span of 11 yrs - from 1991 Nov. through 2002 Oct. While in the first 5 yrs the main variation was in the relative intensity of the blue and red peaks, in the last years we have also observed an increasing separation between the two peaks, at the same time as the integrated flux in the broad line has decreased. We propose a scenario in which the emission originates in an asymmetric accretion disk around a supermassive black hole, whose source of ionization is getting dimmer, causing the region of maximum emission to come closer to the center (and thus to regions of higher projected velocity). We use the observations to constrain the evolution of the accretion disk emission and to evaluate two models: the elliptical disk model previously found to reproduce the observations from 1991 to 1996 and a model of a circular disk with a single spiral arm. We favor the latter, because the whole set of data is consistent with a monotonic precession of the spiral pattern, which has completed almost two revolutions since 1991. The precession period implies a black hole mass of approximately 5x10^7 solar masses. Finally, we have found tentative evidence of the emergence of an accretion disk wind, which we hope to explore further with future observations.Comment: 34 pages, Latex, 14 eps figures, to appear in ApJ, Main Journal, Dec. 1st issu