Quiet Moments: My Artistic Exploration

I believe that fate led me to dive into my artistic study on the human form. I firmly believe all things happen for a reason. Every year, every day, every hour, every minute, and every second of my life play a significant role in how things turn out. Looking back on the past two decades, there have been numerous accounts that have brought me to where I am today. The classes I have taken and the interactions with various artists have led me to pursue art, one of my strongest passions, and have influenced the development of my current collection of work, Quiet Moments

Expression of bacterial genes in transgenic tobacco: methods, applications and future prospects

Tobacco is the most commonly used plant for expression of transgenes from a variety of organisms, because it is easily grown and transformed, it provides abundant amounts of fresh tissue and has a well-established cell culture system. Many bacterial proteins involved in the synthesis of commercial products are currently engineered for production in tobacco. Bacterial enzymes synthesized in tobacco can enhance protection against abiotic stresses and diseases, and provide a system to test applied strategies such as phytoremediation. Examples of bacterial gene expression in tobacco include production of antigen proteins from several human bacterial pathogens as vaccines, bacterial proteins for enhancing resistance against insects, pathogens and herbicides, and bacterial enzymes for the production of polymers, sugars, and bioethanol. Further improvements in the expression of recombinant proteins and their recovery from tobacco will enhance production and commercial use of these proteins. This review highlights the dynamic use of tobacco in bacterial protein production by examining the most relevant research in this field

Book Reviews

Reviews of: Why Africa is Poor – and what Africans can do about it. By Greg Mills; Living the End of Empire: Politics and Society in Late Colonial Zambia. Edited by Jan-Bart Gewald, Marja Hinfelaar and Giacomo Macola; Left Behind: Rural Zambia in the Third Republic. By Jeremy Gould; Gender Budgeting as a Tool for Poverty Reduction. By The African Capacity Building Foundation. African Capacity Building Foundatio

Book Reviews

Reviews of: Why Africa is Poor – and what Africans can do about it. By Greg Mills; Living the End of Empire: Politics and Society in Late Colonial Zambia. Edited by Jan-Bart Gewald, Marja Hinfelaar and Giacomo Macola; Left Behind: Rural Zambia in the Third Republic. By Jeremy Gould; Gender Budgeting as a Tool for Poverty Reduction. By The African Capacity Building Foundation. African Capacity Building Foundatio

'Debating 'The Rediscovery of Liberalism' in Zambia: Responses to Harri Englund

In Africa 83(4) (November 2013), Harri Englund discussed several recent books on Zambia published preceding the country’s fiftieth independence anniversary. His article explored the ways in which recent publications by Zambian and Zambianist authors have launched a fresh research agenda, and he focused in particular on the scholarly engagement with liberalism. Below, we publish responses from David M.Gordon, Bizeck Jube Phiri and Giacomo Macola, whose work was discussed in this article, and a comment by James Ferguson on more scholarly directions

Intracellular CD24 disrupts the ARF–NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation

CD24 is overexpressed in nearly 70% human cancers, whereas TP53 is the most frequently mutated tumour-suppressor gene that functions in a context-dependent manner. Here we show that both targeted mutation and short hairpin RNA (shRNA) silencing of CD24 retard the growth, progression and metastasis of prostate cancer. CD24 competitively inhibits ARF binding to NPM, resulting in decreased ARF, increase MDM2 and decrease levels of p53 and the p53 target p21/CDKN1A. CD24 silencing prevents functional inactivation of p53 by both somatic mutation and viral oncogenes, including the SV40 large T antigen and human papilloma virus 16 E6-antigen. In support of the functional interaction between CD24 and p53, in silico analyses reveal that TP53 mutates at a higher rate among glioma and prostate cancer samples with higher CD24 mRNA levels. These data provide a general mechanism for functional inactivation of ARF and reveal an important cellular context for genetic and viral inactivation of TP53. P53 is a tumour suppressor that is frequently mutated or downregulated in cancer. Here, Wang et al. show that CD24, a molecule frequently overexpressed in cancer, promotes p53 degradation by disrupting a regulatory ARF–MDM2 interaction, and silencing CD24 prevents the downregulation of p53

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus on the overall mmunobiology of neoplastic cells. It is now clear that cancer cells can succumb to some anticancer therapies by undergoing a peculiar form of cell death that is characterized by an increased immunogenic potential, owing to the emission of the so-called "damage-associated molecular patterns" (DAMPs). The emission of DAMPs and other mmunostimulatory factors by cells succumbing to immunogenic cell death (ICD) favors the establishment of a productive interface with the immune system. This results in the elicitation of tumor-targeting immune responses associated with the elimination of residual, treatment-resistant cancer cells, as well as with the establishment of immunological memory. Although ICD has been characterized with increased precision since its discovery, several questions remain to be addressed. Here, we summarize and tabulate the main molecular, immunological, preclinical, and clinical aspects of ICD, in an attempt to capture the essence of this phenomenon, and identify future challenges for this rapidly expanding field of investigation.Peer reviewe

Anna Haynes, Westbrook Seminary Student, 1860s

An 1860s carte de visite by Jube\u27s Photograph Gallery, Bowery, N.Y., shows the face and shoulders of Miss Anna Haynes, Westbrook Seminary student.https://dune.une.edu/wchc_photos_students1860s/1008/thumbnail.jp

Reggae

Reggae adalah musik perlawanan! Sosok Bob Marley dalam musik reggae telah mewariskan sikap perlawanan terhadap segala bentuk penindasan.Tidak semua pemusik bisa memainkan reggae, reggae adalah soul! Memainkan reggae butuh penghayatan khusus dan merupakan pekerjaan jiwa.Reggae adalah musik yang menarik, apalagi dengan unsur rastafarian di dalamnya, yang mengajarkan tentang arti dan makna hidup