Community and economic development model for low-income and underserved neighborhoods

Thesis (M.C.P.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning, 2011.Cataloged from PDF version of thesis.Includes bibliographical references (p. 128-133).Swap meets, a type of public marketplace, are sites that provide low income and minority communities a place to buy and sell affordable merchandise, as well as create a regular meeting space. In particular, open-air swap meets are places where many social networks form between individuals of different ages, residency status, cultures, and race. From my personal experience of growing up selling with my family in a swap meet in California over eighteen years, I believe that these sites have the potential to serve a greater purpose in their respective communities; one in which they occupy not solely an economic niche, but also incorporate social and cultural programs that serve even the most disadvantaged groups in society. Currently, it appears that only a few swap meets have taken advantage of the potential for creating dynamic places where patrons and participants can partake in activities not solely concerned with buying or selling goods. These "best practice" swap meets understand the value of having a lively environment and the importance of using the physical space innovatively. They open up the venue for performing musicians and non-profit groups to outreach and fundraise, as well as expose the interesting resources and talents that exist within the vending site. These types of activities could benefit other swap meets by increasing awareness as to what makes the community a great place to live and engaging participants in cultural and social resources. In short, a strategy like this improves the overall quality of life for everyone inside the swap meet community and the neighborhood as well.by Jeffrey Edwin Juarez.M.C.P

Habitat relationships of seven breeding bird species in the Leon River Watershed investigated at local scales

Over the past 100150 years Texas rangelands have dramatically changed from native open savannahs to dense woodlands. On the Edwards plateau, a major management concern is the increasing encroachment of Ashe juniper (Juniperus ashei). Preceding an anticipated brush management program, I investigated the presence, co-occurrence, and habitat relationships of 7 breeding bird species in the Leon River Watershed in central Texas, USA: black-capped vireo (Vireo atricapillus), golden-cheeked warbler (Dendroica chrysoparia), northern bobwhite (Colinus virginianus), white-eyed vireo (Vireo griseus), Bells vireo (Vireo bellii), painted bunting (Passerina ciris), and brown-headed cowbird (Molothrus ater). Vegetation characteristics were compared between sites occupied by each species and unoccupied sites using univariate analysis. Models for predicting species site occupancy were developed (using logistic regression) based on habitat characteristics correlated with the presence of each species. Two species of special concern, the endangered black-capped vireo and golden-cheeked warbler occupied 5.6% of sites and 13.8% of sites respectively, while the brood parasite brown-headed cowbird was the most widespread, occupying 86.8% of sites. Species co-occurrence patterns revealed significant associations between the golden-cheeked warbler and each of 5 other species. For most species, variables included in habitat models could be explained by knowledge of species known habitat associations. For example, the black-capped vireo was positively associated with increasing low-growing (<1.5 m) hardwood cover and with Low Stony Hill ecological sites. The golden-cheeked warbler was positively associated with increasing density of larger juniper trees, increasing variability in vertical vegetation structure, and decreasing midstory canopy of deciduous nonoaks (e.g., cedar elm [Ulmus crasifolia]). It also preferred Low Stony Hill and Steep Adobe ecological sites. Site occupancy seemed to be driven by variables that describe overall vegetation structure. In particular, cover of low-growing non-juniper vegetation and juniper tree density appeared to be important in determining site occupancy for several species. Although the models constructed were not very robust, resource managers can still benefit from such models because they provide a preliminary examination of important controlling variables. Managing rangelands to maintain or restore a mosaic of juniper patches and open shrublands are likely to help meet the habitat requirements of these bird communities

Implementación de reingeniería de procesos y su influencia en la reducción de costos de producción en una empresa del sector gráfico

La presente tesis se basó en una propuesta de aplicación de reingeniería de procesos. Tiene como objetivo el estudio de la influencia de reducción de los costos de producción en una empresa del sector gráfico. Como metodología la investigación es, descriptiva – correlacional y no experimental. Su población y muestra se basó en los procesos de fabricación de un libro. Se utilizo como técnica la observación, la entrevista y el análisis documental. Sus resultados fueron que se evidencio que la falta de procesos no establecidos para la fabricación de un libro, Se utilizo la herramienta DAP y el diagrama de recorrido, obteniendo así un ahorro en recorrido entre procesos de 80.3metros y de 8.9 minutos en tiempo de traslado de material. Se manejó un tir y van de 3 periodos, El VAN es aceptable y positivo en los 3 periodos de proyección y El TIR es mayor al costo por rentabilidad de proyecto (12.1%). En el cual tiene un valor de 124%. Se concluye que la propuesta de aplicación de reingeniería de procesos y su influencia en la reducción de los costos de producción, demostró el cambio de proceso del recorrido del libro de forma radical y que, al utilizar herramientas de ingeniería, se redujo los costos de producción.This thesis was based on a proposal for the application of process reengineering. Its objective is to study the influence of reducing production costs on a company in the graphic sector. As a methodology, the research is descriptive – correlational and non-experimental. Its population and sample were based on the manufacturing processes of a book. Observation, interview and documentary analysis were used as a technique. Its results were that it was evidenced that the lack of processes not established for the manufacture of a book, the DAP tool and the route diagram were used, thus obtaining a saving in travel between processes of 80.3 meters and 8.9 minutes in material transfer time. an IRR and 3 periods were handled, the NPV is acceptable and positive in the 3 projection periods and the IRR is higher than the cost for project profitability (12.1%). In which it has a value of 124%. It is concluded that the proposal for the application of process reengineering and its influence on the reduction of production costs, demonstrated the radical change of the book tour process and that, by using engineering tools, production costs were reduced

Competitividad y calidad del servicio a los clientes en el área de encomiendas de la empresa El Dorado S.A.C. Trujillo, 2022

La presente investigación titulada “Competitividad y calidad del servicio a los clientes en el área de encomiendas de la empresa El Dorado S.A.C Trujillo, 2022. Presenta como objetivo general analizar la competitividad y la calidad del servicio a los clientes en el área de encomiendas de la empresa El Dorado S.A.C Trujillo, 2022. Como metodología se utilizó un enfoque cuantitativo, tipo aplicada, diseño no experimental y de corte transversal. La población estuvo conformada por los clientes de la empresa El Dorado S.A.C. se utilizó como técnica la encuesta e instrumento un cuestionario estructurado y validado por expertos. Se concluye que lo más rescatado dentro de este estudio fue calidad de servicio a los clientes, respecto al nivel de competitividad se obtuvo que el 100% de los encuestados están satisfechos respecto a la competitividad de la empresa, rescatando que las ventajas competitivas se van creando día a día. Por lo tanto, con la obtención de dichos resultados se concluye que la empresa El Dorado S.A.C Trujillo, se encuentra en un estado de crecimiento y por ende en mejorar la atención que se brinda en el área de encomiendas ya que se refleja que los trabajadores carecen de capacitación

An Interactive Web-Based Lethal Means Safety Decision Aid for Suicidal Adults (Lock to Live): Pilot Randomized Controlled Trial

BACKGROUND: Counseling to reduce access to lethal means such as firearms and medications is recommended for suicidal adults but does not routinely occur. We developed the Web-based Lock to Live (L2L) decision aid to help suicidal adults and their families choose options for safer home storage. OBJECTIVE: This study aimed to test the feasibility and acceptability of L2L among suicidal adults in emergency departments (EDs). METHODS: At 4 EDs, we enrolled participants (English-speaking, community-dwelling, suicidal adults) in a pilot randomized controlled trial. Participants were randomized in a 13:7 ratio to L2L or control (website with general suicide prevention information) groups and received a 1-week follow-up telephone call. RESULTS: Baseline characteristics were similar between the intervention (n=33) and control (n=16) groups. At baseline, many participants reported having access to firearms (33/49, 67%), medications (46/49, 94%), or both (29/49, 59%). Participants viewed L2L for a median of 6 min (IQR 4-10 min). L2L also had very high acceptability; almost all participants reported that they would recommend it to someone in the same situation, that the options felt realistic, and that L2L was respectful of values about firearms. In an exploratory analysis of this pilot trial, more participants in the L2L group reported reduced firearm access at follow-up, although the differences were not statistically significant. CONCLUSIONS: The L2L decision aid appears feasible and acceptable for use among adults with suicide risk and may be a useful adjunct to lethal means counseling and other suicide prevention interventions. Future large-scale studies are needed to determine the effect on home access to lethal means. TRIAL REGISTRATION: ClinicalTrials.gov NCT03478501; https://clinicaltrials.gov/ct2/show/NCT03478501

Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression

Dependence on the 26S proteasome is an Achilles' heel for triple-negative breast cancer (TNBC) and multiple myeloma (MM). The therapeutic proteasome inhibitor, bortezomib, successfully targets MM but often leads to drug-resistant disease relapse and fails in breast cancer. Here we show that a 26S proteasome-regulating kinase, DYRK2, is a therapeutic target for both MM and TNBC. Genome editing or small-molecule mediated inhibition of DYRK2 significantly reduces 26S proteasome activity, bypasses bortezomib resistance, and dramatically delays in vivo tumor growth in MM and TNBC thereby promoting survival. We further characterized the ability of LDN192960, a potent and selective DYRK2-inhibitor, to alleviate tumor burden in vivo. The drug docks into the active site of DYRK2 and partially inhibits all 3 core peptidase activities of the proteasome. Our results suggest that targeting 26S proteasome regulators will pave the way for therapeutic strategies in MM and TNBC

第942回千葉医学会例会・第31回肺癌研究施設例会

Example of CellPD’s outputs. This folder contains two examples of the outputs generated by CellPD (using the data from Fig. 2 and Additional file 6). (ZIP 36462 kb

MultiCellDS: a standard and a community for sharing multicellular data

Cell biology is increasingly focused on cellular heterogeneity and multicellular systems. To make the fullest use of experimental, clinical, and computational efforts, we need standardized data formats, community-curated "public data libraries", and tools to combine and analyze shared data. To address these needs, our multidisciplinary community created MultiCellDS (MultiCellular Data Standard): an extensible standard, a library of digital cell lines and tissue snapshots, and support software. With the help of experimentalists, clinicians, modelers, and data and library scientists, we can grow this seed into a community-owned ecosystem of shared data and tools, to the benefit of basic science, engineering, and human health

MultiCellDS: a community-developed standard for curating microenvironment-dependent multicellular data

Exchanging and understanding scientific data and their context represents a significant barrier to advancing research, especially with respect to information siloing. Maintaining information provenance and providing data curation and quality control help overcome common concerns and barriers to the effective sharing of scientific data. To address these problems in and the unique challenges of multicellular systems, we assembled a panel composed of investigators from several disciplines to create the MultiCellular Data Standard (MultiCellDS) with a use-case driven development process. The standard includes (1) digital cell lines, which are analogous to traditional biological cell lines, to record metadata, cellular microenvironment, and cellular phenotype variables of a biological cell line, (2) digital snapshots to consistently record simulation, experimental, and clinical data for multicellular systems, and (3) collections that can logically group digital cell lines and snapshots. We have created a MultiCellular DataBase (MultiCellDB) to store digital snapshots and the 200+ digital cell lines we have generated. MultiCellDS, by having a fixed standard, enables discoverability, extensibility, maintainability, searchability, and sustainability of data, creating biological applicability and clinical utility that permits us to identify upcoming challenges to uplift biology and strategies and therapies for improving human health

Model-based assessment of mammalian cell metabolic functionalities using omics data.

Omics experiments are ubiquitous in biological studies, leading to a deluge of data. However, it is still challenging to connect changes in these data to changes in cell functions because of complex interdependencies between genes, proteins, and metabolites. Here, we present a framework allowing researchers to infer how metabolic functions change on the basis of omics data. To enable this, we curated and standardized lists of metabolic tasks that mammalian cells can accomplish. Genome-scale metabolic networks were used to define gene sets associated with each metabolic task. We further developed a framework to overlay omics data on these sets and predict pathway usage for each metabolic task. We demonstrated how this approach can be used to quantify metabolic functions of diverse biological samples from the single cell to whole tissues and organs by using multiple transcriptomic datasets. To facilitate its adoption, we integrated the approach into GenePattern (www.genepattern.org-CellFie)