A NEW HIGH-INTENSITY ULTRASONIC TECHNOLOGY FOR FOOD DEHYDRATION

12 páginas, 7 figurasAt present, there is a growing interest in the field of dehydration for preserving food. Ultrasonic energy represents a means to obtain dehydration without affecting the food. This paper deals with an experimental study about the use of high-intensity ultrasound for vegetable dehydration by using a new power ultrasound generator and a procedure in which ultrasonic vibrations are applied in direct contact with the product and under a certain static pressure. The drying effect of this new process is compared with that obtained from forced-air drying assisted by air-borne ultrasonic radiation and from a conventional hot-air drying. The results show that by using the new technology and procedure it is possible to reduce dramatically the treatment time and it is relatively easy to reach a final moisture content in the samples less than 1%. In addition, the product qualities are well preserved, the sample rehydration is higher than 70% and, because of the high efficiency of the new ultrasonic system employed, the energy consumption is low. As a consequence of the results a new technology for industrial applications is under development.Peer reviewe

Quantifying farmers’ preferences for cropping systems intensification: A choice experiment approach applied in coastal Bangladesh’s risk prone farming systems

Sustainable intensification (SI) is envisioned as an effective strategy for developing countries to increase farm productivity while reducing negative environmental and social externalities. The development of regionally appropriate SI options however requires accounting for the knowledge and preferences of key stakeholders. In Bangladesh, the Government has requested international donors to support the development of dry season rice expansion in the coastal region. Policies however tend to be made without adequate study of farmers’ preferences and ambitions; this can render crop intensification efforts ineffective. Understanding farmers’ preferences for alternative crops and crop management practices are therefore crucial for success where agricultural development investments aim at incorporating the principles of SI. OBJECTIVE(S): Using coastal Bangladesh as a case study– we aim to (1) quantify farmers’ preferences for alternative irrigated crop and crop management options in comparison to the status quo (land fallowing), (2) analyze whether farmers’ preferences are conditioned by concerns regarding the cost and availability of irrigation and fertilizer inputs in comparison to expected net revenues, (3) understand how the heterogeneity in preferences can be attributed to farmer and/or farm characteristics, institutional, and biophysical factors, (4) determine how much farmers’ are willing to invest in different crops and crop management options – including those reliant and not reliant on irrigation. METHODS: Taking 300 farmers in two diverse coastal environments, a choice experiment (CE) was employed to explore the heterogeneity in farmers’ preferences for different dry “rabi” season intensification options (‘boro’ rice, maize, wheat and mungbean) against the status quo (dry season land fallowing after harvest of the monsoon season rice crop). Analyses included random parameter logit modeling followed by willingness-to-invest and profit simulations. RESULTS AND CONCLUSIONS: Analyses revealed strong farmer preferences against rice and in favor of irrigated maize, and also in favor of rainfed or partially irrigated mungbean as an alternative to land fallowing. Irrespective of their location and environmental conditions, respondents had largely a negative preference for irrigation and fertilizer use due to high investment costs and associated production risks in the dry season. Nonetheless, a significant positive effect on their willingness-to-intensify cropping was observed where farmers felt it feasible to provide in-field drainage to limit waterlogging risks.Estación Experimental Agropecuaria BarilocheFil: Aravindakshan, Sreejith. Wageningen University and Research. Farming Systems Ecology, ; HolandaFil: Aravindakshan, Sreejith. International Maize and Wheat Improvement Center (CIMMYT); BangladeshFil: Krupnik, Timothy J. International Maize and Wheat Improvement Center (CIMMYT); BangladeshFil: Amjath-Babu, T.S. International Maize and Wheat Improvement Center (CIMMYT); BangladeshFil: Speelman, Stijn. Ghent University. Department of Agricultural Economics; BélgicaFil: Tur-Cardona, Juan. Ghent University. Department of Agricultural Economics; BélgicaFil: Tittonell, Pablo Adrian. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche; ArgentinaFil: Tittonell, Pablo Adrian. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Investigaciones Forestales y Agropecuarias Bariloche; ArgentinaFil: Tittonell, Pablo Adrian. Groningen University. Groningen Institute of Evolutionary Life Sciences; HolandaFil: Groot, Jeroen C.J. Wageningen University and Research. Farming Systems Ecology; HolandaFil: Groot, Jeroen C.J. Bioversity International; ItaliaFil: Groot, Jeroen C.J. International Maize and Wheat Improvement Center (CIMMYT); Mexic

Phosphoprotein enrichment from soluble and microsomal fractions of grapevine (vitis vinifera cv. gamay) cell culture using metal oxide affinity chromatography (MOAC)

Comunicaciones a congreso

Determination of Electromagnetic Source Direction as an Eigenvalue Problem

Low-frequency solar and interplanetary radio bursts are generated at frequencies below the ionospheric plasma cutoff and must therefore be measured in space, with deployable antenna systems. The problem of measuring both the general direction and polarization of an electromagnetic source is commonly solved by iterative fitting methods such as linear regression that deal simultaneously with both directional and polarization parameters. We have developed a scheme that separates the problem of deriving the source direction from that of determining the polarization, avoiding iteration in a multi-dimensional manifold. The crux of the method is to first determine the source direction independently of concerns as to its polarization. Once the source direction is known, its direct characterization in terms of Stokes vectors in a single iteration if desired, is relatively simple. This study applies the source-direction determination to radio signatures of flares received by STEREO. We studied two previously analyzed radio type III bursts and found that the results of the eigenvalue decomposition technique are consistent with those obtained previously by Reiner et al. (Solar Phys. 259, 255, 2009). For the type III burst observed on 7 December 2007, the difference in travel times from the derived source location to STEREO A and B is the same as the difference in the onset times of the burst profiles measured by the two spacecraft. This is consistent with emission originating from a single, relatively compact source. For the second event of 29 January 2008, the relative timing does not agree, suggesting emission from two sources separated by 0.1 AU, or perhaps from an elongated region encompassing the apparent source locations.Comment: 22 pages, 7 figures, Accepted in Solar Physic

The Indonesian EQ-5D-5L Value Set

Background: The EQ-5D is one of the most used generic health-related quality-of-life (HRQOL) instruments worldwide. To make the EQ-5D suitable for use in economic evaluations, a societal-based value set is needed. Indonesia does not have such a value set. Objective: The aim of this study was to derive an EQ-5D-5L value set from the Indonesian general population. Methods: A representative sample aged 17 years and over was recruited from the Indonesian general population. A multi-stage stratified quota method with respect to residence, gender, age, level of education, religion and ethnicity was utilized. Two elicitation techniques, the composite time trade-off (C-TTO) and discrete choice experiments (DCE) were applied. Interviews were undertaken by trained interviewers using computer-assisted face-to-face interviews with the EuroQol Valuation Technology (EQ-VT) platform. To estimate the value set, a hybrid regression model combining C-TTO and DCE data was used. Results: A total of 1054 respondents who completed the interview formed the sample for the analysis. Their characteristics were similar to those of the Indonesian population. Most self-reported health problems were observed in the pain/discomfort dimension (39.66%) and least in the self-care dimension (1.89%). In the value set, the maximum value was 1.000 for full health (health state ‘11111’) followed by the health state ‘11112’ with value 0.921. The minimum value was −0.865 for the worst state (‘55555’). Preference values were most affected by mobility and least by pain/discomfort. Conclusions: We now have a representative EQ-5D-5L value set for Indonesia. We expect our results will promote and facilitate health economic evaluations and HRQOL research in Indonesia

INTELLANCE 2/EORTC 1410 randomized phase II study of Depatux-M alone and with temozolomide vs temozolomide or lomustine in recurrent EGFR amplified glioblastoma

BACKGROUND: Depatuxizumab mafodotin (Depatux-M) is a tumor-specific antibody-drug conjugate consisting of an antibody (ABT-806) directed against activated epidermal growth factor receptor (EGFR) and the toxin monomethylauristatin-F. We investigated Depatux-M in combination with temozolomide or as a single agent in a randomized controlled phase II trial in recurrent EGFR amplified glioblastoma. METHODS: Eligible were patients with centrally confirmed EGFR amplified glioblastoma at first recurrence after chemo-irradiation with temozolomide. Patients were randomized to either Depatux-M 1.25 mg/kg every 2 weeks intravenously, or this treatment combined with temozolomide 150-200 mg/m2 day 1-5 every 4 weeks, or either lomustine or temozolomide. The primary endpoint of the study was overall survival. RESULTS: Two hundred sixty patients were randomized. In the primary efficacy analysis with 199 events (median follow-up 15.0 mo), the hazard ratio (HR) for the combination arm compared with the control arm was 0.71 (95% CI = 0.50, 1.02; P = 0.062). The efficacy of Depatux-M monotherapy was comparable to that of the control arm (HR = 1.04, 95% CI = 0.73, 1.48; P = 0.83). The most frequent toxicity in Depatux-M treated patients was a reversible corneal epitheliopathy, occurring as grades 3-4 adverse events in 25-30% of patients. In the long-term follow-up analysis with median follow-up of 28.7 months, the HR for the comparison of the combination arm versus the control arm was 0.66 (95% CI = 0.48, 0.93). CONCLUSION: This trial suggests a possible role for the use of Depatux-M in combination with temozolomide in EGFR amplified recurrent glioblastoma, especially in patients relapsing well after the end of first-line adjuvant temozolomide treatment. (NCT02343406)

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function

Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European (N = 60,552), African (N = 8429), Asian (N = 9959), and Hispanic/Latino (N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses. Using recent fine-mapping methods incorporating functional annotation, gene expression, and differences in linkage disequilibrium between ethnicities, we further shed light on potential causal variants and genes at known and newly identified loci. Several of the novel genes encode proteins with predicted or established drug targets, including KCNK2 and CDK12. Our study highlights the utility of multiethnic and integrative genomics approaches to extend existing knowledge of the genetics of l