Design and Evaluation of a Vision-Based UI for People with Large Cognitive-Motor Disabilities

Recovering from multiple traumatic brain injury (TBI) is a very difficult task, depending on the severity of the lesions, the affected parts of the brain and the level of damage (locomotor, cognitive or sensory). Although there are some software platforms to help these patients to recover part of the lost capacity, the variety of existing lesions and the different degree to which they affect the patient, do not allow the generalization of the appropriate treatments and tools in each case. The aim of this work is to design and evaluate a machine vision-based UI (User Interface) allowing patients with a high level of injury to interact with a computer. This UI will be a tool for the therapy they follow and a way to communicate with their environment. The interface provides a set of specific activities, developed in collaboration with the multidisciplinary team that is currently evaluating each patient, to be used as a part of the therapy they receive. The system has been successfully tested with two patients whose degree of disability prevents them from using other types of platforms

MVPAlab: A machine learning decoding toolbox for multidimensional electroencephalography data

This research was supported by the Spanish Ministry of Sci- ence and Innovation under the PID2019–111187GB-I00 grant, by the MCIN/AEI/10.13039/50110 0 011033/ and FEDER “Una manera de hacer Europa’’ under the RTI2018-098913-B100 project, by the Consejería de Economía, Innovación, Ciencia y Empleo (Junta de Andalucía) and FEDER under CV20-45250, A-TIC-080-UGR18, B- TIC-586-UGR20 and P20-00525 projects. The first author of this work is supported by a scholarship from the Spanish Ministry of Science and Innovation (BES-2017–079769). Funding for open ac- cess charge: Universidad de Granada / CBUA. The sample EEG dataset was extracted from an original experiment previously ap- proved by the Ethics Committee of the University of Granada.Background and Objective: The study of brain function has recently expanded from classical univariate to multivariate analyses. These multivariate, machine learning-based algorithms afford neuroscientists extracting more detailed and richer information from the data. However, the implementation of these procedures is usually challenging, especially for researchers with no coding experience. To address this problem, we have developed MVPAlab, a MATLAB-based, flexible decoding toolbox for multidimensional electroencephalography and magnetoencephalography data. Methods: The MVPAlab Toolbox implements several machine learning algorithms to compute multivariate pattern analyses, cross-classification, temporal generalization matrices and feature and frequency contri- bution analyses. It also provides access to an extensive set of preprocessing routines for, among others, data normalization, data smoothing, dimensionality reduction and supertrial generation. To draw statisti- cal inferences at the group level, MVPAlab includes a non-parametric cluster-based permutation approach. Results: A sample electroencephalography dataset was compiled to test all the MVPAlab main function- alities. Significant clusters (p < 0.01) were found for the proposed decoding analyses and different config- urations, proving the software capability for discriminating between different experimental conditions. Conclusions: This toolbox has been designed to include an easy-to-use and intuitive graphic user interface and data representation software, which makes MVPAlab a very convenient tool for users with few or no previous coding experience. In addition, MVPAlab is not for beginners only, as it implements several high and low-level routines allowing more experienced users to design their own projects in a highly flexible manner.Spanish Government PID2019-111187GB-I00 BES-2017-079769MCIN/AEIFEDER "Una manera de hacer Europa'' RTI2018-098913-B100Junta de AndalucíaEuropean Commission CV20-45250 A-TIC-080-UGR18 BTIC-586-UGR20 P20-00525Universidad de Granada/CBU

All-Arthroscopic Nanofractured Autologous Matrix-Induced Chondrogenesis (A-NAMIC) Technique for the Treatment of Focal Chondral Lesions of the Knee

Nanofractured autologous matrix-induced chondrogenesis (NAMIC©) is a 1-step technique that combines nanofracture needling to induce bone marrow stimulation (BMS) and the use of cell-free collagen matrix to optimize cartilage regeneration. In this Technical Note, we describe a modification of the NAMIC procedure using mosaicplasty trephines to prepare the lesion surface and to shape collagen implants in an all-arthroscopic approach (A-NAMIC). This technique is indicated for the treatment of International Cartilage Repair Society grade III to IV knee chondral lesions of ≤4 cm 2. After damaged cartilage is debrided, trephines are used to create a flat, circular lesion surfaces. Subsequently, BMS is performed with nanofracture, eliciting reproducible and stop-controlled subchondral bone perforations of 9-mm depth and 1-mm width. The collagen membrane is then cut to size with the trephine, placed over the prepared defect, and secured with fibrin glue, preventing loss of regenerating cells and growth factors to the joint space. Using trephines allows the rapid and precise creation of smooth defect surfaces with known dimensions, ensuring optimal lesion coverage. Additionally, nanofracture reduces trabecular compaction and allows for a deeper access to subchondral bone in comparison with conventional microfracture, improving lesion filling and production of cartilage with higher hyaline content

Hydroxytyrosyl punicate: A first overview of a novel phenolipid with antiproliferative and antitrypanosomal activity

Polyunsaturated fatty acids and phenolic compounds are two families of natural products that have been widely investigated for their health benefits. The aim of this study was to prepare the novel phenolipid hydroxytyrosyl punicate (HT-PA) and evaluate its antiproliferative and antiparasitic properties. HT-PA was synthesized from hydroxytyrosol (HT) and punicic acid (PA) in a two-step chemical synthesis. HT-PA had an EC50 of 8.93 µM against non–small cell lung carcinoma A549 cells and was more active than HT or PA. It achieved a selectivity index of 11.20 for tumor cell line A549 over non-tumor cell line MCR-5. HT-PA displayed 80-fold and 60-fold greater activity against Trypanosoma brucei parasites (EC50 of 0.95 µM) compared with HT and PA, respectively, and > 100-fold selectivity for T. brucei over healthy MRC-5 cells

Implementación de depósitos de muestreo en lisímetros de pesada y sus necesidades

Durante el desarrollo de varios prototipos lisímetros de pesada se requirió la necesidad de introducir en su diseño un depósito de muestreo del agua percolada para la extracción de muestras con el fin de ser analizadas. Asimismo, se estimó conveniente la incorporación de sensores en el depósito de muestreo que permitieran obtener directamente las características del agua drenada y su monitorización para la supervisión remota del cultivo. El principal inconveniente para su diseño fue resolver los recorridos en el espacio interior configurado por el recipiente de cultivo y el cajón exterior, y la separación de los flujos del agua drenada hacia el depósito de drenaje y el depósito de muestreo manteniendo la compacidad del sistema. Los prototipos de lisímetros de pesada más evolucionados permitieron, a través de dos salidas exteriores, recoger muestras del agua o introducir agua destilada para su limpieza, de forma independiente a la supervisión remota

LA PSICOPATOLOGIA DEL SINDROME CULTURAL “SUSTO” EN POBLADORES DEL DISTRITO DE MÓRROPE, PERÚ

The present work tries to characterize psychopathologically the "scare" as a cultural syndrome. For which two phases were designed: analysis of the object of study and design of an explanatory model of this cultural syndrome and another phase to develop a model that allows knowing the therapeutic efficacy of shamanism. The population consisted of 50 inhabitants of the district of Mórrope, who presented the Cultural Syndrome “scare”. An etiology caused by stressful events that affects functionality and quality of life was found, with symptoms such as: lack of mood, anorexia, body pain, sleep disorder and nocturnal fear, and trembling in the body; Also, anxiety, abnormal beliefs (harm, witchcraft), sleep disorders including nightmares, these episodes last from 1 to 3 weeks. It is concluded that the scare was characterized psychopathologically presenting a particular symptomatology that is assumed to be dependent on the territory and culture.El presente trabajo pretende caracterizar psicopatológicamente el “susto” como síndrome cultural.&nbsp; Para lo cual se diseñaron dos fases: análisis del objeto de estudio y diseño de un modelo explicativo de este síndrome cultural y otra fase para elaborar un modelo que permita conocer la eficacia terapéutica del chamanismo. La población estuvo conformada por 50 habitantes del distrito de Mórrope, que presentaron el Síndrome Cultural “susto”. Se encontró una etiología causada por eventos estresantes que afecta la funcionalidad y calidad de vida, con síntomas como: falta de ánimo, anorexia, dolor corporal, trastorno del sueño y temor nocturno, y temblor en el cuerpo; también ansiedad, creencias anormales (el daño, la brujería), trastornos del sueño que incluyen pesadillas nocturnas, estos episodios tienen una duración de 1 a 3 semanas. Se concluye que el susto fue caracterizado psicopatológicamente presentando una sintomatología particular que se asume es dependiente del territorio y la cultura. &nbsp

THE MEDIA COMPETENCE IN UNIVERSITY EDUCATION MANAGERS

La investigación tuvo por objetivo general analizar la competencia mediática en gerentes de educación universitaria de Venezuela, se sustenta en (Ferrés y Piscitelli (2012), Gozálvez, González, &amp; Caldeiro (2014), Schleifer (2018), Guanipa, Albites, Aldana, &amp; Colina (2019), metodológicamente fue de tipo descriptiva con diseño de campo no experimental, en una población de 46 gerentes educativos de organizaciones de educación universitaria, adscritos en el Estado Falcón – Venezuela. Los encuestados en un 13% conoce e implementa códigos deontológicos de producción y difusión, un 20% opta por seguir los procesos de los organismos oficiales de protección al usuario, un 15% indica conocer la legislación de protección a la infancia, un 20% conoce lo relacionado a los permisos sobre privacidad en redes sociales, un 17% tiene conocimiento sobre los programas para proteger los derechos de autor en la red, mientras que un 15% conoce sobre las precauciones de datos personales. La competencia mediática permite generar personas reflexivas, criticas, construyendo la sociedad del conocimiento con base al uso efectivo, estético, ético, de los medios comunicacionales, digitales y redes sociales. Se devela que los gerentes educativos universitarios, trabajan en base a la competencia mediática esta debe ser incorporada como parte del proceso formativo en las universidades.The research had the general objective of analyzing media competence in managers of university education in Venezuela, it is based on (Ferrés and Piscitelli (2012), Gozálvez, González, &amp; Caldeiro (2014), Schleifer (2018), Guanipa, Albites, Aldana, &amp; Colina (2019), was methodologically descriptive with a non-experimental field design, in a population of 46 educational managers from university education organizations, affiliated in the State of Falcón-Venezuela. Respondents in 13% know and implement deontological codes of production and dissemination, 20% choose to follow the processes of the official user protection organizations, 15% indicate that they know the child protection legislation, 20% know about privacy permissions in social networks, 17% are aware of programs to protect copyright on the web, while 15% know about personal data precautions. Media competence allows generating reflective and critical people, building the knowledge society based on the effective, aesthetic, ethical use of communication, digital and social media. It is revealed that university educational managers work based on media competence, this must be incorporated as part of the training process in universities

THERAPEUTIC EFFECTIVENESS OF SHAMANISM IN TREATMENT OF THE CULTURAL "SUSTO" SYNDROME IN INHABITANTS OF THE DISTRICT OF MÓRROPE, PERÚ

El presente trabajo pretende por medio de una estrategia basada en un diseño descriptivo – propositivo valorar la efectividad terapéutica del shamanismo al tratar el síndrome cultural “susto”; en una muestra de 42 pacientes que radican en el distrito de Mórrope, de la Región Lambayeque en Perú, los que previamente han sido diagnosticados con el “susto” un síndrome cultural típico de esta región. luego se procedió a valorar el rapport entre el paciente con el curandero o shamán, logrando fundamentar epistemológicamente el proceso terapéutico del Shamanismo y su dinámica, se caracterizó un proceso dicotómico donde se expresa una interacción entre la Eficacia Terapéutica Cultural o Relativa y la Eficacia Terapéutica Absoluta o Farmacológica. La primera depende de la aceptación del sistema cultural, actúa principalmente a nivel psicológico demostrando toda su validez en el tratamiento de Síndromes culturales y la segunda es obvia la acción a nivel fisiológico – farmacológico de los principios activos. &nbsp;Se validaron por medio de criterio de especialistas la asociación entre la eficacia “simbólica” de elementos empleados por el shamán con la eficacia “terapéutica”, para su caracterización con fines de investigación; esto dentro del contexto cultural es decir el manejo del “rito terapéutico”.The present work tries by means of a strategy based on a descriptive design - purposeful to value the therapeutic effectiveness of the shamanism when treating the cultural syndrome "susto"; It is in a sample of 42 patients who live in the district of Mórrope, in the Lambayeque Region in Peru, who have previously been diagnosed with "susto", a cultural syndrome typical of this region. Then we proceeded to assess the rapport between the patient and the healer or shaman, achieving an epistemological basis for the therapeutic process of Shamanism and its dynamics. A dichotomous process was characterized where an interaction between Cultural or Relative Therapeutic Efficacy and Absolute Therapeutic Efficacy is expressed. or pharmacological. The first depends on the acceptance of the cultural system, it acts mainly at the psychological level, demonstrating its full validity in the treatment of cultural syndromes and the second is the obvious action at the physiological - pharmacological level of the active ingredients. The association between the "symbolic" efficacy of elements used by the shaman with the "therapeutic" efficacy was validated by means of specialist criteria, for its characterization for research purposes; this within the cultural context, that is, the management of the "therapeutic rite"

Response‐adapted treatment with rituximab, bendamustine, mitoxantrone, and dexamethasone followed by rituximab maintenance in patients with relapsed or refractory follicular lymphoma after first‐line immunochemotherapy: Results of the RBMDGELTAMO08 phase II trial

Background: Consensus is lacking regarding the optimal salvage therapy for patients with follicular lymphoma who relapse after or are refractory to immunochemotherapy. Methods: This phase II trial evaluated the efficacy and safety of response‐adapted therapy with rituximab, bendamustine, mitoxantrone, and dexamethasone (RBMD) in follicular lymphoma patients who relapsed after or were refractory to first‐line immunochemotherapy. Sixty patients received three treatment cycles, and depending on their response received an additional one (complete/unconfirmed complete response) or three (partial response) cycles. Patients who responded to induction received rituximab maintenance therapy for 2 years. Results: Thirty‐three (55%) and 42 (70%) patients achieved complete/unconfirmed complete response after three cycles and on completing induction therapy (4‐6 cycles), respectively (final overall response rate, 88.3%). Median progression‐free survival was 56.4 months (median follow‐up, 28.3 months; 95% CI, 15.6‐51.2). Overall survival was not reached. Progression‐free survival did not differ between patients who received four vs six cycles (P = .6665), nor between patients who did/did not receive rituximab maintenance after first‐line therapy (P = .5790). Median progression‐ free survival in the 10 refractory patients was 25.5 months (95% CI, 0.6‐N/A) and was longer in patients who had shown progression of disease after 24 months of first‐line therapy (median, 56.4 months; 95% CI, 19.8‐56.4) than in those who showed early progression (median, 42.31 months; 95% CI, 24.41–NA) (P = .4258). Thirty‐six (60%) patients had grade 3/4 neutropenia. Grade 3/4 febrile neutropenia and infection were recorded during induction (4/60 [6.7%] and 5/60 [8.3%] patients, respectively) and maintenance (2/43 [4.5%] and 4/43 [9.1%] patients, respectively). Conclusions: This response‐adapted treatment with RBMD followed by rituximab maintenance is an effective and well‐tolerated salvage treatment for relapsed/refractory follicular lymphoma following first‐line immunochemotherapy. Clinical trial registration: ClinicalTrials.gov # NCT01133158