De la felicidad mínima a la plena felicidad

Men prosecute happiness; we are born to be happy. But, what is happiness? There is no universally accepted answer. The purpose of this study is two-faced: 1st. To justify that there are certain minimum elements in every form of happiness; 2nd. That different historical, sociological, anthropological...reasons support the rational and reasonable defence of different objective models of happiness. As a proof, two different models (the Christian and the lay models of happiness) are described. We conclude that full happiness is a utopia, and advance as an adequate model the rational and reasonable employ of the ¿carpe diem¿ maxim

Validation and measurement invariance of the Scale of Positive and Negative Experience (SPANE) in a spanish general sample

Well-being has been measured based on different perspectives in positive psychology. However, it is necessary to measure affects and emotions correctly and to explore the independence of positive and negative affect. This cross-sectional study adapts and validates the Scale of Positive and Negative Experience (SPANE) with a non-probabilistic sample of 821 Spanish adults. A confirmatory factor analysis confirmed two related factors with two correlated errors. The average variance extracted was 0.502 for negative affect (SPANE-N) and 0.588 for positive affect (SPANE-P). The composite reliability was 0.791 for SPANE-N and 0.858 for SPANE-P. Measurement invariance analysis showed evidence of scalar invariance. Item-total corrected polyserial correlations showed values between 0.47 and 0.76. The path analysis used to test temporal stability, and the structural equation models used to test convergent and concurrent validity with other well-being measures, showed good fit. All path coefficients were statistically significant and over 0.480. For the validity models, the magnitude of the correlations was large and in the expected direction. The Spanish version of the SPANE show good psychometric properties. Future studies of emotional well-being in Spain can benefit from the use of this scale, and new studies must test cross-cultural invarianc

Impact of Biomedical and Biopsychosocial Training Sessions on the Attitudes, Beliefs and Recommendations of Health Care Providers about Low Back Pain: A Randomised Clinical Trial

Impact of Biomedical and Biopsychosocial Training Sessions on the Attitudes, Beliefs and Recommendations of Health Care Providers about Low Back Pai

Short-term effects of kinesio taping in the treatment of latent and active upper trapezius trigger points: two prospective, randomized, sham-controlled trials

The presence of myofascial trigger points (MTrPs) is one of the most common causes of musculoskeletal problems and may lead to limited professional activity. Among the various treatment methods proposed for MTrPs, Kinesio Taping (KT) is a non-invasive, painless, and less time-consuming method with fewer side efects that has become widely used as a therapeutic tool in a variety of prevention and rehabilitation protocols. The aim of the study was to evaluate the immediate and short-term efcacy of the space correction KT technique in patients with latent or active MTrPs in the upper trapezius muscle. Two parallel randomized sham-controlled trials were simultaneously executed: in trial A, ninety-seven participants with latent MTrPs were randomly assigned to either the KT (n=51) or sham (n=46) group; in trial B, thirty-seven participants with active MTrPs were assigned to the KT (n=20) or sham (n=17) group. The primary outcome was pressure pain threshold (PPT) in the upper trapezius muscle, measured with algometry. Secondary outcomes included the active range of motion (ROM) of the cervical spine (lateral fexion and rotation), measured with a cervical ROM goniometer. In each trial, two-way ANOVA tests were used to compare the study efects on the outcome measures between the groups, with time serving as the intra-group factor (baseline, immediately, and 72h after the application) and the intervention type (KT and sham) as the between-group factor. At 72h, participants receiving KT did not show signifcant diferences in PPT (trial A: mean diference −1.8N; 95% CI: [−8.1, 4.4], trial B: mean diference −1.2N; 95% CI: [−7.4, 5.1]), cervical lateral fexion (trial A: mean diference 0.2 degrees; 95% CI: [−2.7, 3.1], trial B: mean diference −2.4 degrees; 95% CI: [−8.4, 3.6]), and cervical rotation (trial A: mean diference 3.7 degrees; 95% CI: [−0.1, 7.5], trial B: mean diference 1.4 degrees; 95% CI: [−5.7, 8.4]), compared to the sham groups. Thus, the results of this study do not support the use of the space correction KT technique to treat patients with latent or active myofascial trigger points in the upper trapezius muscle

Impact of a Web-Based Exercise and Nutritional Education Intervention in Patients Who Are Obese With Hypertension: Randomized Wait-List Controlled Trial

Background: Internet-based interventions are a promising strategy for promoting healthy lifestyle behaviors. These have a tremendous potential for delivering electronic health interventions in scalable and cost-effective ways. There is strong evidence that the use of these programs can lead to weight loss and can lower patients’ average blood pressure (BP) levels. So far, few studies have investigated the effects of internet-based programs on patients who are obese with hypertension (HTN). Objective: The aim of this study is to investigate the short- and long-term efficacy, in terms of body composition and BP parameters, of a self-administered internet-based intervention involving different modules and learning techniques aimed at promoting lifestyle changes (both physical activity and healthy eating) in patients who are obese with HTN. Methods: A randomized wait-list controlled trial design was used. We recruited 105 adults with HTN who were overweight or obese and randomly assigned them to either a 3-month internet-based intervention group (n=55) or the wait-list control group (n=50). We assessed BMI (primary outcome), body fat mass (BFM), systolic (S)BP and diastolic (D)BP, blood glucose and insulin levels, physical activity levels, and functional capacity for aerobic exercise at Time 0 (preintervention) and Time 1 (postintervention). All the patients in the wait-list control group subsequently received the intervention, and a secondary within-group analysis, which also included these participants, was conducted at Time 2 (12-month follow-up). Results: A 2-way mixed analysis of covariance showed a significant decrease in BMI, BFM, and blood glucose at 3 months in the internet-based intervention group; the effect size for the BMI and BFM parameters was moderate to large, and there was also a borderline significant trend for DBP and insulin. These results were either maintained or improved upon at Time 2 and showed significant changes for BMI (mean difference −0.4, 95% CI −0.1 to −0.6; P=.005), BFM (mean difference −2.4, 95% CI −1.1 to −3.6; P<.001), DBP (mean difference −1.8, 95% CI −0.2 to −3.3; P=.03), and blood glucose (mean difference −2, 95% CI 0 to −4; P=.04). Conclusions: Implementation of our self-administered internet-based intervention, which involved different learning techniques aimed to promote lifestyle changes, resulted in positive short- and long-term health benefits in patients who are obese with HTN

Efectos de diferentes intensidades del entrenamiento de lafuerza sobre los parámetros relacionados con la salud en la atracción hacia la actividad física de las personas mayores

To assess the effects of a progressive resistance training program at different intensities on health-related quality of life, anxiety, and motivation towards engaging in physical activity among older people. Prospective, municipal multi-centers, non-randomized controlled trial. 76 older adults were assigned to: vigorous intensity (n = 19), vigorous-moderate intensity (n = 21), moderate intensity (n = 19), or control group (n = 17). The exercise groups performed six exercises with elastic bands per session, twice a week, for 8 months. Vigorous intensity, vigorous-moderate intensity and moderate intensity group performed 6, 10 and 15 repetitions, respectively. Health-related quality of life was assessed using the 36-Item Short Form Health Survey, trait and state anxiety using the State-Trait Anxiety Inventory, and motivation towards engaging in physical activity using the Behavioural Regulation in Exercise Questionnaire. The moderate intensity group showed a significant increase in the summary of the physical components of health-related quality of life (p = 0.001; ηp2 = 0.158) and a significant decrease in external regulation (p = 0.002; ηp2= 0.145) and amotivation (p = 0.013; ηp2 = 0.97). In contrast, the vigorous intensity group showed a significant increase in state anxiety (p = 0.004; ηp2 = 0.076) and a significant decrease in introjected regulation (p = 0.018; ηp2 = 0.097). Moderate intensity strength training programs are best suited for older adults because they improve health-related quality of life and decrease less self-determined forms of regulation, all without increasing anxiety states.Evaluar los efectos de un programa de entrenamiento progresivo de la fuerza a diferentes intensidades sobre la calidad de vida relacionada con la salud, la ansiedad y la motivación para atraer hacia la realización de actividad física entre las personas mayores. Ensayo controlado prospectivo, multicéntrico municipal, no aleatorizado. 76 adultos mayores fueron asignados a: grupo de intensidad vigorosa (n = 19), vigorosa-moderada (n = 21), moderada (n = 19), o grupo de control (n = 17). Los grupos de ejercicio realizaron seis ejercicios con bandas elásticas por sesión, dos veces por semana, durante 8 meses. Los grupos de intensidad vigorosa, vigorosa-moderada y moderada realizaron 6, 10 y 15 repeticiones, respectivamente. La calidad de vida relacionada con la salud se evaluó mediante la Encuesta de Salud de formulario corto de 36 elementos, el rasgo y el estado de ansiedad mediante el Inventario de Ansiedad Estado-Rasgo, y la motivación para realizar actividad física mediante el Cuestionario de Regulación del Comportamiento en el Ejercicio. El grupo de intensidad moderada mostró un aumento significativo en el resumen de los componentes físicos de la calidad de vida relacionada con la salud (p = 0.001; ηp2 = 0.158) y una disminución significativa en la regulación externa (p = 0.002; ηp2 = 0.145) y desmotivación (p = 0.013; ηp2 = 0.97). En contraste, el grupo de intensidad vigorosa mostró un aumento significativo en el estado de ansiedad (p = 0.004; ηp2 = 0.076) y una disminución significativa en la regulación introyectada (p = 0.018; ηp2 = 0.097). Los programas de entrenamiento de la fuerza de intensidad moderada son más adecuados para los adultos mayores porque mejoran la calidad de vida relacionada con la salud y disminuyen las formas de regulación menos autodeterminadas, todo sin aumentar los estados de ansiedad.Actividad Física y Deport

“Own doctor” presence in a web-based lifestyle intervention for adults with obesity and hypertension: A randomized controlled trial

Introduction: Online interventions have long been shown to be an effective means to promote a healthy lifestyle, thereby helping to control body weight and blood pressure figures. Likewise, using video modeling is also considered an effective way to guide patients through behavioral interventions. Nonetheless, to the best of our knowledge, this study is the first to analyze how the presence of patients' “own doctor” in the audiovisual content of a web-based lifestyle program (“Living Better”) aimed at promoting regular physical exercise and healthy eating behavior, compared with an “unknown doctor,” influences the outcomes of adults with obesity and hypertension. Materials and methods: A total of 132 patients were randomly assigned either to the experimental (n = 70) or control (n = 62) group (“own doctor” or “unknown doctor”, respectively). The body mass index, systolic and diastolic blood pressure, number of antihypertensive drugs used, physical activity level, and quality of life was assessed and compared at baseline and post-intervention (12 weeks).Results: The intention-to-treat analysis showed intragroup significant improvements in both groups in terms of the body mass index (control group: mean difference −0.3, 95% CI [−0.5, −0.1], p = 0.002; experimental group: −0.4 [−0.6, −0.2], p &amp;lt; 0.001) and systolic blood pressure (control group: −2.3 [−4.4, −0.2], p = 0.029; experimental group: −3.6 [−5.5, −1.6], p&amp;lt; 0.001). In addition, there were also significant improvements in the experimental group for the diastolic blood pressure (−2.5 [−3.7, −1.2], p &amp;lt; 0.001), physical activity (479 [9, 949], p = 0.046), and quality of life (5.2 [2.3, 8.2], p = 0.001). However, when comparing the experimental with the control group, no between-group significant differences were found in these variables.Conclusions: This study suggests that the presence of patients' “own doctor” in the audiovisual content of a web-based intervention, aimed at promoting a healthy lifestyle among adults with obesity and hypertension, do not show significant additional benefits over the efficacy of e–counseling.Trial registrationClinicalTrials.gov NCT04426877. First Posted: 11/06/2020. https://clinicaltrials.gov/ct2/show/NCT04426877

Radiation and Stemness Phenotype May Influence Individual Breast Cancer Outcomes: The Crucial Role of MMPs and Microenvironment

Breast cancer is the most common cancer in women. Radiotherapy (RT) is one of the mainstay treatments for cancer but in some cases is not effective. Cancer stem cells (CSCs) within the tumor can be responsible for recurrence and metastasis after RT. Matrix metalloproteases (MMPs), regulated mainly by tissue inhibitors of metalloproteinases (TIMPs) and histone deacetylases (HDACs), may also contribute to tumor development by modifying its activity after RT. The aim of this work was to study the effects of RT on the expression of MMPs, TIMPs and HDACs on different cell subpopulations in MCF-7, MDA-MB-231 and SK-BR-3 cell lines. We assessed the in vitro expression of these genes in different 3D culture models and induced tumors in female NSG mice by orthotopic xenotransplants. Our results showed that gene expression is related to the cell subpopulation studied, the culture model used and the single radiation dose administered. Moreover, the crucial role played by the microenvironment in terms of cell interactions and CSC plasticity in tumor growth and RT outcome is also shown, supporting the use of higher doses (6 Gy) to achieve better control of tumor developmentThis research was funded by the FUNDACIÓN PROGRESO Y SALUD, Consejería de Igualdad, Salud y Políticas Sociales, Junta de Andalucía (PI-730), the INSTITUTO DE SALUD CARLOS III, Ministerio de Ciencia, Innovación y Universidades (PIE16-00045) and by the Chair “Doctors Galera-Requena in cancer stem cell research” (CMC-CTS963)

Matrix metalloproteases and TIMPs as prognostic biomarkers in breast cancer patients treated with radiotherapy: A pilot study

Breast cancer (BC) is the most common tumour in women and one of the most important causes of cancer death worldwide. Radiation therapy (RT) is widely used for BC treatment. Some proteins have been identified as prognostic factors for BC (Ki67, p53, E‐cadherin, HER2). In the last years, it has been shown that variations in the expression of MMPs and TIMPs may contribute to the development of BC. The aim of this pilot work was to study the effects of RT on different MMPs (‐1, ‐2, ‐3, ‐7, ‐8, ‐9, ‐10, ‐12 and ‐13) and TIMPs (‐1 to ‐4), as well as their relationship with other variables related to patient characteristics and tumour biology. A group of 20 BC patients treated with RT were recruited. MMP and TIMP serum levels were analysed by immunoassay before, during and after RT. Our pilot study showed a slight increase in the levels of most MMP and TIMP with RT. However, RT produced a significantly decrease in TIMP‐1 and TIMP‐3 levels. Significant correlations were found between MMP‐3 and TIMP‐4 levels, and some of the variables studied related to patient characteristics and tumour biology. Moreover, MMP‐9 and TIMP‐3 levels could be predictive of RT toxicity. For this reason, MMP‐3, MMP‐9, TIMP‐3 and TIMP‐4 could be used as potential prognostic and predictive biomarkers for BC patients treated with RT.FUNDACIÓN PROGRESO Y SALUD, Grant/Award Number: PI‐730; Instituto de Salud Carlos III, Grant/Award Number: PIE16‐00045; Oncología Básica y Clínica, Grant/Award Number: CTS‐20