Communication: UV photoionization of cytosine catalyzed by Ag+

The photo-induced damages of DNA in interaction with metal cations, which are found in various environments, still remain to be characterized. In this paper, we show how the complexation of a DNA base (cytosine (Cyt)) with a metal cation (Ag+) changes its electronic properties. By means of UV photofragment spectroscopy of cold ions, it was found that the photoexcitation of the CytAg+ complex at low energy (315-282) nm efficiently leads to ionized cytosine (Cyt+) as the single product. This occurs through a charge transfer state in which an electron from the p orbital of Cyt is promoted to Ag+, as confirmed by ab initio calculations at the TD-DFT/B3LYP and RI-ADC(2) theory level using the SV(P) basis set. The low ionization energy of Cyt in the presence of Ag+ could have important implications as point mutation of DNA upon sunlight exposition.Fil: Taccone, Martín Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Féraud, Geraldine. Aix Marseille Université. Physique des Interactions Ioniques et Moléculaires; FranciaFil: Berdakin, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Dedonder Lardeux, Claude. Aix Marseille Université. Physique des Interactions Ioniques et Moléculaires; FranciaFil: Jouvet, Christophe. Physique des Interactions Ioniques et Moléculaires; FranciaFil: Pino, Gustavo Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentin

Numerical analysis and simulation of the dynamics of mountain glaciers

In this chapter, we analyze and approximate a nonlinear stationary Stokes problem that describes the motion of glacier ice. The existence and uniqueness of solutions are proved and an a priori error estimate for the finite element approximation is found. In a second time, we combine the Stokes problem with a transport equation for the volume fraction of ice, which describes the time evolution of a glacier. The accumulation due to snow precipitation and melting are accounted for in the source term of the transport equation. A decoupling algorithm allows the diffusion and the advection problems to be solved using a two-grids method. As an illustration, we simulate the evolution of Aletsch glacier, Switzerland, over the 21st century by using realistic climatic conditions

Speech recognition and statistical approach : CNET's experience

This paper presents the work done at the CNET in speech recognition during the last few years. The authors present the recent generation of speaker-independent systems, based on statistical modeling using the Markov models (PHIL86 software) . Several applications of these systems in the Telecommunications area are described, as well as the lessons drawn front them .Cet article décrit les travaux menés au CNET ces dernières années, dans le domaine de la reconnaissance de la parole. Après avoir rappelé le contexte de cette recherche, on décrit le logiciel PHIL86 destiné à reconnaître des vocabulaires de petite taille, indépendamment du locuteur, et les développements matériels qui lui ont été associés . Deux expérimentations de la reconnaissance dans - le domaine des Télécommunications sont ensuite présentées, en insistant principalement sur les enseignements qui en ont été tirés et les résultats des évaluations menées sur le terrain

Subglacial hydrology from high-resolution ice-flow simulations of the Rhine Glacier during the Last Glacial Maximum: a proxy for glacial erosion

At the Last Glacial Maximum (LGM), the Rhine Glacier complex (Rhine and Linth glaciers) formed large piedmont lobes extending north into the Swiss and German Alpine forelands. Numerous overdeepened valleys there were formed by repeated glaciations. A characteristic of these overdeepened valleys is their location close to the LGM ice margin, away from the Alps. Numerical models of ice flow of the Rhine Glacier indicate a poor fit between the sliding distance, a proxy for glacial erosion, and the location of these overdeepenings. Calculations of the hydraulic potential based on the computed time-dependent ice surface elevations of the Rhine Glacier lobe obtained from a high-resolution thermo-mechanically coupled Stokes flow model are used to estimate the location of subglacial water drainage routes. Results indicate that the subglacial water discharge is high and focused along glacial valleys and overdeepenings when water pressure is equal to the ice overburden pressure. These conditions are necessary for subglacial water to remove basal sediments, expose fresh bedrock, and favor further erosion by quarrying and abrasion. Knowledge of the location of paleo-subglacial water drainage routes may be useful to understand patterns of subglacial erosion beneath paleo-ice masses that do not otherwise relate to the sliding of ice. Comparison of the erosion pattern from subglacial meltwater with those from quarrying and abrasion shows the importance of subglacial water flow in the formation of distal overdeepenings in the Swiss lowlands.</p

Exact Scale Invariance of Composite-Field Coupling Constants

We show that the coupling constant of a quantum-induced composite field is scale invariant due to its compositeness condition. It is first demonstrated in next-to-leading order in 1/N in typical models, and then we argue that it holds exactly.Comment: 4 page

The 2007 WHO Classification of Tumours of the Central Nervous System

The fourth edition of the World Health Organization (WHO) classification of tumours of the central nervous system, published in 2007, lists several new entities, including angiocentric glioma, papillary glioneuronal tumour, rosette-forming glioneuronal tumour of the fourth ventricle, papillary tumour of the pineal region, pituicytoma and spindle cell oncocytoma of the adenohypophysis. Histological variants were added if there was evidence of a different age distribution, location, genetic profile or clinical behaviour; these included pilomyxoid astrocytoma, anaplastic medulloblastoma and medulloblastoma with extensive nodularity. The WHO grading scheme and the sections on genetic profiles were updated and the rhabdoid tumour predisposition syndrome was added to the list of familial tumour syndromes typically involving the nervous system. As in the previous, 2000 edition of the WHO ‘Blue Book’, the classification is accompanied by a concise commentary on clinico-pathological characteristics of each tumour type. The 2007 WHO classification is based on the consensus of an international Working Group of 25 pathologists and geneticists, as well as contributions from more than 70 international experts overall, and is presented as the standard for the definition of brain tumours to the clinical oncology and cancer research communities world-wide

Extractive Text-Based Summarization of Arabic videos: Issues, Approaches and Evaluations

International audienceIn this paper, we present and evaluate a method for extractive text-based summarization of Arabic videos. The algorithm is proposed in the scope of the AMIS project that aims at helping a user to understand videos given in a foreign language (Arabic). For that, the project proposes several strategies to translate and summarize the videos. One of them consists in transcribing the Ara-bic videos, summarizing the transcriptions, and translating the summary. In this paper we describe the video corpus that was collected from YouTube and present and evaluate the transcription-summarization part of this strategy. Moreover, we present the Automatic Speech Recognition (ASR) system used to transcribe the videos, and show how we adapted this system to the Algerian dialect. Then, we describe how we automatically segment into sentences the sequence of words provided by the ASR system, and how we summarize the obtained sequence of sentences. We evaluate objectively and subjectively our approach. Results show that the ASR system performs well in terms of Word Error Rate on MSA, but needs to be adapted for dealing with Algerian dialect data. The subjective evaluation shows the same behaviour than ASR: transcriptions for videos containing dialectal data were better scored than videos containing only MSA data. However, summaries based on transcriptions are not as well rated, even when transcriptions are better rated. Last, the study shows that features, such as the lengths of transcriptions and summaries, and the subjective score of transcriptions, explain only 31% of the subjective score of summaries

The implausibility of ‘usual care’ in an open system: sedation and weaning practices in Paediatric Intensive Care Units (PICUs) in the United Kingdom (UK)

Background: The power of the randomised controlled trial depends upon its capacity to operate in a closed system whereby the intervention is the only causal force acting upon the experimental group and absent in the control group, permitting a valid assessment of intervention efficacy. Conversely, clinical arenas are open systems where factors relating to context, resources, interpretation and actions of individuals will affect implementation and effectiveness of interventions. Consequently, the comparator (usual care) can be difficult to define and variable in multi-centre trials. Hence outcomes cannot be understood without considering usual care and factors that may affect implementation and impact on the intervention. Methods: Using a fieldwork approach, we describe PICU context, ‘usual’ practice in sedation and weaning from mechanical ventilation, and factors affecting implementation prior to designing a trial involving a sedation and ventilation weaning intervention. We collected data from 23 UK PICUs between June and November 2014 using observation, individual and multi-disciplinary group interviews with staff. Results: Pain and sedation practices were broadly similar in terms of drug usage and assessment tools. Sedation protocols linking assessment to appropriate titration of sedatives and sedation holds were rarely used (9 % and 4 % of PICUs respectively). Ventilator weaning was primarily a medical-led process with 39 % of PICUs engaging senior nurses in the process: weaning protocols were rarely used (9 % of PICUs). Weaning methods were variably based on clinician preference. No formal criteria or use of spontaneous breathing trials were used to test weaning readiness. Seventeen PICUs (74 %) had prior engagement in multi-centre trials, but limited research nurse availability. Barriers to previous trial implementation were intervention complexity, lack of belief in the evidence and inadequate training. Facilitating factors were senior staff buy-in and dedicated research nurse provision. Conclusions: We examined and identified contextual and organisational factors that may impact on the implementation of our intervention. We found usual practice relating to sedation, analgesia and ventilator weaning broadly similar, yet distinctively different from our proposed intervention, providing assurance in our ability to evaluate intervention effects. The data will enable us to develop an implementation plan; considering these factors we can more fully understand their impact on study outcomes