A Radar-Shaped Statistic for Testing and Visualizing Uniformity Properties in Computer Experiments

In the study of computer codes, filling space as uniformly as possible is important to describe the complexity of the investigated phenomenon. However, this property is not conserved by reducing the dimension. Some numeric experiment designs are conceived in this sense as Latin hypercubes or orthogonal arrays, but they consider only the projections onto the axes or the coordinate planes. In this article we introduce a statistic which allows studying the good distribution of points according to all 1-dimensional projections. By angularly scanning the domain, we obtain a radar type representation, allowing the uniformity defects of a design to be identified with respect to its projections onto straight lines. The advantages of this new tool are demonstrated on usual examples of space-filling designs (SFD) and a global statistic independent of the angle of rotation is studied

Plans d’expériences numériques d’information de Kullback-Leibler minimale

International audienceLes utilisateurs de codes numériques onéreux en temps de calcul souhaitent réduire le coût en limitant le nombre de simulations suivant un choix judicieux fondé sur l'utilisation de plans d'expériences adaptés au contexte numérique et appelés « space filling designs ». Afin de remplir au mieux l'espace des paramètres, nous proposons une méthode de construction de plans dont les points sont le plus uniformément répartis dans l'hypercube unité. Pour mesurer l'écart entre la fonction de densité associée aux points du plan et celle de la loi uniforme, nous utilisons l'information de Kullback-Leibler, ce qui revient par ailleurs à utiliser l'entropie de Shannon. Celle-ci est estimée par une méthode de Monte Carlo dans laquelle la fonction de densité est remplacée par son estimation par noyaux gaussiens

The natural history and genotype–phenotype correlations of TMPRSS3 hearing loss:an international, multi-center, cohort analysis

TMPRSS3-related hearing loss presents challenges in correlating genotypic variants with clinical phenotypes due to the small sample sizes of previous studies. We conducted a cross-sectional genomics study coupled with retrospective clinical phenotype analysis on 127 individuals. These individuals were from 16 academic medical centers across 6 countries. Key findings revealed 47 unique TMPRSS3 variants with significant differences in hearing thresholds between those with missense variants versus those with loss-of-function genotypes. The hearing loss progression rate for the DFNB8 subtype was 0.3 dB/year. Post-cochlear implantation, an average word recognition score of 76% was observed. Of the 51 individuals with two missense variants, 10 had DFNB10 with profound hearing loss. These 10 all had at least one of 4 TMPRSS3 variants predicted by computational modeling to be damaging to TMPRSS3 structure and function. To our knowledge, this is the largest study of TMPRSS3 genotype–phenotype correlations. We find significant differences in hearing thresholds, hearing loss progression, and age of presentation, by TMPRSS3 genotype and protein domain affected. Most individuals with TMPRSS3 variants perform well on speech recognition tests after cochlear implant, however increased age at implant is associated with worse outcomes. These findings provide insight for genetic counseling and the on-going design of novel therapeutic approaches.</p

Overview of the MOSAiC expedition - Atmosphere

With the Arctic rapidly changing, the needs to observe, understand, and model the changes are essential. To support these needs, an annual cycle of observations of atmospheric properties, processes, and interactions were made while drifting with the sea ice across the central Arctic during the Multidisciplinary drifting Observatory for the Study of Arctic Climate (MOSAiC) expedition from October 2019 to September 2020. An international team designed and implemented the comprehensive program to document and characterize all aspects of the Arctic atmospheric system in unprecedented detail, using a variety of approaches, and across multiple scales. These measurements were coordinated with other observational teams to explore cross-cutting and coupled interactions with the Arctic Ocean, sea ice, and ecosystem through a variety of physical and biogeochemical processes. This overview outlines the breadth and complexity of the atmospheric research program, which was organized into 4 subgroups: atmospheric state, clouds and precipitation, gases and aerosols, and energy budgets. Atmospheric variability over the annual cycle revealed important influences from a persistent large-scale winter circulation pattern, leading to some storms with pressure and winds that were outside the interquartile range of past conditions suggested by long-term reanalysis. Similarly, the MOSAiC location was warmer and wetter in summer than the reanalysis climatology, in part due to its close proximity to the sea ice edge. The comprehensiveness of the observational program for characterizing and analyzing atmospheric phenomena is demonstrated via a winter case study examining air mass transitions and a summer case study examining vertical atmospheric evolution. Overall, the MOSAiC atmospheric program successfully met its objectives and was the most comprehensive atmospheric measurement program to date conducted over the Arctic sea ice. The obtained data will support a broad range of coupled-system scientific research and provide an important foundation for advancing multiscale modeling capabilities in the Arctic

Microphysical and radiative characterization of a subvisible midlevel Arctic ice cloud by airborne observations a case study

During the Arctic Study of Tropospheric Aerosol, Clouds and Radiation (ASTAR) campaign, which was conducted in March and April 2007, an optically thin ice cloud was observed south of Svalbard at around 3 km altitude. The microphysical and radiative properties of this particular subvisible midlevel cloud were investigated with complementary remote sensing and in situ instruments. Collocated airborne lidar remote sensing and spectral solar radiation measurements were performed at a flight altitude of 2300 m below the cloud base. Under almost stationary atmospheric conditions, the same subvisible midlevel cloud was probed with various in situ sensors roughly 30 min later. &lt;br&gt;&lt;br&gt; From individual ice crystal samples detected with the Cloud Particle Imager and the ensemble of particles measured with the Polar Nephelometer, microphysical properties were retrieved with a bi-modal inversion algorithm. The best agreement with the measurements was obtained for small ice spheres and deeply rough hexagonal ice crystals. Furthermore, the single-scattering albedo, the scattering phase function as well as the volume extinction coefficient and the effective diameter of the crystal population were determined. A lidar ratio of 21(&amp;plusmn;6) sr was deduced by three independent methods. These parameters in conjunction with the cloud optical thickness obtained from the lidar measurements were used to compute spectral and broadband radiances and irradiances with a radiative transfer code. The simulated results agreed with the observed spectral downwelling radiance within the range given by the measurement uncertainty. Furthermore, the broadband radiative simulations estimated a net (solar plus thermal infrared) radiative forcing of the subvisible midlevel ice cloud of &amp;minus;0.4 W m&lt;sup&gt;&amp;minus;2&lt;/sup&gt; (&amp;minus;3.2 W m&lt;sup&gt;&amp;minus;2&lt;/sup&gt; in the solar and +2.8 W m&lt;sup&gt;&amp;minus;2&lt;/sup&gt; in the thermal infrared wavelength range)