Détection de flamants roses par processus ponctuels marqués pour l'estimation de la taille des populations

Nous présentons dans ce rapport de recherche une nouvelle technique automatique de détection automatique de flamants roses sur des images aériennes. Nous considérons une approche stochastique fondée sur les processus objets, aussi appelés processus ponctuels marqués. Ici, les objets représentent les flamants. Chaque flamant est alors modélisé par une ellipse. La densité associée au processus ponctuel marqué d'ellipses est définie par rapport à une mesure de Poisson. Dans ce cadre gibbsien, cela réduit le problème à une minimisation d'énergie constituée d'un terme de régularisation (densité a priori), qui introduit des contraintes sur les objets et leurs interactions; et d'un terme d'attache aux données, qui permet de localiser sur l'image les flamants à extraire. Nous échantillonnons le processus pour extraire la configuration d'objets minimisant l'énergie grâce à une nouvelle dynamique de Naissances et Morts multiples, amenant finalement au nombre total de flamants présents sur l'image. Cette approche donne des comptes avec une bonne précision comparée aux comptes manuels. De plus, elle ne nécessite aucun traitement préalable ou intervention manuelle, ce qui réduit considérablement le temps d'obtention des comptes

Flamingo detection using Marked Point Processes for estimating the size of populations

In this paper, we present a new technique to automatically detect and count breeding Greater flamingos (Phoenicopterus roseus) on aerial photographs of their colonies. We consider a stochastic approach based on marked point processes also called object processes. Here, the objects represent flamingos which are defined as ellipses. The Gibbs density associated with the marked point process of ellipses is defined w.r.t the Poisson measure. Thus, the issue is reduced to an energy minimization, where the energy is composed of a regularization term (prior density), which introduces some constraints on the objects and their interactions, and a data term, which links the objects to the features to be extracted in the image. The prior energy is defined as a sum of local energies for each object. For a given object o, we consider the set S(o) of objects in the current configuration which overlap o. An overlapping coefficient between two objects is defined by the intersection area normalised by the minimum size between the two objects. The local energy, associated to o, is then proportional to the maximum overlapping coefficient between o and any element of S(o). The data term is also defined by a sum local energies over each object in the configuration. The local energy is obtained from the computation of a radiometric distance between pixels in the ellipse, modeling the flamingo, and pixels in the neighborhood of this ellipse....Nous présentons dans cet article une nouvelle technique de détection de flamants roses sur des images aériennes. Nous considérons une approche stochastique fondée sur les processus ponctuels marqués, aussi appelés processus objets. Ici, les objets représentent les flamants, qui sont modélisés par des ellipses. La densité associée au processus ponctuel marqué d'ellipses est définie par rapport à une mesure de Poisson. Dans un cadre gibbsien, le problème se réduit à la minimisation d'une énergie, qui est constituée d'un terme de régularisation (densité a priori), qui introduit des contraintes sur les objets et leurs interactions; et un terme d'attache aux données, qui permet de localiser sur l'image les flamants à extraire. Nous échantillonnons le processus pour extraire la configuration d'objets minimisant l'énergie grâce à une nouvelle dynamique de Naissances et Morts multiples, amenant finalement à une estimation du nombre total de flamants présents sur l'image. Cette approche donne des comptes avec une bonne précision comparée aux comptes manuels. De plus, elle ne nécessite aucun traitement préalable ou intervention manuelle, ce qui réduit considérablement le temps d'obtention des comptes

Rickets: An Overview and Future Directions, with Special Reference to Bangladesh: A Summary of the Rickets Convergence Group Meeting, Dhaka, 26–27 January 2006

Rickets has emerged as a public-health problem in Bangladesh during the past two decades, with up to 8% of children clinically affected in some areas. Insufficiency of dietary calcium is thought to be the underlying cause, and treatment with calcium (350–1,000 mg elemental calcium daily) is curative. Despite this apparently simple treatment, little is known about the most appropriate management of bone deformities of affected children, and further studies are needed to determine the details of dosing and duration of calcium therapy, the role of bracing, and specific indications for surgical intervention. Effective preventive measures that can feasibly reach entire communities are needed, and these may differ between various affected regions

Clinical expression of Menkes disease in females with normal karyotype

<p>Abstract</p> <p>Background</p> <p>Menkes Disease (MD) is a rare X-linked recessive fatal neurodegenerative disorder caused by mutations in the <it>ATP7A </it>gene, and most patients are males. Female carriers are mosaics of wild-type and mutant cells due to the random X inactivation, and they are rarely affected. In the largest cohort of MD patients reported so far which consists of 517 families we identified 9 neurologically affected carriers with normal karyotypes.</p> <p>Methods</p> <p>We investigated at-risk females for mutations in the <it>ATP7A </it>gene by sequencing or by multiplex ligation-dependent probe amplification (MLPA). We analyzed the X-inactivation pattern in affected female carriers, unaffected female carriers and non-carrier females as controls, using the human androgen-receptor gene methylation assay (<it>HUMAR</it>).</p> <p>Results</p> <p>The clinical symptoms of affected females are generally milder than those of affected boys with the same mutations. While a skewed inactivation of the X-chromosome which harbours the mutation was observed in 94% of 49 investigated unaffected carriers, a more varied pattern was observed in the affected carriers. Of 9 investigated affected females, preferential silencing of the normal X-chromosome was observed in 4, preferential X-inactivation of the mutant X chromosome in 2, an even X-inactivation pattern in 1, and an inconclusive pattern in 2. The X-inactivation pattern correlates with the degree of mental retardation in the affected females. Eighty-one percent of 32 investigated females in the control group had moderately skewed or an even X-inactivation pattern.</p> <p>Conclusion</p> <p>The X- inactivation pattern alone cannot be used to predict the phenotypic outcome in female carriers, as even those with skewed X-inactivation of the X-chromosome harbouring the mutation might have neurological symptoms.</p

Rickets: An Overview and Future Directions, with Special Reference to Bangladesh: A Summary of the Rickets Convergence Group Meeting, Dhaka, 26-27 January 2006

Rickets has emerged as a public-health problem in Bangladesh during the past two decades, with up to 8% of children clinically affected in some areas. Insufficiency of dietary calcium is thought to be the underlying cause, and treatment with calcium (350-1,000 mg elemental calcium daily) is curative. Despite this apparently simple treatment, little is known about the most appropriate management of bone deformities of affected children, and further studies are needed to determine the details of dosing and duration of calcium therapy, the role of bracing, and specific indications for surgical intervention. Effective preventive measures that can feasibly reach entire communities are needed, and these may differ between various affected regions

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Influence of delayed separation of plasma from whole blood on Cu, I, Mn, Se, and Zn plasma concentrations

International audienc

Statut en zinc d'enfants présentant un retard de croissance

GRENOBLE1-BU Médecine pharm. (385162101) / SudocSudocFranceF

Influence of temperature of transport of whole blood on plasma Cu, I, Mn, Se and Zn and Mg concentrations in erythrocytes

International audienc

Bon Appétit et Bonne Santé

National audienc