Replicator degrees of freedom allow publication of misleading failures to replicate

In recent years, the field of psychology has begun to conduct replication tests on a large scale. Here, we show that “replicator degrees of freedom” make it far too easy to obtain and publish false-negative replication results, even while appearing to adhere to strict methodological standards. Specifically, using data from an ongoing debate, we show that commonly exercised flexibility at the experimental design and data analysis stages of replication testing can make it appear that a finding was not replicated when, in fact, it was. The debate that we focus on is representative, on key dimensions, of a large number of other replication tests in psychology that have been published in recent years, suggesting that the lessons of this analysis may be far reaching. The problems with current practice in replication science that we uncover here are particularly worrisome because they are not adequately addressed by the field’s standard remedies, including preregistration. Implications for how the field could develop more effective methodological standards for replication are discussed. © 2019 National Academy of Sciences. All rights reserved

Recommendations for research studies on treatment of idiopathic scoliosis: Consensus 2014 between SOSORT and SRS non–operative management committee

The two main societies clinically dealing with idiopathic scoliosis are the Scoliosis Research Society (SRS), founded in 1966, and the international Society on Scoliosis Orthopedic and Rehabilitation Treatment (SOSORT), started in 2004. Inside the SRS, the Non-Operative Management Committee (SRS-NOC) has the same clinical interest of SOSORT, that is the Orthopaedic and Rehabilitation (or Non-Operative, or conservative) Management of idiopathic scoliosis patients. The aim of this paper is to present the results of a Consensus among the best experts of non-operative treatment of Idiopathic Scoliosis, as represented by SOSORT and SRS, on the recommendation for research studies on treatment of Idiopathic Scoliosis. The goal of the consensus statement is to establish a framework for research with clearly delineated inclusion criteria, methodologies, and outcome measures so that future meta- analysis or comparative studies could occur. A Delphi method was used to generate a consensus to develop a set of recommendations for clinical studies on treatment of Idiopathic Scoliosis. It included the development of a reference scheme, which was judged during two Delphi Rounds; after this first phase, it was decided to develop the recommendations and 4 other Delphi Rounds followed. The process finished with a Consensus Meeting, that was held during the SOSORT Meeting in Wiesbaden, 8-10 May 2014, moderated by the Presidents of SOSORT (JP O'Brien) and SRS (SD Glassman) and by the Chairs of the involved Committees (SOSORT Consensus Committee: S Negrini; SRS Non-Operative Committee: MT Hresko). The Boards of the SRS and SOSORT formally accepted the final recommendations. The 18 Recommendations focused: Research needs (3), Clinically significant outcomes (4), Radiographic outcomes (3), Other key outcomes (Quality of Life, adherence to treatment) (2), Standardization of methods of non-operative research (6). © 2015 Negrini et al.; licensee BioMed Central

Outcome Measures Used in the Smartphone Applications for the Management of Low Back Pain:A Systematic Scoping Review

PURPOSE: Smartphone applications (SPApps) have become a key tool for the self-management of low back pain (LBP). However, the scientific evidence behind the outcome measures used in SPApps for LBP is never investigated before. Therefore, this systematic review firstly assess the quality of the free SPApps for LBP, secondly examines the outcome measures used and thirdly evaluates the outcome measures against the International Classification of Functioning, Disability and Health (ICF) core set classifications for LBP. METHODS: A systematic scoping review was conducted in the iTunes and Google Play™ on-line stores for LBP SPApps which are free to download. These searches were conducted using keywords suggested by the Cochrane Back and Neck Group. SPApps were screened and downloaded to assess the quality using the Mobile App Rating Scale (MARS). SPApps using outcome measures were reviewed separately to evaluate whether their outcome measures represented any of the ICF components for LBP. RESULTS: The overall quality of the apps has a mean MARS score of 2.5/5. Out of 74 apps reviewed, only four apps had outcome measures that could be linked to ICF components for LBP. Two of the four categories comprising the LBP core set were well represented. CONCLUSION: The overall quality of the SPApps for LBP is low. Only very few SPApps offer outcome measures to monitor their effectiveness in the management of LBP. There is very limited evidence to show that the outcome measures used in the apps represents all the four core sets of LBP criteria set by ICF

Risk Factors and Outcome of Fontan‐Associated Plastic Bronchitis: A Case‐Control Study

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/139068/1/jah3521.pd

REVIEWS REVIEWS REVIEWS Disturbance and the rising tide: the

low-island ecosystem

Remnants of semiclassical bistability in the few-photon regime of cavity QED

Broadband homodyne detection of the light transmitted by a Fabry-Perot cavity containing a strongly-coupled $^{133}$Cs atom is used to probe the dynamic optical response in a regime where semiclassical theory predicts bistability but strong quantum corrections should apply. While quantum fluctuations destabilize true equilibrium bistability, our observations confirm the existence of metastable states with finite lifetimes and a hysteretic response is apparent when the optical drive is modulated on comparable timescales. Our experiment elucidates remnant semiclassical behavior in the attojoule ($\sim10$ photon) regime of single-atom cavity QED, of potential significance for ultra-low power photonic signal processing.Comment: 14 pages, 7 figure

The Nature of Associated Absorption and the UV-X-ray Connection in 3C 288.1

We discuss new Hubble Space Telescope spectroscopy of the radio-loud quasar, 3C 288.1. The data cover ~590 A to ~1610 A in the quasar rest frame. They reveal a wealth of associated absorption lines (AALs) with no accompanying Lyman-limit absorption. The metallic AALs range in ionization from C III and N III to Ne VIII and Mg X. We use these data and photoionization models to derive the following properties of the AAL gas: 1) There are multiple ionization zones within the AAL region, spanning a factor of at least ~50 in ionization parameter. 2) The overall ionization is consistent with the ``warm'' X-ray continuum absorbers measured in Seyfert 1 nuclei and other QSOs. However, 3) the column densities implied by the AALs in 3C 288.1 are too low to produce significant bound-free absorption at any UV-X-ray wavelengths. Substantial X-ray absorption would require yet another zone, having a much higher ionization or a much lower velocity dispersion than the main AAL region. 4) The total hydrogen column density in the AAL gas is log N_H (cm-2)= 20.2. 5) The metallicity is roughly half solar. 6) The AALs have deconvolved widths of ~900 km/s and their centroids are consistent with no shift from the quasar systemic velocity (conservatively within +/-1000 km/s). 7) There are no direct indicators of the absorber's location in our data, but the high ionization and high metallicity both suggest a close physical relationship to the quasar/host galaxy environment. Finally, the UV continuum shape gives no indication of a ``blue bump'' at higher energies. There is a distinct break of unknown origin at ~1030 A, and the decline toward higher energies (with spectral index alpha = -1.73, for f_nu ~ nu^alpha) is even steeper than a single power-law interpolation from 1030 A to soft X-rays.Comment: 27 pages with figures and tables, in press with Ap

Principles of Good Practice for Decision Analytic Modeling in Health-Care Evaluation: Report of the ISPOR Task Force on Good Research Practices - Modeling Studies

Principles of Good Practice for Decision Analytic Modeling in Health-Care Evaluation: Report of the ISPOR Task Force on Good Research Practices - Modeling Studies Abstract. Objectives: Mathematical modeling is used widely in economic evaluations of pharmaceuticals and other healthcare technologies. Users of models in government and the private sector need to be able to evaluate the quality of models according to scientific criteria of good practice. This report describes the consensus of a task force convened to provide modelers with guidelines for conducting and reporting modeling studies. Methods: The task force was appointed with the advice and consent of the Board of Directors of ISPOR. Members were experienced developers or users of models, worked in academia and industry, and came from several countries in North America and Europe. The task force met on three occasions, conducted frequent correspondence and exchanges of drafts by electronic mail, and solicited comments on three drafts from a core group of external reviewers and more broadly from the membership of ISPOR. Results: Criteria for assessing the quality of models fell into three areas: model structure, data used as inputs to models, and model validation. Several major themes cut across these areas. Models and their results should be represented as aids to decision making, not as statements of scientific fact; therefore, it is inappropriate to demand that models be validated prospectively before use. However, model assumptions regarding causal structure and parameter estimates should be continually assessed against data, and models should be revised accordingly. Structural assumptions and parameter estimates should be reported clearly and explicitly, and opportunities for users to appreciate the conditional relationship between inputs and outputs should be provided through sensitivity analyses. Conclusions: Model-based evaluations are a valuable resource for health-care decision makers. It is the responsibility of model developers to conduct modeling studies according to the best practicable standards of quality and to communicate results with adequate disclosure of assumptions and with the caveat that conclusions are conditional upon the assumptions and data on which the model is built

Prevalence of Psychotic Symptoms and Their Risk Factors in Urban Tanzania

This study aimed to determine the prevalence of psychotic symptoms in urban Tanzania and their relationship with demographic, socio-economic and social factors. A random sample of 899 adults aged 15–59 was surveyed. The main outcome measure was endorsement of one or more psychotic symptoms identified by the Psychosis Screening Questionnaire. 3.9% respondents reported one or more psychotic symptoms in the preceding year. Significantly higher rates of symptoms were found in those who had recently experienced two or more stressful life events, those with CMD and people who had used cannabis in the preceding year