Robotic manipulation for the shoe-packaging process

[EN] This paper presents the integration of a robotic system in a human-centered environment, as it can be found in the shoe manufacturing industry. Fashion footwear is nowadays mainly handcrafted due to the big amount of small production tasks. Therefore, the introduction of intelligent robotic systems in this industry may contribute to automate and improve the manual production steps, such us polishing, cleaning, packaging, and visual inspection. Due to the high complexity of the manual tasks in shoe production, cooperative robotic systems (which can work in collaboration with humans) are required. Thus, the focus of the robot lays on grasping, collision detection, and avoidance, as well as on considering the human intervention to supervise the work being performed. For this research, the robot has been equipped with a Kinect camera and a wrist force/ torque sensor so that it is able to detect human interaction and the dynamic environment in order to modify the robot¿s behavior. To illustrate the applicability of the proposed approach, this work presents the experimental results obtained for two actual platforms, which are located at different research laboratories, that share similarities in their morphology, sensor equipment and actuation system.This work has been partly supported by the Ministerio de Economia y Competitividad of the Spanish Government (Key No.: 0201603139 of Invest in Spain program and Grant No. RTC-2016-5408-6) and by the Deutscher Akademischer Austauschdienst (DAAD) of the German Government (Projekt-ID 54368155).Gracia Calandin, LI.; Perez-Vidal, C.; Mronga, D.; Paco, JD.; Azorin, J.; Gea, JD. (2017). Robotic manipulation for the shoe-packaging process. The International Journal of Advanced Manufacturing Technology. 92(1-4):1053-1067. https://doi.org/10.1007/s00170-017-0212-6S10531067921-4Pedrocchi N, Villagrossi E, Cenati C, Tosatti LM (2017) Design of fuzzy logic controller of industrial robot for roughing the uppers of fashion shoes. 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Dystrophinopathy Phenotypes and Modifying Factors in Exon 45-55 Deletion

Duchenne muscular dystrophy (DMD) exon 45-55 deletion (del45-55) has been postulated as a model that could treat up to 60% of DMD patients, but the associated clinical variability and complications require clarification. We aimed to understand the phenotypes and potential modifying factors of this dystrophinopathy subset. This cross-sectional, multicenter cohort study applied clinical and functional evaluation. Next generation sequencing was employed to identify intronic breakpoints and their impact on the Dp140 promotor, intronic long noncoding RNA, and regulatory splicing sequences. DMD modifiers (SPP1, LTBP4, ACTN3) and concomitant mutations were also assessed. Haplotypes were built using DMD single nucleotide polymorphisms. Dystrophin expression was evaluated via immunostaining, Western blotting, reverse transcription polymerase chain reaction (PCR), and droplet digital PCR in 9 muscle biopsies. The series comprised 57 subjects (23 index) expressing Becker phenotype (28%), isolated cardiopathy (19%), and asymptomatic features (53%). Cognitive impairment occurred in 90% of children. Patients were classified according to 10 distinct index-case breakpoints; 4 of them were recurrent due to founder events. A specific breakpoint (D5) was associated with severity, but no significant effect was appreciated due to the changes in intronic sequences. All biopsies showed dystrophin expression of >67% and traces of alternative del45-57 transcript that were not deemed pathogenically relevant. Only the LTBP4 haplotype appeared associated the presence of cardiopathy among the explored extragenic factors. We confirmed that del45-55 segregates a high proportion of benign phenotypes, severe cases, and isolated cardiac and cognitive presentations. Although some influence of the intronic breakpoint position and the LTBP4 modifier may exist, the pathomechanisms responsible for the phenotypic variability remain largely unresolved. ANN NEUROL 2022;92:793-80

Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the mediterranean diet pattern is low

BACKGROUND: Although the fat mass and obesity (FTO) and melanocortin-4 receptor (MC4R) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is still controversial. In some recent meta-analyses in which significant results have been reported, the associations disappeared after adjustment for body mass index (BMI). However gene-diet interactions with dietary patterns have not been investigated. Our main aim was to analyze whether these associations are modulated by the level of adherence to the Mediterranean Diet (MedDiet). METHODS: Case-control study in 7,052 high cardiovascular risk subjects (3,430 type 2 diabetes cases and 3,622 non-diabetic subjects) with no differences in BMI. Diet was assessed by validated questionnaires. FTO-rs9939609 and MC4R-rs17782313 were determined. An aggregate genetic score was calculated to test additive effects. Gene-diet interactions were analyzed. RESULTS: Neither of the polymorphisms was associated with type 2 diabetes in the whole population. However, we found consistent gene-diet interactions with adherence to the MedDiet both for the FTO-rs9939609 (P-interaction=0.039), the MC4R-rs17782313 (P-interaction=0.009) and for their aggregate score (P-interaction=0.006). When adherence to the MedDiet was low, carriers of the variant alleles had higher type 2 diabetes risk (OR=1.21, 95%CI: 1.03-1.40; P=0.019 for FTO-rs9939609 and OR=1.17, 95%CI:1.01-1.36; P=0.035 for MC4R-rs17782313) than wild-type subjects. However, when adherence to the MedDiet was high, these associations disappeared (OR=0.97, 95%CI: 0.85-1.16; P=0.673 for FTO-rs9939609 and OR=0.89, 95%CI:0.78-1.02; P=0.097 for MC4R-rs17782313). These gene-diet interactions remained significant even after adjustment for BMI. As MedDiet is rich in folate, we also specifically examined folate intake and detected statistically significant interaction effects on fasting plasma glucose concentrations in non-diabetic subjects. However these findings should be interpreted with caution because folate intake may simply reflect a healthy dietary pattern. CONCLUSIONS: These novel results suggest that the association of the FTO-rs9939609 and the MC4R-rs17782313 polymorphisms with type 2 diabetes depends on diet and that a high adherence to the MedDiet counteracts the genetic predisposition

The influence of stakeholders on the environmental perception of managers : a mixed methods study

The purpose of this study is to determine which environmental stakeholders exert more pressure on a firm as well as the degree of cooperation existing between the firm and these groups. In addition, this article analyses how stakeholders´ actions influence the perception of managers about the environment as a competitive opportunity in different sectors. A sequential mixed methods study has been carried out, specifically a QUAL→QUAN design. The first stage (qualitative) is a multiple case study of eight Spanish firms from the primary, secondary and service sectors. The second stage (quantitative) includes a structural equations model for a sample of 239 hotels and 208 manufacturing firms. The findings show that stakeholders´ influence on the managerial perception of the environment as a competitive opportunity depends on the sector analysed. This influence is stronger in the group of manufacturing firms affected by Spain‟s Integrated Pollution Prevention and Control law (IPPC) than in the hotel industry. As for the degree of collaboration between stakeholders and the firm, it is higher among suppliers in the primary and secondary sectors, whereas in the service sector, it is customer participation that has prevailed