Factor structure, psychometric properties, and proposal for a brief-form version of the Levenson Self-Report Psychopathy Scale: Validation in a court-referred partner-violent men sample

Psychopathy has been widely studied among criminal populations. Most analyses address it in institutionalized populations, however, the present study examines the psychometric properties of the Levenson Self-Report Psychopathy Scale (LSRP) in 642 court-referred partner-violent men serving suspended prison sentences. The confirmatory factor analysis confirmed the two-factor structure (primary and secondary psychopathy) of the original scale. The resulting scale was a brief-form version of the LSRP that presents satisfactory data in terms of internal consistency and criterion validity, and significant positive correlations with measures of intimate partner violence (IPV), antisocial personality traits and impulsivity. In terms of known-groups validity, meanwhile, psychopathy was found to decrease with the age of the participants. In this light, the LSRP brief-form offers adequate psychometric reliability as an instrument to measure primary and secondary psychopathy in partner-violent men serving suspended sentencesThis research was supported by Spanish Ministry of Science and Innovation (National Plan I+D+I; Reference number: PSI2008-02215

LanderPick, a Remote Operated Trawled Vehicle to cost-effectively deploy and recover lightweight oceanographic landers.

Landers are modular structures equipped with miscellaneous sensors and monitoring equipment which are positioned directly on the seabed to operate autonomously for a defined timeframe. A drawback of landers intended to operate for prolonged periods in the deep ocean is the high cost of recovery systems, typically depending on buoyancy modules plus expendable ballast, or requiring ROVs assistance. LanderPick concept consists of the design of a specific trawled vehicle to deploy and recover lightweight oceanographic landers not provided with recovery elements, but having a capture mesh that facilitates their hitching. The LanderPick vehicle is technically a ROTV (Remote Operated Trawled Vehicle) controlled through a standard coaxial electromechanical cable that allows real-time control from the vessel. Navigation is enabled by a low-light high-definition camera, aided by spotlights and laser pointers. Small propellers aid in the final precision approach maneuvers. A mechanical release allows the precise placement at the sea bottom of landers carried as a payload, as well as their recovery by means of a triple hook. First sea missions of the system were carried out successfully in 2021 in southern Biscay. A 4-month deployment of a lander array equipped with current-meters along an energetic canyon axis provided unprecedented detail in the progression of the internal tidal bore. Short (48-hours) deployments of a fully-instrumented lander, including lapse-time image and baits in a deep seamount summit within a marine protected area, provided insights on the biodiversity of a unique ecosystem. The LanderPick novel approach to cost-effectively and precisely deploy and recover lightweight oceanographic landers allows to conceive (i) monitoring systems based on the deployment of arrays or fleets of low-cost landers and (ii) experiments associated with deep habitats such as coral reefs in which it is necessary to locate landers with great precision

Perfil clínico de los pacientes tratados con evolocumab en unidades hospitalarias de nefrología en España

Describir las características clínicas de los pacientes tratados con evolocumab, las razones del inicio de la terapia y los efectos del tratamiento en la fase inicial de disponibilidad de evolocumab en las unidades de nefrología de España

Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism

© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Whole-brain radiotherapy (WBRT) is the treatment backbone for many patients with brain metastasis; however, its efficacy in preventing disease progression and the associated toxicity have questioned the clinical impact of this approach and emphasized the need for alternative treatments. Given the limited therapeutic options available for these patients and the poor understanding of the molecular mechanisms underlying the resistance of metastatic lesions to WBRT, we sought to uncover actionable targets and biomarkers that could help to refine patient selection. Through an unbiased analysis of experimental in vivo models of brain metastasis resistant to WBRT, we identified activation of the S100A9-RAGE-NF-κB-JunB pathway in brain metastases as a potential mediator of resistance in this organ. Targeting this pathway genetically or pharmacologically was sufficient to revert the WBRT resistance and increase therapeutic benefits in vivo at lower doses of radiation. In patients with primary melanoma, lung or breast adenocarcinoma developing brain metastasis, endogenous S100A9 levels in brain lesions correlated with clinical response to WBRT and underscored the potential of S100A9 levels in the blood as a noninvasive biomarker. Collectively, we provide a molecular framework to personalize WBRT and improve its efficacy through combination with a radiosensitizer that balances therapeutic benefit and toxicity.info:eu-repo/semantics/publishedVersio

Therapeutic Dynamics of Aggression, Readiness to Change, and Recidivism in a Partner Violent Men Typology

The Transtheoretical Model (TTM) of behavior change predicts that patients go through different stages of change prior to changing their problematic behavior. This study aims to evaluate the utility and validity of this model in a sample of 549 court-ordered partner violent men. Three types of perpetrators with respect to their readiness to change were revealed. Those in more advantage stage of change use more processes to change their problem and present with higher levels of intimate partner violence (IPV). Low readiness to change levels and treatment drop-out predict short-term criminal justice recidivism, while treatment drop-out predicts medium and long-term recidivism. Results highlight the applicability of the TTM in IPV and its usefulness in designing behavioral interventions with this population

Treatment-Induced Changes in Undercontrolled and Overcontrolled Anger Subtypes of Perpetrators of Intimate Partner Violence and 5-Year Recidivism

This study examines different types of partner-violent males based on anger profiles. A cluster analysis of 483 self-reports completed by partner-violent men using the State-Trait Anger Expression Inventory (STAXI-2) identified two clusters of Undercontrolled and Overcontrolled anger profiles. The Undercontrolled men presented with higher pre-intervention scores than Overcontrolled men on Borderline Personality Organization, psychopathic traits, impulsiveness, physical aggression, verbal aggression, alcohol use, and partner-abusive behavior. Following completion of a cognitive-behavioral therapy program, there was a significant reduction in intimate partner violence for both subtypes, although Undercontrolled individuals continued to present more frequent psychological aggression and dominant and jealous tactics. Recidivism was predicted by pretreatment levels of hostility and treatment completion. Men with greater pretreatment to posttreatment changes in anger control were less likely to recidivate at 1, 3, and 5 years after treatment. The results suggest that perpetrators with different profiles would benefit from different types of intervention

The crystalline structure of gold nanorods revisited: evidence for higher‐index lateral facets

A new face of nanorod crystallinity: The structure of single-crystal gold nanorods is reinterpreted on the basis of high-resolution transmission electron microscopy on standing rods. The studies provided evidence for eight identical higher-index lateral facets (see picture for TEM image and proposed model).Ministerio de Educación y Ciencia | Ref. MAT2007-62696Xunta de Galici

Geomorphological Heritage in Viñales National Park (Aspiring UNESCO Geopark): Geomatic Tools Applied to Geotourism in Pinar del Río, Cuba

A detailed analysis of the Viñales National Park (VNP) was carried out to evaluate the main geosites of geomorphological interest inside the park. This allowed the selection of areas (AIG) and localities (LIG) with 20 geosites of geological interest (PIG) suitable to evaluate their importance as geoheritage. Moreover, three field trips and one virtual itinerary encompassing the park aimed to improve the geological–geomorphological knowledge to be used in geotouristic and preservation issues. The methodology included preparing five maps: relief, drainage pattern, slopes, lithology and geomorphology (forms and structures) and representing them on a digital terrain model (DTM) for a better visualisation and selecting the geosites (poljes, valleys and mountain fronts). The evaluation of the selected PIG is based on the criteria proposed by Spanish Institute of Geology and Mining, grouping them in places and areas of interest. The virtual itinerary favour real-time usage of web sites and geoportals. As a result, this paper presents map layers and geomorphological descriptions of the AIG and LIG with the most relevant aspects and valuations of the PIG, AIG and LIG. The PIG reached values between 1050 (Viñales Valley) and 365 (La Jutia Valley). The AIG and LIG ranged between 2190 (Santo Tomás Polje) and 675 (La Cuevita Polje)