11 research outputs found
Euro-Par 2017: 23rd international conference on parallel and distributed computing, Santiago de Compostela, Spain, August 28 - September 1, 2017, proceedings
Confirmacion del informe dado en 26 de abril del presente año 1735 por Thomas Comes ... y Doña Theresa Meseguer, viuda, y heredera de Don Francisco Comes ... en el pleyto con ... Pedro Juan Comes ... Francisco Comes ... y Esperanza Comes, hijos de Migue
A 111/083(07
Memorial ajustado del pleyto que en este S.S.R.C. de Aragon pende por letras causavidendi, & recognocendi, entre ... Ines Maria de Palafox, Condesa de Buñol, como madre ... del Egregio Conde de Buñol, y Cerbellò D. Franco Maria Pasqual Mercader y Cerbe
A 109/113(14
Hepatitis C and G Virus Infection and Liver Dysfunction After Allogeneic Bone Marrow Transplantation: Results From a Prospective Study
Effect of a Prolonged-Release System of Urea on Nitrogen Losses and Microbial Population Changes in Two Types of Agricultural Soil
Separation of Isomeric Forms of Urolithin Glucuronides Using Supercritical Fluid Chromatography
Urolithins are gut microbiota metabolites produced in
humans after
consuming foods containing ellagitannins and ellagic acid. Three urolithin
metabotypes have been reported for different individuals depending
on the final urolithins produced. After absorption, they are conjugated
with glucuronic acid (phase II metabolism), and these are the main
circulating metabolites in plasma and reach different tissues. Different
regioisomeric isomers of urolithin glucuronides have been described.
Still, their identification and quantification in humans have not
been properly reported due to resolution limitations in their analysis
by reversed-phase high-performance liquid chromatography. In the present
study, we report a novel method for separating these isomers using
supercritical fluid chromatography. With this method, urolithin A
3- and 8-glucuronide, isourolithin A 3- and 9- glucuronide, and urolithin
B 3-glucuronide (8-hydroxy urolithin 3-glucuronide; 3-hydroxy urolithin
8-glucuronide; 3-hydroxyurolithin 9-glucuronide; 9-hydroxyurolithin
3-glucuronide; and urolithin 3-glucuronide) were separated in less
than 15 min. The proposed method was applied to successfully analyze
these metabolites in urine samples from different volunteers belonging
to different metabotypes
Predictive Value for Event-Free Survival of Interim 18F-FDG-PET In Patients with Diffuse Large B-Cell Lymphoma (DLBCL) Treated with 6 Cycles of Dose-Dense R-CHOP-14 Immunochemotherapy Plus Pegfilgrastim as First-Line Treatment: An Open-Label Clinical Trial In Spain.
Magnetite Nanoparticles for Stem Cell Labeling with High Efficiency and Long-Term in Vivo Tracking
Superparamagnetic
iron oxide nanoparticles (<b>SPIO-PAA</b>), ultrasmall iron
oxide nanoparticles (<b>USPIO-PAA</b>),
and glucosamine-modified iron oxide nanoparticles (<b>USPIO-PAA-GlcN</b>) were studied as mesenchymal stem cell (MSCs) labels for cell tracking
applications by magnetic resonance imaging (MRI). Pronounced differences
were found in the labeling performance of the three samples in terms
of cellular dose and labeling efficiency. In combination with polylysine, <b>SPIO-PAA</b> showed nonhomogeneous cell internalization, while
for <b>USPIO-PAA</b> no uptake was found. On the contrary, <b>USPIO-PAA-GlcN</b> featured high cellular uptake and biocompatibility,
and sensitive detection in both in vitro and in vivo experiments was
found by MRI, showing that glucosamine functionalization can be an
efficient strategy to increase cell uptake of ultrasmall iron oxide
nanoparticles by MSCs
New Advances in the One-Dimensional Coordination Polymer Copper(II) Alkanoates Series: Monotropic Polymorphism and Mesomorphism
The polymorphism in the copper(II)
alkanoates, recently discovered
for one member, has been thoroughly studied for the whole series,
from 3 to 16 C atoms. Three polymorphic phases have been found, all
of them sharing the same molecular unit, the <i>paddle-wheel</i>, which grows forming a 1D coordination polymer or <i>catena</i>. The three polymorphs are defined by a different packing of these
catenae and a specific arrangement of the alkyl chains. Ten new crystal
structures of those compounds have been solved by high resolution
powder diffraction and presented in this paper. The polymorphism in
this series has been found to be monotropic and is responsible for
the complex thermal behavior observed. The most characteristic feature,
the endothermic–exothermic effect, has been explained for the
first time in these compounds by a combination of data from differential
scanning calorimetry (in normal and modulated modes), powder X-ray
diffraction and Fourier transform infrared spectroscopy. These techniques,
together with small-angle X-ray scattering and optical microscopy,
were used to analyze the hexagonal columnar discotic liquid crystal
phase of copper(II) alkanoates. Thus, new information has been found
in the packing and stacking of the discs formed by the paddle-wheel
units, also maintained in the mesophase
A Dietary Resveratrol-Rich Grape Extract Prevents the Developing of Atherosclerotic Lesions in the Aorta of Pigs Fed an Atherogenic Diet
The presence of grape and wine polyphenol resveratrol
(RES) in
the diet is negligible. Therefore, the cardiovascular benefits of
this molecule, in a dietary context, remain to be established. We
aimed to investigate, through dietary intervention, the effects of
a resveratrol-rich grape extract (GE-RES) on the prevention of early
aortic lesions in pigs fed an atherogenic diet (AD). These effects
were compared with those produced by a grape extract lacking RES (GE)
or RES alone. Pigs fed the AD for 4 months showed early atherosclerotic
lesions in the thoracic aorta: degeneration and fragmentation of elastic
fibers, increase of intima thickness, subendothelial fibrosis, and
accumulation of fatty cells and anion superoxide radicals. GE-RES
was the most effective treatment and prevented the disruption of aortic
elastic fibers, decreased their alteration (57%), and reduced the
intima thickness (33%) and the accumulation of fatty cells (42%) and
O<sub>2</sub><sup>•–</sup> (38%) in aortic tissue. In
addition, GE-RES moderately downregulated the expression of the suppressors
of cytokine signaling 1 (<i>SOCS1</i>) and 3 (<i>SOCS3</i>), key regulators of vascular cell responses, in peripheral mononuclear
blood cells. Our results suggest that the consumption of this GE-RES
nutraceutical, in a dietary prevention context, could prevent early
atherosclerotic events. The presence of RES in the grape extract strengthened
these effects