Anxiety in women with lymphedema following treatment for breast cancer

Aim: The aim of the present study was to evaluate anxiety in women with lymphedema following treatment for breast cancer. Method: A cross-sectional study was conducted involving 32 consecutive patients with lymphedema stemming from breast cancer treatment. Women with lymphedema due to other causes were excluded. Anxiety was evaluated using the Beck Anxiety Inventory. Descriptive statistics were used for the analysis of events. Results: Among the 32 patients evaluated, 10 (31.25%) had a minimal level of anxiety, 10 (31.25%) had mild anxiety, seven (21.85%) has moderate anxiety and had mild to moderate depression and five (15.62%) had severe anxiety. Conclusion: In this study anxiety occurs in different degrees in women with lymphedema following treatment for breast cancer of moderate to severe anxiety.Introduction: The aim of the present study was to evaluate anxiety in women with lymphedema following treatmentfor breast cancer. Material and methods: A cross-sectional study was conducted involving 32 consecutive patients with lymphedemastemming from breast cancer treatment. Women with lymphedema due to other causes were excluded. Anxiety wasevaluated using the Beck Anxiety Inventory. Descriptive statistics were used for the analysis of events. Results: Among the 32 patients evaluated, 10 (31.25%) had a minimal level of anxiety, 10 (31.25%) had mild anxiety,seven (21.85%) has moderate anxiety and had mild to moderate depression and five (15.62%) had severe anxiety. Conclusions: In this study anxiety occurs in different degrees in women with lymphedema following treatment forbreast cancer of moderate to severe anxiety

Bioqueries: a collaborative environment to create, explore and share SPARQL queries in Life Sciences

Bioqueries provides a collaborative environment to create, explore, execute, clone and share SPARQL queries (including Federated Queries). Federated SPARQL queries can retrieve information from more than one data source.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

A New Multi-Objective Approach for Molecular Docking Based on RMSD and Binding Energy

Ligand-protein docking is an optimization problem based on predicting the position of a ligand with the lowest binding energy in the active site of the receptor. Molecular docking problems are traditionally tackled with single-objective, as well as with multi-objective approaches, to minimize the binding energy. In this paper, we propose a novel multi-objective formulation that considers: the Root Mean Square Deviation (RMSD) difference in the coordinates of ligands and the binding (intermolecular) energy, as two objectives to evaluate the quality of the ligand-protein interactions. To determine the kind of Pareto front approximations that can be obtained, we have selected a set of representative multi-objective algorithms such as NSGA-II, SMPSO, GDE3, and MOEA/D. Their performances have been assessed by applying two main quality indicators intended to measure convergence and diversity of the fronts. In addition, a comparison with LGA, a reference single-objective evolutionary algorithm for molecular docking (AutoDock) is carried out. In general, SMPSO shows the best overall results in terms of energy and RMSD (value lower than 2A for successful docking results). This new multi-objective approach shows an improvement over the ligand-protein docking predictions that could be promising in in silico docking studies to select new anticancer compounds for therapeutic targets that are multidrug resistant.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Adaptations in the Treatment of Congenital Lymphedema Centered on the Quality of Life

Case Description. This report describes the evolution, necessary adaptations, and complications in the treatment of a 9-year-old child with primary congenital lymphedema. Description of Intervention. The clinical treatment of lymphedema was started in the first year of the patient’s life and for five years she was only treated using the Godoy & Godoy technique of cervical stimulation. Three years ago the patient was prescribed a compression stocking made from a cotton-polyester fabric (grosgrain) because of a sudden increase in the lymphedema after she started to take growth hormones. Outcome and Conclusion. The combination of cervical stimulation and a compression stocking was effective to keep the child’s life relatively normal, performing all day-to-day and recreational activities

A genome-wide 20 K citrus microarray for gene expression analysis

<p>Abstract</p> <p>Background</p> <p>Understanding of genetic elements that contribute to key aspects of citrus biology will impact future improvements in this economically important crop. Global gene expression analysis demands microarray platforms with a high genome coverage. In the last years, genome-wide EST collections have been generated in citrus, opening the possibility to create new tools for functional genomics in this crop plant.</p> <p>Results</p> <p>We have designed and constructed a publicly available genome-wide cDNA microarray that include 21,081 putative unigenes of citrus. As a functional companion to the microarray, a web-browsable database <abbrgrp><abbr bid="B1">1</abbr></abbrgrp> was created and populated with information about the unigenes represented in the microarray, including cDNA libraries, isolated clones, raw and processed nucleotide and protein sequences, and results of all the structural and functional annotation of the unigenes, like general description, BLAST hits, putative Arabidopsis orthologs, microsatellites, putative SNPs, GO classification and PFAM domains. We have performed a Gene Ontology comparison with the full set of Arabidopsis proteins to estimate the genome coverage of the microarray. We have also performed microarray hybridizations to check its usability.</p> <p>Conclusion</p> <p>This new cDNA microarray replaces the first 7K microarray generated two years ago and allows gene expression analysis at a more global scale. We have followed a rational design to minimize cross-hybridization while maintaining its utility for different citrus species. Furthermore, we also provide access to a website with full structural and functional annotation of the unigenes represented in the microarray, along with the ability to use this site to directly perform gene expression analysis using standard tools at different publicly available servers. Furthermore, we show how this microarray offers a good representation of the citrus genome and present the usefulness of this genomic tool for global studies in citrus by using it to catalogue genes expressed in citrus globular embryos.</p

Motivación laboral y compromiso organizacional en el personal de una empresa del sector manufactura de la ciudad de Lima, 2017

La presente investigación cuenta como principal objetivo determinar la relación entre la motivación laboral y el compromiso organizacional en el personal de una empresa del sector manufactura de la ciudad de Lima. Se trata de un estudio cuantitativo, aplicado; en cuanto a su diseño es de tipo no experimental por no haber presencia de manipulación alguna de las variables involucradas, y de nivel correlacional. Asimismo se han considerado teorías relacionadas a las variables como la teoría de la autoderteminación (Ryan 1997) para la variable motivación laboral y la teoría del compromiso organizacional (Meyer y Allen 1991) para la variable de compromiso organizacional. En cuanto a la muestra se contemplo un total de 300 colaboradores comprendidos entre las diferentes áreas de la organización. Por otro lado se emplearon los siguientes instrumentos de medición y evaluación de las variables, la escala de Motivación Laboral R-Maws, de los autores Gagné y Forest y la escala de Compromiso Organizacional de los autores Meyer y Allen, para medir la variable motivación laboral y compromiso organizacional respectivamente. En los resultados obtenidos se aprecia que existe una relación directa y significativa entre la motivación laboral y el compromiso organizacional, con un coeficiente de correlación de 0.864. Determinando de esta forma que a mayor sentido de motivación laboral dentro de los colaboradores existe una mayor percepción de compromiso organizacional. En base a la presente investigación se recomienda continuar con investigaciones con orientación al comportamiento organizacional, en el sentido que existen factores que influyen de forma directa en la relación del empleado frente a la organización empleadora que determinan continuidad de la organización dentro del contexto empresarial

Lymphatic therapy by godoy method in the treatment of dyspnea after Covid- 19: case report

Despite all efforts, this disease has been a major cause of mortality as well as sequelae after the infectious event. Issues regarding an effective form of treatment for the virus have led to efforts focused on the acute manifestations of the disease. The aim of the present study is to describe the first observational result of the treatment of a pulmonary sequela of COVID-19 with important symptomatic limitations. One month ago, the patient contracted COVID-19 and was treated clinically, but the case progressed with important respiratory and physical limitations. An increase occurred in the lymphedema and the patient sought treatment. She would waken at night with dyspnea and was unable to walk more than a few steps or climb stairs. Intensive treatment of the lymphedema was proposed using the Godoy Method®. The Godoy method for reversing fibrosis was useful in improving dyspnea in a short period of time in a patient with sequelae resulting from COVID-1

Estudio de mercado para la leche fresca en la ciudad de Talca

135 p.Esta investigación esta dirigida principalmente a instituciones, pequenos/medianos productores de leche y en general, a todos aquellos agentes relacionados con el sector lechero, esto, debido a que el trabajo realizado analiza el comportamiento del consumidor ante el consumo de leche fresca. El objetivo general del estudio radica en determinar si existe un nicho de mercado en el ciudad de Talca, para un producto de origen regional con certificación de calidad como la leche fresca. Para lograr este objetivo fue necesario realizar diversas acciones, desde la búsqueda de bibliografía referente al tema, hasta la aplicación de un cuestionario estructurado a una muestra total de 381 personas, segmentadas por estratos socioeconómicos. Finalmente, se puede inferir de los resultados obtenidos que en general, las decisiones de compra varían según el estrato al que pertenezca cada consumidor. Las características de nicho de mercado, variaran de acuerdo al estrato al que pertenece el consumidor. Es así, como en el estrato alto la distribución del producto, deberá realizarse por intermedio del supermercado, sin embargo, es para los estratos medio y bajo, dicha intermediación puede realizarse a través de los distribuidores informales. En cuanto a la percepción que tienen los consumidores acerca de un producto de origen artesanal, esta no variara significativamente de un estrato a otro, sin embargo, la evaluación con respecto a un producto con cobertura nacional es definitivamente menor. El nicho que se considera como atrayente para realizar un proceso de penetración, con un producto como la leche fresca seria el constituido por el estrato medio

Superficial Thrombophlebitis of Great Saphenous Vein Following Vaccine

This paper reports on the occurrence of thrombose of the left great saphenous vein (GSV) soon after being given the AstraZeneca vaccine and two recurrent events within three days after the suspension of the anticoagulant. A 53-year-old patient had superficial thrombophlebitis of the GSV in the left leg three days after taking the second dose of the AstraZeneca vaccine for COVID-19 and initiated treatment with rivaroxaban (XareltoTM) 15 mg twice a day, subsequently increasing to 20 mg. After 45 days, the patient contracted dengue and stopped taking the anticoagulant. Two days later, the patient had another thrombosis in the left GSV. The patient is currently in outpatient care with a prophylactic dose of 10mg/day of anticoagulant and undergoes evaluations at three-month intervals. The result of our study is a rare event