Saúde Perinatal e Medicina Translacional

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THE RESIDENTS PARTICIPATION IN THE CREATION OF EXTRACTIVE IRIRI RIVER RESERVE AND CURRENT PERCEPTION OF TERRITORIAL SECURITY

PARTICIPAÇÃO DOS MORADORES NA CRIAÇÃO DA RESERVA EXTRATIVISTA DO RIO IRIRI E ATUAL PERCEPÇÃO DE SEGURANÇA TERRITORIALPARTICIPACIÓN DE LOS RESIDENTES EN LA CREACIÓN DE LA RESERVA EXTRACTIVA DEL RÍO IRIRI Y LA ACTUAL PERCEPCIÓN DE SEGURIDAD TERRITORIALABSTRACTThe Extractive Reserve Iriri River (RESEX Iriri) is located in the Amazon biome, in the region known as Terra do Meio (TM), in the interfluve of the Xingu and Iriri Rivers in the State of Pará, Brazil. This area is marked by a confrontational territorial occupation history, in which the local population had its permanence and its threatened traditional way of life, which allowed land ownership by loggers, land grabbers and farmers. Our research assessed the participation and awareness of the territorial security of bordering the Rio Iriri Extractive Reserve, with the creation of this Conservation Unit. The results showed us that had a significant decrease in threats. However, we emphasize that, to ensure the traditional way of extractive life, it is necessary to consolidate the territorial security measures and public policies.Keywords: Qualitative Research; Conservations Unities; Eastern Amazonia.RESUMOA Reserva Extrativista do Rio Iriri (RESEX Iriri) está localizada, no bioma amazônico, na região conhecida como Terra do Meio (TM), no interflúvio dos rios Xingu e Iriri, no Estado do Pará, Brasil. Esta área é marcada por um histórico de ocupação territorial conflituoso, no qual a população ribeirinha teve sua permanência e seu modo de vida tradicional ameaçado, o que permitiu a apropriação fundiária por madeireiros, grileiros e fazendeiros. Nossa pesquisa avaliou a participação e a percepção da segurança territorial dos ribeirinhos da Reserva Extrativista Rio Iriri, com a criação desta Unidade de Conservação. O resultado nos mostrou que teve uma diminuição significativa nas ameaças. Porém, ressaltamos que, para garantir o modo de vida tradicional extrativista, é preciso consolidar as medidas de segurança territorial como politicas públicas.Palavras-chave: Pesquisa Qualitativa; Unidades De Conservação; Amazônia Oriental.RESUMENLa reserva extractiva del río Iriri (RESEX Iriri) se encuentra en el bioma amazónico, en la región conocida como Terra do Meio (TM) en el interfluvio de los ríos Xingu e Iriri en el Estado de Pará, Brasil. Esta zona está marcada por una historia de ocupación territorial conflictiva, en el que la población local vio su permanencia y su forma de vida tradicional amenazada, lo que permitió propiedad de la tierra por parte de madereros, ganaderos y usurpadores de tierras. Nuestra investigación evaluó la participación y el conocimiento de la seguridad territorial de la Reserva de Extracción bordeando el Río Iriri, con la creación de este espacio protegido. Los resultados mostraron que había una disminución significativa de las amenazas. Sin embargo, hacemos hincapié en que para garantizar el modo de vida tradicional de extracción, es necesario consolidar las medidas de seguridad y políticas públicas territoriales.Palabras clave: Investigación Cualitativa; Unidades de Conservación; Amazonia Oriental

Cardiac sodium channel, its mutations and their spectrum of arrhythmia phenotypes

The mechanisms of cellular excitability and propagation of electrical signals in the cardiac muscle are very important functionally and pathologically. The heart is constituted by three types of muscle: atrial, ventricular, and specialized excitatory and conducting fi bers. From a physiological and pathophysiological point of view, the conformational states of the sodium channel during heart function constitute a signifi cant aspect for the diagnosis and treatment of heart diseases. Functional states of the sodium channel (closed, open, and inactivated) and their structure help to understand the cardiac regulation processes. There are areas in the cardiac muscle with anatomical and functional differentiation that present automatism, thus subjecting the rest of the fi bers to their own rhythm. The rate of these (pacemaker) areas could be altered by modifi cations in ions, temperature and especially, the autonomic system. Excitability is a property of the myocardium to react when stimulated. Another electrical property is conductivity, which is characterized by a conduction and activation process, where the action potential, by the all-or-nothing law, travels throughout the heart. Heart relaxation also stands out as an active process, dependent on the energetic output and on specificion and enzymatic actions, with the role of sodium channel being outstanding in the functional process. In the gene mutation aspects that encode the rapid sodium channel (SCN5A gene), this channel is responsible for several phenotypes, such as Brugada syndrome, idiopathic ventricular fibrillation, dilated cardiomyopathy, early repolarization syndrome, familial atrial fibrillation, variant 3 of long QT syndrome, multifocal ectopic ventricular contractions originating in Purkinje arborizations, progressive cardiac conduction defect (Lenègre disease), sudden infant death syndrome, sick sinus syndrome, sudden unexplained nocturnal death syndrome, among other sodium channel alterations with clinical overlapping. Finally, it seems appropriate to consider the “sodium channel syndrome” (mutations in the gene of the α subunit of the sodium channel, SCN5A gene) as a single clinical entity that may manifest in a wide range of phenotypes, to thus have a better insight on these cardiac syndromes and potential outcomes for their clinical treatment

Pulmonary metastasectomy from soft tissue sarcomas

INTRODUCTION: Isolated pulmonary metastases from soft tissue sarcomas occur in 20-50% of these(the issue is about metastases, not lung cancer )patients, and 70% of these patients will present disease limited only to the lungs. Surgical resection is well accepted as a standard approach to treat metastases from soft tissue sarcomas isolated in the lungs, and many studies investigating this technique have reported an overall 5-year survival ranging from 30-40%. The most consistent predictor of survival in these patients is complete resection. The aim of the present study was to determine the demographics and clinical treatment-related variables associated with long-term (90-month) overall survival in patients with lung metastases undergoing pulmonary metastasectomy from soft tissue sarcomas. METHODS: We performed a retrospective review of patients admitted in the Thoracic Surgery Department with lung metastases who underwent thoracotomy for resection following treatment of the primary tumor. Data regarding primary tumor features, demographics, treatment, and outcome were collected. RESULTS: One hundred twenty-two thoracotomies and 273 nodules were resected from 77 patients with previously treated soft tissue sarcomas. The median follow-up time of all patients was 36.7 months (range: 10-138 months). The postoperative complication rate was 9.1%, and the 30-day mortality rate was 0%. The 90-month overall survival rate for all patients was 34.7%. Multivariate analysis identified the following independent prognostic factors for overall survival: the number of metastases resected, the disease-free interval, and the number of complete resections. CONCLUSION: These results confirm that lung metastasectomy is a safe and potentially curative procedure for patients with treated primary tumors. A select group of patients can achieve long-term survival after lung resection

Emprego, estratificação e desigualdade

The relationships between the social division of labor and social stratification are regarded as the key explanatory nexus of recent changes in income distribution in Brazil. The paper highlights the role of class divisions at the level of the job structure, to which are added status groups, segmentation factors and educational credentials. The determinants in question capture changes in the socially organized dimensions of the distribution of rewards. Reductions in the spatial, sectorial and educational inequalities are acknowledged. The inequalities in social status wane, showing contradictory signals. The class conditionings on income remain robust, but show differentiated and nuanced effects amidst the reductions in aggregate income inequality.As relações entre divisão social do trabalho e estratificação social são consideradas como nexos explicativos-chave das mudanças recentes na distribuição de renda no Brasil. Destaca-se o papel das divisões de classe ao nível da estrutura do emprego, ao qual se agregam grupos de status, fatores de segmentação e credenciais educacionais. Os determinantes em questão captam alterações em dimensões socialmente organizadas da distribuição das recompensas. Constatam-se reduções nas desigualdades espaciais, setoriais e educacionais. As desigualdades de status social caem mostrando sinais contraditórios. Os condicionamentos de classe da renda se mantêm robustos, mas apresentando efeitos diferenciados e nuançados em meio às reduções na desigualdade agregada de renda

KNOWLEDGE INTENSIVE BUSINESS SERVICES (KIBS): BIBLIOMETRIC ANALYSIS AND THEIR DIFFERENT BEHAVIORS IN THE SCIENTIFIC LITERATURE

This study analyzes scientific articles present in the databases Web of Science, Scopus and SciELO. Two hundred and thirty-five studies were examined, by using variations in bibliometrics. The main objective of this article is to analyze the set of studies that address the different behaviors Knowledge Intensive Business Services in the scientific literature. The results show a concentration of publications in the years 2005, 2010, 2012 and 2013, including the theme’s interdisciplinary perspective. Most studies are quantitative and were published in the last five years. The first study was presented at an international conference in the year 2000. The most quoted authors were Hertog, Miles, and Muller. The set of publications examined presents two groups of behaviors: roles and attributes of Knowledge Intensive Business Services. This research aimed to analyze Knowledge Intensive Business Services over time and contribute to its expansion in Brazil

The ability of the BANA test to detect different levels of P. gingivalis, T. denticola and T. forsythia

The aim of this study was to evaluate the ability of the BANA Test to detect different levels of Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia or their combinations in subgingival samples at the initial diagnosis and after periodontal therapy. Periodontal sites with probing depths between 5-7 mm and clinical attachment level between 5-10 mm, from 53 subjects with chronic periodontitis, were sampled in four periods: initial diagnosis (T0), immediately (T1), 45 (T2) and 60 days (T3) after scaling and root planing. BANA Test and Checkerboard DNA-DNA hybridization identified red complex species in the subgingival biofilm. In all experimental periods, the highest frequencies of score 2 (Checkerboard DNA-DNA hybridization) for P. gingivalis, T. denticola and T. forsythia were observed when strong enzymatic activity (BANA) was present (p < 0.01). The best agreement was observed at initial diagnosis. The BANA Test sensitivity was 95.54% (T0), 65.18% (T1), 65.22% (T2) and 50.26% (T3). The specificity values were 12.24% (T0), 57.38% (T1), 46.27% (T2) and 53.48% (T3). The BANA Test is more effective for the detection of red complex pathogens when the bacterial levels are high, i.e. in the initial diagnosis of chronic periodontitis

ENSINO DE MÚSICA NA EDUCAÇÃO BÁSICA: perspectivas curriculares da rede municipal de Lages – Santa Catarina – Brasil (2008-2021)

Este artigo tem o objetivo de apresentar e discutir o percurso do ensino de música na rede pública de ensino do município de Lages-SC, em um recorte temporal entre 2008 e 2021. Diversos documentos normativos foram incorporados à legislação educacional brasileira, incluindo o ensino de música na educação básica. Tais documentos oferecem possibilidades de interpretação que conduzem à diversidade de inclusão da música nos currículos escolares em diferentes contextos. Metodologicamente, foram realizadas entrevistas com um professor de música e uma coordenadora da área de artes, com o propósito de compreender concepções relacionadas ao ensino de música, assim como analisar as interpretações oriundas da legislação vigente. Os resultados apontam para diferentes interpretações acerca do ensino de música presente naquela rede municipal de ensino, evidenciando a necessidade de diálogo entre a Secretaria de Educação e instituições formadoras de professores de música e das demais linguagens do componente curricular arte, previstas nas orientações educacionais vigentes