Desempenho de genótipos de novilhos para abate aos catorze meses, gerados por fêmeas de dois anos

The objective of the experiment was to study the feedlot performance of Hereford (H), ½ Jersey (J) ½ H and 5/8 H 3/8 Nellore (N) steers, produced by females bred at 14 months of age, confined from weaning to slaughter at 14 months of age when they reached average carcass weight of 195 kg. The roughage:concentrate ratio was 70:30 at the beginning and declined to 40:60 at the end of the trial. The roughages used were sorghum silage, chopped sugar cane and oats hay. Daily dry matter and digestible energy intake of the three genetic groups were similar, but the ½ J ½ H showed higher dry matter intake per 100 kg of live weight than the H and 5/8 H 3/8 N. No significant difference for average daily weight gain occurred during the 193 days feedlot period. Food efficiency, expressed in Mcal of digestible energy and kilograms of dry matter, per kilogram of weight gain also did not differ among the genetic groups.O objetivo deste trabalho foi avaliar o desempenho de machos Hereford (H), ½ Jersey (J) ½ H e 5/8 H 3/8 Nelore (N), gerados por fêmeas acasaladas aos 14 meses de idade, confinados do desmame, aos sete meses, até o abate aos 14 meses, quando atingiram em média 195 kg de carcaça. A relação volumoso:concentrado foi decrescente, iniciando em 70:30 e finalizando em 40:60. O volumoso utilizado incluiu silagem de sorgo forrageiro, cana-de-açúcar e feno de aveia. Os consumos diários de matéria seca e de energia digestível dos três grupos de novilhos não diferiram significativamente, mas os novilhos ½ J ½ H apresentaram maior consumo de matéria seca por 100 kg de peso vivo em relação aos outros dois grupos. Não houve diferença no ganho de peso médio diário durante os 193 dias de confinamento. A eficiência de conversão, expressa em Mcal de energia digestível e em quilogramas de matéria seca, para cada quilograma de ganho de peso, também não diferiu significativamente entre os três grupos testados

Desempenho de genótipos de novilhos para abate aos catorze meses, gerados por fêmeas de dois anos

The objective of the experiment was to study the feedlot performance of Hereford (H), ½ Jersey (J) ½ H and 5/8 H 3/8 Nellore (N) steers, produced by females bred at 14 months of age, confined from weaning to slaughter at 14 months of age when they reached average carcass weight of 195 kg. The roughage:concentrate ratio was 70:30 at the beginning and declined to 40:60 at the end of the trial. The roughages used were sorghum silage, chopped sugar cane and oats hay. Daily dry matter and digestible energy intake of the three genetic groups were similar, but the ½ J ½ H showed higher dry matter intake per 100 kg of live weight than the H and 5/8 H 3/8 N. No significant difference for average daily weight gain occurred during the 193 days feedlot period. Food efficiency, expressed in Mcal of digestible energy and kilograms of dry matter, per kilogram of weight gain also did not differ among the genetic groups.O objetivo deste trabalho foi avaliar o desempenho de machos Hereford (H), ½ Jersey (J) ½ H e 5/8 H 3/8 Nelore (N), gerados por fêmeas acasaladas aos 14 meses de idade, confinados do desmame, aos sete meses, até o abate aos 14 meses, quando atingiram em média 195 kg de carcaça. A relação volumoso:concentrado foi decrescente, iniciando em 70:30 e finalizando em 40:60. O volumoso utilizado incluiu silagem de sorgo forrageiro, cana-de-açúcar e feno de aveia. Os consumos diários de matéria seca e de energia digestível dos três grupos de novilhos não diferiram significativamente, mas os novilhos ½ J ½ H apresentaram maior consumo de matéria seca por 100 kg de peso vivo em relação aos outros dois grupos. Não houve diferença no ganho de peso médio diário durante os 193 dias de confinamento. A eficiência de conversão, expressa em Mcal de energia digestível e em quilogramas de matéria seca, para cada quilograma de ganho de peso, também não diferiu significativamente entre os três grupos testados

CARACTERÍSTICAS DE CARCAÇA E BIOMETRIA TESTICULAR DE MACHOS BOVINOS SUPERJOVENS NÃO CASTRADOS DE DIFERENTES GRUPOS GENÉTICOS

The objective of this work was to evaluate carcass characteristics and testicular biometry of non-castrated Hereford (H), 3/4H 1/4 Nellore (N), 5/8H 3/8N and 3/4 Charolais (C) 1/4 N males, slaughtered at fourteen months of age. No statistical difference occurred among genetic groups for final and carcasses weights and dressing percentages. The sawcut yield was higher in 3/4CN than other genotypes. Ribcut yield was higher for 5/8HN in relation to 3/4HN and 3/4CN. Longissimus dorsi area was higher for 3/4CN (71.5 cm2) animals in relation to Hereford (63.5 cm2). Hereford animals also showed lower leg length than all other groups. The 3/4CN males showed lower (2.6 mm) subcutaneous fat thickness than Hereford (5.0 mm), 5/8HN (4.1 mm) and 3/4HN (4.1 mm) ones. In conclusion, all genetic groups get compatible carcass characteristics for young cattle market. Besides, muscular development related characteristics, such as conformation and sawcut yield, were better in Charolais crossbred genotype, while characteristics related to fat deposition, such as fat thickness and ribcut yield, were better in Hereford and crossbred Hereford genotypes

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection