Evaporation of large black holes in AdS: greybody factor and decay rate

We consider a massless, minimally coupled scalar field propagating through the geometry of a black 3-brane in an asymptotically $AdS_5 \times S^5$ space. The wave equation for modes traveling purely in the holographic direction reduces to a Heun equation and the corresponding greybody factor is obtained numerically. Approximations valid in the low- and high-frequency regimes are also obtained analytically. The greybody factor is then used to determine the rate of evaporation of these large black holes in the context of the evaporon model proposed in \cite{Rocha:2008fe}. This setting represents the evolution of a black hole under Hawking evaporation with a known CFT dual description and is therefore unitary. Information must then be preserved under this evaporation process.Comment: 20 pages, 2 figures; v2: added references, published versio

On solvable models of type IIB superstring in NS-NS and R-R plane wave backgrounds

We consider type IIB string in the two plane-wave backgrounds which may be interpreted as special limits of the AdS_3 x S^3 metric supported by either the NS-NS or R-R 3-form field. The NS-NS plane-wave string model is equivalent to a direct generalization of the Nappi-Witten model, with its spectrum being similar to that of strings in constant magnetic field. The R-R model can be solved in the light-cone gauge, where the Green-Schwarz action describes 4 massive and 4 massless copies of free bosons and fermions. We find the spectra of the two string models and study the asymptotic density of states. We also discuss a more general class of exactly solvable plane-wave models with reduced supersymmetry which is obtained by adding twists in two spatial 2-planes.Comment: 36 pages, harvmac. v2: discussion of equivalence of the supergravity parts of the spectra of the NS-NS and R-R models added in sect.5.3; v3: added remark on periodicity of the NS-NS spectrum; v4: minor correction in sect.6.

Numerical and experimental study of sandwich plates with metallic foam cores

World-wide vehicles safety experts agree that significant further reductions in fatalities and injuries can be achieved as a result of the use of new energy absorbing materials. In this field, passive safety systems still have great potential to reduce fatalities and injuries, as in the case of using new lightweight energy-absorbing materials. On this work, the authors present the development of a procedure able to perform reliable panels of sandwich sheets with metallic foam cores for industrial applications. The mathematical model used to describe the behavior of sandwich shells with metal cores form is presented and some numerical examples are included. The numerical results are validated using the experimental results obtained from the mechanical experiments. Using the crushable foam constitutive model, available on ABAQUS, a set of different mechanical tests were simulated

Demand Response Approach for the Coordination Between Aggregators and Providers

Nowadays electricity system is looking for innovation in its role. New approaches are being able to discuss because of several issues as environmental, costs, quality and reliability of the electric energy production. In this paper one more aggregation’s scheme for demand response will be proposed. Based on National Grid’s programs that already exist in the market which will be shown on the current paper. This paper will be a support for a master thesis in electrical engineering based on the same topic.The present work was done and funded in the scope of the following project: H2020 DREAM - GO Project (Marie Sklodowska Curie grant agreement No. 641794)info:eu-repo/semantics/publishedVersio

A study on wear evaluation of railway wheels based on multibody dynamics and wear computation

The wear evolution of railway wheels is a very important issue in railway engineering. In the past, the reprofiling intervals of railway vehicle steel wheels have been scheduled according to designers' experience. Today, more reliable and accurate tools in predicting wheel wear evolution and wheelset lifetime can be used in order to achieve economical and safety benefits. In this work, a computational tool that is able to predict the evolution of the wheel profiles for a given railway system, as a function of the distance run, is presented. The strategy adopted consists of using a commercial multibody software to study the railway dynamic problem and a purpose-built code for managing its pre- and post-processing data in order to compute the wear. The tool is applied here to realistic operation scenarios in order to assess the effect of some service conditions on the wheel wear progression

Identification of regions critical for the integrity of the TSC1-TSC2-TBC1D7 complex

The TSC1-TSC2-TBC1D7 complex is an important negative regulator of the mechanistic target of rapamycin complex 1 that controls cell growth in response to environmental cues. Inactivating TSC1 and TSC2 mutations cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterised by the occurrence of benign tumours in various organs and tissues, notably the brain, skin and kidneys. TBC1D7 mutations have not been reported in TSC patients but homozygous inactivation of TBC1D7 causes megaencephaly and intellectual disability. Here, using an exon-specific deletion strategy, we demonstrate that some regions of TSC1 are not necessary for the core function of the TSC1-TSC2 complex. Furthermore, we show that the TBC1D7 binding site is encoded by TSC1 exon 22 and identify amino acid residues involved in the TSC1-TBC1D7 interaction

FGFR1 and PROKR2 rare variants found in patients with combined pituitary hormone deficiencies.

The genetic aetiology of congenital hypopituitarism (CH) is not entirely elucidated. FGFR1 and PROKR2 loss-of-function mutations are classically involved in hypogonadotrophic hypogonadism (HH), however, due to the clinical and genetic overlap of HH and CH; these genes may also be involved in the pathogenesis of CH. Using a candidate gene approach, we screened 156 Brazilian patients with combined pituitary hormone deficiencies (CPHD) for loss-of-function mutations in FGFR1 and PROKR2. We identified three FGFR1 variants (p.Arg448Trp, p.Ser107Leu and p.Pro772Ser) in four unrelated patients (two males) and two PROKR2 variants (p.Arg85Cys and p.Arg248Glu) in two unrelated female patients. Five of the six patients harbouring the variants had a first-degree relative that was an unaffected carrier of it. Results of functional studies indicated that the new FGFR1 variant p.Arg448Trp is a loss-of-function variant, while p.Ser107Leu and p.Pro772Ser present signalling activity similar to the wild-type form. Regarding PROKR2 variants, results from previous functional studies indicated that p.Arg85Cys moderately compromises receptor signalling through both MAPK and Ca(2) (+) pathways while p.Arg248Glu decreases calcium mobilization but has normal MAPK activity. The presence of loss-of-function variants of FGFR1 and PROKR2 in our patients with CPHD is indicative of an adjuvant and/or modifier effect of these rare variants on the phenotype. The presence of the same variants in unaffected relatives implies that they cannot solely cause the phenotype. Other associated genetic and/or environmental modifiers may play a role in the aetiology of this condition

Excess adiposity and low physical fitness hamper Supine-to-Stand test performance among sedentary adolescents

Objective: The aim of this study was to analyze the relationship between body adiposity and physical fitness with performance in the Supine-to-Stand test (STS-test) in sedentary adolescents. Methods: Sixty-two adolescents, of both sexes, between 10 and 16 years old, participated in the study. Body mass (BM), height, waist circumference (WC), fat mass (FM), fat-free mass (FFM), right and left handgrip strength (HGS-right, HGS-left), abdominal resistance (ABDO), flexibility (FLEX), and cardiorespiratory fitness (VO2peak) were measured. Body mass index (BMI), z-score BMI (BMI-z), tri-ponderal mass index (TMI) and waist-to-height ratio (WHtR) were calculated. The STS-test was applied to evaluate the STS-MC by the movement patterns in the execution of the test. The STS-time in seconds (s) was categorized into terciles: fast (FG  2.6 s). One-way ANOVA, Chi-square, Spearman's correlation coefficient as well as non-parametric tests were used, with significance p ≤ 0.05. Results: The SG presented higher BMI, BMI-z, TMI, WHtR, FM, %FM, as well as lower averages for %FFM, HGS-right, HGS-left, FLEX, ABDO, VO2peak, VO2peak relative to BM (VO2peakBM) in relation to GF. The BMI, BMI-z, TMI, WC, WHtR and FM showed moderate and direct correlations with STS-time and inverse with STS-MC (p < 0.01). HGS-right, HGS-left, ABDO, and VO2peakBM showed moderate and an inverse correlation with STS-time (p < 0.05). The VO2peakBM was moderate and with direct correlations to STS-MC (p < 0.01). Conclusion: It is concluded that excess fat and low physical fitness hamper STS-test performance. Therefore, the STS-test can be used for screening students to assess MC

Tensionless supersymmetric M2 branes in AdS4×S7AdS_4 \times S^7 and Giant Diabolo

We find various supersymmetric configurations of toroidal M2 brane solutions in \AdS_4 \times S^7 or, more generally, in \AdS_4 \times S^7/Z_k. In this class we identify solutions preserving 1/4 and 1/8 supersymmetries of the background. The supersymmetric M2 branes have angular momenta and winding on $S^7$, and null world-volumes. In certain cases they collapse to string-like configurations. These configurations can be viewed as a higher-dimensional (membrane) analog of BMN states. We compute the energy and angular momenta, showing that all supersymmetric configurations obey the BPS relation $E=J/R$,\ $J= \sum_{i=1}^4 |J_i|$ with $E, J\to \infty$. Finally, we also study another class of supersymmetric M2-branes, including uncompact rotating membranes of "diabolo" shape.Comment: 27 pages, 3 figures. Small correction

Cardiovascular disease management in people with diabetes outside North America and Western Europe in 2006 and 2015

Aim: Optimal treatment of cardiovascular disease is essential to decrease mortality among people with diabetes, but information is limited on how actual treatment relates to guidelines. We analysed changes in therapeutic approaches to anti-hypertensive and lipid-lowering medications in people with Type 2 diabetes from 2006 and 2015. Methods: Summary data from clinical services in seven countries outside North America and Western Europe were collected for 39 684 people. Each site summarized individual-level data from outpatient medical records for 2006 and 2015. Data included: demographic information, blood pressure (BP), total cholesterol levels and percentage of people taking statins, anti-hypertensive medication (angiotensin-converting enzyme inhibitors, calcium channel blockers, angiotensin II receptor blockers, thiazide diuretics) and antiplatelet drugs. Results: From 2006 to 2015, mean cholesterol levels decreased in six of eight sites (range: −0.5 to −0.2), whereas the proportion with BP levels > 140/90 mmHg increased in seven of eight sites. Decreases in cholesterol paralleled increases in statin use (range: 3.1 to 47.0 percentage points). Overall, utilization of anti-hypertensive medication did not change. However, there was an increase in the use of angiotensin II receptor blockers and a decrease in angiotensin-converting enzyme inhibitors. The percentage of individuals receiving calcium channel blockers and aspirin remained unchanged. Conclusions: Our findings indicate that control of cholesterol levels improved and coincided with increased use of statins. The percentage of people with BP > 140/90 mmHg was higher in 2015 than in 2006. Hypertension treatment shifted from using angiotensin-converting enzyme inhibitors to angiotensin II receptor blockers. Despite the potentially greater tolerability of angiotensin II receptor blockers, there was no associated improvement in BP levels.Centro de Endocrinología Experimental y Aplicad