Breakdown and asymptotic properties of resampled estimates

In this paper we study the breakdown and asymptotic properties of resampled t-estimates. We find that they retain the finite breakdown point of the exact estimator. We also study their consistency and their order of convergence under nonstandard assumptions on the loss functions

Multifunctional nanocarriers for lung drug delivery

Nanocarriers have been increasingly proposed for lung drug delivery applications. The strategy of combining the intrinsic and more general advantages of the nanostructures with specificities that improve the therapeutic outcomes of particular clinical situations is frequent. These include the surface engineering of the carriers by means of altering the material structure (i.e., chemical modifications), the addition of specific ligands so that predefined targets are reached, or even the tuning of the carrier properties to respond to specific stimuli. The devised strategies are mainly directed at three distinct areas of lung drug delivery, encompassing the delivery of proteins and protein-based materials, either for local or systemic application, the delivery of antibiotics, and the delivery of anticancer drugs-the latter two comprising local delivery approaches. This review addresses the applications of nanocarriers aimed at lung drug delivery of active biological and pharmaceutical ingredients, focusing with particular interest on nanocarriers that exhibit multifunctional properties. A final section addresses the expectations regarding the future use of nanocarriers in the area.UID/Multi/04326/2019; PD/BD/137064/2018info:eu-repo/semantics/publishedVersio

Unsupervised edge map scoring: a statistical complexity approach

We propose a new Statistical Complexity Measure (SCM) to qualify edge maps without Ground Truth (GT) knowledge. The measure is the product of two indices, an \emph{Equilibrium} index $\mathcal{E}$ obtained by projecting the edge map into a family of edge patterns, and an \emph{Entropy} index $\mathcal{H}$, defined as a function of the Kolmogorov Smirnov (KS) statistic. This new measure can be used for performance characterization which includes: (i)~the specific evaluation of an algorithm (intra-technique process) in order to identify its best parameters, and (ii)~the comparison of different algorithms (inter-technique process) in order to classify them according to their quality. Results made over images of the South Florida and Berkeley databases show that our approach significantly improves over Pratt's Figure of Merit (PFoM) which is the objective reference-based edge map evaluation standard, as it takes into account more features in its evaluation

Extreme values for Benedicks-Carleson quadratic maps

We consider the quadratic family of maps given by $f_{a}(x)=1-a x^2$ with $x\in [-1,1]$, where $a$ is a Benedicks-Carleson parameter. For each of these chaotic dynamical systems we study the extreme value distribution of the stationary stochastic processes $X_0,X_1,...$, given by $X_{n}=f_a^n$, for every integer $n\geq0$, where each random variable $X_n$ is distributed according to the unique absolutely continuous, invariant probability of $f_a$. Using techniques developed by Benedicks and Carleson, we show that the limiting distribution of $M_n=\max\{X_0,...,X_{n-1}\}$ is the same as that which would apply if the sequence $X_0,X_1,...$ was independent and identically distributed. This result allows us to conclude that the asymptotic distribution of $M_n$ is of Type III (Weibull).Comment: 18 page

Extreme Value Laws in Dynamical Systems for Non-smooth Observations

We prove the equivalence between the existence of a non-trivial hitting time statistics law and Extreme Value Laws in the case of dynamical systems with measures which are not absolutely continuous with respect to Lebesgue. This is a counterpart to the result of the authors in the absolutely continuous case. Moreover, we prove an equivalent result for returns to dynamically defined cylinders. This allows us to show that we have Extreme Value Laws for various dynamical systems with equilibrium states with good mixing properties. In order to achieve these goals we tailor our observables to the form of the measure at hand

Extreme Value Laws for sequences of intermittent maps

We study non-stationary stochastic processes arising from sequential dynamical systems built on maps with a neutral fixed points and prove the existence of Extreme Value Laws for such processes. We use an approach developed in \cite{FFV16}, where we generalised the theory of extreme values for non-stationary stochastic processes, mostly by weakening the uniform mixing condition that was previously used in this setting. The present work is an extension of our previous results for concatenations of uniformly expanding maps obtained in \cite{FFV16}.Comment: To appear in Proceedings of the American Mathematical Society. arXiv admin note: substantial text overlap with arXiv:1510.0435

Extreme Value Laws for non stationary processes generated by sequential and random dynamical systems

We develop and generalize the theory of extreme value for non-stationary stochastic processes, mostly by weakening the uniform mixing condition that was previously used in this setting. We apply our results to non-autonomous dynamical systems, in particular to {\em sequential dynamical systems}, given by uniformly expanding maps, and to a few classes of random dynamical systems. Some examples are presented and worked out in detail

Wine Quality Assessment under the Eindhoven Classification Method

The identification, classification and recording of events leading to deterioration of wine quality is essential for developing appropriate strategies to avoid them. This work introduces an adverse event reporting and learning system that can help preventing hazards and ensure the quality of the wines. The Eindhoven Classification Method (ECM) has been extended and adapted to the incidents of the wine industry. Logic Programming (LP) was used for Knowledge Representation and Reasoning (KRR) in order to model the universe of discourse, even in the presence of incomplete data, information or knowledge. On the other hand, the evolutionary process of the body of knowledge is to be understood as a process of energy devaluation, enabling the automatic extraction of knowledge and the generation of reports to identify the most relevant causes of errors that can lead to a poor wine quality. In addition, the answers to the problem are object of formal evidence through theorem proving