568 research outputs found
Resource partitioning among African savanna herbivores in North Cameroon: the importance of diet composition, food quality and body mass
The relationship between herbivore diet quality, and diet composition (the range of food plants consumed) and body mass on resource partitioning of herbivores remains the subject of an ongoing scientific debate. In this study we investigated the importance of diet composition and diet quality on resource partitioning among eight species of savanna herbivore in north Cameroon, with different body mass. Dung samples of four to seven wild herbivore and one domesticated species were collected in the field during the dry and wet period. Diet composition was based on microhistological examination of herbivore droppings, epidermis fragments were identified to genus or family level. In addition, the quality of the faecal droppings was determined in terms of phosphorus, nitrogen and fibre concentrations. The results showed that there was no significant correlation between body mass and (differences in) diet composition for wet and dry season. When all species are considered, only significant relationships are found by the Spearman rank correlation analyses during the wet season between body mass and phosphorus and nitrogen, but this relationship did not exist during the dry season. When the analyses focuses on ruminants only (thus leaving out hippo), none of the relationships between body mass and diet quality was significant in either season. During the dry season the proportion of graminoids ranged between 10% (small unidentified herbivore species) to 90% (hippopotamus), during the wet season this proportion ranged from 60% (zebu) to 90% (hippopotamus). All species but zebu had more graminoids in their dung during wet season compared with dry season. However all species but hartebeest had more graminoids old stems in their dung during the dry season, compared with the wet season. The niche breadth for food categories consumed by kob (0.300), hippo (0.090), hartebeest (0.350), roan (0.510) and zebu (0.300) was much greater in the dry season than in the wet season for kob (0.120), hippo (0.020), hartebeest (0.190), roan (0.090) and zebu (0.200). When looking at grass taxa consumed, the niche breadth of kob (0.220), hartebeest (0.140), and roan (0.250) was also greater in the dry season when compared with the wet season for kob (0.050), hartebeest (0.120) and roan (0.120). The opposite was found for zebu and hippo. Comparison of the species’ diet compositions with randomized data showed that dietary overlap between different herbivore species was much higher than what would be expected on the basis of chance, demonstrating surprisingly limited niche separation between species. This offers potential for competition, but it is more likely that the high niche overlap indicates absence of competition, due to low herbivore densities and abundant food resources, permitting species to share non-limiting resources. With increasing herbivore densities and subsequent increasing scarcity of resources, the relationship between diet quality and body mass in combination with increased niche separation is expected to become more visibl
A comparison of faecal analysis with backtracking to determine the diet composition and species preference of the black rhinoceros (Diceros bicornis minor)
The diet of black rhinoceros (Diceros bicornis minor) was studied using backtracking and faecal analysis in South Africa. Both methods yielded different results, with a large bias for dominant species. Results of backtracking showed that the rhinos browsed on 80 plant species. Grasses comprised 4.5% of the diet in the faecal analysis, but were not recorded during the backtracking. The backtracking method, along with a measure of forage availability, was used to identify two groups of plant species, those species taken in a higher proportion than available in the field and those taken in a lower proportion. Chemical analyses showed that these two species groups were similar in in vitro digestibility, macro-elements and fibre constituents. Mean bite size and species contribution to the diet were not correlated with any of the forage quality parameters, indicating that rhinos were not maximising nutrient intake or minimising fibre intake of these consumed plant species
Evidence that the TRH-like peptide pyroglutamyl-glutamyl-prolineamide in human serum may not be secreted by the pituitary gland
Recent studies have revealed that TRH-like immunoreactivity (TRH-LI) in
human serum is predominantly pGlu-Glu-ProNH2 (< EEP-NH2), a peptide
previously found in, among others tissues, the pituitary gland of various
mammalian species. In the rat pituitary, < EEP-NH2 is present in
gonadotrophs and its pituitary content is regulated by gonadal steroids
and gonadotrophin-releasing hormone (GnRH). Hence, we reasoned that <
EEP-NH2 in human serum may also arise, at least in part, from the
pituitary, and that its secretion may correlate with that of
gonadotrophins. Therefore, blood was simultaneously sampled from both
inferior petrosal sinuses, which are major sites of the venous drainage of
the pituitary gland, and a peripheral vein from seven patients with
suspected adrenocorticotrophin-secreting pituitary tumours. In addition,
in six postmenopausal and six cyclic women, peripheral vein blood was
collected at 10-min intervals for 6 h, then a standard 100 micrograms GnRH
test was performed. In the sera, TRH-LI was estimated by RIA with
antiserum 4319, which binds most tripeptides that share the N- and
C-terminal amino acids with TRH (pGlu-His-ProNH2). In addition, LH and FSH
were measured in these sera b
The diet of kudus in a mopane dominated area, South Africa
The composition of the plant species eaten by kudu (Tragelaphus strepsiceros) determines the diet quality, which impacts on kudu condition and mortality levels. The yearround diet composition of kudus in the Limpopo Province, a mopane (Colophospermum mopane) dominated area, was determined by faecal analysis. The most important dietary plant species were Colophospermum mopane, Grewia bicolor, Terminalia prunioides, Tinnea rhodesiana, Boscia albitrunca and Combretum apiculatum, with C. mopane comprising on average 39.2 % of diet per month. Small amounts of herbs, grasses and seeds made up the remaining part of the diet. The contribution of C. mopane in the diet was negatively correlated with precipitation. Colophospermum mopane was consumed, irrespective of its high condensed tannin load (5.2–9.8 % DW) for the majority of the months. No seasonally significant differences were detected for modelled kudu diet crude protein, tannin or phenol concentrations. Colophospermum mopane showed significant seasonal differences with lowest values of protein, tannin and phenols in the late wet season. Surprisingly, crude protein concentrations were positively correlated with high levels of tannins and phenols for C. mopane. The diet of kudus comprised of significantly more species during the wet season compared to the dry season. Diet diversification, instead of protein maximization, seems a potential tool to satisfy protein requirements while reducing potential toxic effects associated with a high intake of secondary compounds. A significant positive correlation was therefore detected between the tannin concentration of C. mopane leaves and the number of plant species in the diet
Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration
Biomarkers can help unravel mechanisms of disease and identify new targets for therapy. They can also be useful in clinical practice for monitoring disease progression, evaluation of treatment efficacy, and risk assessment in multifactorial diseases, such as age-related macular degeneration (AMD). AMD is a highly prevalent progressive retinal disorder for which multiple genetic and environmental risk factors have been described, but the exact etiology is not yet fully understood. Many compounds have been evaluated for their association with AMD. We performed an extensive literature review of all compounds measured in serum, plasma, vitreous, aqueous humor, and urine of AMD patients. Over 3600 articles were screened, resulting in more than 100 different compounds analyzed in AMD studies, involved in neovascularization, immunity, lipid metabolism, extracellular matrix, oxidative stress, diet, hormones, and comorbidities (such as kidney disease). For each compound, we provide a short description of its function and discuss the results of the studies in relation to its usefulness as AMD biomarker. In addition, biomarkers identified by hypothesis-free techniques, including metabolomics, proteomics, and epigenomics, are covered. In summary, compounds belonging to the oxidative stress pathway, the complement system, and lipid metabolism are the most promising biomarker candidates for AMD. We hope that this comprehensive survey of the literature on systemic and ocular fluid compounds as potential biomarkers in AMD will provide a stepping stone for future research and possible implementation in clinical practice
Density dependent hadron field theory for neutron stars with antikaon condensates
We investigate and condensation in -equilibrated
hyperonic matter within a density dependent hadron field theoretical model. In
this model, baryon-baryon and (anti)kaon-baryon interactions are mediated by
the exchange of mesons. Density dependent meson-baryon coupling constants are
obtained from microscopic Dirac Brueckner calculations using Groningen and Bonn
A nucleon-nucleon potential. It is found that the threshold of antikaon
condensation is not only sensitive to the equation of state but also to
antikaon optical potential depth. Only for large values of antikaon optical
potential depth, condensation sets in even in the presence of negatively
charged hyperons. The threshold of condensation is always reached
after condensation. Antikaon condensation makes the equation of state
softer thus resulting in smaller maximum mass stars compared with the case
without any condensate.Comment: 20 pages, 7 figures; final version to appear in Physical Review
Analysis of rare variants in the C3 gene in patients with age-related macular degeneration
Age-related macular degeneration (AMD) is a progressive retinal disorder affecting over 33 million people worldwide. Genome-wide association studies (GWASs) for AMD identified common variants at 19 loci accounting for 15-65% of the heritability and it has been hypothesized that the missing heritability may be attributed to rare variants with large effect sizes. Common variants in the complement component 3 (C3) gene have been associated with AMD and recently a rare C3 variant (Lys155Gln) was identified which exerts a large effect on AMD susceptibility independent of the common variants. To explore whether additional rare variants in the C3 gene are associated with AMD, we sequenced all coding exons in 84 unrelated AMD cases. Subsequently, we genotyped all identified variants in 1474 AMD cases and 2258 controls. Additionally, because of the known genetic overlap between AMD and atypical hemolytic uremic syndrome (aHUS), we genotyped two recurrent aHUS-associated C3 mutations in the entire cohort. Overall, we identified three rare variants (Lys65Gln (P = 0.04), Arg735Trp (OR = 17.4, 95% CI = 2.2-136; P = 0.0003), and Ser1619Arg (OR = 5.2, 95% CI = 1.0-25; P = 0.05) at the C3 locus that are associated with AMD in our EUGENDA cohort. However, the Arg735Trp and Ser1619Arg variants were not found to be associated with AMD in the Rotterdam Study. The Lys65Gln variant was only identified in patients from Nijmegen, the Netherlands, and thus may represent a region-specific AMD risk variant
Risk factors for development and progression of diabetic retinopathy in Dutch patients with type 1 diabetes mellitus
Purpose: To investigate risk factors for the development and progression of diabetic retinopathy (DR) and long-term visual outcomes in Dutch patients with type 1 diabetes mellitus (T1DM). Methods: Cumulative incidences were calculated for DR, vision-threatening DR (VTDR), defined as (pre)proliferative DR and diabetic macular oedema, and best-corrected visual acuity (BCVA) <0.5 and <0.3 at the most recent eye examination. The fo
Long Run Variance Estimation and Robust Regression Testing Using Sharp Origin Kernels with No Truncation
A new family of kernels is suggested for use in long run variance (LRV) estimation and robust regression testing. The kernels are constructed by taking powers of the Bartlett kernel and are intended to be used with no truncation (or bandwidth) parameter. As the power parameter (p) increases, the kernels become very sharp at the origin and increasingly downweight values away from the origin, thereby achieving effects similar to a bandwidth parameter. Sharp origin kernels can be used in regression testing in much the same way as conventional kernels with no truncation, as suggested in the work of Kiefer and Vogelsang [2002a, Heteroskedasticity-autocorrelation robust testing using bandwidth equal to sample size. Econometric Theory 18, 1350-1366, 2002b, Heteroskedasticity-autocorrelation robust standard errors using the Bartlett kernel without truncation, Econometrica 70, 2093-2095] Analysis and simulations indicate that sharp origin kernels lead to tests with improved size properties relative to conventional tests and better power properties than other tests using Bartlett and other conventional kernels without truncation. If p is passed to infinity with the sample size (T), the new kernels provide consistent LRV estimates. Within this new framework, untruncated kernel estimation can be regarded as a form of conventional kernel estimation in which the usual bandwidth parameter is replaced by a power parameter that serves to control the degree of downweighting. A data-driven method for selecting the power parameter is recommended for hypothesis testing. Simulations show that this method gives arise to a test with more accurate size than the conventional HAC t-test at the cost of a very small power loss. (c) 2006 Elsevier B.V. All rights reserved.Statistics & ProbabilitySCI(E)11ARTICLE3985-102313
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