9,277 research outputs found

    Limits of a decoupled out-of-order superscalar architecture

    Get PDF

    An Interview with Edward P. Jones

    Get PDF
    This is the publisher's version, also available electronically from http://www.jstor.org/stable/40301244?seq=1#page_scan_tab_contentsEdward P. Jones is a writer of the kind of fiction one might have thought was going out of style: readable, absorbing, and exquisitely literary. After a startling publishing debut with Lost in the City, stories drawn from his native Washington, D. C, Jones went on to win die Pulitzer Prize for The Known World in 2004, an unusual story about a former slave-turned-slaveowner in antebellum Virginia. He published his third book in die fall of 2006, All Aunt Hagar's Children, a collection of short stories about ordinary people, whom we see as only they can be. Jones pays careful attention to presenting the circumstances of their lives and the consequences of their choices. Neither blaming the victims nor forgetting that they exist, Jones is more concerned with alerting us to the characters' contradictions, i.e., what makes them human. Unlike the brooding sensibility of Faulkner's fiction or the violent rage that characterizes Wright's work, Jones's world has a sober inclusiveness. He mediates his characters' lives with elegant, understated prose that is as compelling as it is persuasive. Each page is a reminder of his artistry and the compassion he feels for each of his characters. This interview was conducted shortly before die release of die hardcover edition of All Aunt's Hagar's Children, August 18, 2006, at Union Station in Washington, D. C. A trade paperback edition of die book was published in August 2007

    Braking characteristics during cutting and pivoting in female soccer players

    Get PDF
    Biomechanical studies into changing direction focus on final contact (FC), whilst limited research has examined penultimate contact (PEN). The aim of this study was to explore the kinematic and kinetic differences between PEN and FC of cutting and pivoting in 22 female soccer players (mean ± SD; age: 21 ± 3.1 years, height: 1.68 ± 0.07 m, mass: 58.9 ± 7.3 kg). Furthermore, the study investigated whether horizontal force-time characteristics during PEN were related to peak knee abduction moments during FC. Three dimensional motion analyses of cutting and pivoting on the right leg were performed using Qualysis ‘Pro-reflex’ infrared cameras (240Hz). Ground reaction forces (GRF) were collected from two AMTI force platforms (1200Hz) to examine PEN and FC. Both manoeuvres involved significantly (P < 0.05) greater knee joint flexion angles, peak horizontal GRF, but lower average horizontal GRF during PEN compared to FC. Average horizontal GRF during PEN (R = -0.569, R2 = 32%, P = 0.006) and average horizontal GRF ratio (R = 0.466, R2 = 22%, P = 0.029) were significantly related to peak knee abduction moments during the FC of cutting and pivoting, respectively. The results indicate PEN during pre-planned changing direction helps reduce loading on the turning leg where there is greater risk of injuries to knee ligaments

    The Regulation of Aggrecanase ADAMTS-4 Expression in Human Achilles Tendon and tendon-Derived Cells

    Get PDF
    Several members of the ADAMTS (A Disintegrin And Metalloproteinase with ThromboSpondin motifs) family have been identified as aggrecanases, whose substrates include versican, the principal large proteoglycan in the tendon extracellular matrix. We have characterized the expression of ADAMTS-4 in human Achilles tendon and tendon-derived cells. ADAMTS-4 mRNA levels were higher in ruptured tendon compared with normal tendon or chronic painful tendinopathy. In tissue extracts probed by Western blotting, mature ADAMTS-4 (68 kDa) was detected only in ruptured tendons, while processed ADAMTS-4 (53 kDa) was detected also in chronic painful tendinopathy and in normal tendon. In cultured Achilles tendon cells, transforming growth factor-ß (TGF-ß) stimulated ADAMTS-4 mRNA expression (typically 20-fold after 24 h), while interleukin-1 induced a smaller, shorter-term stimulation which synergised markedly with that induced by TGF-ß. Increased levels of immunoreactive proteins consistent with mature and processed forms of ADAMTS-4 were detected in TGF-ß-stimulated cells. ADAMTS-4 mRNA was expressed at higher levels by tendon cells in collagen gels than in monolayer cultures. In contrast, the expression of ADAMTS-1 and -5 mRNA was lower in collagen gels compared with monolayers, and these mRNA showed smaller or opposite responses to growth factors and cytokines compared with that of ADAMTS-4 mRNA. We conclude that both ADAMTS-4 mRNA and ADAMTS-4 protein processing may be differentially regulated in normal and damaged tendons and that both the matrix environment and growth factors such as TGF-ß are potentially important factors controlling ADAMTS aggrecanase activities in tendon pathology

    Measurement of the electroweak production of dijets in association with a Z-boson and distributions sensitive to vector boson fusion in proton-proton collisions at √s= 8 TeV using the ATLAS detector

    Get PDF
    Measurements of fiducial cross sections for the electroweak production of two jets in association with a Z-boson are presented. The measurements are performed using 20.3 fb−1 of proton-proton collision data collected at a centre-of-mass energy of s√ = 8 TeV by the ATLAS experiment at the Large Hadron Collider. The electroweak component is extracted by a fit to the dijet invariant mass distribution in a fiducial region chosen to enhance the electroweak contribution over the dominant background in which the jets are produced via the strong interaction. The electroweak cross sections measured in two fiducial regions are in good agreement with the Standard Model expectations and the background-only hypothesis is rejected with significance above the 5σ level. The electroweak process includes the vector boson fusion production of a Z-boson and the data are used to place limits on anomalous triple gauge boson couplings. In addition, measurements of cross sections and differential distributions for inclusive Z-boson-plus-dijet production are performed in five fiducial regions, each with different sensitivity to the electroweak contribution. The results are corrected for detector effects and compared to predictions from the Sherpa and Powheg event generators

    Search for dark matter in events with a hadronically decaying W or Z boson and missing transverse momentum in pp collisions at √s=8  TeV with the ATLAS detector

    Get PDF
    A search is presented for dark matter pair production in association with a W or Z boson in pp collisions representing 20.3  fb−1 of integrated luminosity at s√=8  TeV using data recorded with the ATLAS detector at the Large Hadron Collider. Events with a hadronic jet with the jet mass consistent with a W or Z boson, and with large missing transverse momentum are analyzed. The data are consistent with the standard model expectations. Limits are set on the mass scale in effective field theories that describe the interaction of dark matter and standard model particles, and on the cross section of Higgs production and decay to invisible particles. In addition, cross section limits on the anomalous production of W or Z bosons with large missing transverse momentum are set in two fiducial regions

    Why is reporting quality improvement so hard? A qualitative study in perioperative care.

    Get PDF
    OBJECTIVES: Quality improvement (QI) may help to avert or mitigate the risks of suboptimal care, but it is often poorly reported in the healthcare literature. We aimed to identify the influences on reporting QI in the area of perioperative care, with a view to informing improvements in reporting QI across healthcare. DESIGN: Qualitative interview study. SETTING: Healthcare and academic organisations in Australia, Europe and North America. PARTICIPANTS: Stakeholders involved in or influencing the publication, writing or consumption of reports of QI studies in perioperative care. RESULTS: Forty-two participants from six countries took part in the study. Participants included 15 authors (those who write QI reports), 12 consumers of QI reports (practitioners who apply QI research in practice), 11 journal editors and 4 authors of reporting guidelines. Participants identified three principal challenges in achieving high-quality QI reporting. First, the broad scope of QI reporting-ranging from small local projects to multisite research across different disciplines-causes uncertainty about where QI work should be published. Second, context is fundamental to the success of a QI intervention but is difficult to report in ways that support replication and development. Third, reporting is adversely affected by both proximal influences (such as lack of time to write up QI) and more distal, structural influences (such as norms about the format and content of biomedical research reporting), leading to incomplete reporting of QI findings. CONCLUSIONS: Divergent terminology and understandings of QI, along with existing reporting norms and the challenges of capturing context adequately yet succinctly, make for challenges in reporting QI. We offer suggestions for improvement

    Search for new particles in events with one lepton and missing transverse momentum in pp collisions at s√ = 8 TeV with the ATLAS detector

    Get PDF
    This paper presents a search for new particles in events with one lepton (electron or muon) and missing transverse momentum using 20.3 fb−1 of proton-proton collision data at s√ = 8 TeV recorded by the ATLAS experiment at the Large Hadron Collider. No significant excess beyond Standard Model expectations is observed. A W ′ with Sequential Standard Model couplings is excluded at the 95% confidence level for masses up to 3.24 TeV. Excited chiral bosons (W *) with equivalent coupling strengths are excluded for masses up to 3.21 TeV. In the framework of an effective field theory limits are also set on the dark matter-nucleon scattering cross-section as well as the mass scale M * of the unknown mediating interaction for dark matter pair production in association with a leptonically decaying W

    Searching for gravitational waves from the Crab pulsar - the problem of timing noise

    Get PDF
    Of the current known pulsars, the Crab pulsar (B0531+21) is one of the most promising sources of gravitational waves. The relatively large timing noise of the Crab causes its phase evolution to depart from a simple spin-down model. This effect needs to be taken in to account when performing time domain searches for the Crab pulsar in order to avoid severely degrading the search efficiency. The Jodrell Bank Crab pulsar ephemeris is examined to see if it can be used for tracking the phase evolution of any gravitational wave signal from the pulsar, and we present a method of heterodyning the data that takes account of the phase wander. The possibility of obtaining physical information about the pulsar from comparisons of the electromagnetically and a gravitationally observed timing noise is discussed. Finally, additional problems caused by pulsar glitches are discussed.Comment: 5 pages, 1 figure, Proceedings of the 5th Amaldi Conference on Gravitational Waves, Pisa, Italy, 6-11 July 200
    corecore