Review of the occupational health and safety of Britain’s ethnic minorities

This report sets out an evidence-based review on work-related health and safety issues relating to black and minority ethnic groups. Data included available statistical materials and a systematic review of published research and practice-based reports. UK South Asians are generally under-represented within the most hazardous occupational groups. They have lower accident rates overall, while Black Caribbean workers rates are similar to the general population; Bangladeshi and Chinese workers report lowest workplace injury rates UK South Asian people exhibit higher levels of limiting long-term illness (LLI) and self reported poor health than the general population while Black Africans and Chinese report lower levels. Ethnic minority workers with LLI are more likely than whites to withdraw from the workforce, or to experience lower wage rates. Some of these findings conflict with evidence of differentials from USA, Europe and Australasia, but there is a dearth of effective primary research or reliable monitoring data from UK sources. There remains a need to improve monitoring and data collection relating to black and ethnic minority populations and migrant workers. Suggestions are made relating to workshops on occupational health promotion programmes for ethnic minorities, and ethnic minority health and safety 'Beacon' sites

Patients' experiences of transitioning between different renal replacement therapy modalities : a qualitative study

BACKGROUND: Different kidney replacement therapy modalities are available to manage end-stage kidney disease, such as home-based dialysis, in-center hemodialysis, and kidney transplantation. Although transitioning between modalities is common, data on how patients experience these transitions are scarce. This study explores patients' perspectives of transitioning from a home-based to an in-center modality. METHODS: Patients transitioning from peritoneal dialysis to in-center hemodialysis were purposively selected. Semi-structured interviews were performed, digitally recorded, and transcribed verbatim. Data analysis, consistent with Charmaz' constructivist approach of grounded theory was performed. RESULTS: Fifteen patients (10 males; mean age 62 years) participated. The conditions of the transitioning process impacted the participants' experiences, resulting in divergent experiences and associated emotions. Some participants experienced a loss of control due to the therapy-related changes. Some felt tied down and having lost independence, whereas others stated they regained control as they felt relieved from responsibility. This paradox of control was related to the patient having or not having (1) experienced a fit of hemodialysis with their personal lifestyle, (2) a frame of reference, (3) higher care requirements, (4) insight into the underlying reasons for transitioning, and (5) trust in the healthcare providers. CONCLUSIONS: Care teams need to offer opportunities to elicit patients' knowledge and fears, dispel myths, forge connections with other patients, and visit the dialysis unit before transition to alleviate anxiety. Interventions that facilitate a sense of control should be grounded in the meaning that the disorder has for the person and how it impacts their sense of self

Energy stress-mediated cytotoxicity in tuberous sclerosis complex 2-deficient cells with nelfinavir and mefloquine treatment

To find new anti-cancer drug therapies, we wanted to exploit homeostatic vulnerabilities within Tuberous Sclerosis Complex 2 (TSC2)-deficient cells with mechanistic target of rapamycin complex 1 (mTORC1) hyperactivity. We show that nelfinavir and mefloquine synergize to selectively evoke a cytotoxic response in TSC2-deficient cell lines with mTORC1 hyperactivity. We optimize the concentrations of nelfinavir and mefloquine to a clinically viable range that kill cells that lack TSC2, while wild-type cells tolerate treatment. This new clinically viable drug combination causes a significant level of cell death in TSC2-deficient tumor spheroids. Furthermore, no cell recovery was apparent after drug withdrawal, revealing potent cytotoxicity. Transcriptional profiling by RNA sequencing of drug treated TSC2-deficient cells compared to wild-type cells suggested the cytotoxic mechanism of action, involving initial ER stress and an imbalance in energy homeostatic pathways. Further characterization revealed that supplementation with methyl pyruvate alleviated energy stress and reduced the cytotoxic effect, implicating energy deprivation as the trigger of cell death. This work underpins a critical vulnerability with cancer cells with aberrant signaling through the TSC2-mTORC1 pathway that lack flexibility in homeostatic pathways, which could be exploited with combined nelfinavir and mefloquine treatment

The Sage-Grouse Habitat Mortgage: Effective Conifer Management in Space and Time

AbstractManagement of conservation-reliant species can be complicated by the need to manage ecosystem processes that operate at extended temporal horizons. One such process is the role of fire in regulating abundance of expanding conifers that disrupt sage-grouse habitat in the northern Great Basin of the United States. Removing conifers by cutting has a beneficial effect on sage-grouse habitat. However, effects may last only a few decades because conifer seedlings are not controlled and the seed bank is fully stocked. Fire treatment may be preferred because conifer control lasts longer than for mechanical treatments. The amount of conservation needed to control conifers at large temporal and spatial scales can be quantified by multiplying land area by the time needed for conifer abundance to progress to critical thresholds (i.e., “conservation volume”). The contribution of different treatments in arresting conifer succession can be calculated by dividing conservation volume by the duration of treatment effect. We estimate that fire has approximately twice the treatment life of cutting at time horizons approaching 100 yr, but, has high up-front conservation costs due to temporary loss of sagebrush. Cutting has less up-front conservation costs because sagebrush is unaffected, but it is more expensive over longer management time horizons because of decreased durability. Managing conifers within sage-grouse habitat is difficult because of the necessity to maintain the majority of the landscape in sagebrush habitat and because the threshold for negative conifer effects occurs fairly early in the successional process. The time needed for recovery of sagebrush creates limits to fire use in managing sage-grouse habitat. Utilizing a combination of fire and cutting treatments is most financially and ecologically sustainable over long time horizons involved in managing conifer-prone sage-grouse habitat

Arguments for F-theory

After a brief review of string and $M$-Theory we point out some deficiencies. Partly to cure them, we present several arguments for ``$F$-Theory'', enlarging spacetime to $(2, 10)$ signature, following the original suggestion of C. Vafa. We introduce a suggestive Supersymmetric 27-plet of particles, associated to the exceptional symmetric hermitian space $E_{6}/Spin^{c}(10)$. Several possible future directions, including using projective rather than metric geometry, are mentioned. We should emphasize that $F$-Theory is yet just a very provisional attempt, lacking clear dynamical principles.Comment: To appear in early 2006 in Mod. Phys. Lett. A as Brief Revie

To burn or not to burn: Comparing reintroducing fire with cutting an encroaching conifer for conservation of an imperiled shrub‐steppe

Woody vegetation has increased on rangelands worldwide for the past 100– 200 years, often because of reduced fire frequency. However, there is a general aversion to reintroducing fire, and therefore, fire surrogates are often used in its place to reverse woody plant encroachment. Determining the conservation effectiveness of reintroducing fire compared with fire surrogates over different time scales is needed to improve conservation efforts. We evaluated the conservation effectiveness of reintroducing fire with a fire surrogate (cutting) applied over the last ~30 years to control juniper (Juniperus occidentalis Hook.) encroachment on 77 sagebrush‐steppe sites. Critical to conservation of this imperiled ecosystem is to limit juniper, not encourage exotic annual grasses, and promote sagebrush dominance of the overstory. Reintroducing fire was more effective than cutting at reducing juniper abundance and extending the period of time that juniper was not dominating the plant community. Sagebrush was reduced more with burning than cutting. Sagebrush, however, was predicted to be a substantial component of the overstory longer in burned than cut areas because of more effective juniper control. Variation in exotic annual grass cover was explained by environmental variables and perennial grass abundance, but not treatment, with annual grasses being problematic on hotter and drier sites with less perennial grass. This suggests that ecological memory varies along an environmental gradient. Reintroducing fire was more effective than cutting at conserving sagebrush‐steppe encroached by juniper over extended time frames; however, cutting was more effective for short‐term conservation. This suggests fire and fire surrogates both have critical roles in conservation of imperiled ecosystems

Incidence of medically attended paediatric burns across the UK

Objective: Childhood burns represent a burden on health services, yet the full extent of the problem is difficult to quantify. We estimated the annual UK incidence from primary care (PC), emergency attendances (EA), hospital admissions (HA) and deaths.Methods: The population was children (0-15 years), across England, Wales, Scotland and Northern Ireland (NI), with medically attended burns 2013-2015. Routinely collected data sources included PC attendances from Clinical Practice Research Datalink 2013-2015), EAs from Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI, 2014) and National Health Services Wales Informatics Services, HAs from Hospital Episode Statistics, National Services Scotland and Social Services and Public Safety (2014), and mortality from the Office for National Statistics, National Records of Scotland and NI Statistics and Research Agency 2013-2015. The population denominators were based on Office for National Statistics mid-year population estimates.Results: The annual PC burns attendance was 16.1/10 000 persons at risk (95% CI 15.6 to 16.6); EAs were 35.1/10 000 persons at risk (95% CI 34.7 to 35.5) in England and 28.9 (95% CI 27.5 to 30.3) in Wales. HAs ranged from 6.0/10 000 person at risk (95% CI 5.9 to 6.2) in England to 3.1 in Wales and Scotland (95% CI 2.7 to 3.8 and 2.7 to 3.5, respectively) and 2.8 (95% CI 2.4 to 3.4) in NI. In England, Wales and Scotland, 75% of HAs were aged < 5 years. Mortality was low with 0.1/1 000 000 persons at risk (95% CI 0.06 to 0.2).Conclusions: With an estimated 19 574 PC attendances, 37 703 EAs (England and Wales only), 6639 HAs and 1–6 childhood deaths annually, there is an urgent need to improve UK childhood burns prevention

Effects of Integrating Mowing and Imazapyr Application on African Rue (Peganum harmala) and Native Perennial Grasses

African rue is a poisonous, perennial forb that readily invades salt-desert shrub and sagebrush-steppe rangelands. Information detailing options for integrated management of African rue is lacking. To date, a few studies have researched the efficacy of different herbicides for controlling African rue, but none have investigated integrated approaches to its management. Broadcast applications of imazapyr at three rates (0.275, 0.55, and 0.85 kg ae ha⁻¹) were made, with and without a prior mowing treatment, to African rue when it was in full bloom. Imazapyr resulted in significant reductions in both the cover and density of African rue, regardless of application rate or mowing treatment (P 0.05). Higher rates of imazapyr resulted in significant reductions in the cover of native perennial bunchgrasses (P 0.05). Integrating a mowing treatment with imazapyr applications was less effective for controlling African rue than applying herbicide alone. Mowing before imazapyr application did not increase survival of perennial grasses. Our results suggest that the recommended rate of imazapyr for controlling African rue (0.85 kg ae ha⁻¹) could be reduced by as much as one-third on dry floodplain ecological sites within the northern Great Basin without comprising its effectiveness for controlling African rue. This lower rate would reduce nontarget damage to native perennial grasses, which are the dominant functional group in the herbaceous understory. Less damage to native perennial grasses would probably accelerate understory recovery and help prevent invasion by other invasive species.Keywords: Sagebrush steppe, Weeds, Invasive plantsKeywords: Sagebrush steppe, Weeds, Invasive plant

Precision determination of band offsets in strained InGaAs/GaAs quantum wells by C-V-profiling and Schroedinger-Poisson self-consistent simulation

The results of measurements and numerical simulation of charge carrier distribution and energy states in strained quantum wells In_xGa_{1-x}As/GaAs (0.06 < x < 0.29) by C-V-profiling are presented. Precise values of conduction band offsets for these pseudomorphic QWs have been obtained by means of self-consistent solution of Schroedinger and Poisson equations and following fitting to experimental data. For the conduction band offsets in strained In_xGa_{1-x}As/GaAs - QWs the expression DE_C(x) = 0.814x - 0.21x^2 has been obtained.Comment: 9 pages, 12 figures, RevTeX