OMI/TROPOMI Data Support from GES DISC

The NASA GES DISC has been the official archive center for data from the Ozone Monitoring Instrument (OMI) aboard NASA's Aura mission since 2004. In recent years, the GES DISC has been evolving and improving its data management and services in order to promote its data to be easily discovered and accessed, as well as to facilitate data "interoperability". This presentation will summarize metrics collected of OMI data usage and GES DISC data services. In order to support the recently released Sentinel-5P/TROPOMI data from ESA at the NASA GES DISC, a new End User License Agreement (EULA) has been implemented for users accessing these data from the GES DISC

455 Pegasus Lung, a platform study of SAR444245 (THOR-707, a pegylated recombinant non-alpha IL-2) with anti-cancer agents in patients with non-small cell lung cancer (NSCLC) and mesothelioma

BackgroundSAR444245 (THOR-707) is a recombinant human IL-2 molecule that includes a PEG moiety irreversibly bound to a novel amino acid via click chemistry to block the alpha-binding domain while retaining near-native affinity for the beta/gamma subunits. In animal models, SAR444245 showed anti-tumor benefits, but with no severe side effects, both as single agent and when combined with anti-PD1 comparing with historical data from aldesleukin. The HAMMER trial, which is the FIH study shows preliminary encouraging clinical results: initial efficacy and safety profile with SAR444245 monotherapy and in combination with pembrolizumab support a non-alpha preferential activity, validating preclinical models. The Pegasus Lung Ph2 study will evaluate the clinical benefit of SAR444245 in combination with other anticancer therapies for the treatment of patients with lung cancer or pleural mesotheliomaMethodsThe Pegasus Lung (NCT04914897) will enroll approximately 354 patients in 6 separate cohorts concurrently or sequentially. In cohorts A1 & A2, patients with first line (L) NSCLC will receive SAR444245 + pembrolizumab. In cohort A3, patients with 1L non-squamous NSCLC will receive SAR444245 + pembrolizumab + pemetrexed + carboplatin/cisplatin. In cohort B1 & B2 patients with 2/3L NSCLC who have progressed on a checkpoint inhibitor (CPI)-based therapy will receive SAR444245 + pembrolizumab, or SAR444245 + pembrolizumab + nab-paclitaxel. In cohort C patients with 2/3L CPI naïve mesothelioma will receive SAR444245 + pembrolizumab. SAR444245 is administered IV at a dose of 24 ug/kg Q3W in an outpatient setting until disease progression or completion of 35 cycles. Pembrolizumab is administered at a dose of 200 mg Q3W until PD or completion of 35 cycles. The study primary objective is to determine the antitumor activity of SAR444245 in combination with other anticancer therapies. Secondary objectives include confirmation of dose and safety profile, assess other indicators of antitumor activity, and assess the pharmacokinetic profile and immunogenicity of SAR444245. The study will be conducted in the US, Australia, France, Italy, Japan, Poland, South Korea, Spain, and Taiwan.AcknowledgementsThe Pegasus Lung study is sponsored by Sanofi.Trial RegistrationNCT04914897Ethics ApprovalThis study has been approved by applicable ethics committees or institutional review boards. All participants gave informed consent before taking part.ConsentWritten informed consent was obtained from the patient for publication of this abstract and any accompanying images. A copy of the written consent is available for review by the Editor of this journal

Species-Specific Activity of HIV-1 Vpu and Positive Selection of Tetherin Transmembrane Domain Variants

Tetherin/BST-2/CD317 is a recently identified antiviral protein that blocks the release of nascent retrovirus, and other virus, particles from infected cells. An HIV-1 accessory protein, Vpu, acts as an antagonist of tetherin. Here, we show that positive selection is evident in primate tetherin sequences and that HIV-1 Vpu appears to have specifically adapted to antagonize variants of tetherin found in humans and chimpanzees. Tetherin variants found in rhesus macaques (rh), African green monkeys (agm) and mice were able to inhibit HIV-1 particle release, but were resistant to antagonism by HIV-1 Vpu. Notably, reciprocal exchange of transmembrane domains between human and monkey tetherins conferred sensitivity and resistance to Vpu, identifying this protein domain as a critical determinant of Vpu function. Indeed, differences between hu-tetherin and rh-tetherin at several positions in the transmembrane domain affected sensitivity to antagonism by Vpu. Two alterations in the hu-tetherin transmembrane domain, that correspond to differences found in rh- and agm-tetherin proteins, were sufficient to render hu-tetherin completely resistant to HIV-1 Vpu. Interestingly, transmembrane and cytoplasmic domain sequences in primate tetherins exhibit variation at numerous codons that is likely the result of positive selection, and some of these changes coincide with determinants of HIV-1 Vpu sensitivity. Overall, these data indicate that tetherin could impose a barrier to viral zoonosis as a consequence of positive selection that has been driven by ancient viral antagonists, and that the HIV-1 Vpu protein has specialized to target the transmembrane domains found in human/chimpanzee tetherin proteins

Short Communication Reflectance-based detection of oxidizers in ambient air

This study used two types of paper supported materials with a prototype, reflectance-based detector for indication of hydrogen peroxide vapor under ambient laboratory conditions. Titanyl based indicators provide detection through reaction of the indicator resulting in a dosimeter type sensor, while porphyrin based indicators provide a reversible interaction more suitable to continuous monitoring applications. These indicators provide the basis for discussion of characteristics important to design of a sensor system including the application environment and duration, desired reporting frequency, and target specificity

Short Communication Reflectance-based detection of oxidizers in ambient air

This study used two types of paper supported materials with a prototype, reflectance-based detector for indication of hydrogen peroxide vapor under ambient laboratory conditions. Titanyl based indicators provide detection through reaction of the indicator resulting in a dosimeter type sensor, while porphyrin based indicators provide a reversible interaction more suitable to continuous monitoring applications. These indicators provide the basis for discussion of characteristics important to design of a sensor system including the application environment and duration, desired reporting frequency, and target specificity

Heavy Quarkonium Potential Model and the 1P1{}^1P_1 State of Charmonium

A theoretical explanation of the observed splittings among the P~states of charmonium is given with the use of a nonsingular potential model for heavy quarkonia. We also show that the recently observed mass difference between the center of gravity of the ${}^3P_J$ states and the ${}^1P_1$ state of $c\bar{c}$ does not provide a direct test of the color hyperfine interaction in heavy quarkonia. Our theoretical value for the mass of the ${}^1P_1$ state is in agreement with the experimental result, and its E1 transition width is 341.8~keV. The mass of the $\eta_c'$ state is predicted to be 3622.3~MeV.Comment: 15 page REVTEX documen

Observations of the dispersion characteristics and meridional sea level structure of equatorial waves in the Pacific Ocean

Author Posting. © American Meteorological Society, 2008. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 38 (2008): 1669-1689, doi:10.1175/2007JPO3890.1.Spectral techniques applied to altimetry data are used to examine the dispersion relation and meridional sea level structure of wavelike variability with periods of about 20 to 200 days in the equatorial Pacific Ocean. Zonal wavenumber–frequency power spectra of sea surface height, when averaged over about 7°S–7°N, exhibit spectral peaks near the theoretical dispersion curves of first baroclinic-mode equatorial Kelvin and Rossby waves. There are distinct, statistically significant ridges of power near the first and second meridional-mode Rossby wave dispersion curves. Sea level variability near the theoretical Kelvin wave and first meridional-mode Rossby wave dispersion curves is dominantly (but not perfectly) symmetric about the equator, while variability near the theoretical second meridional-mode Rossby wave dispersion curve is dominantly antisymmetric. These results are qualitatively consistent with expectations from classical or shear-modified theories of equatorial waves. The meridional structures of these modes resemble the meridional modes of equatorial wave theory, but there are some robust features of the meridional profiles that were not anticipated. The meridional sea level structure in the intraseasonal Kelvin wave band closely resembles the theoretically expected Gaussian profile, but sea level variability coherent with that at the equator is detected as far away as 11.75°S, possibly as a result of the forced nature of these Kelvin waves. Both first and second meridional-mode Rossby waves have larger amplitude in the Northern Hemisphere. The meridional sea level structure of tropical instability waves closely resembles that predicted by Lyman et al. using a model linearized about a realistic equatorial zonal current system.This work was supported in part by the NOAA Climate Prediction Program for the Americas (Grant NA17RJ1223)

Structure of Human DNA Polymerase κ Inserting dATP Opposite an 8-OxoG DNA Lesion

Background: Oxygen-free radicals formed during normal aerobic cellular metabolism attack bases in DNA and 7,8-dihydro-8-oxoguanine (8-oxoG) is one of the major lesions formed. It is amongst the most mutagenic lesions in cells because of its dual coding potential, wherein 8-oxoG(syn) can pair with an A in addition to normal base pairing of 8-oxoG(anti) with a C. Human DNA polymerase κ (Polκ) is a member of the newly discovered Y-family of DNA polymerases that possess the ability to replicate through DNA lesions. To understand the basis of Polκ\u27s preference for insertion of an A opposite 8-oxoG lesion, we have solved the structure of Polκ in ternary complex with a template-primer presenting 8-oxoG in the active site and with dATP as the incoming nucleotide. Methodology and Principal Findings: We show that the Polκ active site is well-adapted to accommodate 8-oxoG in the syn conformation. That is, the polymerase and the bound template-primer are almost identical in their conformations to that in the ternary complex with undamaged DNA. There is no steric hindrance to accommodating 8-oxoG in the syn conformation for Hoogsteen base-paring with incoming dATP. Conclusions and Significance: The structure we present here is the first for a eukaryotic translesion synthesis (TLS) DNA polymerase with an 8-oxoG:A base pair in the active site. The structure shows why Polκ is more efficient at inserting an A opposite the 8-oxoG lesion than a C. The structure also provides a basis for why Polκ is more efficient at inserting an A opposite the lesion than other Y-family DNA polymerases

Theory of anyon excitons: Relation to excitons of nu=1/3 and nu=2/3 incompressible liquids

Elementary excitations of incompressible quantum liquids (IQL's) are anyons, i.e., quasiparticles carrying fractional charges and obeying fractional statistics. To find out how the properties of these quasiparticles manifest themselves in the optical spectra, we have developed the anyon exciton model (AEM) and compared the results with the finite-size data for excitons of nu=1/3 and nu=2/3 IQL's. The model considers an exciton as a neutral composite consisting of three quasielectrons and a single hole. The AEM works well when the separation between electron and hole confinement planes, h, is larger than the magnetic length l. In the framework of the AEM an exciton possesses momentum k and two internal quantum numbers, one of which can be chosen as the angular momentum, L, of the k=0 state. Existence of the internal degrees of freedom results in the multiple branch energy spectrum, crater-like electron density shape and 120 degrees density correlations for k=0 excitons, and the splitting of the electron shell into bunches for non-zero k excitons. For h larger than 2l the bottom states obey the superselection rule L=3m (m are integers starting from 2), all of them are hard core states. For h nearly 2l there is one-to-one correspondence between the low-energy spectra found for the AEM and the many- electron exciton spectra of the nu=2/3 IQL, whereas some states are absent from the many-electron spectra of the nu=1/3 IQL. We argue that this striking difference in the spectra originates from the different populational statistics of the quasielectrons of charge conjugate IQL's and show that the proper account of the statistical requirements eliminates excessive states from the spectrum. Apparently, this phenomenon is the first manifestation of the exclusion statistics in the anyon bound states.Comment: 26 pages with 9 figures, typos correcte

Vector-Virus Mutualism Accelerates Population Increase of an Invasive Whitefly

The relationships between plant viruses, their herbivore vectors and host plants can be beneficial, neutral, or antagonistic, depending on the species involved. This variation in relationships may affect the process of biological invasion and the displacement of indigenous species by invaders when the invasive and indigenous organisms occur with niche overlap but differ in the interactions. The notorious invasive B biotype of the whitefly complex Bemisia tabaci entered China in the late 1990s and is now the predominant or only biotype in many regions of the country. Tobacco curly shoot virus (TbCSV) and Tomato yellow leaf curl China virus (TYLCCNV) are two whitefly-transmitted begomoviruses that have become widespread recently in south China. We compared the performance of the invasive B and indigenous ZHJ1 whitefly biotypes on healthy, TbCSV-infected and TYLCCNV-infected tobacco plants. Compared to its performance on healthy plants, the invasive B biotype increased its fecundity and longevity by 12 and 6 fold when feeding on TbCSV-infected plants, and by 18 and 7 fold when feeding on TYLCCNV-infected plants. Population density of the B biotype on TbCSV- and TYLCCNV-infected plants reached 2 and 13 times that on healthy plants respectively in 56 days. In contrast, the indigenous ZHJ1 performed similarly on healthy and virus-infected plants. Virus-infection status of the whiteflies per se of both biotypes showed limited effects on performance of vectors on cotton, a nonhost plant of the viruses. The indirect mutualism between the B biotype whitefly and these viruses via their host plants, and the apparent lack of such mutualism for the indigenous whitefly, may contribute to the ability of the B whitefly biotype to invade, the displacement of indigenous whiteflies, and the disease pandemics of the viruses associated with this vector