The Inland Empire in 2015

Presents projections for international and local migration, demographics, education, economic and employment conditions, and political participation for Southern California's Riverside and San Bernardino counties

Educational Progress Across Immigrant Generations in California

Explores the disparities in levels of educational progress among different immigrant population groups in California. Examines factors that influence educational attainment among youth by race, ethnicity, and generation. Includes policy considerations

Development and validation of a model for training maintenance supervisors for productivity improvements in manufacturing operations

The problem of this study was to develop and validate a training model for training maintenance supervisors. This training model focused on those areas, defined by industrial managers, where additional supervisory training was most likely to improve the performance of the maintenance departments. Research of industrial and maintenance publications identified the maintenance function as having one of the lowest productivity levels in manufacturing organizations. Supervisor training was identified as a means to improve productivity in maintenance departments. An industrial survey completed by maintenance managers in manufacturing organizations in Iowa, Illinois, Minnesota, and Wisconsin identified those activities that were the responsibility of maintenance supervisors. The managers rated the potential for each activity to improve productivity in maintenance if the supervisors received training. Research in training and educational journals identified models in use, the structure and components of models, and means of model validation. Training journals and maintenance publications were used to identify training methodology for types of activities, training logistics design, and measures of productivity evaluation for maintenance departments. A jury of 15 experts with proficiency in maintenance operations, maintenance publications, and industrial training was used to validate the training model and its components. A maintenance supervisor training model was constructed with five major components: needs assessment, content analysis, instructional methodology, instructional design, and evaluation. A number of instruments were developed to provide industrial managers and trainers with a sequential and logical approach to work through the model. Results of the validation by the jury of experts revealed that the model contained the required components and approach to achieve productivity improvements in maintenance departments. The logical and structured approach of the model was essential due to time and budget constraints, and the limited number of maintenance supervisors in manufacturing organizations. Additional measures of maintenance productivity were identified and other industrial applications of this type of model were discussed

Version Control Integration of Build Maintenance Tools with Formiga

The task of build maintenance consists of creating, configuring, and updating the build system of a software engineering project. A project of sufficient size and scope is likely to have some sort of build system due to the complexity and time required to create a finished product. Build maintenance has been shown to greatly increase the cost of developing software due to the common need to modify a build system at the same time as the source code. Unfortunately, there is little in the way of tool support to assist developers with build maintenance. Formiga is a build maintenance and dependency discovery tool developed by Hardt. Formiga provides support for build refactoring, dependency identification, and automatic build updating based on modifications to source code. This thesis expands upon the original Formiga tool by investigating what kind of hurdles would be involved in integrating it with a production-quality version control system. An initial implementation of version control integration is built on top of the Formiga IDE plugin. It makes use of a mock version control system to keep track of file and file dependency history. This work, while not integrating with a production-quality version control system, lays a basis on which to perform that full integration in future iterations of Formiga

Angular momentum and clustering properties of early dark matter halos

In this paper we study the angular momentum properties of simulated dark matter halos at high redshift that likely host the first stars in the Universe. Calculating the spin distributions of these 10^6 - 10^7 \Msun halos in redshift slices from $z = 15 - 6$, we find that they are well fit by a log-normal distribution as is found for lower redshift and more massive halos in earlier work. We find that both the mean value of the spin and dispersion are largely unchanged with redshift for all halos. Our key result is that subsamples of low and high spin 10^6 \Msun and 10^7 \Msun halos show difference in clustering strength. In both mass bins, higher spin halos are more strongly clustered in concordance with a tidal torquing picture for the growth of angular momentum in dark matter halos in the CDM paradigm.Comment: 6 pages, 3 figures. Accepted MNRA

Process, Ideology, and Willingness to Pay for Reducing Childhood Poverty

We investigated the perceived value of government programs on early-childhood development as a means of reducing childhood poverty. We incorporated preferences for the process as well as the outcome by developing two stated-preference survey instruments. One survey directly elicited respondents’ willingness to pay specifically for high-quality, intensive, early-childhood development programs at federal and state levels. A second survey elicited respondents’ preferences for increasing or decreasing taxes and reallocating expenditures between other government programs and early-childhood programs. We found that respondents cared greatly about how childhood poverty was reduced, not just reducing poverty per se. The perceived effectiveness of a program and ideological perspective were found to be important determinants of preferences for a poverty-reduction program. Respondents across all groups, including conservatives and respondents who perceived the effectiveness of early-childhood programs to be low, were not in favor of reducing the early-childhood program.</jats:p

Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration.

PurposeTo redesign a complement-inhibiting peptide with the potential to become a therapeutic for dry and wet age-related macular degeneration (AMD).MethodsWe present a new potent peptide (Peptide 2) of the compstatin family. The peptide is developed by rational design, based on a mechanistic binding hypothesis, and structural and physicochemical properties derived from molecular dynamics (MD) simulation. The inhibitory activity, efficacy, and solubility of Peptide 2 are evaluated using a hemolytic assay, a human RPE cell-based assay, and ultraviolet (UV) absorption properties, respectively, and compared to the respective properties of its parent peptide (Peptide 1).ResultsThe sequence of Peptide 2 contains an arginine-serine N-terminal extension (a characteristic of parent Peptide 1) and a novel 8-polyethylene glycol (PEG) block C-terminal extension. Peptide 2 has significantly improved aqueous solubility compared to Peptide 1 and comparable complement inhibitory activity. In addition, Peptide 2 is more efficacious in inhibiting complement activation in a cell-based model that mimics the pathobiology of dry AMD.ConclusionsWe have designed a new peptide analog of compstatin that combines N-terminal polar amino acid extensions and C-terminal PEGylation extensions. This peptide demonstrates significantly improved aqueous solubility and complement inhibitory efficacy, compared to the parent peptide. The new peptide overcomes the aggregation limitation for clinical translation of previous compstatin analogs and is a candidate to become a therapeutic for the treatment of AMD