Evolution of the discrete cosine transform using genetic programming

Compression of 2 dimensional data is important for the efficient transmission, storage and manipulation of Images. The most common technique used for lossy image compression relies on fast application of the Discrete Cosine Transform (DCT). The cosine transform has been heavily researched and many efficient methods have been determined and successfully applied in practice; this paper presents a novel method for evolving a DCT algorithm using genetic programming. We show that it is possible to evolve a very close approximation to a 4 point transform. In theory, an 8 point transform could also be evolved using the same technique

Method of resolving clock synchronization error and means therefor Patent

Development of method for synchronizing clocks at several ground stations based on signals received from spacecraft or satellite

Laxatives do not improve symptoms of opioid-induced constipation: results of a patient survey

Introduction: Laxatives are commonly used to treat opioid-induced constipation, the commonest and most bothersome complication of opioids. However, laxatives have a non-specific action and do not target underlying mechanisms of opioid-induced constipation; their use is associated with abdominal symptoms that negatively impact quality of life. Objective: To assess the effects of laxatives in patients taking opioids for chronic pain. Methods: 198 UK patients who had taken opioid analgesics for at least one month completed a cross-sectional online or telephone survey. Questions addressed their pain condition and medication, and laxative use (including efficacy and side-effects). The survey also assessed bowel function using the Bowel Function Index. Results: Since starting their current opioid, 134/184 patients (73%) had used laxatives at some point and 122 (91%) of these were currently taking them. The most common laxatives were osmotics and stimulants. Laxative side-effects were reported in 75%, most commonly gas, bloating/fullness and a sudden urge to defecate. Side-effects were more common in patients <40 years old. Approximately half of patients said laxatives interfered with work and social activities, and one-fifth had needed an overnight hospital stay because of their pain condition and/or constipation. Laxatives did not improve the symptoms of constipation, as assessed by the Bowel Function Index. Constipation was not related to opioid strength or dose of opioid or number of laxatives taken. Conclusions: Use of laxatives to treat opioid-induced constipation is often ineffective and associated with side-effects. Instead of relieving the burden of opioid-induced constipation, laxative use is associated with a negative impact

INTERNATIONAL TRADE: HOW IT AFFECTS VIRGINIA AGRICULTURE

International Relations/Trade,

Empowering Developing Countries to Lead the Aid Partnership

human development, aid, trade, security

Tolerability, safety, and efficacy of adjunctive brivaracetam for focal seizures in older patients: A pooled analysis from three phase III studies

Introduction: This analysis was conducted to assess the tolerability, safety, and efficacy of brivaracetam (BRV) for adjunctive treatment of focal (partial-onset) seizures in patients aged ≥65 years. Methods: Safety/tolerability and efficacy data for patients aged ≥65 years were pooled from three randomized, double-blind, placebo-controlled, fixed-dose Phase III studies (NCT00490035, NCT00464269, and NCT01261325). Data were pooled by treatment group: placebo or the proposed therapeutic dose range of 50–200 mg/day: BRV 50, 100, 200 mg/day. Results: Thirty-two patients aged ≥65 years were randomized to placebo or BRV 50–200 mg/day. Of these, 30 patients (93.8%) completed their respective study. In the safety population (n = 32), 87.5% placebo- vs 73.3% BRV-treated patients reported treatment-emergent adverse events (TEAEs) during the treatment period; most commonly, headache (25.0% vs 12.5%), paresthesia (0% vs 12.5%), and somnolence (50.0% vs 12.5%) for placebo- vs BRV-treated patients, respectively. During the treatment period, drug-related TEAEs were reported by 62.5% of placebo- vs 53.3% of BRV-treated patients, and serious TEAEs (SAEs) were reported by 0% of placebo- and 4.2% of BRV-treated patients; there were no drug-related SAEs and no deaths. Three SAEs (placebo 1/8; BRV 2/24) and two deaths (placebo 1/8; BRV 1/24) occurred in the post-treatment period. In the efficacy population (n = 31), median percent reduction from baseline in focal seizure frequency/28 days was 14.0% for placebo vs 25.5%, 49.6%, and 74.9% for BRV 50, 100, and 200 mg/day, respectively. The ≥50% responder rate was 14.3% for placebo vs 25.0%, 50.0%, and 66.7% for BRV 50, 100, and 200 mg/day, respectively. Conclusions: Safety/tolerability and efficacy findings in this small subgroup of older patients treated with adjunctive BRV are consistent with those observed in the much larger overall pooled population. BRV may be a suitable adjunctive treatment for older patients with uncontrolled focal seizures. Further larger studies in this population are warranted

Consumer Credit in America: Past, Present, and Future

In September 2016, in conjunction with Law & Contemporary Problems at Duke University School of Law, we organized a symposium on Consumer Credit in America. We sought to assess the state of consumer credit in America — to review and examine its recent history, to consider arguments for and against regulation, and to discuss the potential for future innovation. This is the introduction to the volume of articles coming out of that symposium

Do we really need to catch them all? A new User-guided Social Media Crawling method

With the growing use of popular social media services like Facebook and Twitter it is challenging to collect all content from the networks without access to the core infrastructure or paying for it. Thus, if all content cannot be collected one must consider which data are of most importance. In this work we present a novel User-guided Social Media Crawling method (USMC) that is able to collect data from social media, utilizing the wisdom of the crowd to decide the order in which user generated content should be collected to cover as many user interactions as possible. USMC is validated by crawling 160 public Facebook pages, containing content from 368 million users including 1.3 billion interactions, and it is compared with two other crawling methods. The results show that it is possible to cover approximately 75% of the interactions on a Facebook page by sampling just 20% of its posts, and at the same time reduce the crawling time by 53%. In addition, the social network constructed from the 20% sample contains more than 75% of the users and edges compared to the social network created from all posts, and it has similar degree distribution

Optimization of leaf morphology in relation to leaf water status: A theory.

The leaf economic traits such as leaf area, maximum carbon assimilation rate, and venation are all correlated and related to water availability. Furthermore, leaves are often broad and large in humid areas and narrower in arid/semiarid and hot and cold areas. We use optimization theory to explain these patterns. We have created a constrained optimization leaf model linking leaf shape to vein structure that is integrated into coupled transpiration and carbon assimilation processes. The model maximizes net leaf carbon gain (NPPleaf) over the loss of xylem water potential. Modeled relations between leaf traits are consistent with empirically observed patterns. As the results of the leaf shape-venation relation, our model further predicts that a broadleaf has overall higher NPPleaf compared to a narrowleaf. In addition, a broadleaf has a lower stomatal resistance compared to a narrowleaf under the same level of constraint. With the same leaf area, a broadleaf will have, on average, larger conduits and lower total leaf xylem resistance and thus be more efficient in water transportation but less resistant to cavitation. By linking venation structure to leaf shape and using water potential as the constraint, our model provides a physical explanation for the general pattern of the covariance of leaf traits through the safety-efficiency trade-off of leaf hydraulic design